From 455dfe18a3e12564c99df7235ed4ae6cb9abec68 Mon Sep 17 00:00:00 2001 From: "Wang, Benjamin" Date: Wed, 30 Oct 2024 15:39:28 -0400 Subject: [PATCH 01/10] tidy style the program --- R/collect.R | 16 +- R/format_base_char_subgroup.R | 62 +++---- R/format_sl_summary.R | 10 +- R/meta_sl.R | 24 +-- R/meta_sl_example.R | 91 +++++----- R/prepare_base_char.R | 13 +- R/prepare_base_char_subgroup.R | 50 +++-- R/prepare_disposition.R | 15 +- R/prepare_exp_duration.R | 16 +- R/prepare_sl_summary.R | 6 +- R/prepare_trt_compliance.R | 16 +- R/rtf_base_char_subgroup.R | 155 ++++++++-------- R/rtf_exp_duration.R | 10 +- R/rtf_sl_summary.R | 8 +- R/utils.R | 6 +- R/zzz.R | 2 +- .../test-independent-testing-disposition.R | 40 ++-- ...-independent-testing-format_exp_duration.R | 166 ++++++++--------- ...independent-testing-prepare_exp_duration.R | 171 +++++++++--------- .../test-independent-testing-rtf_base_char.R | 22 +-- ...est-independent-testing-rtf_exp_duration.R | 25 ++- .../test-independent-testing-trt_compliance.R | 56 +++--- vignettes/Disposition.Rmd | 22 +-- vignettes/baseline-character.Rmd | 79 +++++--- vignettes/exp_duration.Rmd | 105 +++++------ vignettes/metalite-sl.Rmd | 49 ++--- 26 files changed, 618 insertions(+), 617 deletions(-) diff --git a/R/collect.R b/R/collect.R index 7ce61da..38ecad1 100644 --- a/R/collect.R +++ b/R/collect.R @@ -205,18 +205,17 @@ collect_baseline <- function( # variable lower level if (!is.null(par_var_lower)) { - # Obtain number of subjects - pop_num_lower <- apply(pop_num, 1, function (x) { + pop_num_lower <- apply(pop_num, 1, function(x) { pop_lower <- pop[pop[[par_var]] == x[["name"]] & !is.na(pop[[par_var_lower]]), ] id_lower <- seq(pop_lower[[pop_id]]) group_lower <- pop_lower[[pop_group]] varlower <- pop_lower[[par_var_lower]] stopifnot(inherits(varlower, c("factor", "character"))) if (any(c("character") %in% class_var)) { - varlower <- factor(varlower, exclude = NULL) + varlower <- factor(varlower, exclude = NULL) } - + if (length(varlower) > 0) { lower <- metalite::n_subject(id_lower, group_lower, par = varlower) max_length <- sapply(pop_num, function(x) max(nchar(x))) @@ -231,16 +230,16 @@ collect_baseline <- function( } }) pop_num <- do.call(rbind, pop_num_lower) - + # Obtain proportion - pop_prop_lower <- apply(pop_prop, 1, function (x) { + pop_prop_lower <- apply(pop_prop, 1, function(x) { pop_lower <- pop[pop[[par_var]] == x[["name"]] & !is.na(pop[[par_var_lower]]), ] id_lower <- seq(pop_lower[[pop_id]]) group_lower <- pop_lower[[pop_group]] varlower <- pop_lower[[par_var_lower]] stopifnot(inherits(varlower, c("factor", "character"))) varlower <- factor(varlower, exclude = NULL) - + if (length(varlower) > 0) { lower <- metalite::n_subject(id_lower, group_lower, par = varlower) for (i in seq(names(lower))) { @@ -256,9 +255,8 @@ collect_baseline <- function( } }) pop_prop <- do.call(rbind, pop_prop_lower) - } - + pop_n["var_label"] <- label pop_num["var_label"] <- label pop_prop["var_label"] <- label diff --git a/R/format_base_char_subgroup.R b/R/format_base_char_subgroup.R index 9f29a57..c79ad13 100644 --- a/R/format_base_char_subgroup.R +++ b/R/format_base_char_subgroup.R @@ -18,7 +18,7 @@ #' Prepare data for Subgroup Analysis for Baseline Characteristic #' -#' @param outdata A metadata object created by [prepare_base_char_subgroup()]. +#' @param outdata A metadata object created by [prepare_base_char_subgroup()]. #' @param display Column wants to display on the table. #' The term could be selected from `c("n", "prop", "total")`. #' @param display_stat A vector of statistics term name. @@ -30,25 +30,23 @@ #' #' @examples #' meta <- meta_sl_example() -#' +#' #' outdata <- prepare_base_char_subgroup( -#' meta, -#' population = "apat", -#' parameter = "age", -#' subgroup_var = "TRTA", -#' subgroup_header = c("SEX","TRTA"), -#' display_subgroup_total = TRUE +#' meta, +#' population = "apat", +#' parameter = "age", +#' subgroup_var = "TRTA", +#' subgroup_header = c("SEX", "TRTA"), +#' display_subgroup_total = TRUE #' ) -#' +#' #' outdata |> format_base_char_subgroup() - format_base_char_subgroup <- function( outdata, - display = c("n","prop","total"), + display = c("n", "prop", "total"), display_stat = c("mean", "sd", "median", "range")) { - out_all <- outdata$out_all - + outlst <- list() for (i in seq_along(out_all)) { tbl <- out_all[[i]] |> @@ -57,42 +55,42 @@ format_base_char_subgroup <- function( digits_prop = 1, display_stat = display_stat ) - - #names(tbl$tbl)[-1] <- paste0(names(out_all[i]), names(tbl$tbl)[-1]) - names(tbl$tbl)[-1] <- ifelse(grepl("_label",names(tbl$tbl)[-1]) %in% "FALSE", paste0(names(out_all[i]), names(tbl$tbl)[-1]),names(tbl$tbl)[-1]) - + + # names(tbl$tbl)[-1] <- paste0(names(out_all[i]), names(tbl$tbl)[-1]) + names(tbl$tbl)[-1] <- ifelse(grepl("_label", names(tbl$tbl)[-1]) %in% "FALSE", paste0(names(out_all[i]), names(tbl$tbl)[-1]), names(tbl$tbl)[-1]) + tbl$tbl$order <- as.numeric(rownames(tbl$tbl)) - + outlst[[i]] <- tbl$tbl } - + names(outlst) <- names(out_all) outlst <- outlst[-length(outlst)] - + i <- 1 while (i < length(outlst)) { if (i == 1) { - tbl <- merge(outlst[[i]], outlst[[i + 1]], by = c("name","var_label","order"), all = TRUE) + tbl <- merge(outlst[[i]], outlst[[i + 1]], by = c("name", "var_label", "order"), all = TRUE) } - + i <- i + 1 - + if (i > 1 && i < length(outlst)) { - tbl <- merge(tbl, outlst[[i + 1]], by = c("name","var_label","order"), all = TRUE) + tbl <- merge(tbl, outlst[[i + 1]], by = c("name", "var_label", "order"), all = TRUE) } } - - + + # If outdata$display_subgroup_total = FALSE, remove that part - #if (!outdata$display_subgroup_total) { + # if (!outdata$display_subgroup_total) { # rm_tot <- names(outlst$Total) # Columns from Total Section # rm_tot <- rm_tot[!rm_tot %in% c("name", "order")] - + # tbl <- tbl[, -which(names(tbl) %in% rm_tot)] - #} - - outdata$tbl <- tbl[order(tbl$order),] + # } + + outdata$tbl <- tbl[order(tbl$order), ] outdata$display <- display outdata$display_stat <- display_stat outdata -} \ No newline at end of file +} diff --git a/R/format_sl_summary.R b/R/format_sl_summary.R index 54eebdb..b954597 100644 --- a/R/format_sl_summary.R +++ b/R/format_sl_summary.R @@ -41,21 +41,19 @@ format_sl_summary <- function( display_col = c("n", "prop", "total"), digits_prop = 1, display_stat = c("mean", "sd", "se", "median", "q1 to q3", "range")) { - - n_group <- length(outdata$group_label) - + # Check if the "tbl" element exists in the "outdata" object if ("tbl" %in% names(outdata)) { # If the element exists, delete it outdata$tbl <- NULL - } - + } + # Select statistics want to display for (i in 1:length(outdata$var_type)) { - if ( ("integer" %in% outdata$var_type[[i]]) || ("numeric" %in% outdata$var_type[[i]]) ) { + if (("integer" %in% outdata$var_type[[i]]) || ("numeric" %in% outdata$var_type[[i]])) { n_num <- outdata$char_n[[i]] n_num_group <- n_num[which(!tolower(n_num$name) %in% c( diff --git a/R/meta_sl.R b/R/meta_sl.R index 4f87715..992a20c 100644 --- a/R/meta_sl.R +++ b/R/meta_sl.R @@ -26,7 +26,7 @@ #' If there are multiple terms, they are separated by the semicolon (;). #' @param parameter_var A character value of parameter variable name. #' If there are multiple variables, they are separated by the semicolon (;). -#' A group variable can be specified followed by a variable +#' A group variable can be specified followed by a variable #' and the hat symbol (^). #' @param parameter_labels A character vector of parameter label name. #' The length of vector should be the same as the number of parameter terms. @@ -65,7 +65,6 @@ meta_sl <- function( observation_subset = NULL, population_label = "All Participants as Treated", treatment_group = "TRT01A") { - # Check input if (is.null(dataset_observation)) { dataset_observation <- dataset_population @@ -84,11 +83,11 @@ meta_sl <- function( stop("The number of parameter labels should be the same as that of parameter terms.") } parameter_vars <- strsplit(unlist(strsplit(parameter_var, ";")), "^", fixed = TRUE) - + meta <- metalite::meta_adam( population = as.data.frame(dataset_population), observation = as.data.frame(dataset_observation) - )|> + ) |> metalite::define_plan(plan = metalite::plan( analysis = analysis_term, population = population_term, @@ -109,7 +108,7 @@ meta_sl <- function( var = names(dataset_observation), label = "" ) - + for (i in seq(parameter_terms)) { var <- parameter_vars[[i]] vargroup <- NULL @@ -120,14 +119,15 @@ meta_sl <- function( vargroup <- parameter_vars[[i]][[2]] } if (!is.null(parameter_labels)) { - varlabel <- ifelse(!is.na(parameter_labels[i]), - parameter_labels[i], - attr(dataset_population[[var]], "label")) + varlabel <- ifelse(!is.na(parameter_labels[i]), + parameter_labels[i], + attr(dataset_population[[var]], "label") + ) } else { varlabel <- attr(dataset_population[[var]], "label") } - - meta <- meta |> + + meta <- meta |> metalite::define_parameter( name = parameter_terms[[i]], var = var, @@ -144,6 +144,6 @@ meta_sl <- function( var_name = unlist(parameter_vars) ) |> metalite::meta_build() - + meta -} \ No newline at end of file +} diff --git a/R/meta_sl_example.R b/R/meta_sl_example.R index d684db7..964bc35 100644 --- a/R/meta_sl_example.R +++ b/R/meta_sl_example.R @@ -35,42 +35,50 @@ meta_sl_example <- function() { labels = c("Placebo", "Low Dose", "High Dose") ) adsl$SEX <- factor(adsl$SEX, - levels = c("F", "M"), - labels = c("Female", "Male") + levels = c("F", "M"), + labels = c("Female", "Male") ) - set.seed(123) + set.seed(123) # Create a variable EOSSTT indicating the end of end of study status - adsl$EOSSTT <- sample(x = c("Participants Ongoing", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.8, 0.2), replace = TRUE) - adsl[adsl[["EOSSTT"]] == "Discontinued", "DCSREAS"] <- sample(x = c("Adverse Event", "I/E Not Met", "Withdrew Consent", "Lack of Efficacy"), - size = length(adsl[adsl[["EOSSTT"]] == "Discontinued", "USUBJID"]), - prob = c(0.7, 0.1, 0.1, 0.1), replace = TRUE) + adsl$EOSSTT <- sample( + x = c("Participants Ongoing", "Discontinued"), + size = length(adsl$USUBJID), + prob = c(0.8, 0.2), replace = TRUE + ) + adsl[adsl[["EOSSTT"]] == "Discontinued", "DCSREAS"] <- sample( + x = c("Adverse Event", "I/E Not Met", "Withdrew Consent", "Lack of Efficacy"), + size = length(adsl[adsl[["EOSSTT"]] == "Discontinued", "USUBJID"]), + prob = c(0.7, 0.1, 0.1, 0.1), replace = TRUE + ) # Create a variable EOTSTT1 indicating the end of treatment status part 1 - adsl$EOTSTT1 <- sample(x = c("Completed", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.85, 0.15), replace = TRUE) - adsl[adsl[["EOTSTT1"]] == "Discontinued", "DCTREAS"] <- sample(x = c("Adverse Event", "Lack of Efficacy"), - size = length(adsl[adsl[["EOTSTT1"]] == "Discontinued", "USUBJID"]), - prob = c(0.9, 0.1), replace = TRUE) - + adsl$EOTSTT1 <- sample( + x = c("Completed", "Discontinued"), + size = length(adsl$USUBJID), + prob = c(0.85, 0.15), replace = TRUE + ) + adsl[adsl[["EOTSTT1"]] == "Discontinued", "DCTREAS"] <- sample( + x = c("Adverse Event", "Lack of Efficacy"), + size = length(adsl[adsl[["EOTSTT1"]] == "Discontinued", "USUBJID"]), + prob = c(0.9, 0.1), replace = TRUE + ) + plan <- metalite::plan( analysis = "base_char", population = "apat", observation = "apat", parameter = "age;gender;race" - ) |> + ) |> metalite::add_plan( analysis = "trt_compliance", population = "apat", observation = "apat", parameter = "comp8;comp16;comp24" ) |> metalite::add_plan( analysis = "disp", population = "apat", - observation = "apat", parameter = "disposition;medical-disposition" - ) |> + observation = "apat", parameter = "disposition;medical-disposition" + ) |> metalite::add_plan( analysis = "base_char_subgroup", population = "apat", observation = "apat", parameter = "age" ) - + meta <- metalite::meta_adam( population = adsl, observation = adsl @@ -160,34 +168,35 @@ meta_sl_example <- function() { #' meta_sl_exposure_example() meta_sl_exposure_example <- function() { adsl <- r2rtf::r2rtf_adsl - + # Create ADEXSUM dataset - adexsum <- data.frame(USUBJID=adsl$USUBJID) + adexsum <- data.frame(USUBJID = adsl$USUBJID) adexsum$TRTA <- factor(adsl$TRT01A, - levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), - labels = c("Placebo", "Low Dose", "High Dose") + levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), + labels = c("Placebo", "Low Dose", "High Dose") ) - + adexsum$APERIODC <- "Base" adexsum$APERIOD <- 1 - - set.seed(123) # Set a seed for reproducibility - adexsum$AVAL <- sample(x = 0:(24*7), size = length(adexsum$USUBJID), replace = TRUE) + + set.seed(123) # Set a seed for reproducibility + adexsum$AVAL <- sample(x = 0:(24 * 7), size = length(adexsum$USUBJID), replace = TRUE) adexsum$EXDURGR <- "not treated" - adexsum$EXDURGR[adexsum$AVAL>=1] <- ">=1 day" - adexsum$EXDURGR[adexsum$AVAL>=7] <- ">=7 days" - adexsum$EXDURGR[adexsum$AVAL>=28] <- ">=28 days" - adexsum$EXDURGR[adexsum$AVAL>=12*7] <- ">=12 weeks" - adexsum$EXDURGR[adexsum$AVAL>=24*7] <- ">=24 weeks" - + adexsum$EXDURGR[adexsum$AVAL >= 1] <- ">=1 day" + adexsum$EXDURGR[adexsum$AVAL >= 7] <- ">=7 days" + adexsum$EXDURGR[adexsum$AVAL >= 28] <- ">=28 days" + adexsum$EXDURGR[adexsum$AVAL >= 12 * 7] <- ">=12 weeks" + adexsum$EXDURGR[adexsum$AVAL >= 24 * 7] <- ">=24 weeks" + adexsum$EXDURGR <- factor(adexsum$EXDURGR, - levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks")) - + levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks") + ) + plan <- metalite::plan( analysis = "exp_dur", population = "apat", observation = "apat", parameter = "expdur" - ) - + ) + meta <- metalite::meta_adam( population = adexsum, observation = adexsum @@ -196,18 +205,18 @@ meta_sl_exposure_example <- function() { metalite::define_population( name = "apat", group = "TRTA", - subset = quote(APERIOD==1 & AVAL>0) + subset = quote(APERIOD == 1 & AVAL > 0) ) |> metalite::define_parameter( name = "expdur", var = "AVAL", label = "Exposure Duration (Days)", vargroup = "EXDURGR" - )|> + ) |> metalite::define_analysis( name = "exp_dur", title = "Summary of Exposure Duration", label = "exposure duration table" ) |> metalite::meta_build() -} \ No newline at end of file +} diff --git a/R/prepare_base_char.R b/R/prepare_base_char.R index ea33ab7..167b1e5 100644 --- a/R/prepare_base_char.R +++ b/R/prepare_base_char.R @@ -38,14 +38,13 @@ #' meta |> prepare_base_char() prepare_base_char <- function(meta, analysis = "base_char", - population = meta$plan[meta$plan$analysis==analysis,]$population, - parameter = paste(meta$plan[meta$plan$analysis==analysis,]$parameter, collapse = ";") -) { + population = meta$plan[meta$plan$analysis == analysis, ]$population, + parameter = paste(meta$plan[meta$plan$analysis == analysis, ]$parameter, collapse = ";")) { return( prepare_sl_summary(meta, - analysis = analysis, - population = population, - parameter = parameter + analysis = analysis, + population = population, + parameter = parameter ) ) -} \ No newline at end of file +} diff --git a/R/prepare_base_char_subgroup.R b/R/prepare_base_char_subgroup.R index b8bd609..4f64f9b 100644 --- a/R/prepare_base_char_subgroup.R +++ b/R/prepare_base_char_subgroup.R @@ -38,14 +38,13 @@ #' @examples #' meta <- meta_sl_example() #' outdata <- prepare_base_char_subgroup( -#' meta, -#' population = "apat", -#' parameter = "age", -#' subgroup_var = "TRTA", -#' subgroup_header = c("SEX","TRTA"), -#' display_subgroup_total = TRUE) - - +#' meta, +#' population = "apat", +#' parameter = "age", +#' subgroup_var = "TRTA", +#' subgroup_header = c("SEX", "TRTA"), +#' display_subgroup_total = TRUE +#' ) prepare_base_char_subgroup <- function( meta, population, @@ -54,12 +53,11 @@ prepare_base_char_subgroup <- function( subgroup_var, subgroup_header = c(meta$population[[population]]$group, subgroup_var), display_subgroup_total = TRUE) { - meta_original <- meta - - observation <- meta$plan[meta$plan$analysis==analysis,]$observation - - #Factor Level 1 Subgroup + + observation <- meta$plan[meta$plan$analysis == analysis, ]$observation + + # Factor Level 1 Subgroup meta$data_population[[subgroup_header[1]]] <- factor( as.character(meta$data_population[[subgroup_header[1]]]), levels = sort(unique(meta$data_population[[subgroup_header[1]]])) @@ -68,8 +66,8 @@ prepare_base_char_subgroup <- function( as.character(meta$data_observation[[subgroup_header[1]]]), levels = sort(unique(meta$data_observation[[subgroup_header[1]]])) ) - - #Factor Level 2 Subgroup + + # Factor Level 2 Subgroup meta$data_population[[subgroup_var]] <- factor( as.character(meta$data_population[[subgroup_var]]), levels = sort(unique(meta$data_population[[subgroup_var]])) @@ -78,36 +76,36 @@ prepare_base_char_subgroup <- function( as.character(meta$data_observation[[subgroup_var]]), levels = sort(unique(meta$data_observation[[subgroup_var]])) ) - + meta$observation[[observation]]$group <- subgroup_header[1] meta$population[[population]]$group <- subgroup_header[1] - + # Obtain variables par_var <- metalite::collect_adam_mapping(meta, parameter)$var - + meta_subgroup <- metalite::meta_split(meta, subgroup_header[2]) - + outdata_all <- prepare_sl_summary( meta, analysis = analysis, - population = meta$plan[meta$plan$analysis==analysis,]$population, + population = meta$plan[meta$plan$analysis == analysis, ]$population, parameter = parameter ) - + outdata_subgroup <- lapply( meta_subgroup, prepare_sl_summary, analysis = analysis, - population = meta$plan[meta$plan$analysis==analysis,]$population, + population = meta$plan[meta$plan$analysis == analysis, ]$population, parameter = parameter ) - + out_all <- outdata_subgroup out_all$Total <- outdata_all - + group <- as.character(outdata_subgroup[[1]]$group_label) group <- group[!group %in% "Total"] - + outdata <- list( group = group, subgroup = tools::toTitleCase(tolower(names(outdata_subgroup))), @@ -118,6 +116,4 @@ prepare_base_char_subgroup <- function( parameter = parameter, out_all = out_all ) - } - \ No newline at end of file diff --git a/R/prepare_disposition.R b/R/prepare_disposition.R index a9e9437..bb23fce 100644 --- a/R/prepare_disposition.R +++ b/R/prepare_disposition.R @@ -37,15 +37,14 @@ #' meta <- meta_sl_example() #' meta |> prepare_base_char() prepare_disposition <- function(meta, - analysis = "disp", - population = meta$plan[meta$plan$analysis==analysis,]$population, - parameter = paste(meta$plan[meta$plan$analysis==analysis,]$parameter, collapse = ";") -) { + analysis = "disp", + population = meta$plan[meta$plan$analysis == analysis, ]$population, + parameter = paste(meta$plan[meta$plan$analysis == analysis, ]$parameter, collapse = ";")) { return( prepare_sl_summary(meta, - analysis = analysis, - population = population, - parameter = parameter + analysis = analysis, + population = population, + parameter = parameter ) ) -} \ No newline at end of file +} diff --git a/R/prepare_exp_duration.R b/R/prepare_exp_duration.R index e308e9c..5b93ee0 100644 --- a/R/prepare_exp_duration.R +++ b/R/prepare_exp_duration.R @@ -37,16 +37,14 @@ #' meta <- meta_sl_exposure_example() #' meta |> prepare_exp_duration() prepare_exp_duration <- function(meta, - analysis = "exp_dur", - population = meta$plan[meta$plan$analysis==analysis,]$population, - parameter = paste(meta$plan[meta$plan$analysis==analysis,]$parameter, collapse = ";") -) { + analysis = "exp_dur", + population = meta$plan[meta$plan$analysis == analysis, ]$population, + parameter = paste(meta$plan[meta$plan$analysis == analysis, ]$parameter, collapse = ";")) { return( prepare_sl_summary(meta, - analysis = analysis, - population = population, - parameter = parameter + analysis = analysis, + population = population, + parameter = parameter ) ) - -} \ No newline at end of file +} diff --git a/R/prepare_sl_summary.R b/R/prepare_sl_summary.R index 71d35af..f0a68fe 100644 --- a/R/prepare_sl_summary.R +++ b/R/prepare_sl_summary.R @@ -39,7 +39,7 @@ prepare_sl_summary <- function( analysis, parameter = paste(names(meta$parameter), collapse = ";")) { parameters <- unlist(strsplit(parameter, ";")) - observation <- meta$plan[meta$plan$analysis==analysis,]$observation + observation <- meta$plan[meta$plan$analysis == analysis, ]$observation # obtain variables pop_var <- metalite::collect_adam_mapping(meta, population)$var obs_var <- metalite::collect_adam_mapping(meta, observation)$var @@ -50,11 +50,11 @@ prepare_sl_summary <- function( par_var_group <- do.call(c, lapply(parameters, function(x) { metalite::collect_adam_mapping(meta, x)$vargroup })) - + par_var_lower <- do.call(c, lapply(parameters, function(x) { metalite::collect_adam_mapping(meta, x)$var_lower })) - + pop_group <- metalite::collect_adam_mapping(meta, population)$group obs_group <- metalite::collect_adam_mapping(meta, observation)$group diff --git a/R/prepare_trt_compliance.R b/R/prepare_trt_compliance.R index 7bb0b66..42baecf 100644 --- a/R/prepare_trt_compliance.R +++ b/R/prepare_trt_compliance.R @@ -38,15 +38,13 @@ #' meta |> prepare_trt_compliance() prepare_trt_compliance <- function(meta, analysis = "trt_compliance", - population = meta$plan[meta$plan$analysis==analysis,]$population, - parameter = paste(meta$plan[meta$plan$analysis==analysis,]$parameter, collapse = ";") - ) { + population = meta$plan[meta$plan$analysis == analysis, ]$population, + parameter = paste(meta$plan[meta$plan$analysis == analysis, ]$parameter, collapse = ";")) { return( prepare_sl_summary(meta, - analysis = analysis, - population = population, - parameter = parameter - ) + analysis = analysis, + population = population, + parameter = parameter + ) ) - -} +} diff --git a/R/rtf_base_char_subgroup.R b/R/rtf_base_char_subgroup.R index a3e52e7..33faa04 100644 --- a/R/rtf_base_char_subgroup.R +++ b/R/rtf_base_char_subgroup.R @@ -33,24 +33,24 @@ #' @examples #' \dontrun{ #' meta <- meta_sl_example() -#' +#' #' outdata <- prepare_base_char_subgroup( -#' meta, -#' population = "apat", -#' parameter = "age", -#' subgroup_var = "TRTA", -#' subgroup_header = c("SEX","TRTA"), -#' display_subgroup_total = TRUE +#' meta, +#' population = "apat", +#' parameter = "age", +#' subgroup_var = "TRTA", +#' subgroup_header = c("SEX", "TRTA"), +#' display_subgroup_total = TRUE #' ) -#' +#' #' outdata |> -#' format_base_char_subgroup() |> -#' rtf_base_char_subgroup( +#' format_base_char_subgroup() |> +#' rtf_base_char_subgroup( #' source = "Source: [CDISCpilot: adam-adsl]", #' path_outdata = tempfile(fileext = ".Rdata"), #' path_outtable = tempfile(fileext = ".rtf") -#' ) -#' } +#' ) +#' } rtf_base_char_subgroup <- function( outdata, source, @@ -61,7 +61,6 @@ rtf_base_char_subgroup <- function( title = NULL, path_outdata = NULL, path_outtable = NULL) { - out_all <- outdata$out_all tbl <- outdata$tbl @@ -73,7 +72,7 @@ rtf_base_char_subgroup <- function( n_tgroup <- length(tgroup) n_row <- nrow(tbl1) n_col <- ncol(tbl1) - + if (!is.null(col_rel_width) && !n_col == length(col_rel_width)) { stop( "col_rel_width must have the same length (has ", @@ -82,44 +81,45 @@ rtf_base_char_subgroup <- function( n_col, ")." ) } - + # Define title if (is.null(title)) { - title <- metalite::collect_title(outdata$meta, - outdata$population, - "", - outdata$parameter, - analysis = "base_char_subgroup") + title <- metalite::collect_title(outdata$meta, + outdata$population, + "", + outdata$parameter, + analysis = "base_char_subgroup" + ) } - + # Set default footnote footnotes_stat <- NULL if ("sd" %in% tolower(outdata$display_stat)) { - footnotes_stat <- c(footnotes_stat, "SD=Standard deviation") + footnotes_stat <- c(footnotes_stat, "SD=Standard deviation") } if ("se" %in% tolower(outdata$display_stat)) { - footnotes_stat <- c(footnotes_stat, paste0("SE=Standard err", "or")) + footnotes_stat <- c(footnotes_stat, paste0("SE=Standard err", "or")) } if ("q1 to q3" %in% tolower(outdata$display_stat)) { - footnotes_stat <- c(footnotes_stat, "Q1=First quartile, Q3=Third quartile") + footnotes_stat <- c(footnotes_stat, "Q1=First quartile, Q3=Third quartile") } # combine footnotes for abbreviation of statistics footnotes_stat <- paste(footnotes_stat, collapse = "; ") # combine with user defined footnotes if not NULL if (nchar(footnotes_stat) > 0) { if (!is.null(footnotes)) { - footnotes <- paste0(footnotes_stat, ".\n", footnotes) + footnotes <- paste0(footnotes_stat, ".\n", footnotes) } else { - footnotes <- paste0(footnotes_stat, ".") + footnotes <- paste0(footnotes_stat, ".") } } - + col_tbl_within <- outdata$display - + col_tbl_within <- col_tbl_within |> - (\(list) list[list %in% c("n","prop")])() |> + (\(list) list[list %in% c("n", "prop")])() |> unique() - + colhead_within <- paste( vapply( X = col_tbl_within, @@ -130,11 +130,11 @@ rtf_base_char_subgroup <- function( ), collapse = " | " ) - + colhead_1_within <- paste(sgroup, collapse = " |") colhead_2_within <- paste(rep(tgroup, n_sgroup), collapse = " | ") colhead_3_within <- paste(rep(colhead_within, n_sgroup * n_tgroup), collapse = " | ") - + colborder_within <- vapply( X = col_tbl_within, FUN.VALUE = "character", @@ -143,142 +143,143 @@ rtf_base_char_subgroup <- function( "prop" = "", USE.NAMES = FALSE ) - + rwidth_3_within <- rep(1, length(col_tbl_within) * n_sgroup * n_tgroup) - + rwidth_2_within <- tapply( rwidth_3_within, c(rep(1:(n_sgroup * n_tgroup), each = length(col_tbl_within))), sum ) names(rwidth_2_within) <- NULL - + rwidth_1_within <- tapply( rwidth_3_within, c(rep(1:n_sgroup, each = length(col_tbl_within) * n_tgroup)), sum ) names(rwidth_1_within) <- NULL - - + + colborder_within <- rep(colborder_within, n_sgroup * n_tgroup) - + # Column headers - + colheader <- c( paste0(" | ", colhead_1_within), paste0(" | ", colhead_2_within), paste0(" | ", colhead_3_within) ) - + # Relative width - + if (is.null(col_rel_width)) { rwidth_1 <- c(2, rwidth_1_within) rwidth_2 <- c(2, rwidth_2_within) rwidth_3 <- c(2, rwidth_3_within) } else { rwidth_3 <- col_rel_width - + rwidth_2 <- tapply( col_rel_width[2:length(col_rel_width)], c(rep(1:(n_sgroup * n_tgroup), each = length(col_tbl_within))), sum ) - + rwidth_2 <- c( rwidth_3[1], rwidth_2 ) - - + + rwidth_1 <- tapply( col_rel_width[2:length(col_rel_width)], c(rep(1:n_sgroup, each = length(col_tbl_within) * n_tgroup)), sum ) - + rwidth_1 <- c( rwidth_3[1], rwidth_1 ) } - + if ((sum(rwidth_1) != sum(rwidth_2)) || (sum(rwidth_1) != sum(rwidth_3))) { stop("Width calculation breaks, contact developer.") } - + # Column border border_top2 <- c("", rep("single", n_sgroup * n_tgroup)) border_top3 <- c("", rep("single", n_sgroup * n_tgroup * 2)) - + border_left2 <- c("single", rep("single", n_sgroup * n_tgroup)) border_left3 <- c("single", colborder_within) - border_left4 <- c(rep("single",2), colborder_within) - + border_left4 <- c(rep("single", 2), colborder_within) + # Using order number to customize row format - + text_justification <- c("l", rep("l", n_sgroup * n_tgroup * 2)) - #text_format <- c(rep("", 1 + n_sgroup * n_tgroup * 2), "b") - + # text_format <- c(rep("", 1 + n_sgroup * n_tgroup * 2), "b") + text_indent <- matrix(0, nrow = n_row, ncol = n_col) text_indent[, 1] <- ifelse(FALSE, 0, 100) text_indent[1, 1] <- 0 - + # Using r2rtf outdata$rtf <- tbl1 |> r2rtf::rtf_page(orientation = orientation) |> r2rtf::rtf_title(title) |> r2rtf::rtf_colheader( - colheader = colheader[1], - col_rel_width = rwidth_1, - text_font_size = text_font_size) |> + colheader = colheader[1], + col_rel_width = rwidth_1, + text_font_size = text_font_size + ) |> r2rtf::rtf_colheader( - colheader = colheader[2], - border_top = border_top2, + colheader = colheader[2], + border_top = border_top2, border_left = border_left2, - col_rel_width = rwidth_2, + col_rel_width = rwidth_2, text_font_size = text_font_size ) |> r2rtf::rtf_colheader( - colheader = colheader[3], - border_top = border_top3, + colheader = colheader[3], + border_top = border_top3, border_left = border_left3, - col_rel_width = rwidth_3, + col_rel_width = rwidth_3, text_font_size = text_font_size ) |> r2rtf::rtf_body( page_by = "var_label", - col_rel_width = c(rwidth_3,1), + col_rel_width = c(rwidth_3, 1), border_left = border_left4, text_justification = text_justification, - text_indent_first = text_indent, - text_indent_left = text_indent, - #text_format = text_format, + text_indent_first = text_indent, + text_indent_left = text_indent, + # text_format = text_format, text_font_size = text_font_size ) - + if (!is.null(footnotes)) { outdata$rtf <- outdata$rtf |> r2rtf::rtf_footnote(footnotes, - text_font_size = text_font_size + text_font_size = text_font_size ) } - + if (!is.null(source)) { outdata$rtf <- outdata$rtf |> r2rtf::rtf_source(source, - text_font_size = text_font_size + text_font_size = text_font_size ) } - + # Prepare output rtf_output(outdata, path_outdata, path_outtable) - - #to_pdf( + + # to_pdf( # path_outtable, # output = gsub("\\.[[:alnum:]]+$", ".pdf", path_outtable), # timeout = 120, # UserInstallation = NULL - #) -} \ No newline at end of file + # ) +} diff --git a/R/rtf_exp_duration.R b/R/rtf_exp_duration.R index 304f453..1da8bf5 100644 --- a/R/rtf_exp_duration.R +++ b/R/rtf_exp_duration.R @@ -47,11 +47,13 @@ rtf_exp_duration <- function(outdata, col_rel_width = NULL, text_font_size = 9, orientation = "portrait", - footnotes = c("Each participant is counted once on each applicable duration category row.", - "Duration of Exposure is the time from the first dose date to the last dose date."), + footnotes = c( + "Each participant is counted once on each applicable duration category row.", + "Duration of Exposure is the time from the first dose date to the last dose date." + ), title = NULL, path_outdata = NULL, - path_outtable = NULL){ + path_outtable = NULL) { return( rtf_sl_summary( outdata, @@ -63,6 +65,6 @@ rtf_exp_duration <- function(outdata, title = title, path_outdata = path_outdata, path_outtable = path_outtable - ) + ) ) } diff --git a/R/rtf_sl_summary.R b/R/rtf_sl_summary.R index 86216dd..3729116 100644 --- a/R/rtf_sl_summary.R +++ b/R/rtf_sl_summary.R @@ -57,9 +57,9 @@ rtf_sl_summary <- function( path_outdata = NULL, path_outtable = NULL) { # Set default column width - - - + + + tbl <- outdata$tbl display_total <- "total" %in% outdata$display_col if (display_total == TRUE) { @@ -265,4 +265,4 @@ rtf_trt_compliance <- rtf_sl_summary #' path_outdata = tempfile(fileext = ".Rdata"), #' path_outtable = tempfile(fileext = ".rtf") #' ) -rtf_disposition <- rtf_sl_summary \ No newline at end of file +rtf_disposition <- rtf_sl_summary diff --git a/R/utils.R b/R/utils.R index fcc1589..b7cffa4 100644 --- a/R/utils.R +++ b/R/utils.R @@ -45,13 +45,13 @@ rtf_output <- function( save(outdata, file = path_outdata) message("The outdata is saved in", normalizePath(path_outdata)) } - + if (!is.null(path_outtable)) { outdata$rtf |> r2rtf::rtf_encode() |> r2rtf::write_rtf(file = path_outtable) message("The output is saved in", normalizePath(path_outtable)) } - + invisible(outdata) -} \ No newline at end of file +} diff --git a/R/zzz.R b/R/zzz.R index b28f2f0..4c5e154 100644 --- a/R/zzz.R +++ b/R/zzz.R @@ -16,4 +16,4 @@ # You should have received a copy of the GNU General Public License # along with this program. If not, see . -utils::globalVariables(c("SAFFL")) \ No newline at end of file +utils::globalVariables(c("SAFFL")) diff --git a/tests/testthat/test-independent-testing-disposition.R b/tests/testthat/test-independent-testing-disposition.R index 56f2161..110d616 100644 --- a/tests/testthat/test-independent-testing-disposition.R +++ b/tests/testthat/test-independent-testing-disposition.R @@ -4,20 +4,22 @@ adsl <- r2rtf::r2rtf_adsl meta <- meta_sl_example() outdata <- prepare_disposition(meta, - analysis = "disp", - population = "apat", - parameter="disposition;medical-disposition") + analysis = "disp", + population = "apat", + parameter = "disposition;medical-disposition" +) #### Test 1 ###### test_that("rtf output: n, prop, total", { path_rtf <- file.path(tempdir(), "disposition1.rtf") path_rdata <- tempfile(fileext = ".Rdata") - - + + tbl <- outdata |> - format_disposition(display_stat = c("mean", "sd", "median", "range"), - display_col = c("n", "prop", "total") - )|> + format_disposition( + display_stat = c("mean", "sd", "median", "range"), + display_col = c("n", "prop", "total") + ) |> rtf_disposition( orientation = "landscape", col_rel_width = c(4, rep(1, 9)), @@ -25,8 +27,8 @@ test_that("rtf output: n, prop, total", { path_outdata = path_rdata, path_outtable = path_rtf ) - - + + testthat::expect_snapshot_file(path_rtf) }) @@ -34,12 +36,13 @@ test_that("rtf output: n, prop, total", { test_that("rtf output: n, prop, total", { path_rtf <- file.path(tempdir(), "disposition2.rtf") path_rdata <- tempfile(fileext = ".Rdata") - - + + tbl <- outdata |> - format_disposition(display_stat = c(), - display_col = c("n", "prop", "total") - )|> + format_disposition( + display_stat = c(), + display_col = c("n", "prop", "total") + ) |> rtf_disposition( orientation = "landscape", col_rel_width = c(4, rep(1, 9)), @@ -47,10 +50,7 @@ test_that("rtf output: n, prop, total", { path_outdata = path_rdata, path_outtable = path_rtf ) - - - testthat::expect_snapshot_file(path_rtf) -}) - + testthat::expect_snapshot_file(path_rtf) +}) diff --git a/tests/testthat/test-independent-testing-format_exp_duration.R b/tests/testthat/test-independent-testing-format_exp_duration.R index 08d2afd..fd6a5a0 100644 --- a/tests/testthat/test-independent-testing-format_exp_duration.R +++ b/tests/testthat/test-independent-testing-format_exp_duration.R @@ -1,18 +1,17 @@ - library(metalite) library(metalite.ae) library(dplyr) -library(tidyr) +library(tidyr) # Read data adsl <- r2rtf::r2rtf_adsl # Create ADEXSUM dataset -adexsum <- data.frame(USUBJID=adsl$USUBJID) +adexsum <- data.frame(USUBJID = adsl$USUBJID) adexsum$TRTA <- factor(adsl$TRT01A, - levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), - labels = c("Placebo", "Low Dose", "High Dose") + levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), + labels = c("Placebo", "Low Dose", "High Dose") ) adexsum$TRTAN <- adsl$TRT01AN @@ -22,23 +21,24 @@ names(adexsum$TRTA) <- "TREATMENT" adexsum$APERIODC <- "Base" adexsum$APERIOD <- 1 -adexsum$AVAL <- sample(x = 0:(24*7), size = length(adexsum$USUBJID), replace = TRUE) +adexsum$AVAL <- sample(x = 0:(24 * 7), size = length(adexsum$USUBJID), replace = TRUE) adexsum$EXDURGR <- "not treated" -adexsum$EXDURGR[adexsum$AVAL>=1] <- ">=1 day" -adexsum$EXDURGR[adexsum$AVAL>=7] <- ">=7 days" -adexsum$EXDURGR[adexsum$AVAL>=28] <- ">=28 days" -adexsum$EXDURGR[adexsum$AVAL>=12*7] <- ">=12 weeks" -adexsum$EXDURGR[adexsum$AVAL>=24*7] <- ">=24 weeks" +adexsum$EXDURGR[adexsum$AVAL >= 1] <- ">=1 day" +adexsum$EXDURGR[adexsum$AVAL >= 7] <- ">=7 days" +adexsum$EXDURGR[adexsum$AVAL >= 28] <- ">=28 days" +adexsum$EXDURGR[adexsum$AVAL >= 12 * 7] <- ">=12 weeks" +adexsum$EXDURGR[adexsum$AVAL >= 24 * 7] <- ">=24 weeks" adexsum$EXDURGR <- factor(adexsum$EXDURGR, - levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks")) + levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks") +) plan <- metalite::plan( - analysis = "exp_dur", + analysis = "exp_dur", population = "apat", - observation = "apat", + observation = "apat", parameter = "expdur" -) +) # Create test metadata meta_test <- metalite::meta_adam( @@ -49,19 +49,19 @@ meta_test <- metalite::meta_adam( metalite::define_population( name = "apat", group = "TRTA", - subset = quote(APERIOD==1 & AVAL>0) + subset = quote(APERIOD == 1 & AVAL > 0) ) |> metalite::define_parameter( name = "expdur", var = "AVAL", label = "Exposure Duration (Days)", vargroup = "EXDURGR" - )|> + ) |> metalite::define_analysis( name = "exp_dur", title = "Summary of Exposure Duration", label = "exposure duration table" - ) + ) # Prepare test data by the tested function @@ -74,13 +74,15 @@ test_meta_exp_dur <- prepare_sl_summary( # Prepare adding more info -adexsum_tot <- adexsum |> select(-c(TRTAN)) |> mutate(TRTA = "Overall") +adexsum_tot <- adexsum |> + select(-c(TRTAN)) |> + mutate(TRTA = "Overall") -adexsum_tot <- adexsum_tot |> mutate(TRTAN=9999) +adexsum_tot <- adexsum_tot |> mutate(TRTAN = 9999) adexsum_tot <- rbind(adexsum, adexsum_tot) -adexsum_tot <- adexsum_tot |> filter(APERIOD==1 & AVAL>0 & SAFFL == "Y") +adexsum_tot <- adexsum_tot |> filter(APERIOD == 1 & AVAL > 0 & SAFFL == "Y") exdurgr_value <- as.character(sort(unique(adexsum_tot$EXDURGR))) @@ -95,9 +97,9 @@ test_that("When display_col contains n and prop then the total column disappears test_meta_exp_dur, display_col = dis ) - + display_total <- "total" %in% dis - + if ("n" %in% dis) { if (display_total) { n_col <- test$char_n[[1]] @@ -108,7 +110,7 @@ test_that("When display_col contains n and prop then the total column disappears } n_col_names <- names(n_col) } - + if ("prop" %in% dis) { if (display_total) { prop_col <- test$char_prop[[1]] @@ -119,46 +121,44 @@ test_that("When display_col contains n and prop then the total column disappears } prop_col_names <- names(prop_col) } - + expect_col_names <- sort(unique(c(n_col_names, prop_col_names))) - + format_tbl_col_names <- sort(names(test$tbl)) - + expect_equal(format_tbl_col_names, expect_col_names) }) # 2 test_that("When digits_prop is specified then the proportions are rounded to the decimal place", { dis <- c("n", "prop", "total") - + test_dig0 <- format_exp_duration( test_meta_exp_dur, display_col = dis, digits_prop = 0 ) - + test_dig2 <- format_exp_duration( test_meta_exp_dur, display_col = dis, digits_prop = 2 ) - + test_meta_exp_dur$char_prop test_meta_prop_char <- NULL - + for (i in (1:length(test_meta_exp_dur$char_var))) { - test_meta_prop_char <- rbind( test_meta_prop_char, tibble(test_meta_exp_dur$char_prop[[i]]) ) - } - + test_meta_prop_char_val <- test_meta_prop_char |> select(-c("name", "var_label")) - + res_frq_prop0 <- data.frame( test_meta_prop_char$name, @@ -168,7 +168,7 @@ test_that("When digits_prop is specified then the proportions are rounded to the \(x) formatC(paste0("(", formatC(x, digits = 0, format = "f"), ")"), format = "f") ) ) - + res_frq_prop2 <- data.frame( test_meta_prop_char$name, @@ -178,7 +178,7 @@ test_that("When digits_prop is specified then the proportions are rounded to the \(x) formatC(paste0("(", formatC(x, digits = 2, format = "f"), ")"), format = "f") ) ) - + if ("total" %in% dis) { names(res_frq_prop0) <- c("name", paste0("p_", seq(1, length(test_meta_exp_dur$group_label))), "p_9999") names(res_frq_prop2) <- c("name", paste0("p_", seq(1, length(test_meta_exp_dur$group_label))), "p_9999") @@ -186,50 +186,49 @@ test_that("When digits_prop is specified then the proportions are rounded to the names(res_frq_prop0) <- c("name", paste0("p_", seq(1, length(test_meta_exp_dur$group_label)))) names(res_frq_prop2) <- c("name", paste0("p_", seq(1, length(test_meta_exp_dur$group_label)))) } - + test_dig0dat <- test_dig0$tbl |> filter(!name %in% c("Participants in population", "Mean", "SD", "SE", "Median", "Q1 to Q3", "Range", "Min", "Max")) |> - select(c("name", starts_with("p_")) - ) - - + select(c("name", starts_with("p_"))) + + # Filter out empty line with NA test_dig0dat <- na.omit(test_dig0dat) # Remove the na.action attribute from the object to avoid inequality comparsion at below expect_equal" step - attr(test_dig0dat, 'na.action') <- NULL - + attr(test_dig0dat, "na.action") <- NULL + res_frq_prop0_tst <- res_frq_prop0 |> - filter(!name %in% c("Participants in population", "Mean", "SD", "SE", "Median", "Q1 to Q3", "Range", "Min", "Max")) + filter(!name %in% c("Participants in population", "Mean", "SD", "SE", "Median", "Q1 to Q3", "Range", "Min", "Max")) # Filter out empty line with (NA) res_frq_prop0_tst <- na.omit(res_frq_prop0_tst) # Remove the na.action attribute from the object to avoid inequality comparsion at below expect_equal" step - attr(res_frq_prop0_tst, 'na.action') <- NULL - + attr(res_frq_prop0_tst, "na.action") <- NULL + expect_equal( test_dig0dat, res_frq_prop0_tst ) - - + + test_dig2_tst <- test_dig2$tbl |> filter(!name %in% c("Participants in population", "Mean", "SD", "SE", "Median", "Q1 to Q3", "Range", "Min", "Max")) |> select(c("name", starts_with("p_"))) - + # Filter out empty line with NA test_dig2_tst <- na.omit(test_dig2_tst) # Remove the na.action attribute from the object to avoid inequality comparsion at below expect_equal" step - attr(test_dig2_tst, 'na.action') <- NULL - - + attr(test_dig2_tst, "na.action") <- NULL + + res_frq_prop2_tst <- res_frq_prop2 |> filter(!name %in% c("Participants in population", "Mean", "SD", "SE", "Median", "Q1 to Q3", "Range", "Min", "Max")) - + # Filter out empty line with NA res_frq_prop2_tst <- na.omit(res_frq_prop2_tst) # Remove the na.action attribute from the object to avoid inequality comparsion at below expect_equal" step - attr(res_frq_prop2_tst, 'na.action') <- NULL - - + attr(res_frq_prop2_tst, "na.action") <- NULL + + expect_equal( test_dig2_tst, res_frq_prop2_tst @@ -238,97 +237,88 @@ test_that("When digits_prop is specified then the proportions are rounded to the # 3 test_that("When display_stat contains mean then Mean row is included", { - hold <- c("SD", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range") - + test <- format_exp_duration( test_meta_exp_dur, display_col = c("n", "prop", "total"), display_stat = c("mean") ) - + test_nm3 <- test$tbl[["name"]][!as.vector(test$tbl[["name"]]) %in% hold] - + expect_equal( as.vector(c( "Participants in population", "not treated", exdurgr_value, "Mean" )), - test_nm3[!is.na(test_nm3)] - ) }) # 4 test_that("When display_stat contains sd then SD row is included", { - hold <- c("Mean", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range") - + test <- format_exp_duration( test_meta_exp_dur, display_col = c("n", "prop", "total"), display_stat = c("sd") ) - + test_nm4 <- test$tbl[["name"]][!as.vector(test$tbl[["name"]]) %in% hold] - + expect_equal( as.vector(c( "Participants in population", "not treated", exdurgr_value, "SD" )), - test_nm4[!is.na(test_nm4)] ) }) # 5 test_that("When display_stat contains se then SE row is included", { - hold <- c("Mean", "SD", "Median", "Min", "Max", "Q1 to Q3", "Range") - + test <- format_exp_duration( test_meta_exp_dur, display_col = c("n", "prop", "total"), display_stat = c("se") ) - + test_nm4 <- test$tbl[["name"]][!as.vector(test$tbl[["name"]]) %in% hold] - + expect_equal( as.vector(c( "Participants in population", "not treated", exdurgr_value, "SE" - ) ), - - test_nm4[!is.na(test_nm4)] + )), + test_nm4[!is.na(test_nm4)] ) }) # 6 test_that("When display_stat contains median then Median row is included", { - hold <- c("Mean", "SD", "SE", "Min", "Max", "Q1 to Q3", "Range") - + test <- format_exp_duration( test_meta_exp_dur, display_col = c("n", "prop", "total"), display_stat = c("median") ) - + test_nm6 <- test$tbl[["name"]][!as.vector(test$tbl[["name"]]) %in% hold] - + expect_equal( as.vector(c( "Participants in population", "not treated", exdurgr_value, "Median" )), - test_nm6[!is.na(test_nm6)] ) }) @@ -336,24 +326,22 @@ test_that("When display_stat contains median then Median row is included", { # 7 test_that("When display_stat contains q1 to q3 then q1 to q3 row is included", { - hold <- c("Mean", "SD", "SE", "Min", "Max", "Median", "Range") - + test <- format_exp_duration( test_meta_exp_dur, display_col = c("n", "prop", "total"), display_stat = c("q1 to q3") ) - + test_nm7 <- test$tbl[["name"]][!as.vector(test$tbl[["name"]]) %in% hold] - + expect_equal( as.vector(c( "Participants in population", "not treated", exdurgr_value, "Q1 to Q3" )), - test_nm7[!is.na(test_nm7)] ) }) @@ -361,24 +349,22 @@ test_that("When display_stat contains q1 to q3 then q1 to q3 row is included", { # 8 test_that("When display_stat contains range then Range row is included", { - hold <- c("Mean", "SD", "SE", "Min", "Max", "Median", "Q1 to Q3") - + test <- format_exp_duration( test_meta_exp_dur, display_col = c("n", "prop", "total"), display_stat = c("range") ) - + test_nm8 <- test$tbl[["name"]][!as.vector(test$tbl[["name"]]) %in% hold] - + expect_equal( as.vector(c( "Participants in population", "not treated", exdurgr_value, "Range" )), - test_nm8[!is.na(test_nm8)] ) }) diff --git a/tests/testthat/test-independent-testing-prepare_exp_duration.R b/tests/testthat/test-independent-testing-prepare_exp_duration.R index 5fcc771..ddb8644 100644 --- a/tests/testthat/test-independent-testing-prepare_exp_duration.R +++ b/tests/testthat/test-independent-testing-prepare_exp_duration.R @@ -1,18 +1,17 @@ - library(metalite) library(metalite.ae) library(dplyr) -library(tidyr) +library(tidyr) # Read data adsl <- r2rtf::r2rtf_adsl # Create ADEXSUM dataset -adexsum <- data.frame(USUBJID=adsl$USUBJID) +adexsum <- data.frame(USUBJID = adsl$USUBJID) adexsum$TRTA <- factor(adsl$TRT01A, - levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), - labels = c("Placebo", "Low Dose", "High Dose") + levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), + labels = c("Placebo", "Low Dose", "High Dose") ) adexsum$TRTAN <- adsl$TRT01AN @@ -22,23 +21,24 @@ names(adexsum$TRTA) <- "TREATMENT" adexsum$APERIODC <- "Base" adexsum$APERIOD <- 1 -adexsum$AVAL <- sample(x = 0:(24*7), size = length(adexsum$USUBJID), replace = TRUE) +adexsum$AVAL <- sample(x = 0:(24 * 7), size = length(adexsum$USUBJID), replace = TRUE) adexsum$EXDURGR <- "not treated" -adexsum$EXDURGR[adexsum$AVAL>=1] <- ">=1 day" -adexsum$EXDURGR[adexsum$AVAL>=7] <- ">=7 days" -adexsum$EXDURGR[adexsum$AVAL>=28] <- ">=28 days" -adexsum$EXDURGR[adexsum$AVAL>=12*7] <- ">=12 weeks" -adexsum$EXDURGR[adexsum$AVAL>=24*7] <- ">=24 weeks" +adexsum$EXDURGR[adexsum$AVAL >= 1] <- ">=1 day" +adexsum$EXDURGR[adexsum$AVAL >= 7] <- ">=7 days" +adexsum$EXDURGR[adexsum$AVAL >= 28] <- ">=28 days" +adexsum$EXDURGR[adexsum$AVAL >= 12 * 7] <- ">=12 weeks" +adexsum$EXDURGR[adexsum$AVAL >= 24 * 7] <- ">=24 weeks" adexsum$EXDURGR <- factor(adexsum$EXDURGR, - levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks")) + levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks") +) plan <- metalite::plan( - analysis = "exp_dur", + analysis = "exp_dur", population = "apat", - observation = "apat", + observation = "apat", parameter = "expdur" -) +) meta_test <- metalite::meta_adam( @@ -49,19 +49,19 @@ meta_test <- metalite::meta_adam( metalite::define_population( name = "apat", group = "TRTA", - subset = quote(APERIOD==1 & AVAL>0) + subset = quote(APERIOD == 1 & AVAL > 0) ) |> metalite::define_parameter( name = "expdur", var = "AVAL", label = "Exposure Duration (Days)", vargroup = "EXDURGR" - )|> + ) |> metalite::define_analysis( name = "exp_dur", title = "Summary of Exposure Duration", label = "exposure duration table" - ) + ) # Prepare test data by the tested function @@ -111,13 +111,15 @@ for (i in (1:length(test_meta_exp_dur$char_var))) { # Prepare compare data for calculation -adexsum_tot <- adexsum |> select(-c(TRTAN)) |> mutate(TRTA = "Overall") +adexsum_tot <- adexsum |> + select(-c(TRTAN)) |> + mutate(TRTA = "Overall") -adexsum_tot <- adexsum_tot |> mutate(TRTAN=9999) +adexsum_tot <- adexsum_tot |> mutate(TRTAN = 9999) adexsum_tot <- rbind(adexsum, adexsum_tot) -adexsum_tot <- adexsum_tot |> filter(APERIOD==1 & AVAL>0 & SAFFL == "Y") +adexsum_tot <- adexsum_tot |> filter(APERIOD == 1 & AVAL > 0 & SAFFL == "Y") res_tot <- adexsum_tot |> @@ -130,7 +132,7 @@ test_that("Group matching", { expect_equal( test_meta_exp_dur$group_label, factor(c("Placebo", "High Dose", "Low Dose"), - levels = c("Placebo", "Low Dose", "High Dose") + levels = c("Placebo", "Low Dose", "High Dose") ) ) }) @@ -138,30 +140,29 @@ test_that("Group matching", { # 2 test_that("Participants in population", { - - res <- res_tot |> - arrange( TRTAN) |> + arrange(TRTAN) |> mutate(x = case_when( TRTA == "Overall" ~ "n_9999", TRUE ~ paste0("n_", row_number()) )) - - - pop_cnt <- res |> select(-c(TRTA, TRTAN)) |> + + + pop_cnt <- res |> + select(-c(TRTA, TRTAN)) |> pivot_wider( names_from = "x", values_from = n, values_fill = list(n = 0) ) - - + + expect_equal( test_meta_n_all |> select(c(n_1, n_2, n_3, n_9999)), - tibble(pop_cnt) + tibble(pop_cnt) ) - + expect_equal(test_meta_exp_dur$n[["name"]], "Participants in population") expect_equal(test_meta_exp_dur$n[["var_label"]], "-----") }) @@ -170,10 +171,10 @@ test_that("Participants in population", { # 3 test_that("Character variables count", { - char_var <- c("EXDURGR") + char_var <- c("EXDURGR") res_frq_n <- NULL res_frq_prop <- NULL - + for (var in char_var) { res_frq <- adexsum_tot |> @@ -186,12 +187,12 @@ test_that("Character variables count", { TRTAN == 9999 ~ "Total" )) |> rename(name = !!var) - + attr(res_frq[["name"]], "label") <- NULL - + res_frq <- data.frame(full_join( - res_frq, res_tot |> rename(z = n, TRTA_=TRTA), + res_frq, res_tot |> rename(z = n, TRTA_ = TRTA), by = c("TRTAN"), multiple = "all" )) |> @@ -204,17 +205,18 @@ test_that("Character variables count", { TRTAN == 81 ~ "High Dose", TRTAN == 9999 ~ "Total" )) - - res_frq1 <- res_frq |> select(-c(TRTA_)) |> + + res_frq1 <- res_frq |> + select(-c(TRTA_)) |> pivot_wider( id_cols = c("name"), names_from = "x", values_from = n, values_fill = c(n = 0) ) |> - arrange(name) - - + arrange(name) + + res_frq2 <- res_frq |> pivot_wider( id_cols = c("name"), @@ -222,63 +224,62 @@ test_that("Character variables count", { values_from = pct, values_fill = c(pct = 0) ) |> - arrange(name) - - + arrange(name) + + res_frq_n <- rbind(res_frq_n, res_frq1) res_frq_prop <- rbind(res_frq_prop, res_frq2) } - - + + for (col in (names(res_frq_n))) { names(res_frq_n[[col]]) <- NULL names(res_frq_prop[[col]]) <- NULL } - - + + test_meta_n_num <- dplyr::select(test_meta_n_char, -var_label) - + test_meta_prop_num <- dplyr::select(test_meta_prop_char, -var_label) - - - test_meta_n_num1 <- test_meta_n_num[!(test_meta_n_num$name %in% c('Mean', 'SD', 'SE', 'Median', 'Min', 'Max', 'Q1 to Q3', 'Range', 'not treated')), ] - - test_meta_prop_num1 <- test_meta_prop_num[!(test_meta_prop_num$name %in% c('Mean', 'SD', 'SE', 'Median', 'Min', 'Max', 'Q1 to Q3', 'Range', 'not treated')), ] - - + + + test_meta_n_num1 <- test_meta_n_num[!(test_meta_n_num$name %in% c("Mean", "SD", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range", "not treated")), ] + + test_meta_prop_num1 <- test_meta_prop_num[!(test_meta_prop_num$name %in% c("Mean", "SD", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range", "not treated")), ] + + test_meta_n_num1$name <- factor(test_meta_n_num1$name, levels = levels(res_frq_n$name)) test_meta_prop_num1$name <- factor(test_meta_prop_num1$name, levels = levels(res_frq_prop$name)) - + # Specify the variables to be updated vars_to_update <- c("Placebo", "Low Dose", "High Dose", "Total") - + # Update selected variables to character type - test_meta_n_num1 <- test_meta_n_num1 %>% + test_meta_n_num1 <- test_meta_n_num1 %>% mutate_at(vars_to_update, as.integer) - + # Filter out empty line with NA test_meta_n_num1 <- na.omit(test_meta_n_num1) - + # Remove the na.action attribute from the object to avoid inequality comparsion at below expect_equal" step - attr(test_meta_n_num1, 'na.action') <- NULL - + attr(test_meta_n_num1, "na.action") <- NULL + # Filter out empty line with NA test_meta_prop_num1 <- na.omit(test_meta_prop_num1) # Remove the na.action attribute from the object to avoid inequality comparsion at below "expect_equal" step - attr(test_meta_prop_num1, 'na.action') <- NULL - + attr(test_meta_prop_num1, "na.action") <- NULL + # Test n expect_equal( test_meta_n_num1, tibble(res_frq_n) ) - + # Test proportion expect_equal( test_meta_prop_num1, tibble(res_frq_prop) ) - }) @@ -289,10 +290,10 @@ test_that("Numeric variables summary", { char_var <- c("AVAL") res_stat_n <- NULL res_stat_prop <- NULL - + for (var in char_var) { res_stat <- - adexsum_tot |> + adexsum_tot |> summarise( n = n_distinct(USUBJID, na.rm = TRUE), Mean = mean(AVAL, na.rm = TRUE), @@ -316,13 +317,13 @@ test_that("Numeric variables summary", { TRTAN == 81 ~ "High Dose", TRTAN == 9999 ~ "Total" )) - + res_stat[c("n", "Mean", "SD", "SE", "Median", "Min", "Max")] <- lapply( res_stat[c("n", "Mean", "SD", "SE", "Median", "Min", "Max")], \(x) formatC(x, format = "f", digits = 1) ) - + res_stat1 <- res_stat |> filter(SAFFL == "Y") |> select(-Q1, -Q3) |> @@ -342,34 +343,32 @@ test_that("Numeric variables summary", { mutate(var_label = case_when( !!var == "AVAL" ~ "Exposure Duration (Days)" )) - + res_stat1$name <- factor(res_stat1$name, - levels = c("Mean", "SD", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range") + levels = c("Mean", "SD", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range") ) - + res_stat_n <- rbind( res_stat_n, res_stat1 |> arrange(name) ) } - + res_stat_n$name <- as.character(res_stat_n$name) - + for (col in (names(res_stat_n))) { names(res_stat_n[[col]]) <- NULL } - - - - test_meta_n_num1 <- test_meta_n_char[(test_meta_n_char$name %in% c('Mean', 'SD', 'SE', 'Median', 'Min', 'Max', 'Q1 to Q3', 'Range')), ] - + + + + test_meta_n_num1 <- test_meta_n_char[(test_meta_n_char$name %in% c("Mean", "SD", "SE", "Median", "Min", "Max", "Q1 to Q3", "Range")), ] + # Test n expect_equal( - test_meta_n_num1 , + test_meta_n_num1, tibble(res_stat_n) ) - - }) test_that("Population matching", { @@ -387,5 +386,3 @@ test_that("Parameter matching", { test_that("Output from prepare_sl_summary is a list", { expect_true("outdata" %in% class(test_meta_exp_dur)) }) - - diff --git a/tests/testthat/test-independent-testing-rtf_base_char.R b/tests/testthat/test-independent-testing-rtf_base_char.R index a19ed8f..87f58ba 100644 --- a/tests/testthat/test-independent-testing-rtf_base_char.R +++ b/tests/testthat/test-independent-testing-rtf_base_char.R @@ -1,16 +1,16 @@ # library(metalite) -# +# # meta <- meta_sl_example() # outdata <- prepare_base_char(meta, # population = "apat", # parameter = "age;gender" # ) -# +# # #### Test 1 ###### # test_that("rtf output: n, and prop, NO total. With 2 decimal places.", { # path_rtf <- file.path(tempdir(), "base0char1.rtf") # path_rdata <- tempfile(fileext = ".Rdata") -# +# # tbl <- outdata |> # format_base_char( # display_col = c("n", "prop"), @@ -21,15 +21,15 @@ # path_outdata = path_rdata, # path_outtable = path_rtf # ) -# +# # testthat::expect_snapshot_file(path_rtf) # }) -# +# # #### Test 2 ##### # test_that("rtf output: n, prop and total, with Landscape, manual entory of col_rel_width", { # path_rtf <- file.path(tempdir(), "base0char2.rtf") # path_rdata <- tempfile(fileext = ".Rdata") -# +# # tbl <- outdata |> # format_base_char() |> # rtf_base_char( @@ -39,16 +39,16 @@ # path_outdata = path_rdata, # path_outtable = path_rtf # ) -# +# # testthat::expect_snapshot_file(path_rtf) # }) -# -# +# +# # #### Test 3 ##### # test_that("rtf output: n, prop and total, with no value of col_rel_width", { # path_rtf <- file.path(tempdir(), "base0char3.rtf") # path_rdata <- tempfile(fileext = ".Rdata") -# +# # tbl <- outdata |> # format_base_char(display_col = c("n", "prop", "total")) |> # rtf_base_char( @@ -57,6 +57,6 @@ # path_outdata = path_rdata, # path_outtable = path_rtf # ) -# +# # testthat::expect_snapshot_file(path_rtf) # }) diff --git a/tests/testthat/test-independent-testing-rtf_exp_duration.R b/tests/testthat/test-independent-testing-rtf_exp_duration.R index 816327b..6071277 100644 --- a/tests/testthat/test-independent-testing-rtf_exp_duration.R +++ b/tests/testthat/test-independent-testing-rtf_exp_duration.R @@ -1,12 +1,12 @@ - library(metalite) metatest <- meta_sl_exposure_example() -outdata <- prepare_sl_summary(meta=metatest, - population = "apat", - analysis = "exp_dur", - parameter = "expdur" +outdata <- prepare_sl_summary( + meta = metatest, + population = "apat", + analysis = "exp_dur", + parameter = "expdur" ) @@ -14,7 +14,7 @@ outdata <- prepare_sl_summary(meta=metatest, test_that("rtf output: n, and prop, NO total. With 2 decimal places.", { path_rtf <- file.path(tempdir(), "exp0duration1.rtf") path_rdata <- tempfile(fileext = ".Rdata") - + tbl <- outdata |> format_exp_duration( display_col = c("n", "prop"), @@ -25,7 +25,7 @@ test_that("rtf output: n, and prop, NO total. With 2 decimal places.", { path_outdata = path_rdata, path_outtable = path_rtf ) - + testthat::expect_snapshot_file(path_rtf) }) @@ -33,7 +33,7 @@ test_that("rtf output: n, and prop, NO total. With 2 decimal places.", { test_that("rtf output: n, prop and total, with Landscape", { path_rtf <- file.path(tempdir(), "exp0duration2.rtf") path_rdata <- tempfile(fileext = ".Rdata") - + tbl <- outdata |> format_exp_duration() |> rtf_exp_duration( @@ -43,7 +43,7 @@ test_that("rtf output: n, prop and total, with Landscape", { path_outdata = path_rdata, path_outtable = path_rtf ) - + testthat::expect_snapshot_file(path_rtf) }) @@ -52,8 +52,8 @@ test_that("rtf output: n, prop and total, with Landscape", { test_that("rtf output: n, prop and total, with no value of col_rel_width", { path_rtf <- file.path(tempdir(), "exp0duration3.rtf") path_rdata <- tempfile(fileext = ".Rdata") - - tbl <- outdata |> + + tbl <- outdata |> format_exp_duration(display_col = c("n", "prop", "total")) |> rtf_exp_duration( col_rel_width = c(4, 2, 2, 2, 2, 2, 2, 3, 3, 3), @@ -61,7 +61,6 @@ test_that("rtf output: n, prop and total, with no value of col_rel_width", { path_outdata = path_rdata, path_outtable = path_rtf ) - + testthat::expect_snapshot_file(path_rtf) }) - diff --git a/tests/testthat/test-independent-testing-trt_compliance.R b/tests/testthat/test-independent-testing-trt_compliance.R index 5b5284d..a7725ce 100644 --- a/tests/testthat/test-independent-testing-trt_compliance.R +++ b/tests/testthat/test-independent-testing-trt_compliance.R @@ -4,42 +4,45 @@ adsl <- r2rtf::r2rtf_adsl meta <- meta_sl_example() outdata <- prepare_trt_compliance(meta, - analysis = "trt_compliance", - population = "apat", - parameter="comp8;comp16;comp24") + analysis = "trt_compliance", + population = "apat", + parameter = "comp8;comp16;comp24" +) #### Test 1 ###### test_that("rtf output: n, prop, total", { path_rtf <- file.path(tempdir(), "trt_compliance.rtf") path_rdata <- tempfile(fileext = ".Rdata") - - -tbl <- outdata |> - format_trt_compliance(display_stat = c("mean", "sd", "median", "range"), - display_col = c("n", "prop", "total") - )|> - rtf_trt_compliance( - orientation = "landscape", - col_rel_width = c(4, rep(1, 9)), - "Source: [CDISCpilot: adam-adsl]", - path_outdata = path_rdata, - path_outtable = path_rtf - ) - - -testthat::expect_snapshot_file(path_rtf) + + + tbl <- outdata |> + format_trt_compliance( + display_stat = c("mean", "sd", "median", "range"), + display_col = c("n", "prop", "total") + ) |> + rtf_trt_compliance( + orientation = "landscape", + col_rel_width = c(4, rep(1, 9)), + "Source: [CDISCpilot: adam-adsl]", + path_outdata = path_rdata, + path_outtable = path_rtf + ) + + + testthat::expect_snapshot_file(path_rtf) }) #### Test 2 ###### test_that("rtf output: n, prop, total", { path_rtf <- file.path(tempdir(), "trt_compliance1.rtf") path_rdata <- tempfile(fileext = ".Rdata") - - + + tbl <- outdata |> - format_trt_compliance(display_stat = c(), - display_col = c("n", "prop", "total") - )|> + format_trt_compliance( + display_stat = c(), + display_col = c("n", "prop", "total") + ) |> rtf_trt_compliance( orientation = "landscape", col_rel_width = c(4, rep(1, 9)), @@ -47,8 +50,7 @@ test_that("rtf output: n, prop, total", { path_outdata = path_rdata, path_outtable = path_rtf ) - - + + testthat::expect_snapshot_file(path_rtf) }) - diff --git a/vignettes/Disposition.Rmd b/vignettes/Disposition.Rmd index ef3a936..9aebf5b 100644 --- a/vignettes/Disposition.Rmd +++ b/vignettes/Disposition.Rmd @@ -57,7 +57,6 @@ Additional information can be accessed on the ```{r} - adsl <- r2rtf::r2rtf_adsl adsl$TRTA <- adsl$TRT01A adsl$TRTA <- factor(adsl$TRTA, @@ -66,21 +65,22 @@ adsl$TRTA <- factor(adsl$TRTA, ) # Create a variable EOSSTT indicating the end of end of study status -adsl$EOSSTT <- sample(x = c("Participants Ongoing", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.8, 0.2), replace = TRUE) +adsl$EOSSTT <- sample( + x = c("Participants Ongoing", "Discontinued"), + size = length(adsl$USUBJID), + prob = c(0.8, 0.2), replace = TRUE +) # Create a variable EOTSTT1 indicating the end of treatment status part 1 adsl$EOTSTT1 <- ifelse(adsl$DISCONFL == "Y", "Discontinued", "Completed") -adsl$DCTREAS<- ifelse(adsl$EOTSTT1 == "Discontinued" & adsl$EOSSTT == "Discontinued", adsl$DCREASCD, NA) +adsl$DCTREAS <- ifelse(adsl$EOTSTT1 == "Discontinued" & adsl$EOSSTT == "Discontinued", adsl$DCREASCD, NA) head(adsl) - ``` ```{r} plan <- plan( analysis = "disp", population = "apat", - observation = "apat", parameter = "disposition;medical-disposition" + observation = "apat", parameter = "disposition;medical-disposition" ) ``` @@ -95,9 +95,8 @@ meta <- meta_adam( name = "apat", group = "TRTA", subset = quote(SAFFL == "Y") - ) |> - define_parameter( + define_parameter( name = "disposition", var = "EOSSTT", label = "Trial Disposition", @@ -220,7 +219,6 @@ knitr::include_graphics("outtable/pdf/disposition.pdf") The rtf_trt_compliance() function also provides some commonly used arguments to customize the table. ```{r} - x <- outdata |> format_disposition() @@ -233,8 +231,8 @@ x |> col_rel_width = c(4, rep(1, 9)), "Source: [CDISCpilot: adam-adsl]", path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = "outtable/disposition1.rtf" - ) + path_outtable = "outtable/disposition1.rtf" + ) ``` ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} diff --git a/vignettes/baseline-character.Rmd b/vignettes/baseline-character.Rmd index 2a5a40b..2cdac64 100644 --- a/vignettes/baseline-character.Rmd +++ b/vignettes/baseline-character.Rmd @@ -49,8 +49,10 @@ plan <- plan( ``` ```{r} -meta <- meta_adam(population = adsl, - observation = adsl) |> +meta <- meta_adam( + population = adsl, + observation = adsl +) |> define_plan(plan = plan) |> define_population( name = "apat", @@ -64,15 +66,21 @@ meta <- meta_adam(population = adsl, label = "Age (years)", vargroup = "AGEGR1" ) |> - define_parameter(name = "gender", - var = "SEX", - label = "Gender") |> - define_parameter(name = "race", - var = "RACE", - label = "Race") |> - define_analysis(name = "base_char", - title = "Participant Baseline Characteristics by Treatment Group", - label = "baseline characteristic table") |> + define_parameter( + name = "gender", + var = "SEX", + label = "Gender" + ) |> + define_parameter( + name = "race", + var = "RACE", + label = "Race" + ) |> + define_analysis( + name = "base_char", + title = "Participant Baseline Characteristics by Treatment Group", + label = "baseline characteristic table" + ) |> meta_build() ``` @@ -98,8 +106,10 @@ outdata$char_prop ```{r} outdata <- - outdata |> format_base_char(display_col = c("n", "prop", "total"), - digits_prop = 2) + outdata |> format_base_char( + display_col = c("n", "prop", "total"), + digits_prop = 2 + ) outdata$tbl ``` @@ -142,7 +152,6 @@ adsl$TRTA <- factor( levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), labels = c("Placebo", "Low Dose", "High Dose") ) - ``` ```{r} @@ -157,12 +166,14 @@ plan <- plan( population = "apat", observation = "apat", parameter = "age" - ) + ) ``` ```{r} -meta <- meta_adam(population = adsl, - observation = adsl) |> +meta <- meta_adam( + population = adsl, + observation = adsl +) |> define_plan(plan = plan) |> define_population( name = "apat", @@ -176,18 +187,26 @@ meta <- meta_adam(population = adsl, label = "Age (years)", vargroup = "AGEGR1" ) |> - define_parameter(name = "gender", - var = "SEX", - label = "Gender") |> - define_parameter(name = "race", - var = "RACE", - label = "Race") |> - define_analysis(name = "base_char", - title = "Participant Baseline Characteristics by Treatment Group", - label = "baseline characteristic table") |> - define_analysis(name = "base_char_subgroup", - title = "Participant by Age Category and Sex", - label = "baseline characteristic sub group table") |> + define_parameter( + name = "gender", + var = "SEX", + label = "Gender" + ) |> + define_parameter( + name = "race", + var = "RACE", + label = "Race" + ) |> + define_analysis( + name = "base_char", + title = "Participant Baseline Characteristics by Treatment Group", + label = "baseline characteristic table" + ) |> + define_analysis( + name = "base_char_subgroup", + title = "Participant by Age Category and Sex", + label = "baseline characteristic sub group table" + ) |> meta_build() ``` @@ -259,4 +278,4 @@ outdata <- format_base_char_subgroup(outdata) |> path_outdata = tempfile(fileext = ".Rdata"), path_outtable = "outtable/base0charsubgroup.rtf" ) -``` \ No newline at end of file +``` diff --git a/vignettes/exp_duration.Rmd b/vignettes/exp_duration.Rmd index 042af34..24653cc 100644 --- a/vignettes/exp_duration.Rmd +++ b/vignettes/exp_duration.Rmd @@ -40,27 +40,28 @@ Step1: ADEXSUM, the ADaM dataset for Drug Exposrue Summary Data, is utilized to: - Assign duration category `adexsum$EXDURGR` i.e.">=1 day", ">=7 days",">=28 days", ">=12 weeks" and ">=24 weeks". ```{r} - adsl <- r2rtf::r2rtf_adsl - adexsum <- data.frame(USUBJID=adsl$USUBJID) - adexsum$TRTA <- factor(adsl$TRT01A, - levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), - labels = c("Placebo", "Low Dose", "High Dose") - ) - - adexsum$APERIODC <- "Base" - adexsum$APERIOD <- 1 - - set.seed(123) # Set a seed for reproducibility - adexsum$AVAL <- sample(x = 0:(24*7), size = length(adexsum$USUBJID), replace = TRUE) - adexsum$EXDURGR <- "not treated" - adexsum$EXDURGR[adexsum$AVAL>=1] <- ">=1 day" - adexsum$EXDURGR[adexsum$AVAL>=7] <- ">=7 days" - adexsum$EXDURGR[adexsum$AVAL>=28] <- ">=28 days" - adexsum$EXDURGR[adexsum$AVAL>=12*7] <- ">=12 weeks" - adexsum$EXDURGR[adexsum$AVAL>=24*7] <- ">=24 weeks" - - adexsum$EXDURGR <- factor(adexsum$EXDURGR, - levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks")) +adsl <- r2rtf::r2rtf_adsl +adexsum <- data.frame(USUBJID = adsl$USUBJID) +adexsum$TRTA <- factor(adsl$TRT01A, + levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), + labels = c("Placebo", "Low Dose", "High Dose") +) + +adexsum$APERIODC <- "Base" +adexsum$APERIOD <- 1 + +set.seed(123) # Set a seed for reproducibility +adexsum$AVAL <- sample(x = 0:(24 * 7), size = length(adexsum$USUBJID), replace = TRUE) +adexsum$EXDURGR <- "not treated" +adexsum$EXDURGR[adexsum$AVAL >= 1] <- ">=1 day" +adexsum$EXDURGR[adexsum$AVAL >= 7] <- ">=7 days" +adexsum$EXDURGR[adexsum$AVAL >= 28] <- ">=28 days" +adexsum$EXDURGR[adexsum$AVAL >= 12 * 7] <- ">=12 weeks" +adexsum$EXDURGR[adexsum$AVAL >= 24 * 7] <- ">=24 weeks" + +adexsum$EXDURGR <- factor(adexsum$EXDURGR, + levels = c("not treated", ">=1 day", ">=7 days", ">=28 days", ">=12 weeks", ">=24 weeks") +) unique(adexsum$EXDURGR) ``` @@ -68,32 +69,32 @@ Step2: Save analysis plan and metadata(parameter and analysis) information, then ```{r} plan <- metalite::plan( - analysis = "exp_dur", population = "apat", - observation = "apat", parameter = "expdur" - ) - + analysis = "exp_dur", population = "apat", + observation = "apat", parameter = "expdur" +) + meta <- metalite::meta_adam( - population = adexsum, - observation = adexsum + population = adexsum, + observation = adexsum +) |> + metalite::define_plan(plan) |> + metalite::define_population( + name = "apat", + group = "TRTA", + subset = quote(APERIOD == 1 & AVAL > 0) + ) |> + metalite::define_parameter( + name = "expdur", + var = "AVAL", + label = "Exposure Duration (Days)", + vargroup = "EXDURGR" + ) |> + metalite::define_analysis( + name = "exp_dur", + title = "Summary of Exposure Duration", + label = "exposure duration table" ) |> - metalite::define_plan(plan) |> - metalite::define_population( - name = "apat", - group = "TRTA", - subset = quote(APERIOD==1 & AVAL>0) - ) |> - metalite::define_parameter( - name = "expdur", - var = "AVAL", - label = "Exposure Duration (Days)", - vargroup = "EXDURGR" - )|> - metalite::define_analysis( - name = "exp_dur", - title = "Summary of Exposure Duration", - label = "exposure duration table" - ) |> - metalite::meta_build() + metalite::meta_build() ``` ## Analysis preparation @@ -108,28 +109,28 @@ outdata Number of participants in population ```{r} -outdata$n[,1:5] +outdata$n[, 1:5] ``` Number of participants in each duration category ```{r} -charn<-data.frame(outdata$char_n[1]) -head(charn[,1:5],6) +charn <- data.frame(outdata$char_n[1]) +head(charn[, 1:5], 6) ``` Proportion of participants in each duration category ```{r} -charp<-data.frame(outdata$char_prop[1]) -head(charp[,1:5],6) +charp <- data.frame(outdata$char_prop[1]) +head(charp[, 1:5], 6) ``` Statistical summary of exposure duration for each treatment ```{r} -chars<-data.frame(outdata$char_n[1]) -tail(chars[,1:5],8) +chars <- data.frame(outdata$char_n[1]) +tail(chars[, 1:5], 8) ``` ## Format output diff --git a/vignettes/metalite-sl.Rmd b/vignettes/metalite-sl.Rmd index c2850eb..3250c51 100644 --- a/vignettes/metalite-sl.Rmd +++ b/vignettes/metalite-sl.Rmd @@ -28,27 +28,31 @@ adsl$TRTA <- factor(adsl$TRTA, ) # Create a variable EOSSTT indicating the end of end of study status -adsl$EOSSTT <- sample(x = c("Participants Ongoing", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.8, 0.2), replace = TRUE) +adsl$EOSSTT <- sample( + x = c("Participants Ongoing", "Discontinued"), + size = length(adsl$USUBJID), + prob = c(0.8, 0.2), replace = TRUE +) # Create a variable EOTSTT1 indicating the end of treatment status part 1 -adsl$EOTSTT1 <- sample(x = c("Completed", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.85, 0.15), replace = TRUE) +adsl$EOTSTT1 <- sample( + x = c("Completed", "Discontinued"), + size = length(adsl$USUBJID), + prob = c(0.85, 0.15), replace = TRUE +) ``` ```{r} plan <- plan( - analysis = "base_char", population = "apat", - observation = "apat", parameter = "age;gender;race" - ) |> + analysis = "base_char", population = "apat", + observation = "apat", parameter = "age;gender;race" +) |> add_plan( analysis = "disp", population = "apat", - observation = "apat", parameter = "disposition;medical-disposition" + observation = "apat", parameter = "disposition;medical-disposition" ) |> add_plan( analysis = "trt_compliance", population = "apat", - observation = "apat", parameter = "comp8;comp16;comp24" + observation = "apat", parameter = "comp8;comp16;comp24" ) ``` @@ -63,7 +67,6 @@ meta <- meta_adam( group = "TRTA", subset = quote(SAFFL == "Y"), var = c("USUBJID", "TRTA", "SAFFL", "AGEGR1", "SEX", "RACE", "EOSSTT", "EOTSTT1", "COMP8FL", "COMP16FL", "COMP24FL") - ) |> define_parameter( name = "age", @@ -173,13 +176,13 @@ outdata ``` ```{r} -outdata |> +outdata |> format_trt_compliance(display_col = c("n", "prop"), digits_prop = 3) |> rtf_trt_compliance( - source = "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = tempfile(fileext = ".rtf") -) + source = "Source: [CDISCpilot: adam-adsl]", + path_outdata = tempfile(fileext = ".Rdata"), + path_outtable = tempfile(fileext = ".rtf") + ) ``` # Create Treatment Compliance Table @@ -191,11 +194,11 @@ outdata ``` ```{r, eval=FALSE} -outdata |> +outdata |> format_disposition() |> rtf_disposition( - source = "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = tempfile(fileext = ".rtf") -) -``` \ No newline at end of file + source = "Source: [CDISCpilot: adam-adsl]", + path_outdata = tempfile(fileext = ".Rdata"), + path_outtable = tempfile(fileext = ".rtf") + ) +``` From 25b7a3df31e97b2aad98cfe1679ec9731e4d8abe Mon Sep 17 00:00:00 2001 From: "Wang, Benjamin" Date: Tue, 12 Nov 2024 21:20:46 -0500 Subject: [PATCH 02/10] clean up the package --- R/prepare_sl_summary.R | 5 +- vignettes/baseline-character.Rmd | 126 ++--- .../{Disposition.Rmd => disposition.Rmd} | 55 +- vignettes/exp_duration.Rmd | 7 + vignettes/fig/base0char.png | Bin 0 -> 75100 bytes vignettes/interactive-baseline.Rmd | 3 +- vignettes/metalite-sl.Rmd | 254 +++------ vignettes/outtable/bar0char0subgroup.rtf | 505 ------------------ vignettes/outtable/base0char.rtf | 368 +++++++------ vignettes/outtable/base0charsubgroup.rtf | 304 ++++++++++- vignettes/outtable/base_char.rtf | 323 ----------- vignettes/outtable/disposition.rtf | 206 ++++--- vignettes/outtable/disposition1.rtf | 366 ------------- vignettes/outtable/pdf/disposition1.pdf | Bin 92020 -> 0 bytes vignettes/outtable/treatment0compliance1.rtf | 269 ---------- vignettes/pdf/base0char.pdf | Bin 0 -> 48429 bytes vignettes/pdf/base0charsubgroup.pdf | Bin 0 -> 35559 bytes vignettes/{outtable => }/pdf/disposition.pdf | Bin vignettes/pdf/exp0duration.pdf | Bin 0 -> 49081 bytes .../pdf/treatment0compliance.pdf | Bin .../pdf/treatment0compliance1.pdf | Bin vignettes/trt_compliance.Rmd | 74 +-- 22 files changed, 852 insertions(+), 2013 deletions(-) rename vignettes/{Disposition.Rmd => disposition.Rmd} (85%) create mode 100644 vignettes/fig/base0char.png delete mode 100644 vignettes/outtable/bar0char0subgroup.rtf delete mode 100644 vignettes/outtable/base_char.rtf delete mode 100644 vignettes/outtable/disposition1.rtf delete mode 100644 vignettes/outtable/pdf/disposition1.pdf delete mode 100644 vignettes/outtable/treatment0compliance1.rtf create mode 100644 vignettes/pdf/base0char.pdf create mode 100644 vignettes/pdf/base0charsubgroup.pdf rename vignettes/{outtable => }/pdf/disposition.pdf (100%) create mode 100644 vignettes/pdf/exp0duration.pdf rename vignettes/{outtable => }/pdf/treatment0compliance.pdf (100%) rename vignettes/{outtable => }/pdf/treatment0compliance1.pdf (100%) diff --git a/R/prepare_sl_summary.R b/R/prepare_sl_summary.R index f0a68fe..0e6ca83 100644 --- a/R/prepare_sl_summary.R +++ b/R/prepare_sl_summary.R @@ -39,10 +39,9 @@ prepare_sl_summary <- function( analysis, parameter = paste(names(meta$parameter), collapse = ";")) { parameters <- unlist(strsplit(parameter, ";")) - observation <- meta$plan[meta$plan$analysis == analysis, ]$observation + observation <- population # obtain variables pop_var <- metalite::collect_adam_mapping(meta, population)$var - obs_var <- metalite::collect_adam_mapping(meta, observation)$var par_var <- do.call(c, lapply(parameters, function(x) { metalite::collect_adam_mapping(meta, x)$var })) @@ -56,10 +55,8 @@ prepare_sl_summary <- function( })) pop_group <- metalite::collect_adam_mapping(meta, population)$group - obs_group <- metalite::collect_adam_mapping(meta, observation)$group pop_id <- metalite::collect_adam_mapping(meta, population)$id - obs_id <- metalite::collect_adam_mapping(meta, observation)$id # obtain data pop <- metalite::collect_population_record(meta, population, var = c(par_var, par_var_group, par_var_lower)) diff --git a/vignettes/baseline-character.Rmd b/vignettes/baseline-character.Rmd index 2cdac64..83c7046 100644 --- a/vignettes/baseline-character.Rmd +++ b/vignettes/baseline-character.Rmd @@ -23,9 +23,9 @@ library(metalite.sl) The baseline characteristic analysis aims to provide tables to summarize details of participants. The development of baseline characteristic analysis involves functions: -- `prepare_base_cha`: prepare analysis raw datasets. -- `format_base_char`: prepare analysis (mock) outdata with proper format. -- `rtf_base_char`: transfer (mock) output dataset to RTF table. +- `prepare_base_char`: prepare analysis raw datasets. +- `format_base_char`: prepare analysis outdata with proper format. +- `rtf_base_char`: transfer output dataset to RTF table. ## Build a metadata @@ -40,49 +40,21 @@ adsl$TRTA <- factor( ``` ```{r} -plan <- plan( - analysis = "base_char", - population = "apat", - observation = "apat", - parameter = "age;gender;race" +meta <- meta_sl( + dataset_population = adsl, + population_term = "apat", + parameter_term = "age;gender;race", + parameter_var = "AGE^AGEGR1;SEX;RACE", + treatment_group = "TRTA" ) ``` +
+Click to show the output ```{r} -meta <- meta_adam( - population = adsl, - observation = adsl -) |> - define_plan(plan = plan) |> - define_population( - name = "apat", - group = "TRTA", - subset = quote(SAFFL == "Y"), - var = c("USUBJID", "TRTA", "SAFFL", "AGEGR1", "SEX", "RACE") - ) |> - define_parameter( - name = "age", - var = "AGE", - label = "Age (years)", - vargroup = "AGEGR1" - ) |> - define_parameter( - name = "gender", - var = "SEX", - label = "Gender" - ) |> - define_parameter( - name = "race", - var = "RACE", - label = "Race" - ) |> - define_analysis( - name = "base_char", - title = "Participant Baseline Characteristics by Treatment Group", - label = "baseline characteristic table" - ) |> - meta_build() +meta ``` +
## Analysis preparation @@ -93,12 +65,19 @@ outdata <- meta |> prepare_base_char(parameter = "age;gender;race") outdata +``` + +
+Click to show the output +```{r} outdata$n outdata$char_n outdata$char_var outdata$char_prop ``` +
+ ## Format the numbers @@ -110,16 +89,14 @@ outdata <- display_col = c("n", "prop", "total"), digits_prop = 2 ) - -outdata$tbl ``` +
+Click to show the output ```{r} -outdata <- - outdata |> format_base_char(display_col = c("n", "prop"), digits_prop = 3) - outdata$tbl ``` +
## Output as RTF @@ -133,14 +110,18 @@ outdata |> rtf_base_char( ) ``` +```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} +knitr::include_graphics("pdf/base0char.pdf") +``` + # Create Baseline Characteristic Table for Subgroup Analysis The baseline characteristic subgroup analysis aims to provide tables to summarize details of participants by subgroup. The development of baseline characteristic subgroup analysis involves functions: - `prepare_base_char_subgroup()`: prepare analysis raw datasets. -- `format_base_char_subgroup()`: prepare analysis (mock) outdata with proper format. -- `rtf_base_char_subgroup()`: transfer (mock) output dataset to RTF table. +- `format_base_char_subgroup()`: prepare analysis outdata with proper format. +- `rtf_base_char_subgroup()`: transfer output dataset to RTF table. ## Build a metadata @@ -156,16 +137,10 @@ adsl$TRTA <- factor( ```{r} plan <- plan( - analysis = "base_char", - population = "apat", - observation = "apat", - parameter = "age;gender;race" -) |> - add_plan( analysis = "base_char_subgroup", population = "apat", observation = "apat", - parameter = "age" + parameter = "age;gender;race" ) ``` @@ -187,21 +162,11 @@ meta <- meta_adam( label = "Age (years)", vargroup = "AGEGR1" ) |> - define_parameter( - name = "gender", - var = "SEX", - label = "Gender" - ) |> define_parameter( name = "race", var = "RACE", label = "Race" ) |> - define_analysis( - name = "base_char", - title = "Participant Baseline Characteristics by Treatment Group", - label = "baseline characteristic table" - ) |> define_analysis( name = "base_char_subgroup", title = "Participant by Age Category and Sex", @@ -210,11 +175,14 @@ meta <- meta_adam( meta_build() ``` -## Analysis preparation - +
+Click to show the output ```{r} -meta <- meta_sl_example() +meta ``` +
+ +## Analysis preparation The input of the function `prepare_base_char_subgroup()` is a `meta` object created by the metalite package. @@ -228,13 +196,15 @@ raw datasets. Key arguments are: outdata <- prepare_base_char_subgroup( meta, population = "apat", - parameter = "age", + parameter = "age;race", subgroup_var = "TRTA", subgroup_header = c("SEX", "TRTA"), display_subgroup_total = TRUE ) ``` +
+Click to show the output The output dataset contains commonly used statistics within each `subgroup_var`. ```{r} @@ -257,25 +227,37 @@ outdata$out_all$`Placebo`$n outdata$out_all$`High Dose`$n outdata$out_all$`Low Dose`$n ``` +
## Format output `format_base_char_subgroup` to prepare analysis dataset before generate RTF output ```{r} -tbl <- format_base_char_subgroup(outdata) -head(tbl$tbl) +outdata <- format_base_char_subgroup(outdata) ``` +
+Click to show the output +```{r} +outdata$tbl +``` +
+ ## Output as RTF `rtf_base_char_subgroup` to generate RTF output ```{r, warning=FALSE} -outdata <- format_base_char_subgroup(outdata) |> +outdata |> rtf_base_char_subgroup( source = "Source: [CDISCpilot: adam-adsl]", path_outdata = tempfile(fileext = ".Rdata"), path_outtable = "outtable/base0charsubgroup.rtf" ) ``` + + +```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} +knitr::include_graphics("pdf/base0charsubgroup.pdf") +``` diff --git a/vignettes/Disposition.Rmd b/vignettes/disposition.Rmd similarity index 85% rename from vignettes/Disposition.Rmd rename to vignettes/disposition.Rmd index 9aebf5b..f2b8c10 100644 --- a/vignettes/Disposition.Rmd +++ b/vignettes/disposition.Rmd @@ -24,7 +24,7 @@ library(dplyr) -## Overview +# Create Disposition Table The objective of this tutorial is to generate a production-ready Disposition table specification analyses. @@ -40,7 +40,7 @@ To accomplish this using metalite.sl, four essential functions are required: An example output: ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} -knitr::include_graphics("outtable/pdf/disposition.pdf") +knitr::include_graphics("pdf/disposition.pdf") ``` @@ -53,7 +53,7 @@ within metalite.sl. Additional information can be accessed on the [metalite package website](https://merck.github.io/metalite/articles/metalite.html). -# Build a metadata +## Build a metadata ```{r} @@ -123,7 +123,7 @@ meta ``` -### Analysis preparation +## Analysis preparation The function `prepare_disposition()` is written to prepare data for subject disposition analysis.The function takes four arguments: @@ -144,6 +144,11 @@ a collection of raw datasets for analysis and reporting. ```{r} outdata <- prepare_disposition(meta) +``` + +
+Click to show the output +```{r} outdata ``` - `parameter`: parameter name @@ -181,6 +186,7 @@ outdata$char_var ```{r} outdata$char_prop ``` +
## Format output @@ -188,23 +194,26 @@ Once the raw analysis results are obtained, the `format_disposition()` function can be employed to prepare the outdata,ensuring its compatibility with production-ready RTF tables. ```{r} -tbl <- outdata |> format_disposition() -head(tbl$tbl) +outdata <- outdata |> format_disposition() ``` +
+Click to show the output +```{r} +outdata$tbl +``` +
+ ## RTF tables The last step is to prepare the RTF table using `rtf_trt_compliance`. ```{r} -x <- outdata |> - format_disposition() - -x$tbl <- x$tbl %>% +outdata$tbl <- outdata$tbl %>% mutate(name = ifelse(trimws(name) == "Status Not Recorded", " Status Not Recorded", name)) -x |> +outdata |> rtf_disposition( "Source: [CDISCpilot: adam-adsl]", path_outdata = tempfile(fileext = ".Rdata"), @@ -213,28 +222,6 @@ x |> ``` ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} -knitr::include_graphics("outtable/pdf/disposition.pdf") +knitr::include_graphics("pdf/disposition.pdf") ``` -The rtf_trt_compliance() function also provides some commonly used arguments to customize the table. - -```{r} -x <- outdata |> - format_disposition() - -x$tbl <- x$tbl %>% - mutate(name = ifelse(trimws(name) == "Status Not Recorded", " Status Not Recorded", name)) - -x |> - rtf_disposition( - orientation = "landscape", - col_rel_width = c(4, rep(1, 9)), - "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = "outtable/disposition1.rtf" - ) -``` - -```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} -knitr::include_graphics("outtable/pdf/disposition1.pdf") -``` diff --git a/vignettes/exp_duration.Rmd b/vignettes/exp_duration.Rmd index 24653cc..adb5c81 100644 --- a/vignettes/exp_duration.Rmd +++ b/vignettes/exp_duration.Rmd @@ -28,6 +28,10 @@ The development of exposure duration analysis involves functions: - `format_exp_duration`: prepare analysis outdata with proper format. - `rtf_exp_duration`: transfer (mock) output dataset to RTF table. +```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} +knitr::include_graphics("pdf/exp0duration.pdf") +``` + ## Build a metadata There are two steps in `meta_sl_exposure_example` function in order to build the metadata (`meta` object): processing the ADaM dataset and save meta information for A&R reporting. @@ -156,3 +160,6 @@ outdata <- format_exp_duration(outdata) |> ) ``` +```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} +knitr::include_graphics("pdf/exp0duration.pdf") +``` \ No newline at end of file diff --git a/vignettes/fig/base0char.png b/vignettes/fig/base0char.png new file mode 100644 index 0000000000000000000000000000000000000000..1f9a110b5ebfc3d414d0e9ede29968ecd59968d0 GIT binary patch literal 75100 zcmb@uby!qg`!B9i3eqJ~f}o@*AV`aXG!g=Xbc-}dcS#AtFmx%Y(%s!di~Cz=)1$h~bOP8)RfzO*) z@xi}zTx6DkKQ6my$UV7KGR&|JzQDDTR*}ARsr)_BsRuFIuMH0;plWd#kk z-Ak7)@)TsGUw9a9W?XC1(xh#x_2H1smQfFRV!=hNa8r$y4ITn#?N9zl#-&Lpt4KM- z%EFHr`6QUEm?sUtZt+@m-Dj-t3Mmv@X}<4t=#^oCsCY)fLMdw(X3(vl3l z`jt3Mf@=0>-RDz2YZj!6xU44g>ea}fKbJaVyP#&*okBV7#Za>^o}OXmS99J=@@I&; z^4m<5Jgk2GoxdQCp4&l-28*ex6v^1AI)H<5KIKO-0zCB|New~!aFjoXN=9T!tpulQ70W+1z z?spv{&w7zH%)Gy_1rqT|LgZ0-Bfk$gu{(}U}KDX?ej9UHX z3aE&-EWUn_UhSqe5(Mk``Ljk|Btj~Z52yDE9$_+O&Ku=jo6W|;(G&@vo^k4Byk3;P 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zPgo>KQ|^q#csueOdG=iz!t$=;9F5V=f8ZWa6t}in62&80Y0GDKLLxEiA6-|$^3+po zI(Gem61j(o=%{COvwpw|N%7T@bK84f9-KoFG*PZ|7q%glPnQpw#6}f@wEPtF_A!RB z^vJjRot$lpytMbIw~5DQ_N1qyNGBFymK=n$S8k7K>I(nUvEbY~wnmP%NE%!*g1HY8 zxFf_4vG8W_d&S(1b50N4wNh%7K_(c8?ADl$N6q%%pygt2k_DLCV(^tE6Yza-vm+_r zi;Q^n0BL48&<5O}bO library(r2rtf) library(metalite) library(metalite.ae) -library(metalite.sl) +# library(metalite.sl) +devtools::load_all() ``` There are 2 key metadata types: diff --git a/vignettes/metalite-sl.Rmd b/vignettes/metalite-sl.Rmd index 3250c51..18a1749 100644 --- a/vignettes/metalite-sl.Rmd +++ b/vignettes/metalite-sl.Rmd @@ -13,192 +13,102 @@ vignette: > %\VignetteIndexEntry{Getting Started with metalite.sl} --- -```{r} -library(metalite) -library(metalite.sl) -``` - -# Build a metadata -```{r} -adsl <- r2rtf::r2rtf_adsl -adsl$TRTA <- adsl$TRT01A -adsl$TRTA <- factor(adsl$TRTA, - levels = c("Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"), - labels = c("Placebo", "Low Dose", "High Dose") +```{r, include=FALSE} +knitr::opts_chunk$set( + comment = "#>", + collapse = TRUE, + out.width = "100%", + dpi = 150, + eval = TRUE ) - -# Create a variable EOSSTT indicating the end of end of study status -adsl$EOSSTT <- sample( - x = c("Participants Ongoing", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.8, 0.2), replace = TRUE -) -# Create a variable EOTSTT1 indicating the end of treatment status part 1 -adsl$EOTSTT1 <- sample( - x = c("Completed", "Discontinued"), - size = length(adsl$USUBJID), - prob = c(0.85, 0.15), replace = TRUE -) -``` - -```{r} -plan <- plan( - analysis = "base_char", population = "apat", - observation = "apat", parameter = "age;gender;race" -) |> - add_plan( - analysis = "disp", population = "apat", - observation = "apat", parameter = "disposition;medical-disposition" - ) |> - add_plan( - analysis = "trt_compliance", population = "apat", - observation = "apat", parameter = "comp8;comp16;comp24" - ) -``` - -```{r} -meta <- meta_adam( - population = adsl, - observation = adsl -) |> - define_plan(plan = plan) |> - define_population( - name = "apat", - group = "TRTA", - subset = quote(SAFFL == "Y"), - var = c("USUBJID", "TRTA", "SAFFL", "AGEGR1", "SEX", "RACE", "EOSSTT", "EOTSTT1", "COMP8FL", "COMP16FL", "COMP24FL") - ) |> - define_parameter( - name = "age", - var = "AGE", - label = "Age (years)", - vargroup = "AGEGR1" - ) |> - define_parameter( - name = "gender", - var = "SEX", - label = "Gender" - ) |> - define_parameter( - name = "race", - var = "RACE", - label = "Race" - ) |> - define_parameter( - name = "disposition", - var = "EOSSTT", - label = "Trial Disposition" - ) |> - define_parameter( - name = "medical-disposition", - var = "EOTSTT1", - label = "Participant Study Medication Disposition" - ) |> - metalite::define_parameter( - name = "comp8", - var = "COMP8FL", - label = "Compliance (Week 8)", - ) |> - metalite::define_parameter( - name = "comp16", - var = "COMP16FL", - label = "Compliance (Week 16)", - ) |> - metalite::define_parameter( - name = "comp24", - var = "COMP24FL", - label = "Compliance (Week 24)", - ) |> - define_analysis( - name = "base_char", - title = "Participant Baseline Characteristics by Treatment Group", - label = "baseline characteristic table" - ) |> - define_analysis( - name = "trt_compliance", - title = "Summary of Treatment Compliance", - label = "treatment compliance table" - ) |> - define_analysis( - name = "disp", - title = "Disposition of Participant", - label = "disposition table" - ) |> - meta_build() -``` - -# Prepare the numbers - -```{r} -outdata <- meta |> - prepare_base_char( - parameter = "age;gender;race" - ) - -outdata - -outdata$n -outdata$char_n -outdata$char_var -outdata$char_prop ``` -# Format the numbers - ```{r} -outdata <- outdata |> format_base_char(display_col = c("n", "prop", "total"), digits_prop = 2) - -outdata$tbl +library(metalite) +# library(metalite.sl) +devtools::load_all() ``` -```{r} -outdata <- outdata |> format_base_char(display_col = c("n", "prop"), digits_prop = 3) - -outdata$tbl +# Overview + +metalite.sl R package designed for the analysis & reporting of subject-level analysis in clinical trials. +It operates on ADaM datasets and adheres to the metalite structure. +The package encompasses the following components: + +
+Baseline Characteristics. + +
+ +This R package offers a comprehensive software development lifecycle (SDLC) +solution, encompassing activities such as definition, development, +validation, and finalization of the analysis. + +# Highlighted features + +- Avoid duplicated input by using metadata structure. + - For example, define analysis population once to use + in all subject level analysis. +- Consistent input and output in standard functions. +- Provide workflow to add interactive features to subject-level analysis table. + +# Workflow + +The overall workflow includes the following steps: + +1. Define metadata information using metalite R package. +1. Prepare outdata using `prepare_*()` functions. +1. Extend outdata using `extend_*()` functions (optional). +1. Format outdata using `format_*()` functions. +1. Create TLFs using `tlf_*()` functions. + +For instance, we can illustrate the creation of a straightforward +Baseline characteristic table as shown below. + +```{r, eval = FALSE} +meta_sl_example() |> + prepare_base_char( + population = "apat", + analysis = "base_char", + parameter = "age;gender" + ) |> + format_base_char() |> + rtf_base_char( + source = "Source: [CDISCpilot: adam-adsl]", + path_outdata = tempfile(fileext = ".Rdata"), + path_outtable = tempfile(fileext = ".rtf") ``` -# Output as RTF - -```{r} -outdata |> rtf_base_char( - source = "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = "base_char.rtf" -) +```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} +knitr::include_graphics("pdf/base0char.pdf") ``` -# Create Treatment Compliance Table +An example for interactive baseline characteristic table: ```{r} -outdata <- meta |> - prepare_trt_compliance() -outdata -``` - -```{r} -outdata |> - format_trt_compliance(display_col = c("n", "prop"), digits_prop = 3) |> - rtf_trt_compliance( - source = "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = tempfile(fileext = ".rtf") + react_base_char( + metadata_sl = meta_sl_example(), + metadata_ae = metalite.ae::meta_ae_example(), + population = "apat", + observation = "wk12", + display_total = TRUE, + sl_parameter = "age;race", + ae_subgroup = c("age", "race"), + ae_specific = "rel", + width = 1200 ) + ``` -# Create Treatment Compliance Table +Additional examples and tutorials can be found on the +[package website](https://merck.github.io/metalite.sl/articles/), +offering further guidance and illustrations. -```{r} -outdata <- meta |> - prepare_disposition() -outdata -``` +## Input -```{r, eval=FALSE} -outdata |> - format_disposition() |> - rtf_disposition( - source = "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = tempfile(fileext = ".rtf") - ) -``` +To implement the workflow in metalite.sl, it is necessary to establish +a metadata structure using the metalite R package. +For detailed instructions, please consult the +[metalite tutorial](https://merck.github.io/metalite/articles/metalite.html) +and refer to the source code of the function +[`meta_sl_example()`](https://github.com/Merck/metalite.sl/blob/main/R/meta_sl_example.R). diff --git a/vignettes/outtable/bar0char0subgroup.rtf b/vignettes/outtable/bar0char0subgroup.rtf deleted file mode 100644 index 31b2758..0000000 --- a/vignettes/outtable/bar0char0subgroup.rtf +++ /dev/null @@ -1,505 +0,0 @@ -{\rtf1\ansi -\deff0\deflang1033 -{\fonttbl{\f0\froman\fcharset161\fprq2 Times New Roman;} -{\f1\froman\fcharset161\fprq2 Times New Roman Greek;} -{\f2\fswiss\fcharset161\fprq2 Arial Greek;} -{\f3\fswiss\fcharset161\fprq2 Arial;} -{\f4\fswiss\fcharset161\fprq2 Helvetica;} -{\f5\fswiss\fcharset161\fprq2 Calibri;} -{\f6\froman\fcharset161\fprq2 Georgia;} 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[CDISCpilot: adam-adsl]}\par} - -} diff --git a/vignettes/outtable/base0char.rtf b/vignettes/outtable/base0char.rtf index 5eb3529..95f9c83 100644 --- a/vignettes/outtable/base0char.rtf +++ b/vignettes/outtable/base0char.rtf @@ -21,23 +21,27 @@ \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx7363 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@@ -45,15 +49,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (%)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 n}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (%)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 n}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (%)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 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\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 65-80}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 42}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (48.837)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (48.84)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 47}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (55.952)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (55.95)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 55}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (65.476)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (65.48)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 144}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (56.69)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 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+\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -129,15 +153,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Mean}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 75.2}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -145,15 +173,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 74.4}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 75.1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 SD}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8.6}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -161,15 +193,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 7.9}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8.2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 SE}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0.9}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -177,15 +213,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0.9}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0.5}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Median}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 76.0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -193,15 +233,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 76.0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 77.0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Q1 to Q3}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 69.25 to 81.75}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -209,15 +253,19 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 70.75 to 80}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 70 to 81}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Range}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 52 to 89}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell @@ -225,94 +273,116 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 56 to 88}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 51 to 89}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx9000 -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs18{\f0\b Gender}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs18{\f0\b Sex}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 F}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 53}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (61.628)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (61.63)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 50}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (59.524)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (59.52)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 40}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (47.619)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (47.62)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 143}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (56.30)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 M}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 33}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (38.372)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (38.37)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 34}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (40.476)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (40.48)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 44}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (52.381)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (52.38)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 111}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (43.70)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx9000 \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs18{\f0\b Race}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 AMERICAN INDIAN OR ALASKA NATIVE}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.000)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.00)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.000)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.00)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.19)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.190)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.39)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 BLACK OR AFRICAN AMERICAN}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.302)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.30)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.143)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.14)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 9}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (10.714)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (10.71)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 23}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.06)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx9000 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 WHITE}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 78}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (90.698)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (90.70)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 78}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (92.857)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (92.86)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 74}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (88.095)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (88.10)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 230}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (90.55)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx9000 diff --git a/vignettes/outtable/base0charsubgroup.rtf b/vignettes/outtable/base0charsubgroup.rtf index 645f8b9..a8e8e42 100644 --- a/vignettes/outtable/base0charsubgroup.rtf +++ b/vignettes/outtable/base0charsubgroup.rtf @@ -42,14 +42,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx11016 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx12240 \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 }\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Female}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Male}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 F}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 M}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Total}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Female}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Male}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 F}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 M}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Total}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Female}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Male}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 F}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 M}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs16{\f0 Total}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc @@ -166,7 +166,7 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 5}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (10.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 3}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (8.8)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (8.8)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 8}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (9.5)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 5}\cell @@ -206,7 +206,7 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 17}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (34.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 12}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (35.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (35.3)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 29}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (34.5)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 7}\cell @@ -246,7 +246,7 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 28}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (56.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 19}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (55.9)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (55.9)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 47}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 (56.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 28}\cell @@ -456,6 +456,292 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 56 to 88}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs16{\f0 }\cell \intbl\row\pard + + +{\pard\fs2\par}\page{\pard\fs2\par} +\paperw15840\paperh12240\landscape + +\margl1440\margr1440\margt2880\margb1800\headery1800\footery1800 + +{\pard\hyphpar\sb180\sa180\fi0\li0\ri0\qc\fs24{\f0 Participant by Age 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-\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx9000 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 AMERICAN INDIAN OR ALASKA NATIVE}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.000)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.000)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell 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-\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 9}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (10.714)}\cell -\intbl\row\pard -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx3000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx4000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx5000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx6000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx7000 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx8000 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx9000 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 WHITE}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 78}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (90.698)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 78}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (92.857)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 74}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (88.095)}\cell -\intbl\row\pard -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx9000 -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\ql\fs18{\f0 SD=Standard deviation; SE=Standard error; Q1=First quartile, Q3=Third quartile.}\cell -\intbl\row\pard -{\pard\hyphpar\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 Source: [CDISCpilot: adam-adsl]}\par} - -} diff --git a/vignettes/outtable/disposition.rtf b/vignettes/outtable/disposition.rtf index d076267..fd749eb 100644 --- a/vignettes/outtable/disposition.rtf +++ b/vignettes/outtable/disposition.rtf @@ -87,14 +87,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Discontinued}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 24}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (27.9)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 15}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (17.9)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 15}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (17.9)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 54}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (21.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 27}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (31.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 12}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (14.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 19}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (22.6)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 58}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (22.8)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -107,14 +107,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Adverse Event}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 3}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (3.5)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 7}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (8.3)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 7}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (8.3)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 17}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (6.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 4}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (4.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.5)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 18}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -126,13 +126,13 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 I/E Not Met}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Death}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell \intbl\row\pard @@ -146,13 +146,13 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Lack of Efficacy}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 I/E Not Met}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell \intbl\row\pard @@ -166,7 +166,7 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Sponsor Decision}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Physician Decision}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell @@ -186,15 +186,55 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Withdrew Consent}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 3}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (3.5)}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Protocol Violation}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell +\intbl\row\pard +\trowd\trgaph108\trleft0\trqc +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Sponsor Decision}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 5}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell +\intbl\row\pard +\trowd\trgaph108\trleft0\trqc +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Withdrew Consent}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -207,14 +247,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Participants Ongoing}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 62}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (72.1)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 69}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (82.1)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 69}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (82.1)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 200}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (78.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 59}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (68.6)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 72}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (85.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 65}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (77.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 196}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (77.2)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx9000 @@ -271,14 +311,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Adverse Event}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 3}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (3.5)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 7}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (8.3)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 7}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (8.3)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 17}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (6.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 4}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (4.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.5)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 18}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -290,13 +330,13 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 I/E Not Met}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Death}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell \intbl\row\pard @@ -310,13 +350,13 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Lack of Efficacy}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 I/E Not Met}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell \intbl\row\pard @@ -330,7 +370,7 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Sponsor Decision}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Physician Decision}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell @@ -341,6 +381,46 @@ \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Protocol Violation}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell +\intbl\row\pard +\trowd\trgaph108\trleft0\trqc +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 +\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 +\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Sponsor Decision}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell +\intbl\row\pard +\trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx2455 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx3273 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx4091 @@ -351,14 +431,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Withdrew Consent}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 3}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (3.5)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 5}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.0)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \intbl\row\pard {\pard\hyphpar\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 Source: [CDISCpilot: adam-adsl]}\par} diff --git a/vignettes/outtable/disposition1.rtf b/vignettes/outtable/disposition1.rtf deleted file mode 100644 index 3ed8554..0000000 --- a/vignettes/outtable/disposition1.rtf +++ /dev/null @@ -1,366 +0,0 @@ -{\rtf1\ansi -\deff0\deflang1033 -{\fonttbl{\f0\froman\fcharset161\fprq2 Times New Roman;} -{\f1\froman\fcharset161\fprq2 Times New Roman Greek;} -{\f2\fswiss\fcharset161\fprq2 Arial Greek;} -{\f3\fswiss\fcharset161\fprq2 Arial;} -{\f4\fswiss\fcharset161\fprq2 Helvetica;} -{\f5\fswiss\fcharset161\fprq2 Calibri;} -{\f6\froman\fcharset161\fprq2 Georgia;} -{\f7\ffroman\fcharset161\fprq2 Cambria;} -{\f8\fmodern\fcharset161\fprq2 Courier New;} -{\f9\ftech\fcharset161\fprq2 Symbol;} -} - - -\paperw15840\paperh12240\landscape - -\margl1440\margr1440\margt2880\margb1800\headery1800\footery1800 - -{\pard\hyphpar\sb180\sa180\fi0\li0\ri0\qc\fs24{\f0 Disposition of Participant}\line\fs24{\f0 All Participants as Treated}\par} - - -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx4080 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx6120 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx8160 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrb\brdrw15\clvertalb\cellx10200 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrdb\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx12240 -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 Placebo}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 Low Dose}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 High Dose}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 Total}\cell -\intbl\row\pard -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalb\cellx4080 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx5100 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx6120 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx7140 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx8160 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx9180 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx10200 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx11220 -\clbrdrl\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalb\cellx12240 -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 }\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 n}\cell 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+Click to show the output +```{r} outdata ``` - `parameter`: parameter name @@ -181,11 +186,9 @@ outdata$parameter outdata$n ``` - The resulting dataset contains frequently used statistics, with variables indexed according to the order specified in `outdata$group`. - ```{r} outdata$group ``` @@ -204,6 +207,7 @@ outdata$char_var ```{r} outdata$char_prop ``` +
## Format output @@ -211,35 +215,31 @@ Once the raw analysis results are obtained, the `format_trt_compliance()` function can be employed to prepare the outdata,ensuring its compatibility with production-ready RTF tables. ```{r} -tbl <- outdata |> format_trt_compliance() -head(tbl$tbl) +outdata <- outdata |> format_trt_compliance() +``` + +
+Click to show the output +```{r} +outdata$tbl ``` -### Additional statistics +
+ +## Additional statistics By using the `display` argument, we can choose specific statistics to include. ```{r} tbl <- outdata |> format_trt_compliance(display_stat = c("mean", "sd", "median", "range"), display_col = c("n", "prop", "total")) -tbl$tbl ``` -### Mock data preparation - -The `mock` argument facilitates the creation of a mock table with ease. - -Please note that the intention of the `mock` argument is not to provide -an all-encompassing mock table template. -Instead, it serves as a convenient method to assist users in generating -a mock table that closely resembles the desired output layout. -To develop a more versatile mock table generation tool, further efforts -are necessary. -This could potentially involve the creation of a dedicated mock table -generation package or similar solutions. +
+Click to show the output ```{r} -tbl <- outdata |> format_trt_compliance() -head(tbl$tbl) +tbl$tbl ``` +
## RTF tables @@ -255,23 +255,5 @@ outdata |> ``` ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} -knitr::include_graphics("outtable/pdf/treatment0compliance.pdf") -``` - -The rtf_trt_compliance() function also provides some commonly used arguments to customize the table. - - -```{r} -outdata |> - format_trt_compliance() |> - rtf_trt_compliance( - orientation = "landscape", - col_rel_width = c(4, rep(1, 9)), - "Source: [CDISCpilot: adam-adsl]", - path_outtable = "outtable/treatment0compliance1.rtf" - ) -``` - -```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} -knitr::include_graphics("outtable/pdf/treatment0compliance1.pdf") +knitr::include_graphics("pdf/treatment0compliance.pdf") ``` From 9d81623b50b21963e9f4d4c587b0eddcaf80045f Mon Sep 17 00:00:00 2001 From: "Fukuda, Hiroaki" Date: Sun, 17 Nov 2024 18:37:54 -0500 Subject: [PATCH 03/10] Update vignettes to build their output appropreately --- vignettes/disposition.Rmd | 7 +- vignettes/interactive-baseline.Rmd | 3 +- vignettes/metalite-sl.Rmd | 4 +- vignettes/outtable/disposition.rtf | 186 ++++++++--------------------- vignettes/pdf/disposition.pdf | Bin 89417 -> 48816 bytes 5 files changed, 62 insertions(+), 138 deletions(-) diff --git a/vignettes/disposition.Rmd b/vignettes/disposition.Rmd index f2b8c10..2cf2ea8 100644 --- a/vignettes/disposition.Rmd +++ b/vignettes/disposition.Rmd @@ -70,6 +70,11 @@ adsl$EOSSTT <- sample( size = length(adsl$USUBJID), prob = c(0.8, 0.2), replace = TRUE ) +adsl[adsl[["EOSSTT"]] == "Discontinued", "DCSREAS"] <- sample( + x = c("Adverse Event", "I/E Not Met", "Withdrew Consent", "Lack of Efficacy"), + size = length(adsl[adsl[["EOSSTT"]] == "Discontinued", "USUBJID"]), + prob = c(0.7, 0.1, 0.1, 0.1), replace = TRUE +) # Create a variable EOTSTT1 indicating the end of treatment status part 1 adsl$EOTSTT1 <- ifelse(adsl$DISCONFL == "Y", "Discontinued", "Completed") @@ -100,7 +105,7 @@ meta <- meta_adam( name = "disposition", var = "EOSSTT", label = "Trial Disposition", - var_lower = "DCTREAS" + var_lower = "DCSREAS" ) |> define_parameter( name = "medical-disposition", diff --git a/vignettes/interactive-baseline.Rmd b/vignettes/interactive-baseline.Rmd index 75b315a..776b15d 100644 --- a/vignettes/interactive-baseline.Rmd +++ b/vignettes/interactive-baseline.Rmd @@ -18,8 +18,7 @@ vignette: > library(r2rtf) library(metalite) library(metalite.ae) -# library(metalite.sl) -devtools::load_all() +library(metalite.sl) ``` There are 2 key metadata types: diff --git a/vignettes/metalite-sl.Rmd b/vignettes/metalite-sl.Rmd index 18a1749..3badc5e 100644 --- a/vignettes/metalite-sl.Rmd +++ b/vignettes/metalite-sl.Rmd @@ -25,8 +25,7 @@ knitr::opts_chunk$set( ```{r} library(metalite) -# library(metalite.sl) -devtools::load_all() +library(metalite.sl) ``` # Overview @@ -77,6 +76,7 @@ meta_sl_example() |> source = "Source: [CDISCpilot: adam-adsl]", path_outdata = tempfile(fileext = ".Rdata"), path_outtable = tempfile(fileext = ".rtf") + ) ``` ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} diff --git a/vignettes/outtable/disposition.rtf b/vignettes/outtable/disposition.rtf index fd749eb..a4b4f8e 100644 --- a/vignettes/outtable/disposition.rtf +++ b/vignettes/outtable/disposition.rtf @@ -87,14 +87,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Discontinued}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 27}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (31.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 24}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (27.9)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 12}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (14.3)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 19}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (22.6)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 58}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (22.8)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 20}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (23.8)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 56}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (22.0)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -107,14 +107,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Adverse Event}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 4}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (4.7)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.5)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 18}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 18}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (20.9)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 9}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (10.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 13}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (15.5)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 40}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (15.7)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -126,15 +126,15 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Death}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 I/E Not Met}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 3}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (3.5)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 4}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (4.8)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 7}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.8)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -146,15 +146,15 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 I/E Not Met}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Lack of Efficacy}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -166,75 +166,15 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Physician Decision}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Withdrew Consent}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell -\intbl\row\pard -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Protocol Violation}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell -\intbl\row\pard -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Sponsor Decision}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 3}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell -\intbl\row\pard -\trowd\trgaph108\trleft0\trqc -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx3273 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4091 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx4909 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx5727 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx6545 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 -\clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 -\clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Withdrew Consent}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.3)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx2455 @@ -247,14 +187,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Participants Ongoing}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 59}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (68.6)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 62}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (72.1)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 72}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (85.7)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 65}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (77.4)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 196}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (77.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 64}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (76.2)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 198}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (78.0)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrs\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrs\brdrw15\clvertalt\cellx9000 @@ -311,14 +251,14 @@ \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Adverse Event}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 4}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (4.7)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.3)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 8}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (9.5)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 18}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (7.1)}\cell 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-\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Physician Decision}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 0}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.0)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell \intbl\row\pard @@ -390,7 +310,7 @@ \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx7363 \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8181 \clbrdrl\brdrw15\clbrdrt\brdrw15\clbrdrr\brdrs\brdrw15\clbrdrb\brdrw15\clvertalt\cellx8999 -\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Protocol Violation}\cell +\pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Lack of Efficacy}\cell 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-\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.8)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (0.4)}\cell \intbl\row\pard \trowd\trgaph108\trleft0\trqc \clbrdrl\brdrs\brdrw15\clbrdrt\brdrw15\clbrdrb\brdrdb\brdrw15\clvertalt\cellx2455 @@ -433,12 +353,12 @@ \pard\hyphpar0\sb15\sa15\fi100\li100\ri0\ql\fs18{\f0 Withdrew Consent}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.3)}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 1}\cell +\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (1.2)}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell \pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 2}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 (2.4)}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 6}\cell -\pard\hyphpar0\sb15\sa15\fi0\li0\ri0\qc\fs18{\f0 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z`vd61(SSZ2DWmoW(1#;-)Nu~<;fNhIuYf)rv7`0}(1#vNzFM;=E4c?H(zKp&3yg8l$J2l{Zt7vvRKp96h3@;Xh>A7FhB z^x=pv7$0DL4)o!OFUTvfJ_q`6#21VYus#R+aO6=ikXK-R4)o!OFUTvfJ_q`6#24fh z;5pETBaf9O%OlUyxUT=RhBh_=3CwJO}!47s94bfC+{43Hk?cXyT+`Uy z$wQHh(82HX*XnQ#==6C^h5?H+hecG;7R(`+(#WWpGk-481(;_rU+;gmuu|018zbc7 zYwPVB=59u From efce870d77df596f2aa222356d294967d4a0767d Mon Sep 17 00:00:00 2001 From: "Fukuda, Hiroaki" Date: Sun, 17 Nov 2024 18:38:37 -0500 Subject: [PATCH 04/10] Auto-update of style --- man/format_base_char_subgroup.Rd | 12 ++++++------ man/prepare_base_char_subgroup.Rd | 13 +++++++------ man/rtf_base_char_subgroup.Rd | 20 ++++++++++---------- 3 files changed, 23 insertions(+), 22 deletions(-) diff --git a/man/format_base_char_subgroup.Rd b/man/format_base_char_subgroup.Rd index 34a34e8..3fae7e7 100644 --- a/man/format_base_char_subgroup.Rd +++ b/man/format_base_char_subgroup.Rd @@ -30,12 +30,12 @@ Prepare data for Subgroup Analysis for Baseline Characteristic meta <- meta_sl_example() outdata <- prepare_base_char_subgroup( - meta, - population = "apat", - parameter = "age", - subgroup_var = "TRTA", - subgroup_header = c("SEX","TRTA"), - display_subgroup_total = TRUE + meta, + population = "apat", + parameter = "age", + subgroup_var = "TRTA", + subgroup_header = c("SEX", "TRTA"), + display_subgroup_total = TRUE ) outdata |> format_base_char_subgroup() diff --git a/man/prepare_base_char_subgroup.Rd b/man/prepare_base_char_subgroup.Rd index c7096c5..449927e 100644 --- a/man/prepare_base_char_subgroup.Rd +++ b/man/prepare_base_char_subgroup.Rd @@ -44,10 +44,11 @@ Prepare data for treatment compliance table \examples{ meta <- meta_sl_example() outdata <- prepare_base_char_subgroup( - meta, - population = "apat", - parameter = "age", - subgroup_var = "TRTA", - subgroup_header = c("SEX","TRTA"), - display_subgroup_total = TRUE) + meta, + population = "apat", + parameter = "age", + subgroup_var = "TRTA", + subgroup_header = c("SEX", "TRTA"), + display_subgroup_total = TRUE +) } diff --git a/man/rtf_base_char_subgroup.Rd b/man/rtf_base_char_subgroup.Rd index 9dd1623..d4e1425 100644 --- a/man/rtf_base_char_subgroup.Rd +++ b/man/rtf_base_char_subgroup.Rd @@ -49,20 +49,20 @@ Subgroup Analysis for Baseline Characteristic meta <- meta_sl_example() outdata <- prepare_base_char_subgroup( - meta, - population = "apat", - parameter = "age", - subgroup_var = "TRTA", - subgroup_header = c("SEX","TRTA"), - display_subgroup_total = TRUE + meta, + population = "apat", + parameter = "age", + subgroup_var = "TRTA", + subgroup_header = c("SEX", "TRTA"), + display_subgroup_total = TRUE ) outdata |> - format_base_char_subgroup() |> - rtf_base_char_subgroup( + format_base_char_subgroup() |> + rtf_base_char_subgroup( source = "Source: [CDISCpilot: adam-adsl]", path_outdata = tempfile(fileext = ".Rdata"), path_outtable = tempfile(fileext = ".rtf") - ) - } + ) +} } From cdcd7d0b74356309900aa05ea80ca481a0320b1b Mon Sep 17 00:00:00 2001 From: "Fukuda, Hiroaki" Date: Sun, 17 Nov 2024 18:39:13 -0500 Subject: [PATCH 05/10] Add a navigation in `_pkgdown.yml` --- _pkgdown.yml | 70 ++++++++++++++++++++++++++++++++++++++++++++++++++++ 1 file changed, 70 insertions(+) diff --git a/_pkgdown.yml b/_pkgdown.yml index 02e1d46..925fd96 100644 --- a/_pkgdown.yml +++ b/_pkgdown.yml @@ -22,3 +22,73 @@ footer: components: legal: "
Copyright © 2024 Merck & Co., Inc., Rahway, NJ, USA and its affiliates. All rights reserved." blank: "" + +navbar: + left: + - text: "Home" + href: index.html + - text: "Reference" + href: reference/index.html + - text: "Get Started" + href: articles/metalite-sl.html + - text: "Articles" + href: articles/index.html + - text: "Changelog" + href: news/index.html + +reference: +- title: Subject-level analysis + contents: + - meta_sl + - prepare_sl_summary + - format_sl_summary + - rtf_sl_summary +- title: Baseline characteristics + contents: + - prepare_base_char + - format_base_char + - rtf_base_char + - prepare_base_char_subgroup + - format_base_char_subgroup + - rtf_base_char_subgroup +- title: Interactive baseline characteristics + contents: + - react_base_char + - react_subgroup_table + - format_ae_specific_subgroup +- title: Disposition + contents: + - prepare_disposition + - format_disposition + - rtf_disposition +- title: Exposure duration + contents: + - prepare_exp_duration + - format_exp_duration + - rtf_exp_duration +- title: Treatment compliance + contents: + - prepare_trt_compliance + - format_trt_compliance + - rtf_trt_compliance +- title: Collect components + contents: + - collect_baseline +- title: Example data + contents: + - meta_sl_example + - meta_sl_exposure_example +- title: Deformat + contents: + - defmt_pct +articles: +- title: Get started + contents: + - metalite-sl +- title: Tutorial + contents: + - baseline-character + - disposition + - exp_duration + - trt_compliance + - interactive-baseline \ No newline at end of file From a21cd2d7ccd3f562bb9b01b56cc43c1483c3876f Mon Sep 17 00:00:00 2001 From: "Fukuda, Hiroaki" Date: Sun, 17 Nov 2024 18:39:50 -0500 Subject: [PATCH 06/10] Add a badge of code overage --- .Rbuildignore | 2 ++ README.md | 1 + codecov.yml | 14 ++++++++++++++ 3 files changed, 17 insertions(+) create mode 100644 codecov.yml diff --git a/.Rbuildignore b/.Rbuildignore index 1d2a652..7c30a65 100644 --- a/.Rbuildignore +++ b/.Rbuildignore @@ -7,3 +7,5 @@ ^LICENSE\.md$ ^LICENSE_THIRD_PARTY\.md$ ^\.github$ +^codecov\.yml$ +^tests/testthat/_snaps$ \ No newline at end of file diff --git a/README.md b/README.md index 4143017..9aa67b6 100644 --- a/README.md +++ b/README.md @@ -1,6 +1,7 @@ # metalite.sl +[![Codecov test coverage](https://codecov.io/gh/Merck/metalite.sl/branch/main/graph/badge.svg)](https://app.codecov.io/gh/Merck/metalite.sl?branch=main) [![R-CMD-check](https://github.com/Merck/metalite.sl/actions/workflows/R-CMD-check.yaml/badge.svg)](https://github.com/Merck/metalite.sl/actions/workflows/R-CMD-check.yaml) diff --git a/codecov.yml b/codecov.yml new file mode 100644 index 0000000..d6a6357 --- /dev/null +++ b/codecov.yml @@ -0,0 +1,14 @@ +comment: false + +coverage: + status: + project: + default: + target: auto + threshold: 1% + informational: true + patch: + default: + target: auto + threshold: 1% + informational: true \ No newline at end of file From 9d66058183b45a9fa579e7f2159f463d7cae7cb4 Mon Sep 17 00:00:00 2001 From: "Wang, Benjamin" Date: Tue, 19 Nov 2024 13:16:41 -0500 Subject: [PATCH 07/10] change yaml file --- .github/workflows/style.yaml | 73 ++++++++++++++++++++++++++++ .github/workflows/test-coverage.yaml | 50 +++++++++++++++++++ _pkgdown.yml | 2 +- 3 files changed, 124 insertions(+), 1 deletion(-) create mode 100644 .github/workflows/style.yaml create mode 100644 .github/workflows/test-coverage.yaml diff --git a/.github/workflows/style.yaml b/.github/workflows/style.yaml new file mode 100644 index 0000000..24803b7 --- /dev/null +++ b/.github/workflows/style.yaml @@ -0,0 +1,73 @@ +# Workflow derived from https://github.com/r-lib/actions/tree/v2/examples +# Need help debugging build failures? Start at https://github.com/r-lib/actions#where-to-find-help +on: + push: + paths: ["**.[rR]", "**.[qrR]md", "**.[rR]markdown", "**.[rR]nw", "**.[rR]profile"] + +name: Style + +jobs: + style: + runs-on: ubuntu-latest + env: + GITHUB_PAT: ${{ secrets.GITHUB_TOKEN }} + steps: + - name: Checkout repo + uses: actions/checkout@v4 + with: + fetch-depth: 0 + + - name: Setup R + uses: r-lib/actions/setup-r@v2 + with: + use-public-rspm: true + + - name: Install dependencies + uses: r-lib/actions/setup-r-dependencies@v2 + with: + extra-packages: any::styler, any::roxygen2 + needs: styler + + - name: Enable styler cache + run: styler::cache_activate() + shell: Rscript {0} + + - name: Determine cache location + id: styler-location + run: | + cat( + "location=", + styler::cache_info(format = "tabular")$location, + "\n", + file = Sys.getenv("GITHUB_OUTPUT"), + append = TRUE, + sep = "" + ) + shell: Rscript {0} + + - name: Cache styler + uses: actions/cache@v4 + with: + path: ${{ steps.styler-location.outputs.location }} + key: ${{ runner.os }}-styler-${{ github.sha }} + restore-keys: | + ${{ runner.os }}-styler- + ${{ runner.os }}- + + - name: Style + run: styler::style_pkg() + shell: Rscript {0} + + - name: Commit and push changes + run: | + if FILES_TO_COMMIT=($(git diff-index --name-only ${{ github.sha }} \ + | egrep --ignore-case '\.(R|[qR]md|Rmarkdown|Rnw|Rprofile)$')) + then + git config --local user.name "$GITHUB_ACTOR" + git config --local user.email "$GITHUB_ACTOR@users.noreply.github.com" + git commit ${FILES_TO_COMMIT[*]} -m "Style code (GHA)" + git pull --ff-only + git push origin + else + echo "No changes to commit." + fi \ No newline at end of file diff --git a/.github/workflows/test-coverage.yaml b/.github/workflows/test-coverage.yaml new file mode 100644 index 0000000..4ff0e90 --- /dev/null +++ b/.github/workflows/test-coverage.yaml @@ -0,0 +1,50 @@ +# Workflow derived from https://github.com/r-lib/actions/tree/v2/examples +# Need help debugging build failures? Start at https://github.com/r-lib/actions#where-to-find-help +on: + push: + branches: [main, master] + pull_request: + branches: [main, master] + +name: test-coverage + +jobs: + test-coverage: + runs-on: ubuntu-latest + env: + GITHUB_PAT: ${{ secrets.GITHUB_TOKEN }} + + steps: + - uses: actions/checkout@v4 + + - uses: r-lib/actions/setup-r@v2 + with: + use-public-rspm: true + + - uses: r-lib/actions/setup-r-dependencies@v2 + with: + extra-packages: any::covr + needs: coverage + + - name: Test coverage + run: | + covr::codecov( + quiet = FALSE, + clean = FALSE, + install_path = file.path(normalizePath(Sys.getenv("RUNNER_TEMP"), winslash = "/"), "package") + ) + shell: Rscript {0} + + - name: Show testthat output + if: always() + run: | + ## -------------------------------------------------------------------- + find ${{ runner.temp }}/package -name 'testthat.Rout*' -exec cat '{}' \; || true + shell: bash + + - name: Upload test results + if: failure() + uses: actions/upload-artifact@v4 + with: + name: coverage-test-failures + path: ${{ runner.temp }}/package \ No newline at end of file diff --git a/_pkgdown.yml b/_pkgdown.yml index 925fd96..1158378 100644 --- a/_pkgdown.yml +++ b/_pkgdown.yml @@ -55,7 +55,7 @@ reference: contents: - react_base_char - react_subgroup_table - - format_ae_specific_subgroup + - react_disposition - title: Disposition contents: - prepare_disposition From db00a826445d761a0510feabe6d538e216a2416e Mon Sep 17 00:00:00 2001 From: "Wang, Benjamin" Date: Tue, 19 Nov 2024 13:34:08 -0500 Subject: [PATCH 08/10] remove duplicated function --- DESCRIPTION | 2 +- R/react_base_char.R | 2 +- R/react_subgroup_table.R | 88 ------------------------------ man/format_ae_specific_subgroup.Rd | 49 ----------------- vignettes/interactive-baseline.Rmd | 3 +- 5 files changed, 4 insertions(+), 140 deletions(-) delete mode 100644 man/format_ae_specific_subgroup.Rd diff --git a/DESCRIPTION b/DESCRIPTION index 4e986b7..396e3f5 100644 --- a/DESCRIPTION +++ b/DESCRIPTION @@ -27,5 +27,5 @@ Suggests: VignetteBuilder: knitr Encoding: UTF-8 Roxygen: list(markdown = TRUE) -RoxygenNote: 7.3.1 +RoxygenNote: 7.3.2 Config/testthat/edition: 3 diff --git a/R/react_base_char.R b/R/react_base_char.R index 0e8e1b8..79b4438 100644 --- a/R/react_base_char.R +++ b/R/react_base_char.R @@ -116,7 +116,7 @@ react_base_char <- function( subgroup_var = y_subgrp, display_subgroup_total = FALSE # total display for subgroup is not needed ) |> - format_ae_specific_subgroup() + metalite.ae::format_ae_specific_subgroup() tbl_ae <- c(tbl_ae, list(tbl_ae_temp$tbl)) # get group labels for AE analysis diff --git a/R/react_subgroup_table.R b/R/react_subgroup_table.R index 6f01dfe..99ce925 100644 --- a/R/react_subgroup_table.R +++ b/R/react_subgroup_table.R @@ -80,91 +80,3 @@ react_subgroup_table <- function( columnGroups = col_group_defs ) } - -# Borrowed from metalite.ae -#' Format AE specific analysis -#' -#' @inheritParams metalite.ae::format_ae_specific -#' @param digits_prop A numeric value of number of digits for proportion value. -#' @param digits_ci A numeric value of number of digits for confidence interval -#' @param digits_p A numeric value of number of digits for p-value . -#' @param digits_dur A numeric value of number of digits for -#' average duration of AE. -#' @param digits_events A numeric value of number of digits for -#' average of number of AE per subjects. -#' @param display A character vector of measurement to be displayed. -#' - `n`: Number of subjects with AE. -#' - `prop`: Proportion of subjects with AE. -#' - `total`: Total columns. -#' - `dur`: Average of AE duration. -#' - `events`: Average number of AE per subject. -#' @param mock Logical. Display mock table or not. -#' -#' @return A list of analysis raw datasets. -format_ae_specific_subgroup <- function( - outdata, - display = c("n", "prop"), - digits_prop = 1, - digits_ci = 1, - digits_p = 3, - digits_dur = c(1, 1), - digits_events = c(1, 1), - mock = FALSE) { - if ("total" %in% display) { - display <- display[!display %in% "total"] - message("total is not supported within Sub-Group") - } - - out_all <- outdata$out_all - - outlst <- list() - for (i in seq_along(out_all)) { - tbl <- out_all[[i]] |> - metalite.ae::format_ae_specific( - display = display, - digits_prop = digits_prop, - digits_ci = digits_ci, - digits_p = digits_p, - digits_dur = digits_dur, - digits_events = digits_events, - mock = mock - ) - - names(tbl$tbl)[-1] <- paste0(names(out_all[i]), names(tbl$tbl)[-1]) - if (i == length(out_all)) { - tbl$tbl$order <- tbl$order - } - - outlst[[i]] <- tbl$tbl - } - - names(outlst) <- names(out_all) - - i <- 1 - while (i < length(outlst)) { - if (i == 1) { - tbl <- merge(outlst[[i]], outlst[[i + 1]], by = "name", all = TRUE) - } - - i <- i + 1 - - if (i > 1 && i < length(outlst)) { - tbl <- merge(tbl, outlst[[i + 1]], by = "name", all = TRUE) - } - } - - # Need order column from Total Column for Ordering properly across tables - tbl <- tbl[order(tbl$order), ] - - # If outdata$display_subgroup_total = FALSE, remove that part - if (!outdata$display_subgroup_total) { - rm_tot <- names(outlst$Total) # Columns from Total Section - rm_tot <- rm_tot[!rm_tot %in% c("name", "order")] - - tbl <- tbl[, -which(names(tbl) %in% rm_tot)] - } - - outdata$tbl <- tbl - outdata$display <- display - outdata -} diff --git a/man/format_ae_specific_subgroup.Rd b/man/format_ae_specific_subgroup.Rd deleted file mode 100644 index 1061892..0000000 --- a/man/format_ae_specific_subgroup.Rd +++ /dev/null @@ -1,49 +0,0 @@ -% Generated by roxygen2: do not edit by hand -% Please edit documentation in R/react_subgroup_table.R -\name{format_ae_specific_subgroup} -\alias{format_ae_specific_subgroup} -\title{Format AE specific analysis} -\usage{ -format_ae_specific_subgroup( - outdata, - display = c("n", "prop"), - digits_prop = 1, - digits_ci = 1, - digits_p = 3, - digits_dur = c(1, 1), - digits_events = c(1, 1), - mock = FALSE -) -} -\arguments{ -\item{outdata}{An \code{outdata} object created by \code{\link[metalite.ae:prepare_ae_specific]{prepare_ae_specific()}}.} - -\item{display}{A character vector of measurement to be displayed. -\itemize{ -\item \code{n}: Number of subjects with AE. -\item \code{prop}: Proportion of subjects with AE. -\item \code{total}: Total columns. -\item \code{dur}: Average of AE duration. -\item \code{events}: Average number of AE per subject. -}} - -\item{digits_prop}{A numeric value of number of digits for proportion value.} - -\item{digits_ci}{A numeric value of number of digits for confidence interval} - -\item{digits_p}{A numeric value of number of digits for p-value .} - -\item{digits_dur}{A numeric value of number of digits for -average duration of AE.} - -\item{digits_events}{A numeric value of number of digits for -average of number of AE per subjects.} - -\item{mock}{Logical. Display mock table or not.} -} -\value{ -A list of analysis raw datasets. -} -\description{ -Format AE specific analysis -} diff --git a/vignettes/interactive-baseline.Rmd b/vignettes/interactive-baseline.Rmd index 776b15d..75b315a 100644 --- a/vignettes/interactive-baseline.Rmd +++ b/vignettes/interactive-baseline.Rmd @@ -18,7 +18,8 @@ vignette: > library(r2rtf) library(metalite) library(metalite.ae) -library(metalite.sl) +# library(metalite.sl) +devtools::load_all() ``` There are 2 key metadata types: From 27107168fc0c01d0275674302a3f80fac1bb006d Mon Sep 17 00:00:00 2001 From: "Wang, Benjamin" Date: Tue, 19 Nov 2024 13:34:26 -0500 Subject: [PATCH 09/10] minor change --- vignettes/interactive-baseline.Rmd | 3 +-- 1 file changed, 1 insertion(+), 2 deletions(-) diff --git a/vignettes/interactive-baseline.Rmd b/vignettes/interactive-baseline.Rmd index 75b315a..776b15d 100644 --- a/vignettes/interactive-baseline.Rmd +++ b/vignettes/interactive-baseline.Rmd @@ -18,8 +18,7 @@ vignette: > library(r2rtf) library(metalite) library(metalite.ae) -# library(metalite.sl) -devtools::load_all() +library(metalite.sl) ``` There are 2 key metadata types: From 1cd4d0c32c377d16ee63487d2fa97e577679edb9 Mon Sep 17 00:00:00 2001 From: wangben718 Date: Tue, 19 Nov 2024 18:36:22 +0000 Subject: [PATCH 10/10] Style code (GHA) --- vignettes/baseline-character.Rmd | 10 +++---- vignettes/exp_duration.Rmd | 2 +- vignettes/metalite-sl.Rmd | 45 ++++++++++++++++---------------- 3 files changed, 28 insertions(+), 29 deletions(-) diff --git a/vignettes/baseline-character.Rmd b/vignettes/baseline-character.Rmd index 83c7046..a3f0cf8 100644 --- a/vignettes/baseline-character.Rmd +++ b/vignettes/baseline-character.Rmd @@ -137,11 +137,11 @@ adsl$TRTA <- factor( ```{r} plan <- plan( - analysis = "base_char_subgroup", - population = "apat", - observation = "apat", - parameter = "age;gender;race" - ) + analysis = "base_char_subgroup", + population = "apat", + observation = "apat", + parameter = "age;gender;race" +) ``` ```{r} diff --git a/vignettes/exp_duration.Rmd b/vignettes/exp_duration.Rmd index adb5c81..6b56dec 100644 --- a/vignettes/exp_duration.Rmd +++ b/vignettes/exp_duration.Rmd @@ -162,4 +162,4 @@ outdata <- format_exp_duration(outdata) |> ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} knitr::include_graphics("pdf/exp0duration.pdf") -``` \ No newline at end of file +``` diff --git a/vignettes/metalite-sl.Rmd b/vignettes/metalite-sl.Rmd index 3badc5e..fd60c46 100644 --- a/vignettes/metalite-sl.Rmd +++ b/vignettes/metalite-sl.Rmd @@ -66,17 +66,17 @@ Baseline characteristic table as shown below. ```{r, eval = FALSE} meta_sl_example() |> - prepare_base_char( - population = "apat", - analysis = "base_char", - parameter = "age;gender" - ) |> - format_base_char() |> - rtf_base_char( - source = "Source: [CDISCpilot: adam-adsl]", - path_outdata = tempfile(fileext = ".Rdata"), - path_outtable = tempfile(fileext = ".rtf") - ) + prepare_base_char( + population = "apat", + analysis = "base_char", + parameter = "age;gender" + ) |> + format_base_char() |> + rtf_base_char( + source = "Source: [CDISCpilot: adam-adsl]", + path_outdata = tempfile(fileext = ".Rdata"), + path_outtable = tempfile(fileext = ".rtf") + ) ``` ```{r, out.width = "100%", out.height = "400px", echo = FALSE, fig.align = "center"} @@ -86,18 +86,17 @@ knitr::include_graphics("pdf/base0char.pdf") An example for interactive baseline characteristic table: ```{r} - react_base_char( - metadata_sl = meta_sl_example(), - metadata_ae = metalite.ae::meta_ae_example(), - population = "apat", - observation = "wk12", - display_total = TRUE, - sl_parameter = "age;race", - ae_subgroup = c("age", "race"), - ae_specific = "rel", - width = 1200 - ) - +react_base_char( + metadata_sl = meta_sl_example(), + metadata_ae = metalite.ae::meta_ae_example(), + population = "apat", + observation = "wk12", + display_total = TRUE, + sl_parameter = "age;race", + ae_subgroup = c("age", "race"), + ae_specific = "rel", + width = 1200 +) ``` Additional examples and tutorials can be found on the

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takes four arguments: @@ -170,6 +170,11 @@ a collection of raw datasets for analysis and reporting. ```{r} outdata <- prepare_trt_compliance(meta) +``` + +