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<!DOCTYPE html>
<html lang="en">
<head>
<title>
Jiawei Xing
</title>
<meta name="viewport" content="width=device-width, initial-scale=1">
<link rel="stylesheet" href="https://stackpath.bootstrapcdn.com/bootstrap/4.4.1/css/bootstrap.min.css" integrity="sha384-Vkoo8x4CGsO3+Hhxv8T/Q5PaXtkKtu6ug5TOeNV6gBiFeWPGFN9MuhOf23Q9Ifjh" crossorigin="anonymous">
<link rel="stylesheet" href="style.css">
<script src="index.js"></script>
</head>
<body>
<img src="picture.jpg" title="Alum Creek Lake, OH" style="width:100%">
<img src="header.png" style="display:none">
<h1>Jiawei Xing</h1>
<nav class="navbar navbar-expand-lg navbar-light" style="background-color: white">
<ul class="navbar-nav mr-auto">
<li class="nav-item">
<button class="nav-link" id="home">Home</button>
</li>
<li class="nav-item">
<button class="nav-link" id="research">Research</button>
</li>
<li class="nav-item">
<button class="nav-link" id="publication">Publications</button>
</li>
<li class="nav-item">
<button class="nav-link" id="contact">Contact</button>
</li>
</ul>
</nav>
<br>
<div id="home_view" class="section">
<h3>About Me</h3>
<img src="jiaweixing.jpg">
<p>Hello, I'm Jiawei Xing, a computational biologist. I'm currently a postdoc in the <a href="https://siepellab.labsites.cshl.edu/">Siepel lab</a> at Cold Spring Harbor Laboratory. Before that, I received my PhD degree from the <a href="https://biology.joulinelab.org/">Jouline lab</a> at The Ohio State University. I also received my BS degree from Beijing Normal University. My research interests are computational and evolutionary biology.</p>
<hr>
<h3>Education Background</h3>
<p>2019 - 2023: The Ohio State University. PhD, Microbiology</p>
<p>2015 - 2019: Beijing Normal University. BS, Biological Sciences</p>
<hr>
<h3>Research Experiences</h3>
<p><b>2021.1 - 2023.12: Graduate research assistant at The Ohio State University</b></p>
<ul>
<li>Advisor: Dr. Igor Jouline</li>
<li>Understanding protein structures and evolution using phylogenetic analyses, biological networks, clustering algorithms, and hidden Markov models</li>
<li>Studying ligand-protein interactions using molecular docking and virtual ligand screening</li>
<li>Developing computational tools for bioinformatic analysis</li>
</ul>
<p><b>2018.11 - 2019.4: Undergraduate thesis at Institute of Microbiology, Chinese Academy of Sciences</b></p>
<ul>
<li>Advisor: Dr. Guanghua Huang</li>
<li>Discovery of novel drugs for fungal pathogen <i>Candida auris</i></li>
</ul>
<p><b>2018.7 - 2018.10: Undergraduate summer intern at IMCB (Institute of Molecular and Cell Biology), A*STAR (Agency for Science, Technology and Research), Singapore</b></p>
<ul>
<li>Advisor: Dr. Yue Wang</li>
<li>Genome-wide screening of drug resistance genes in <i>Candida albicans</i></li>
</ul>
<p><b>2017.3 - 2018.6: Undergraduate project at Beijing Normal University</b></p>
<ul>
<li>Advisor: Dr. Wanjie Li</li>
<li>Studied heat-shock protein 82 (Hsp82) and replicative life span in <i>Saccharomyces cerevisiae</i></li>
<li>Developed a Mother Enrichment Program (MEP) using toxin-antitoxin systems</li>
</ul>
<p><b>2017.3 - 2017.11: <a href="http://2017.igem.org/Team:BNU-China">BNU-China</a> team for 2017 iGEM (International Genetically Engineered Machine)</b></p>
<ul>
<li>Advisor: Dr. Dong Yang, Dr. Xudong Zhu</li>
<li>Novel surface display systems on <i>Saccharomyces cerevisiae</i></li>
</ul>
<hr>
<h3>Teaching Experience</h3>
<p><b>2019.8 - 2020.12: Graduate teaching assistant at The Ohio State University</b></p>
<ul>
<li>Professor: Dr. Mette Ibba</li>
<li>Labs for Basic and Practical Microbiology</li>
</ul>
<hr>
<h3>Posters and Presentations</h3>
<ul>
<li>Bacterial Locomotion and Signal Transduction (BLAST) Conference. Charleston, SC. Jan 2023</li>
<li>OSU Microbiology Department Annual Symposium. Columbus, OH. Dec 2022</li>
<li>Sensory Transduction in Microorganisms Conference GRC. Ventura, CA. Sep 2022</li>
<li>Bacterial Locomotion and Signal Transduction (BLAST) Conference. Online. Jan 2021</li>
<li>Beijing Normal University Bio-Liyun Annual Symposium. Beijing, China. Mar 2018</li>
<li>International Genetically Engineered Machine (iGEM) Competition. Boston, MA. Nov 2017</li>
</ul>
<hr>
<h3>Skills</h3>
<ul>
<li><b>Bioinformatics:</b> multiple sequence alignment, sequence similarity networks, clustering algorithms, phylogenetic trees, protein structure, molecular docking, virtual ligand screening, hidden Markov models</li>
<li><b>Programming languages:</b> Python, C, R, Bash, JavaScript, SQL, MATLAB, Octave</li>
<li><b>Web development:</b> Flask, Django, HTML, CSS, JavaScript, SQL, API</li>
<li><b>Machine learning:</b> linear regression, logistic regression, neural networks, SVM, clustering, PCA</li>
</ul>
<hr>
<h3>Certificates and Awards</h3>
<ul>
<li><a href="https://certificates.cs50.io/9d7c9992-4670-4f92-a0e8-2be91f3391e2">CS50x: Introduction to Computer Science</a></li>
<li><a href="https://certificates.cs50.io/32e5e902-d10a-4e94-93b1-dc4d18c78231">CS50W: Web Programming with Python and JavaScript</a></li>
<li><a href="https://certificates.cs50.io/7e627635-f86d-4c2d-a29a-8400a9ef4622">CS50T: Understanding Technology</a></li>
<li><a href="https://certificates.cs50.io/a913a3dc-2ac9-494e-ad19-5c5b43ba0064">CS50AI: Introduction to Artificial Intelligence with Python</a></li>
<li><a href="https://certificates.cs50.io/54b01919-6c5a-4071-8b58-dbce4d77787e">CS50P: Introduction to Programming with Python</a></li>
<li><a href="https://www.coursera.org/account/accomplishments/certificate/VBR8Z2H4SAVT">Machine Learning</a></li>
<li><a href="https://www.cell.com/trends/microbiology/fulltext/S0966-842X(23)00096-3">2023 BLAST Board of Directors Award</a></li>
</ul>
</div>
<div id="research_view" class="section" style="display:none">
<h3>Evolution and structure of sensory domains</h3>
<p><a href="https://biology.joulinelab.org/research/">Jouline lab</a></p>
<br>
<h3>Cancer evolution</h3>
<p><a href="https://siepellab.labsites.cshl.edu/research-2/">Siepel lab</a></p>
</div>
<div id="publication_view" class="section" style="display:none">
<a href="https://scholar.google.com/citations?user=RYuABwkAAAAJ&hl=en&authuser=1">Google Scholar</a>
<br>
<ol>
<li>Velando F*, <b>Xing J*</b>, Genova R*, Cerna-Vargas JP, Vázquez-Santiago R, Matilla MA, Zhulin IB, Krell T. Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate. <i>bioRxiv.</i> doi:https://doi.org/10.1101/2024.12.10.627748.</li>
<li>Monteagudo-Cascales E*, Gavira JA*, <b>Xing J*</b>, Velando F, Matilla MA, Zhulin IB, Krell T. Bacterial sensor evolved by decreasing complexity. In Press. <i>PNAS.</i> doi:https://doi.org/10.1101/2024.05.17.594639.</li>
<li>Ruiz N, <b>Xing J</b>, Zhulin IB, Brautigam CA, Hendrixson DR. The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction. <i>mBio</i>. Published online December 13, 2024. doi:10.1128/mbio.03278-24</li>
<li><b>Xing J</b>, Gumerov VM, Zhulin IB. Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor. <i>Sci Adv. </i>2023;9(35):eadi4517. doi:10.1126/sciadv.adi4517. </li>
<li>Demey LM*, Gumerov VM*, <b>Xing J</b>, Zhulin IB, DiRita VJ. Transmembrane Transcription Regulators Are Widespread in Bacteria and Archaea. <i>Microbiol Spectr. </i>2023;11(3):e0026623. doi:10.1128/spectrum.00266-23. </li>
<li><b>Xing J</b>, Gumerov VM, Zhulin IB. Photoactive Yellow Protein Represents a Distinct, Evolutionarily Novel Family of PAS Domains. <i>J Bacteriol. </i>2022;204(11):e0030022. doi:10.1128/jb.00300-22. <b>Editor's Pick</b>.</li>
</ol>
<br>
* Co-first authors
</div>
<div id="contact_view" class="section" style="display:none">
<a href="https://www.linkedin.com/in/jiawei-xing-ba2a35168/"><img src="linkedin.png"></a>
<a href="https://github.com/Jiawei-Xing"><img src="github.png"></a>
<a href="https://www.zhihu.com/people/xing-jia-wei-54-70"><img src="zhihu.png"></a>
<a href="https://www.youtube.com/channel/UC5WtnozEZNdNQbgLejgpURg"><img src="youtube.png"></a>
<a href="https://twitter.com/jiawei_xing"><img src="twitter.png"></a>
<br>
<p>Email: [email protected]</p>
<p>Address: <br>
One Bungtown Rd, Cold Spring Harbor, NY 11724</p>
</div>
</body>
<footer>
Jiawei Xing
</footer>
</html>