do-bridge-has_locus-UBERON.obo

[Term]
id: DOID:0001816 ! angiosarcoma
relationship: has_locus UBERON:0001981 ! blood vessel
! A malignant vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derived_from blood vessels and derived_from the lining of irregular blood-filled spaces.

[Term]
id: DOID:0050012 ! chikungunya
relationship: has_locus UBERON:0000982 ! skeletal joint
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.

[Term]
id: DOID:0050059 ! oropharyngeal anthrax
relationship: has_locus UBERON:0005023 ! mucosa of oropharynx
! A gastrointestinal anthrax that results_in infection located_in mucosa of oropharynx, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite.

[Term]
id: DOID:0050061 ! erysipeloid
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050061 ! erysipeloid
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050061 ! erysipeloid
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050061 ! erysipeloid
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050061 ! erysipeloid
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050061 ! erysipeloid
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050072 ! adiaspiromycosis
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050072 ! adiaspiromycosis
relationship: has_locus UBERON:0002048 ! lung
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050072 ! adiaspiromycosis
relationship: has_locus UBERON:0002097 ! skin of body
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050072 ! adiaspiromycosis
relationship: has_locus UBERON:0002199 ! integument
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050072 ! adiaspiromycosis
relationship: has_locus UBERON:0004530 ! bony projection
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050072 ! adiaspiromycosis
relationship: has_locus UBERON:0009292 ! embryonic nasal process
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050073 ! invasive aspergillosis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050073 ! invasive aspergillosis
relationship: has_locus UBERON:0002048 ! lung
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050084 ! rhinotracheitis
relationship: has_locus UBERON:0001681 ! nasal bone
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050084 ! rhinotracheitis
relationship: has_locus UBERON:0003126 ! trachea
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050084 ! rhinotracheitis
relationship: has_locus UBERON:0003127 ! open tracheal system trachea
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050096 ! tinea barbae
relationship: has_locus UBERON:0001037 ! strand of hair
! A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.

[Term]
id: DOID:0050096 ! tinea barbae
relationship: has_locus UBERON:0001705 ! nail
! A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.

[Term]
id: DOID:0050096 ! tinea barbae
relationship: has_locus UBERON:0000974 ! neck
! A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.

[Term]
id: DOID:0050096 ! tinea barbae
relationship: has_locus UBERON:0001456 ! face
! A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.

[Term]
id: DOID:0050096 ! tinea barbae
relationship: has_locus UBERON:0002027 ! stratum corneum of epidermis
! A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.

[Term]
id: DOID:0050097 ! ectothrix infectious disease
relationship: has_locus UBERON:0002074 ! hair shaft
! A tinea capitis that results_in fungal infection located_in cuticle of hair, has_material_basis_in Microsporum canis, has_material_basis_in Microsporum gypseum, has_material_basis_in Trichophyton equinum, and has_material_basis_in Trichophyton verrucosum, which produce arthroconidia on the exterior of the hair shaft.

[Term]
id: DOID:0050097 ! ectothrix infectious disease
relationship: has_locus UBERON:0002076 ! cuticle of hair
! A tinea capitis that results_in fungal infection located_in cuticle of hair, has_material_basis_in Microsporum canis, has_material_basis_in Microsporum gypseum, has_material_basis_in Trichophyton equinum, and has_material_basis_in Trichophyton verrucosum, which produce arthroconidia on the exterior of the hair shaft.

[Term]
id: DOID:0050105 ! endothrix infectious disease
relationship: has_locus UBERON:0002074 ! hair shaft
! A tinea capitis that results_in fungal infection located_in hair, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which produce arthroconidia within the hair shaft only.

[Term]
id: DOID:0050116 ! tinea imbricata
relationship: has_locus UBERON:0000014 ! zone of skin
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition.

[Term]
id: DOID:0050116 ! tinea imbricata
relationship: has_locus UBERON:0002097 ! skin of body
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition.

[Term]
id: DOID:0050116 ! tinea imbricata
relationship: has_locus UBERON:0002199 ! integument
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050125 ! dengue shock syndrome
relationship: has_locus UBERON:0000165 ! mouth
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050125 ! dengue shock syndrome
relationship: has_locus UBERON:0000167 ! oral cavity
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050125 ! dengue shock syndrome
relationship: has_locus UBERON:0000178 ! blood
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_locus UBERON:0000160 ! intestine
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_locus UBERON:0003907 ! left atrioventricular canal
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_locus UBERON:0005613 ! left dorsal aorta
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050131 ! motility-related diarrhea
relationship: has_locus UBERON:0000160 ! intestine
! Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
relationship: has_locus UBERON:0001007 ! digestive system
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050133 ! superficial mycosis
relationship: has_locus UBERON:0002074 ! hair shaft
! A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_locus UBERON:0000014 ! zone of skin
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_locus UBERON:0001003 ! epidermis
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_locus UBERON:0001037 ! strand of hair
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_locus UBERON:0001705 ! nail
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_locus UBERON:0002097 ! skin of body
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_locus UBERON:0002199 ! integument
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050135 ! subcutaneous mycosis
relationship: has_locus UBERON:0002067 ! dermis
! A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma.

[Term]
id: DOID:0050135 ! subcutaneous mycosis
relationship: has_locus UBERON:0011818 ! superficial fascia
! A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma.

[Term]
id: DOID:0050136 ! systemic mycosis
relationship: has_locus UBERON:0000479 ! tissue
! A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.

[Term]
id: DOID:0050136 ! systemic mycosis
relationship: has_locus UBERON:0003103 ! compound organ
! A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.

[Term]
id: DOID:0050140 ! acute diarrhea
relationship: has_locus UBERON:0001191 ! common iliac artery
! A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

[Term]
id: DOID:0050140 ! acute diarrhea
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

[Term]
id: DOID:0050140 ! acute diarrhea
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

[Term]
id: DOID:0050141 ! intestinal botulism
relationship: has_locus UBERON:0000160 ! intestine
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins.

[Term]
id: DOID:0050145 ! adenoiditis
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050145 ! adenoiditis
relationship: has_locus UBERON:0000341 ! throat
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050145 ! adenoiditis
relationship: has_locus UBERON:0001042 ! chordate pharynx
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050145 ! adenoiditis
relationship: has_locus UBERON:0001732 ! pharyngeal tonsil
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050145 ! adenoiditis
relationship: has_locus UBERON:0002393 ! pharyngotympanic tube
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050147 ! otomycosis
relationship: has_locus UBERON:0001191 ! common iliac artery
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050147 ! otomycosis
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050147 ! otomycosis
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050147 ! otomycosis
relationship: has_locus UBERON:0001352 ! external acoustic meatus
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050148 ! laryngotracheitis
relationship: has_locus UBERON:0003126 ! trachea
! An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_locus UBERON:0002048 ! lung
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_locus UBERON:0003215 ! alveolus
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_locus UBERON:0009060 ! air sac
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050158 ! respiratory bronchiolitis-associated interstitial lung disease
relationship: has_locus UBERON:0002188 ! respiratory bronchiole
! A idiopathic interstitial pneumonia which involves bronchiolocentric alveolar macrophage accumulation, mild bronchiolar fibrosis and chronic inflammation. Respiratory bronchiolitis is a histopathologic lesion found in cigarette smokers and is characterized by the presence of pigmented intralumenal macrophages within first- and second-order respiratory bronchioles.

[Term]
id: DOID:0050158 ! respiratory bronchiolitis-associated interstitial lung disease
relationship: has_locus UBERON:0005385 ! nasal cavity respiratory epithelium
! A idiopathic interstitial pneumonia which involves bronchiolocentric alveolar macrophage accumulation, mild bronchiolar fibrosis and chronic inflammation. Respiratory bronchiolitis is a histopathologic lesion found in cigarette smokers and is characterized by the presence of pigmented intralumenal macrophages within first- and second-order respiratory bronchioles.

[Term]
id: DOID:0050160 ! inhalation anthrax
relationship: has_locus UBERON:0002048 ! lung
! An anthrax disease that results_in infection located_in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches.

[Term]
id: DOID:0050166 ! tuberculous salpingitis
relationship: has_locus UBERON:0003889 ! fallopian tube
! An urogenital tuberculosis that results_in formation of granulomas located_in fallopian tube.

[Term]
id: DOID:0050167 ! autoimmune polyendocrine syndrome type 1
relationship: has_locus UBERON:0002405 ! immune system
! An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.

[Term]
id: DOID:0050168 ! autoimmune polyendocrine syndrome type 2
relationship: has_locus UBERON:0002405 ! immune system
! An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050185 ! erythema multiforme
relationship: has_locus UBERON:0000014 ! zone of skin
! A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness.

[Term]
id: DOID:0050185 ! erythema multiforme
relationship: has_locus UBERON:0002097 ! skin of body
! A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness.

[Term]
id: DOID:0050185 ! erythema multiforme
relationship: has_locus UBERON:0002199 ! integument
! A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_locus UBERON:0001826 ! nasal cavity mucosa
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0000161 ! orifice
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0001690 ! ear
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0001846 ! internal ear
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_locus UBERON:0003103 ! compound organ
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_locus UBERON:0000018 ! compound eye
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_locus UBERON:0000019 ! camera-type eye
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_locus UBERON:0001456 ! face
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_locus UBERON:0000080 ! mesonephros
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_locus UBERON:0002120 ! pronephros
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_locus UBERON:0000080 ! mesonephros
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_locus UBERON:0002120 ! pronephros
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_locus UBERON:0002107 ! liver
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_locus UBERON:0000065 ! respiratory tract
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_locus UBERON:0001004 ! respiratory system
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050218 ! polycystic echinococcosis
relationship: has_locus UBERON:0002107 ! liver
! An echinococcosis that is caused by the larvae of Echinococcus vogeli or Echinococcus oligarthrus, which infect the liver.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_locus UBERON:0000955 ! brain
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_locus UBERON:0001017 ! central nervous system
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050246 ! granulomatous amebic encephalitis
relationship: has_locus UBERON:0000071 ! death stage
! A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

[Term]
id: DOID:0050246 ! granulomatous amebic encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_locus UBERON:0000160 ! intestine
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_locus UBERON:0000071 ! death stage
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_locus UBERON:0000955 ! brain
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_locus UBERON:0002240 ! spinal cord
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_locus UBERON:0000160 ! intestine
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050266 ! tungiasis
relationship: has_locus UBERON:0000474 ! female reproductive system
! A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

[Term]
id: DOID:0050266 ! tungiasis
relationship: has_locus UBERON:0003100 ! female organism
! A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0000383 ! musculature of body
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0001015 ! musculature
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0001630 ! muscle organ
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0001137 ! dorsum
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0001443 ! chest
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0002101 ! limb
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_locus UBERON:0011818 ! superficial fascia
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050279 ! conidiobolomycosis
relationship: has_locus UBERON:0000009 ! submucosa
! An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.

[Term]
id: DOID:0050279 ! conidiobolomycosis
relationship: has_locus UBERON:0001681 ! nasal bone
! An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.

[Term]
id: DOID:0050279 ! conidiobolomycosis
relationship: has_locus UBERON:0001681 ! nasal bone
! An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_locus UBERON:0005385 ! nasal cavity respiratory epithelium
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050290 ! trichosporonosis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body.

[Term]
id: DOID:0050292 ! primary systemic mycosis
relationship: has_locus UBERON:0000065 ! respiratory tract
! A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

[Term]
id: DOID:0050292 ! primary systemic mycosis
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

[Term]
id: DOID:0050292 ! primary systemic mycosis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

[Term]
id: DOID:0050292 ! primary systemic mycosis
relationship: has_locus UBERON:0001004 ! respiratory system
! A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

[Term]
id: DOID:0050331 ! LADD syndrome
relationship: has_locus UBERON:0000058 ! duct
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050331 ! LADD syndrome
relationship: has_locus UBERON:0001044 ! salivary gland
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050331 ! LADD syndrome
relationship: has_locus UBERON:0001091 ! calcareous tooth
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050331 ! LADD syndrome
relationship: has_locus UBERON:0001690 ! ear
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050331 ! LADD syndrome
relationship: has_locus UBERON:0001846 ! internal ear
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050331 ! LADD syndrome
relationship: has_locus UBERON:0003672 ! dentition
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050338 ! primary bacterial infectious disease
relationship: has_locus UBERON:0011222 ! intra-ocular muscle
! A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.

[Term]
id: DOID:0050339 ! commensal bacterial infectious disease
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.

[Term]
id: DOID:0050339 ! commensal bacterial infectious disease
relationship: has_locus UBERON:0000479 ! tissue
! A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_locus UBERON:0000033 ! head
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_locus UBERON:0000160 ! intestine
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050382 ! glandular tularemia
relationship: has_locus UBERON:0000029 ! lymph node
! A tularemia that results_in swelling of regional lymph glands.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0000059 ! large intestine
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0001901 ! epithelium of trachea
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0001951 ! epithelium of nasopharynx
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0002340 ! epithelium of main bronchus
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003229 ! epithelium of elbow
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003230 ! epithelium of carpal region
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003231 ! epithelium of hip
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003232 ! epithelium of knee
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003233 ! epithelium of shoulder
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003235 ! epithelium of upper jaw
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003236 ! epithelium of lower jaw
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003238 ! epithelium of superior semicircular canal
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003239 ! epithelium of posterior semicircular canal
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003240 ! epithelium of lateral semicircular canal
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003241 ! epithelium of utricle
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003242 ! epithelium of saccule
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003243 ! epithelium of cochlear duct
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003244 ! epithelium of mammary gland
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003246 ! epithelium of endolymphatic sac
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003247 ! epithelium of forearm
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003248 ! epithelium of footplate
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0003249 ! epithelium of otic placode
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0005384 ! nasal cavity epithelium
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_locus UBERON:0006957 ! submandibular gland primordium epithelium
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_locus UBERON:0001713 ! lower eyelid
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050445 ! X-linked hypophosphatemia
relationship: has_locus UBERON:0000174 ! excreta
! A metal metabolism disorder that results from the inactivation of hormone-like substances (phosphatonins) that promote phosphate excretion which has_material_basis_in a X-linked mutation in the PHEX gene.

[Term]
id: DOID:0050456 ! Buruli ulcer disease
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.

[Term]
id: DOID:0050456 ! Buruli ulcer disease
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.

[Term]
id: DOID:0050456 ! Buruli ulcer disease
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.

[Term]
id: DOID:0050456 ! Buruli ulcer disease
relationship: has_locus UBERON:0011818 ! superficial fascia
! A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.

[Term]
id: DOID:0050463 ! campomelic dysplasia
relationship: has_locus UBERON:0000979 ! tibia
! An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur.

[Term]
id: DOID:0050463 ! campomelic dysplasia
relationship: has_locus UBERON:0000981 ! femur
! An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur.

[Term]
id: DOID:0050463 ! campomelic dysplasia
relationship: has_locus UBERON:0003131 ! arthropod tibia
! An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_locus UBERON:0000104 ! life cycle
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_locus UBERON:0002360 ! meninx
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_locus UBERON:0001235 ! adrenal cortex
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_locus UBERON:0001280 ! liver parenchyma
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0000383 ! musculature of body
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0000978 ! leg
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0001015 ! musculature
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0001460 ! arm
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0001630 ! muscle organ
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0002458 ! spinal artery
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0005895 ! insect leg
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0000955 ! brain
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_locus UBERON:0002240 ! spinal cord
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0000974 ! neck
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0000978 ! leg
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0002100 ! trunk
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0005895 ! insect leg
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050495 ! exanthema subitum
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050508 ! variola major
relationship: has_locus UBERON:0000014 ! zone of skin
! A smallpox that results_in severe infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:0050508 ! variola major
relationship: has_locus UBERON:0002097 ! skin of body
! A smallpox that results_in severe infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:0050508 ! variola major
relationship: has_locus UBERON:0002199 ! integument
! A smallpox that results_in severe infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0000978 ! leg
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0001460 ! arm
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0005895 ! insect leg
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0002240 ! spinal cord
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_locus UBERON:0001988 ! feces
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0000978 ! leg
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0001460 ! arm
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0005895 ! insect leg
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0002240 ! spinal cord
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_locus UBERON:0001988 ! feces
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050515 ! paralytic poliomyelitis
relationship: has_locus UBERON:0000955 ! brain
! A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:0050515 ! paralytic poliomyelitis
relationship: has_locus UBERON:0001017 ! central nervous system
! A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:0050515 ! paralytic poliomyelitis
relationship: has_locus UBERON:0001988 ! feces
! A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:0050516 ! O'nyong'nyong fever
relationship: has_locus UBERON:0000982 ! skeletal joint
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.

[Term]
id: DOID:0050517 ! Barmah Forest virus disease
relationship: has_locus UBERON:0000982 ! skeletal joint
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050518 ! Ross River fever
relationship: has_locus UBERON:0000982 ! skeletal joint
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_locus UBERON:0000080 ! mesonephros
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_locus UBERON:0002120 ! pronephros
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050563 ! nonsyndromic deafness
relationship: has_locus UBERON:0001756 ! middle ear
! An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

[Term]
id: DOID:0050563 ! nonsyndromic deafness
relationship: has_locus UBERON:0001846 ! internal ear
! An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

[Term]
id: DOID:0050568 ! spondylocostal dysostosis
relationship: has_locus UBERON:0001130 ! vertebral column
! A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together.

[Term]
id: DOID:0050568 ! spondylocostal dysostosis
relationship: has_locus UBERON:0002228 ! rib
! A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together.

[Term]
id: DOID:0050568 ! spondylocostal dysostosis
relationship: has_locus UBERON:0002412 ! vertebra
! A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together.

[Term]
id: DOID:0050578 ! occult macular dystrophy
relationship: has_locus UBERON:0001160 ! fundus of stomach
! A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.

[Term]
id: DOID:0050578 ! occult macular dystrophy
relationship: has_locus UBERON:0003951 ! ocular fundus
! A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.

[Term]
id: DOID:0050578 ! occult macular dystrophy
relationship: has_locus UBERON:0006082 ! fundus of urinary bladder
! A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_locus UBERON:0000160 ! intestine
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0001264 ! pancreas
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0001555 ! digestive tract
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0002107 ! liver
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0002358 ! peritoneum
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0003281 ! mesentery of stomach
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0003282 ! mesentery of heart
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0003283 ! mesentery of oesophagus
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0003284 ! mesentery of midgut
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0003688 ! omentum
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
relationship: has_locus UBERON:0007826 ! peritoneal mesentery
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_locus UBERON:0000403 ! scalp
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_locus UBERON:0001850 ! lacrimal duct
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_locus UBERON:0002030 ! nipple
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_locus UBERON:0007774 ! secondary dentition
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_locus UBERON:0009472 ! axilla
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050615 ! respiratory system cancer
relationship: has_locus UBERON:0000065 ! respiratory tract
! An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

[Term]
id: DOID:0050615 ! respiratory system cancer
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

[Term]
id: DOID:0050615 ! respiratory system cancer
relationship: has_locus UBERON:0001004 ! respiratory system
! An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

[Term]
id: DOID:0050615 ! respiratory system cancer
relationship: has_locus UBERON:0001004 ! respiratory system
! An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

[Term]
id: DOID:0050621 ! respiratory system benign neoplasm
relationship: has_locus UBERON:0001004 ! respiratory system
! An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm.

[Term]
id: DOID:0050621 ! respiratory system benign neoplasm
relationship: has_locus UBERON:0001103 ! diaphragm
! An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm.

[Term]
id: DOID:0050622 ! reproductive organ benign neoplasm
relationship: has_locus UBERON:0003133 ! reproductive organ
! An organ system benign neoplasm that is located_in reproductive system organs.

[Term]
id: DOID:0050624 ! gastrointestinal system benign neoplasm
relationship: has_locus UBERON:0001555 ! digestive tract
! An organ system benign neoplasm located_in gastrointestinal tract organs.

[Term]
id: DOID:0050624 ! gastrointestinal system benign neoplasm
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system benign neoplasm located_in gastrointestinal tract organs.

[Term]
id: DOID:0050624 ! gastrointestinal system benign neoplasm
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! An organ system benign neoplasm located_in gastrointestinal tract organs.

[Term]
id: DOID:0050631 ! Allan-Herndon-Dudley syndrome
relationship: has_locus UBERON:0000955 ! brain
! An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.

[Term]
id: DOID:0050631 ! Allan-Herndon-Dudley syndrome
relationship: has_locus UBERON:0002046 ! thyroid gland
! An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.

[Term]
id: DOID:0050650 ! familial atrial fibrillation
relationship: has_locus UBERON:0001712 ! upper eyelid
! A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.

[Term]
id: DOID:0050650 ! familial atrial fibrillation
relationship: has_locus UBERON:0002081 ! cardiac atrium
! A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_locus UBERON:0000383 ! musculature of body
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_locus UBERON:0000955 ! brain
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_locus UBERON:0000956 ! cerebral cortex
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_locus UBERON:0001015 ! musculature
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_locus UBERON:0001630 ! muscle organ
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_locus UBERON:0001851 ! cortex
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0000383 ! musculature of body
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0000411 ! visual cortex
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0001015 ! musculature
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0001630 ! muscle organ
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0002037 ! cerebellum
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0002101 ! limb
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_locus UBERON:0000383 ! musculature of body
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_locus UBERON:0002420 ! basal ganglion
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_locus UBERON:0002707 ! pyramidal tract
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_locus UBERON:0010011 ! collection of basal ganglia
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050673 ! mixed cerebral palsy
relationship: has_locus UBERON:0000955 ! brain
! A cerebral palsy that is caused by injury to both the pyramidal and extra pyramidal areas of the brain, which results in both the tight muscle tone and the involuntary movements. The individual have difficulty with speaking and swallowing.

[Term]
id: DOID:0050700 ! cardiomyopathy
relationship: has_locus UBERON:0002349 ! myocardium
! A heart disease that is characterized by deterioration of the funciton of the heart muscle.

[Term]
id: DOID:0050711 ! aceruloplasminemia
relationship: has_locus UBERON:0000966 ! retina
! An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.

[Term]
id: DOID:0050711 ! aceruloplasminemia
relationship: has_locus UBERON:0002420 ! basal ganglion
! An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.

[Term]
id: DOID:0050711 ! aceruloplasminemia
relationship: has_locus UBERON:0010011 ! collection of basal ganglia
! An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.

[Term]
id: DOID:0050714 ! alcaptonuria
relationship: has_locus UBERON:0000178 ! blood
! An organic acidemia that has_material_basis_in an autosomal recessive mutation in the HGD (homogentisate 1,2-dioxygenase gene ) gene affecting the production of the homogentisate 1,2-dioxygenase enzyme resulting in the accumulation of homogentisic acid in the blood.

[Term]
id: DOID:0050719 ! cerebral folate receptor alpha deficiency
relationship: has_locus UBERON:0000955 ! brain
! A vitamin metabolic disorder that has_material_basis_in mutations in the folate receptor 1 (FOLR1) gene coding for folate receptor alpha (FRalpha), is located_in the brain and is characterized by progressive movement disturbance, psychomotor decline, and epilepsy.

[Term]
id: DOID:0050720 ! ornithine translocase deficiency
relationship: has_locus UBERON:0000178 ! blood
! An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood.

[Term]
id: DOID:0050723 ! PSAT deficiency
relationship: has_locus UBERON:0001359 ! cerebrospinal fluid
! A serine deficiency that has_material_basis_in deficiency of phosphoserine aminotransferase and is characterized by low concentartions of serine and flycine in plasma and cerebrospinal fluid.

[Term]
id: DOID:0050723 ! PSAT deficiency
relationship: has_locus UBERON:0001969 ! blood plasma
! A serine deficiency that has_material_basis_in deficiency of phosphoserine aminotransferase and is characterized by low concentartions of serine and flycine in plasma and cerebrospinal fluid.

[Term]
id: DOID:0050725 ! tyrosinemia type II
relationship: has_locus UBERON:0001977 ! serum
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050725 ! tyrosinemia type II
relationship: has_locus UBERON:0002107 ! liver
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050726 ! tyrosinemia type I
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A tyrosinemia that has_material_basis_in deficiency of the enzyme fumarylacetoacetate hydrolase resulting in an increase in fumarylacetoacetate which inhibits previous steps in tyrosine degradation leading to an accumulation of tyrosine in the body.

[Term]
id: DOID:0050729 ! neutral lipid storage disease
relationship: has_locus UBERON:0000383 ! musculature of body
! A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.

[Term]
id: DOID:0050729 ! neutral lipid storage disease
relationship: has_locus UBERON:0000479 ! tissue
! A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.

[Term]
id: DOID:0050729 ! neutral lipid storage disease
relationship: has_locus UBERON:0001015 ! musculature
! A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.

[Term]
id: DOID:0050729 ! neutral lipid storage disease
relationship: has_locus UBERON:0001630 ! muscle organ
! A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.

[Term]
id: DOID:0050729 ! neutral lipid storage disease
relationship: has_locus UBERON:0002107 ! liver
! A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.

[Term]
id: DOID:0050750 ! splenic marginal zone lymphoma
relationship: has_locus UBERON:0004879 ! marginal zone of embryo
! A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp.

[Term]
id: DOID:0050750 ! splenic marginal zone lymphoma
relationship: has_locus UBERON:0001959 ! white pulp of spleen
! A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp.

[Term]
id: DOID:0060000 ! infective endocarditis
relationship: has_locus UBERON:0000948 ! heart
! A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection.

[Term]
id: DOID:0060000 ! infective endocarditis
relationship: has_locus UBERON:0002165 ! endocardium
! A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection.

[Term]
id: DOID:0060002 ! C1 inhibitor deficiency
relationship: has_locus UBERON:0001981 ! blood vessel
! A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue.

[Term]
id: DOID:0060002 ! C1 inhibitor deficiency
relationship: has_locus UBERON:0002384 ! connective tissue
! A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue.

[Term]
id: DOID:0060053 ! peripheral neuropathy
relationship: has_locus UBERON:0000010 ! peripheral nervous system
! A neuropathy that is located_in nerves of the peripheral nervous system.

[Term]
id: DOID:0060053 ! peripheral neuropathy
relationship: has_locus UBERON:0000011 ! parasympathetic nervous system
! A neuropathy that is located_in nerves of the peripheral nervous system.

[Term]
id: DOID:0060053 ! peripheral neuropathy
relationship: has_locus UBERON:0000013 ! sympathetic nervous system
! A neuropathy that is located_in nerves of the peripheral nervous system.

[Term]
id: DOID:0060053 ! peripheral neuropathy
relationship: has_locus UBERON:0001021 ! nerve
! A neuropathy that is located_in nerves of the peripheral nervous system.

[Term]
id: DOID:0060067 ! Pearson syndrome
relationship: has_locus UBERON:0000017 ! exocrine pancreas
! A mitochondrial disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.

[Term]
id: DOID:0060073 ! lymphatic system cancer
relationship: has_locus UBERON:0001744 ! lymphoid tissue
! An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

[Term]
id: DOID:0060073 ! lymphatic system cancer
relationship: has_locus UBERON:0002465 ! lymphoid system
! An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

[Term]
id: DOID:0060073 ! lymphatic system cancer
relationship: has_locus UBERON:0006558 ! lymphatic part of lymphoid system
! An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

[Term]
id: DOID:0060083 ! immune system cancer
relationship: has_locus UBERON:0002405 ! immune system
! An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.

[Term]
id: DOID:0060083 ! immune system cancer
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.

[Term]
id: DOID:0060083 ! immune system cancer
relationship: has_locus UBERON:0002405 ! immune system
! An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.

[Term]
id: DOID:0060089 ! endocrine organ benign neoplasm
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

[Term]
id: DOID:0060089 ! endocrine organ benign neoplasm
relationship: has_locus UBERON:0002368 ! endocrine gland
! An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

[Term]
id: DOID:0060091 ! cardiovascular organ benign neoplasm
relationship: has_locus UBERON:0000178 ! blood
! An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.

[Term]
id: DOID:0060091 ! cardiovascular organ benign neoplasm
relationship: has_locus UBERON:0000948 ! heart
! An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.

[Term]
id: DOID:0060091 ! cardiovascular organ benign neoplasm
relationship: has_locus UBERON:0001981 ! blood vessel
! An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.

[Term]
id: DOID:0060091 ! cardiovascular organ benign neoplasm
relationship: has_locus UBERON:0002465 ! lymphoid system
! An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.

[Term]
id: DOID:0060091 ! cardiovascular organ benign neoplasm
relationship: has_locus UBERON:0006558 ! lymphatic part of lymphoid system
! An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.

[Term]
id: DOID:0060092 ! immune system organ benign neoplasm
relationship: has_locus UBERON:0002405 ! immune system
! An organ system benign neoplasm located_in the immune system organs.

[Term]
id: DOID:0060092 ! immune system organ benign neoplasm
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system benign neoplasm located_in the immune system organs.

[Term]
id: DOID:0060097 ! thoracic benign neoplasm
relationship: has_locus UBERON:0002416 ! integumental system
! An organ system benign neoplam that is located_in the thoracic cavity.

[Term]
id: DOID:0060097 ! thoracic benign neoplasm
relationship: has_locus UBERON:0002224 ! thoracic cavity
! An organ system benign neoplam that is located_in the thoracic cavity.

[Term]
id: DOID:0060099 ! musculoskeletal system benign neoplasm
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system benign neoplasm that is located_in the muscular and skeletal organs.

[Term]
id: DOID:0060100 ! musculoskeletal system cancer
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system cancer located_in the muscular and skeltal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.

[Term]
id: DOID:0060100 ! musculoskeletal system cancer
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system cancer located_in the muscular and skeltal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.

[Term]
id: DOID:0060115 ! nervous system benign neoplasm
relationship: has_locus UBERON:0000010 ! peripheral nervous system
! An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:0060115 ! nervous system benign neoplasm
relationship: has_locus UBERON:0000011 ! parasympathetic nervous system
! An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:0060115 ! nervous system benign neoplasm
relationship: has_locus UBERON:0000013 ! sympathetic nervous system
! An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:0060115 ! nervous system benign neoplasm
relationship: has_locus UBERON:0000955 ! brain
! An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:0060115 ! nervous system benign neoplasm
relationship: has_locus UBERON:0001017 ! central nervous system
! An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:0060116 ! sensory system cancer
relationship: has_locus UBERON:0000020 ! sense organ
! A nervous system cancer that is located_in the sensory system.

[Term]
id: DOID:0060116 ! sensory system cancer
relationship: has_locus UBERON:0002540 ! lateral line system
! A nervous system cancer that is located_in the sensory system.

[Term]
id: DOID:0060117 ! peritoneal benign neoplasm
relationship: has_locus UBERON:0000042 ! serous membrane
! An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom.

[Term]
id: DOID:0060117 ! peritoneal benign neoplasm
relationship: has_locus UBERON:0000916 ! abdomen
! An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom.

[Term]
id: DOID:0060117 ! peritoneal benign neoplasm
relationship: has_locus UBERON:0003684 ! abdominal cavity
! An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom.

[Term]
id: DOID:0060118 ! thoracic disease
relationship: has_locus UBERON:0001062 ! anatomical entity
! A diseae of anatomical entity that is located_in the thoracic cavity.

[Term]
id: DOID:0060118 ! thoracic disease
relationship: has_locus UBERON:0002224 ! thoracic cavity
! A diseae of anatomical entity that is located_in the thoracic cavity.

[Term]
id: DOID:0060122 ! integumentary system cancer
relationship: has_locus UBERON:0000014 ! zone of skin
! An organ system cancer that is located_in the skin, hair and nails.

[Term]
id: DOID:0060122 ! integumentary system cancer
relationship: has_locus UBERON:0001037 ! strand of hair
! An organ system cancer that is located_in the skin, hair and nails.

[Term]
id: DOID:0060122 ! integumentary system cancer
relationship: has_locus UBERON:0001705 ! nail
! An organ system cancer that is located_in the skin, hair and nails.

[Term]
id: DOID:0060122 ! integumentary system cancer
relationship: has_locus UBERON:0002097 ! skin of body
! An organ system cancer that is located_in the skin, hair and nails.

[Term]
id: DOID:0060122 ! integumentary system cancer
relationship: has_locus UBERON:0002199 ! integument
! An organ system cancer that is located_in the skin, hair and nails.

[Term]
id: DOID:0060124 ! skeletal system cancer
relationship: has_locus UBERON:0001434 ! skeletal system
! A musculoskeletal system cancer that is located_in the skeletal system.

[Term]
id: DOID:0060124 ! skeletal system cancer
relationship: has_locus UBERON:0004288 ! skeleton
! A musculoskeletal system cancer that is located_in the skeletal system.

[Term]
id: DOID:0060158 ! acquired metabolic disease
relationship: has_locus UBERON:0003103 ! compound organ
! A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

[Term]
id: DOID:0060162 ! dentatorubral-pallidoluysian atrophy
relationship: has_locus UBERON:0001018 ! axon tract
! A spinocerebellar degeneration that has_material_basis_in an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein.

[Term]
id: DOID:0060174 ! GABA aminotransferase deficiency
relationship: has_locus UBERON:0000955 ! brain
! A gamma-amino butyric acid metabolism disorder that is characterized by a defect in the gene coding for gamma-aminobutyrate transaminase, which is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.

[Term]
id: DOID:0060174 ! GABA aminotransferase deficiency
relationship: has_locus UBERON:0001017 ! central nervous system
! A gamma-amino butyric acid metabolism disorder that is characterized by a defect in the gene coding for gamma-aminobutyrate transaminase, which is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.

[Term]
id: DOID:0060177 ! homocarnosinosis
relationship: has_locus UBERON:0000955 ! brain
! A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0080005 ! bone remodeling disease
relationship: has_locus UBERON:0001474 ! bone
! A bone disease that results_in formation or resorption abnormalities located_in bone.

[Term]
id: DOID:0080006 ! bone development disease
relationship: has_locus UBERON:0001474 ! bone
! A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.

[Term]
id: DOID:0080006 ! bone development disease
relationship: has_locus UBERON:0002418 ! cartilage tissue
! A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.

[Term]
id: DOID:0080006 ! bone development disease
relationship: has_locus UBERON:0007844 ! cartilaginous element
! A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.

[Term]
id: DOID:0080007 ! bone deterioration disease
relationship: has_locus UBERON:0001474 ! bone
! A bone structure disease that results_in change or damage of structure located_in bone.

[Term]
id: DOID:0080008 ! ischemic bone disease
relationship: has_locus UBERON:0001474 ! bone
! A bone disease that results_in an interruption of blood supply located_in bone.

[Term]
id: DOID:0080018 ! dysbaric osteonecrosis
relationship: has_locus UBERON:0001474 ! bone
! An ischemic bone disease the has_material_basis_in nitrogen embolization located_in bone.

[Term]
id: DOID:0080019 ! metaphyseal dysplasia
relationship: has_locus UBERON:0001474 ! bone
! An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone.

[Term]
id: DOID:0080021 ! Schmid metaphyseal chondrodysplasia
relationship: has_locus UBERON:0000978 ! leg
! A metaphyseal dysplasia that results_in dwarfism and bowed legs.

[Term]
id: DOID:0080021 ! Schmid metaphyseal chondrodysplasia
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A metaphyseal dysplasia that results_in dwarfism and bowed legs.

[Term]
id: DOID:0080021 ! Schmid metaphyseal chondrodysplasia
relationship: has_locus UBERON:0005895 ! insect leg
! A metaphyseal dysplasia that results_in dwarfism and bowed legs.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_locus UBERON:0001437 ! epiphysis
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_locus UBERON:0001905 ! pineal body
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_locus UBERON:0002387 ! foot
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_locus UBERON:0002387 ! pes
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_locus UBERON:0002398 ! hand
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_locus UBERON:0002398 ! manus
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080027 ! spondyloepimetaphyseal dysplasia
relationship: has_locus UBERON:0001130 ! vertebral column
! An osteochondrodysplasia that results_in abnormalities of the located_in vertebral column, located_in epiphysis, located_in metaphysis.

[Term]
id: DOID:0080027 ! spondyloepimetaphyseal dysplasia
relationship: has_locus UBERON:0001437 ! epiphysis
! An osteochondrodysplasia that results_in abnormalities of the located_in vertebral column, located_in epiphysis, located_in metaphysis.

[Term]
id: DOID:0080027 ! spondyloepimetaphyseal dysplasia
relationship: has_locus UBERON:0001438 ! metaphysis
! An osteochondrodysplasia that results_in abnormalities of the located_in vertebral column, located_in epiphysis, located_in metaphysis.

[Term]
id: DOID:0080027 ! spondyloepimetaphyseal dysplasia
relationship: has_locus UBERON:0001905 ! pineal body
! An osteochondrodysplasia that results_in abnormalities of the located_in vertebral column, located_in epiphysis, located_in metaphysis.

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_locus UBERON:0001437 ! epiphysis
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_locus UBERON:0001438 ! metaphysis
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080031 ! fibrous dysplasia
relationship: has_locus UBERON:0001474 ! bone
! A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue.

[Term]
id: DOID:0080031 ! fibrous dysplasia
relationship: has_locus UBERON:0002481 ! bone tissue
! A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue.

[Term]
id: DOID:0080032 ! craniodiaphyseal dysplasia
relationship: has_locus UBERON:0003128 ! cranium
! An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal.

[Term]
id: DOID:0080032 ! craniodiaphyseal dysplasia
relationship: has_locus UBERON:0003129 ! skull
! An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal.

[Term]
id: DOID:0080032 ! craniodiaphyseal dysplasia
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0002101 ! limb
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0002495 ! long bone
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0003128 ! cranium
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0003129 ! skull
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_locus UBERON:0003128 ! cranium
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_locus UBERON:0003129 ! skull
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_locus UBERON:0001474 ! bone
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080037 ! Worth's syndrome
relationship: has_locus UBERON:0001716 ! secondary palate
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080037 ! Worth's syndrome
relationship: has_locus UBERON:0005620 ! primary palate
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080038 ! pycnodysostosis
relationship: has_locus UBERON:0003221 ! phalanx
! An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.

[Term]
id: DOID:0080039 ! axial osteomalacia
relationship: has_locus UBERON:0002483 ! trabecular bone tissue
! An osteosclerosis that results_in coarsening located_in trabecular bone.

[Term]
id: DOID:0080041 ! hypochondroplasia
relationship: has_locus UBERON:0002418 ! cartilage tissue
! An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.

[Term]
id: DOID:0080041 ! hypochondroplasia
relationship: has_locus UBERON:0007844 ! cartilaginous element
! An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_locus UBERON:0000071 ! death stage
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_locus UBERON:0003128 ! cranium
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_locus UBERON:0003129 ! skull
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080044 ! hypochondrogenesis
relationship: has_locus UBERON:0001130 ! vertebral column
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen.

[Term]
id: DOID:0080044 ! hypochondrogenesis
relationship: has_locus UBERON:0002355 ! pelvis
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_locus UBERON:0000018 ! compound eye
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_locus UBERON:0000019 ! camera-type eye
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_locus UBERON:0000982 ! skeletal joint
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_locus UBERON:0002101 ! limb
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080050 ! acromesomelic dysplasia, Maroteaux type
relationship: has_locus UBERON:0001130 ! vertebral column
! An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb.

[Term]
id: DOID:0080050 ! acromesomelic dysplasia, Maroteaux type
relationship: has_locus UBERON:0002101 ! limb
! An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb.

[Term]
id: DOID:0080050 ! acromesomelic dysplasia, Maroteaux type
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb.

[Term]
id: DOID:0080050 ! acromesomelic dysplasia, Maroteaux type
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0002387 ! foot
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0002387 ! pes
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0002398 ! hand
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0002398 ! manus
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0001130 ! vertebral column
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0001474 ! bone
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0002090 ! postcranial axial skeleton
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0005944 ! axial skeleton
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
relationship: has_locus UBERON:0005944 ! axial skeleton plus cranial skeleton
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080052 ! acromesomelic dysplasia, Grebe type
relationship: has_locus UBERON:0001448 ! metatarsal bone
! An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones.

[Term]
id: DOID:0080052 ! acromesomelic dysplasia, Grebe type
relationship: has_locus UBERON:0002374 ! metacarpal bone
! An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones.

[Term]
id: DOID:0080052 ! acromesomelic dysplasia, Grebe type
relationship: has_locus UBERON:0003221 ! phalanx
! An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_locus UBERON:0001456 ! face
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_locus UBERON:0002387 ! foot
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_locus UBERON:0002387 ! pes
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_locus UBERON:0002398 ! hand
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_locus UBERON:0002398 ! manus
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_locus UBERON:0002495 ! long bone
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080054 ! achondrogenesis type IA
relationship: has_locus UBERON:0001130 ! vertebral column
! An achondrogenesis that results_in abnormal ossification of the located_in vertebral column or located_in spine.

[Term]
id: DOID:0080055 ! achondrogenesis type IB
relationship: has_locus UBERON:0000916 ! abdomen
! An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen.

[Term]
id: DOID:0080055 ! achondrogenesis type IB
relationship: has_locus UBERON:0003684 ! abdominal cavity
! An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen.

[Term]
id: DOID:0080056 ! achondrogenesis type II
relationship: has_locus UBERON:0001130 ! vertebral column
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:0080056 ! achondrogenesis type II
relationship: has_locus UBERON:0002355 ! pelvis
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:0080056 ! achondrogenesis type II
relationship: has_locus UBERON:0002048 ! lung
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_locus UBERON:0000978 ! leg
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_locus UBERON:0001137 ! dorsum
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_locus UBERON:0005895 ! insect leg
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_locus UBERON:0000955 ! brain
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10035 ! asymptomatic neurosyphilis
relationship: has_locus UBERON:0002360 ! meninx
! A tertiary neurosyphilis that results_in mild meningitis.

[Term]
id: DOID:10154 ! small intestine cancer
relationship: has_locus UBERON:0002108 ! small intestine
! An intestinal cancer that is located_in the small intestine.

[Term]
id: DOID:10155 ! intestinal cancer
relationship: has_locus UBERON:0000160 ! intestine
! A gastrointestinal system cancer that is located_in the intestine.

[Term]
id: DOID:10159 ! osteonecrosis
relationship: has_locus UBERON:0001474 ! bone
! An ischemic bone disease that results_in necrosis located_in bone.

[Term]
id: DOID:1019 ! osteomyelitis
relationship: has_locus UBERON:0001474 ! bone
! A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow.

[Term]
id: DOID:1019 ! osteomyelitis
relationship: has_locus UBERON:0002371 ! bone marrow
! A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow.

[Term]
id: DOID:10205 ! axillary lipoma
relationship: has_locus UBERON:0001013 ! adipose tissue
! An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue.

[Term]
id: DOID:10205 ! axillary lipoma
relationship: has_locus UBERON:0001460 ! arm
! An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue.

[Term]
id: DOID:10205 ! axillary lipoma
relationship: has_locus UBERON:0001470 ! glenohumeral joint
! An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue.

[Term]
id: DOID:10205 ! axillary lipoma
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue.

[Term]
id: DOID:10205 ! axillary lipoma
relationship: has_locus UBERON:0009472 ! axilla
! An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue.

[Term]
id: DOID:1022 ! pinta disease
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic.

[Term]
id: DOID:1022 ! pinta disease
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic.

[Term]
id: DOID:1022 ! pinta disease
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic.

[Term]
id: DOID:1022 ! pinta disease
relationship: has_locus UBERON:0000344 ! mucosa
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_locus UBERON:0000014 ! zone of skin
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_locus UBERON:0000383 ! musculature of body
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_locus UBERON:0001015 ! musculature
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_locus UBERON:0001630 ! muscle organ
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_locus UBERON:0002097 ! skin of body
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_locus UBERON:0002199 ! integument
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0002633 ! motor nucleus of trigeminal nerve
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0000344 ! mucosa
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0000473 ! testis
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0001557 ! upper respiratory tract
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0001766 ! anterior chamber of eyeball
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0002003 ! peripheral nerve
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0000456 ! bodily secretion
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0001681 ! nasal bone
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:1024 ! leprosy
relationship: has_locus UBERON:0003729 ! mouth mucosa
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:10247 ! pleurisy
relationship: has_locus UBERON:0002048 ! lung
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_locus UBERON:0000977 ! pleura
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_locus UBERON:0001713 ! lower eyelid
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_locus UBERON:0002048 ! lung
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_locus UBERON:0002402 ! pleural cavity
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_locus UBERON:0005385 ! nasal cavity respiratory epithelium
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001044 ! salivary gland
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001690 ! ear
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001708 ! jaw
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001708 ! jaw skeleton
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001846 ! internal ear
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001044 ! salivary gland
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0000341 ! throat
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0000912 ! mucus
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_locus UBERON:0001836 ! saliva
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10322 ! berylliosis
relationship: has_locus UBERON:0002048 ! lung
! A pneumoconiosis that involves allergic response located_in lungs caused by inhalation of beryllium compounds.

[Term]
id: DOID:10371 ! yaws
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10371 ! yaws
relationship: has_locus UBERON:0000982 ! skeletal joint
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10371 ! yaws
relationship: has_locus UBERON:0001474 ! bone
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10371 ! yaws
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10371 ! yaws
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10398 ! pneumonic plague
relationship: has_locus UBERON:0002048 ! lung
! A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing.

[Term]
id: DOID:10426 ! Klippel-Feil syndrome
relationship: has_locus UBERON:0002412 ! vertebra
! A congenital disorder that has_material_basis_in abnormal segementation of the vertebra during fetal development which results_in fusion located_in cervical vertebra.

[Term]
id: DOID:10426 ! Klippel-Feil syndrome
relationship: has_locus UBERON:0002413 ! cervical vertebra
! A congenital disorder that has_material_basis_in abnormal segementation of the vertebra during fetal development which results_in fusion located_in cervical vertebra.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_locus UBERON:0000177 ! pus
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_locus UBERON:0000974 ! neck
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_locus UBERON:0001567 ! cheek
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_locus UBERON:0001690 ! ear
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_locus UBERON:0001846 ! internal ear
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_locus UBERON:0002372 ! tonsil
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_locus UBERON:0000065 ! respiratory tract
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_locus UBERON:0001004 ! respiratory system
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0000018 ! compound eye
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0000019 ! camera-type eye
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0000341 ! throat
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0000344 ! mucosa
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0001042 ! chordate pharynx
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10459 ! common cold
relationship: has_locus UBERON:0002393 ! pharyngotympanic tube
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0001191 ! common iliac artery
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0001352 ! external acoustic meatus
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0001691 ! external ear
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0001756 ! middle ear
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_locus UBERON:0001846 ! internal ear
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10518 ! beach ear
relationship: has_locus UBERON:0001690 ! ear
! A otitis externa which is a microbial infection that occurs suddenly, rapidly worsens, and becomes very painful and alarming. It is caused by swimming in polluted water, scratching the ear or inside the ear and object stuck in the ear. It is occasionally associated with middle ear infection or upper respiratory infections such as colds.

[Term]
id: DOID:10518 ! beach ear
relationship: has_locus UBERON:0001846 ! internal ear
! A otitis externa which is a microbial infection that occurs suddenly, rapidly worsens, and becomes very painful and alarming. It is caused by swimming in polluted water, scratching the ear or inside the ear and object stuck in the ear. It is occasionally associated with middle ear infection or upper respiratory infections such as colds.

[Term]
id: DOID:10533 ! viral pneumonia
relationship: has_locus UBERON:0002048 ! lung
! A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.

[Term]
id: DOID:10534 ! stomach cancer
relationship: has_locus UBERON:0000945 ! stomach
! A gastrointestinal system cancer that is located_in the stomach.

[Term]
id: DOID:10567 ! late yaws
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

[Term]
id: DOID:10567 ! late yaws
relationship: has_locus UBERON:0001474 ! bone
! A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

[Term]
id: DOID:10573 ! osteomalacia
relationship: has_locus UBERON:0001474 ! bone
! A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.

[Term]
id: DOID:10579 ! leukodystrophy
relationship: has_locus UBERON:0000955 ! brain
! A cerebral degeneration characterized by dysfunction of the white matter of the brain.

[Term]
id: DOID:10579 ! leukodystrophy
relationship: has_locus UBERON:0002316 ! white matter
! A cerebral degeneration characterized by dysfunction of the white matter of the brain.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_locus UBERON:0009778 ! pleural sac
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_locus UBERON:0000977 ! pleura
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_locus UBERON:0001981 ! blood vessel
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_locus UBERON:0002049 ! vasculature
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_locus UBERON:0000175 ! pleural effusion
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:1060 ! Hartnup disease
relationship: has_locus UBERON:0001231 ! nephron tubule
! An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.

[Term]
id: DOID:1060 ! Hartnup disease
relationship: has_locus UBERON:0002037 ! cerebellum
! An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.

[Term]
id: DOID:10600 ! chronic tic disorder
relationship: has_locus UBERON:0002633 ! motor nucleus of trigeminal nerve
! A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_locus UBERON:0002108 ! small intestine
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_locus UBERON:0007356 ! crop
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10609 ! rickets
relationship: has_locus UBERON:0001474 ! bone
! A bone remodeling disease that has_material_basis_in a vitamin D deficiency in children which results_in softening and deformity located_in bone.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_locus UBERON:0000955 ! brain
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_locus UBERON:0000956 ! cerebral cortex
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_locus UBERON:0001851 ! cortex
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10755 ! petrositis
relationship: has_locus UBERON:0001694 ! petrous part of temporal bone
! An osteomyelitis that has_material_basis_in infection located_in petrous part of temporal bone.

[Term]
id: DOID:10773 ! bubonic plague
relationship: has_locus UBERON:0000029 ! lymph node
! A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration.

[Term]
id: DOID:10773 ! bubonic plague
relationship: has_locus UBERON:0000029 ! lymph node
! A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration.

[Term]
id: DOID:10773 ! bubonic plague
relationship: has_locus UBERON:0001744 ! lymphoid tissue
! A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration.

[Term]
id: DOID:10773 ! bubonic plague
relationship: has_locus UBERON:0002465 ! lymphoid system
! A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration.

[Term]
id: DOID:10811 ! nasal cavity cancer
relationship: has_locus UBERON:0001707 ! nasal cavity
! A respiratory system cancer that is located_in the nasal cavity.

[Term]
id: DOID:10811 ! nasal cavity cancer
relationship: has_locus UBERON:0005870 ! olfactory pit
! A respiratory system cancer that is located_in the nasal cavity.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10844 ! Japanese encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0000341 ! throat
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0001836 ! saliva
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_locus UBERON:0001988 ! feces
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10882 ! epidemic pleurodynia
relationship: has_locus UBERON:0001111 ! intercostal muscle
! A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0001137 ! dorsum
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0001733 ! soft palate
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0000176 ! oronasal secretion
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10883 ! herpangina
relationship: has_locus UBERON:0001988 ! feces
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10887 ! lepromatous leprosy
relationship: has_locus UBERON:0000167 ! oral cavity
! A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

[Term]
id: DOID:10887 ! lepromatous leprosy
relationship: has_locus UBERON:0010163 ! eyebrow
! A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

[Term]
id: DOID:11054 ! urinary bladder cancer
relationship: has_locus UBERON:0001255 ! urinary bladder
! An urinary system cancer that results_in malignant growth located_in the urinary bladder.

[Term]
id: DOID:11060 ! placenta praevia
relationship: has_locus UBERON:0000002 ! uterine cervix
! A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

[Term]
id: DOID:11060 ! placenta praevia
relationship: has_locus UBERON:0000459 ! uterine wall
! A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

[Term]
id: DOID:11060 ! placenta praevia
relationship: has_locus UBERON:0001987 ! placenta
! A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

[Term]
id: DOID:1107 ! esophageal carcinoma
relationship: has_locus UBERON:0001043 ! esophagus
! A esophageal cancer that is located_in the esophagus.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_locus UBERON:0001089 ! sweat
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11100 ! Q fever
relationship: has_locus UBERON:0003103 ! compound organ
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11100 ! Q fever
relationship: has_locus UBERON:0000174 ! excreta
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11100 ! Q fever
relationship: has_locus UBERON:0001913 ! milk
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0000383 ! musculature of body
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0000978 ! leg
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0001015 ! musculature
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0001137 ! dorsum
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0001630 ! muscle organ
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11101 ! trench fever
relationship: has_locus UBERON:0005895 ! insect leg
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:1114 ! esophagus sarcoma
relationship: has_locus UBERON:0001043 ! esophagus
! A sarcoma and malignant neoplasm of esophagus that is_located in the esophagus.

[Term]
id: DOID:1115 ! sarcoma
relationship: has_locus UBERON:0000926 ! mesoderm
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic mesoderm.

[Term]
id: DOID:1116 ! pertussis
relationship: has_locus UBERON:0010168 ! collection of eyelashes
! A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

[Term]
id: DOID:1116 ! pertussis
relationship: has_locus UBERON:0000065 ! respiratory tract
! A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

[Term]
id: DOID:1116 ! pertussis
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

[Term]
id: DOID:1116 ! pertussis
relationship: has_locus UBERON:0001004 ! respiratory system
! A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0001191 ! common iliac artery
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0007029 ! surface
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11165 ! common wart
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000002 ! uterine cervix
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000341 ! throat
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000931 ! proctodeum
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000989 ! penis
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000995 ! uterus
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000996 ! vagina
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0001245 ! anus
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0001300 ! scrotum
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0001353 ! anal region
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0006834 ! uterus or analog
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11168 ! anogenital venereal wart
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11193 ! syndactyly
relationship: has_locus UBERON:0010361 ! synostosis
! A synostosis that results_in the fusion of two or more digits.

[Term]
id: DOID:11193 ! syndactyly
relationship: has_locus UBERON:0002544 ! digit
! A synostosis that results_in the fusion of two or more digits.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
relationship: has_locus UBERON:0000018 ! compound eye
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
relationship: has_locus UBERON:0000019 ! camera-type eye
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
relationship: has_locus UBERON:0001811 ! conjunctiva
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11239 ! appendix cancer
relationship: has_locus UBERON:0001154 ! appendix
! A gastrointestinal system cancer that is located_in the appendix.

[Term]
id: DOID:11256 ! typhus
relationship: has_locus UBERON:0001982 ! capillary
! A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites.

[Term]
id: DOID:11258 ! cat-scratch disease
relationship: has_locus UBERON:0000029 ! lymph node
! A primary bacterial infectious disease that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.

[Term]
id: DOID:11258 ! cat-scratch disease
relationship: has_locus UBERON:0002465 ! lymphoid system
! A primary bacterial infectious disease that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.

[Term]
id: DOID:11258 ! cat-scratch disease
relationship: has_locus UBERON:0001836 ! saliva
! A primary bacterial infectious disease that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.

[Term]
id: DOID:11260 ! rabies
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_locus UBERON:0002240 ! spinal cord
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_locus UBERON:0000344 ! mucosa
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_locus UBERON:0001836 ! saliva
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11265 ! trachoma
relationship: has_locus UBERON:0000018 ! compound eye
! A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

[Term]
id: DOID:11265 ! trachoma
relationship: has_locus UBERON:0000019 ! camera-type eye
! A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

[Term]
id: DOID:11265 ! trachoma
relationship: has_locus UBERON:0000964 ! cornea
! A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

[Term]
id: DOID:11265 ! trachoma
relationship: has_locus UBERON:0010168 ! collection of eyelashes
! A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_locus UBERON:0000080 ! mesonephros
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_locus UBERON:0002120 ! pronephros
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11315 ! African histoplasmosis
relationship: has_locus UBERON:0001474 ! bone
! A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of nodules, results_in_formation_of ulcers and results_in_formation_of osteolytic bone lesions.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0000479 ! tissue
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0000344 ! mucosa
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0001707 ! nasal cavity
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0001737 ! larynx
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0002185 ! bronchus
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_locus UBERON:0005870 ! olfactory pit
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11338 ! tetanus
relationship: has_locus UBERON:0000955 ! brain
! A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

[Term]
id: DOID:11338 ! tetanus
relationship: has_locus UBERON:0002240 ! spinal cord
! A primary bacterial infectious disease that results_in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli.

[Term]
id: DOID:11339 ! pneumocystosis
relationship: has_locus UBERON:0000479 ! tissue
! An opportunistic mycosis that is located_in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has_symptom nonproductive cough, has_symptom shortness of breath, and has_symptom fever.

[Term]
id: DOID:11360 ! Phlebotomus fever
relationship: has_locus UBERON:0000982 ! skeletal joint
! A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia.

[Term]
id: DOID:11360 ! Phlebotomus fever
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0000955 ! brain
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0001130 ! vertebral column
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0001474 ! bone
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0003128 ! cranium
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0003129 ! skull
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0003292 ! meninx of spinal cord
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0000177 ! pus
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0000955 ! brain
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0001130 ! vertebral column
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0001474 ! bone
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0002240 ! spinal cord
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0003128 ! cranium
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0003129 ! skull
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11387 ! epidural abscess
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0001443 ! chest
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0002048 ! lung
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0003279 ! endothelium of trachea
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0003280 ! endothelium of main bronchus
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0005674 ! right lung cranial lobe endothelium
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0005675 ! right lung caudal lobe endothelium
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_locus UBERON:0005676 ! right lung accessory lobe endothelium
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0000080 ! mesonephros
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0000948 ! heart
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0002120 ! pronephros
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0001707 ! nasal cavity
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0002372 ! tonsil
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_locus UBERON:0005870 ! olfactory pit
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11450 ! allergic cutaneous vasculitis
relationship: has_locus UBERON:0000014 ! zone of skin
! A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

[Term]
id: DOID:11450 ! allergic cutaneous vasculitis
relationship: has_locus UBERON:0001981 ! blood vessel
! A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

[Term]
id: DOID:11450 ! allergic cutaneous vasculitis
relationship: has_locus UBERON:0002097 ! skin of body
! A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

[Term]
id: DOID:11450 ! allergic cutaneous vasculitis
relationship: has_locus UBERON:0002199 ! integument
! A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

[Term]
id: DOID:11476 ! osteoporosis
relationship: has_locus UBERON:0001474 ! bone
! A bone resorption disease that has_material_basis_in a drop in estrogen or testosterone which results_in the thinning of bone tissue and loss of bone mineral density.

[Term]
id: DOID:11476 ! osteoporosis
relationship: has_locus UBERON:0002481 ! bone tissue
! A bone resorption disease that has_material_basis_in a drop in estrogen or testosterone which results_in the thinning of bone tissue and loss of bone mineral density.

[Term]
id: DOID:11516 ! hypertensive heart disease
relationship: has_locus UBERON:0000178 ! blood
! A heart disease that is caused by high blood presure.

[Term]
id: DOID:11549 ! Adie syndrome
relationship: has_locus UBERON:0001771 ! pupil
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:11549 ! Adie syndrome
relationship: has_locus UBERON:0003701 ! calcaneal tendon
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:11549 ! Adie syndrome
relationship: has_locus UBERON:0001771 ! pupil
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:11549 ! Adie syndrome
relationship: has_locus UBERON:0002410 ! autonomic nervous system
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:1156 ! pseudogout
relationship: has_locus UBERON:0000982 ! skeletal joint
! An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.

[Term]
id: DOID:1166 ! palindromic rheumatism
relationship: has_locus UBERON:0000982 ! skeletal joint
! A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_locus UBERON:0000479 ! tissue
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_locus UBERON:0002405 ! immune system
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:117 ! heart cancer
relationship: has_locus UBERON:0000948 ! heart
! A cardiovascular cancer located_in the heart.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_locus UBERON:0000948 ! heart
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_locus UBERON:0000982 ! skeletal joint
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_locus UBERON:0001016 ! nervous system
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_locus UBERON:0003907 ! left atrioventricular canal
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_locus UBERON:0005613 ! left dorsal aorta
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11760 ! Kohler's disease
relationship: has_locus UBERON:0001451 ! navicular bone of foot
! An osteochondrosis that results_in death and collapse located_in navicular bone of foot.

[Term]
id: DOID:11760 ! Kohler's disease
relationship: has_locus UBERON:0001451 ! navicular bone of pes
! An osteochondrosis that results_in death and collapse located_in navicular bone of foot.

[Term]
id: DOID:11760 ! Kohler's disease
relationship: has_locus UBERON:0000071 ! death stage
! An osteochondrosis that results_in death and collapse located_in navicular bone of foot.

[Term]
id: DOID:118 ! pericardial effusion
relationship: has_locus UBERON:0001074 ! pericardial cavity
! A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

[Term]
id: DOID:11812 ! bladder sarcoma
relationship: has_locus UBERON:0001255 ! urinary bladder
! A sarcoma and malignant neoplasm of urinary bladder that is located_in the bladder.

[Term]
id: DOID:11819 ! ureter cancer
relationship: has_locus UBERON:0000056 ! ureter
! A urinary system cancer that is located_in the ureter.

[Term]
id: DOID:11819 ! ureter cancer
relationship: has_locus UBERON:0001055 ! ureter
! A urinary system cancer that is located_in the ureter.

[Term]
id: DOID:11838 ! penis sarcoma
relationship: has_locus UBERON:0000989 ! penis
! A sarcoma and malignant neoplasm of penis that is located_in the penis.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0000931 ! proctodeum
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0001245 ! anus
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0001353 ! anal region
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0004262 ! upper leg skin
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0008337 ! inguinal part of abdomen
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0002356 ! perineum
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_locus UBERON:0008337 ! inguinal part of abdomen
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:1192 ! peripheral nervous system neoplasm
relationship: has_locus UBERON:0000010 ! peripheral nervous system
! A nervous system cancer that is located_in the peripheral nervous system.

[Term]
id: DOID:1192 ! peripheral nervous system neoplasm
relationship: has_locus UBERON:0000011 ! parasympathetic nervous system
! A nervous system cancer that is located_in the peripheral nervous system.

[Term]
id: DOID:1192 ! peripheral nervous system neoplasm
relationship: has_locus UBERON:0000013 ! sympathetic nervous system
! A nervous system cancer that is located_in the peripheral nervous system.

[Term]
id: DOID:11920 ! tracheal cancer
relationship: has_locus UBERON:0003126 ! trachea
! A respiratory system cancer that is located_in the trachea.

[Term]
id: DOID:11920 ! tracheal cancer
relationship: has_locus UBERON:0003127 ! open tracheal system trachea
! A respiratory system cancer that is located_in the trachea.

[Term]
id: DOID:11971 ! synostosis
relationship: has_locus UBERON:0001474 ! bone
! A dysostosis that results_in abnormal fusing of adjacent bones.

[Term]
id: DOID:11976 ! botulism
relationship: has_locus UBERON:0001029 ! neuromuscular junction
! A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located_in neuromuscular junction, resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_locus UBERON:0003276 ! skeleton of embryo
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_locus UBERON:0003277 ! skeleton of upper jaw
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_locus UBERON:0003278 ! skeleton of lower jaw
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_locus UBERON:0004288 ! skeleton
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_locus UBERON:0001474 ! bone
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:12002 ! trachea sarcoma
relationship: has_locus UBERON:0003126 ! trachea
! A sarcoma and malignant tumor of trachea that is located_in the trachea.

[Term]
id: DOID:12002 ! trachea sarcoma
relationship: has_locus UBERON:0003127 ! open tracheal system trachea
! A sarcoma and malignant tumor of trachea that is located_in the trachea.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0000018 ! compound eye
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0000019 ! camera-type eye
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0000165 ! mouth
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0000167 ! oral cavity
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0000456 ! bodily secretion
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_locus UBERON:0001088 ! urine
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:1210 ! optic neuritis
relationship: has_locus UBERON:0000941 ! cranial nerve II
! An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_locus UBERON:0000080 ! mesonephros
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_locus UBERON:0001981 ! blood vessel
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_locus UBERON:0002048 ! lung
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_locus UBERON:0002120 ! pronephros
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12140 ! Chagas disease
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

[Term]
id: DOID:12148 ! alveolar echinococcosis
relationship: has_locus UBERON:0000955 ! brain
! An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

[Term]
id: DOID:12148 ! alveolar echinococcosis
relationship: has_locus UBERON:0002048 ! lung
! An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

[Term]
id: DOID:12148 ! alveolar echinococcosis
relationship: has_locus UBERON:0002107 ! liver
! An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0003288 ! meninx of midbrain
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0003289 ! meninx of telencephalon
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0003290 ! meninx of diencephalon
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0003291 ! meninx of hindbrain
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0003292 ! meninx of spinal cord
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_locus UBERON:0010743 ! meningeal cluster
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12177 ! common variable immunodeficiency
relationship: has_locus UBERON:0001977 ! serum
! A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).

[Term]
id: DOID:12179 ! tinea corporis
relationship: has_locus UBERON:0000014 ! zone of skin
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12179 ! tinea corporis
relationship: has_locus UBERON:0001003 ! epidermis
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12179 ! tinea corporis
relationship: has_locus UBERON:0002027 ! stratum corneum of epidermis
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12179 ! tinea corporis
relationship: has_locus UBERON:0002097 ! skin of body
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12179 ! tinea corporis
relationship: has_locus UBERON:0002199 ! integument
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_locus UBERON:0000018 ! compound eye
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_locus UBERON:0000019 ! camera-type eye
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_locus UBERON:0000383 ! musculature of body
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_locus UBERON:0001015 ! musculature
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_locus UBERON:0001630 ! muscle organ
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
relationship: has_locus UBERON:0000014 ! zone of skin
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
relationship: has_locus UBERON:0000178 ! blood
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
relationship: has_locus UBERON:0002097 ! skin of body
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
relationship: has_locus UBERON:0002199 ! integument
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_locus UBERON:0000079 ! male reproductive system
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_locus UBERON:0000479 ! tissue
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_locus UBERON:0000978 ! leg
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_locus UBERON:0005895 ! insect leg
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12215 ! oligohydramnios
relationship: has_locus UBERON:0000068 ! embryo stage
! A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

[Term]
id: DOID:12215 ! oligohydramnios
relationship: has_locus UBERON:0000173 ! amniotic fluid
! A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

[Term]
id: DOID:12215 ! oligohydramnios
relationship: has_locus UBERON:0000305 ! amnion
! A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

[Term]
id: DOID:12215 ! oligohydramnios
relationship: has_locus UBERON:0000922 ! embryo
! A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

[Term]
id: DOID:12252 ! Cushing's syndrome
relationship: has_locus UBERON:0001235 ! adrenal cortex
! An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_locus UBERON:0001088 ! urine
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_locus UBERON:0001716 ! secondary palate
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_locus UBERON:0001988 ! feces
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_locus UBERON:0005620 ! primary palate
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_locus UBERON:0002101 ! limb
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_locus UBERON:0000018 ! compound eye
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_locus UBERON:0000019 ! camera-type eye
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_locus UBERON:0001037 ! strand of hair
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_locus UBERON:0002360 ! meninx
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12341 ! retroperitoneal sarcoma
relationship: has_locus UBERON:0003693 ! retroperitoneal space
! A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space.

[Term]
id: DOID:12347 ! osteogenesis imperfecta
relationship: has_locus UBERON:0001474 ! bone
! An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.

[Term]
id: DOID:12347 ! osteogenesis imperfecta
relationship: has_locus UBERON:0002384 ! connective tissue
! An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.

[Term]
id: DOID:12361 ! Graves' disease
relationship: has_locus UBERON:0002046 ! thyroid gland
! An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland.

[Term]
id: DOID:12365 ! malaria
relationship: has_locus UBERON:0000178 ! blood
! A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_locus UBERON:0000912 ! mucus
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_locus UBERON:0002048 ! lung
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_locus UBERON:0002187 ! terminal bronchiole
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_locus UBERON:0009911 ! lobule
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12385 ! shigellosis
relationship: has_locus UBERON:0000059 ! large intestine
! A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

[Term]
id: DOID:12385 ! shigellosis
relationship: has_locus UBERON:0001262 ! wall of intestine
! A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

[Term]
id: DOID:12385 ! shigellosis
relationship: has_locus UBERON:0000397 ! colonic epithelium
! A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

[Term]
id: DOID:12385 ! shigellosis
relationship: has_locus UBERON:0001988 ! feces
! A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

[Term]
id: DOID:12386 ! balantidiasis
relationship: has_locus UBERON:0001277 ! intestinal epithelium
! A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.

[Term]
id: DOID:1240 ! leukemia
relationship: has_locus UBERON:0000178 ! blood
! A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

[Term]
id: DOID:1240 ! leukemia
relationship: has_locus UBERON:0000178 ! blood
! A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

[Term]
id: DOID:1240 ! leukemia
relationship: has_locus UBERON:0002371 ! bone marrow
! A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells.

[Term]
id: DOID:12403 ! tinea pedis
relationship: has_locus UBERON:0002387 ! foot
! A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot.

[Term]
id: DOID:12403 ! tinea pedis
relationship: has_locus UBERON:0002387 ! pes
! A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot.

[Term]
id: DOID:12403 ! tinea pedis
relationship: has_locus UBERON:0001513 ! skin of foot
! A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot.

[Term]
id: DOID:12403 ! tinea pedis
relationship: has_locus UBERON:0001513 ! skin of pes
! A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot.

[Term]
id: DOID:12474 ! capillariasis
relationship: has_locus UBERON:0000160 ! intestine
! A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species.

[Term]
id: DOID:1251 ! tuberculous epididymitis
relationship: has_locus UBERON:0001301 ! epididymis
! An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_locus UBERON:0000160 ! intestine
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_locus UBERON:0002107 ! liver
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12662 ! paracoccidioidomycosis
relationship: has_locus UBERON:0000029 ! lymph node
! A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.

[Term]
id: DOID:12662 ! paracoccidioidomycosis
relationship: has_locus UBERON:0000344 ! mucosa
! A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.

[Term]
id: DOID:12662 ! paracoccidioidomycosis
relationship: has_locus UBERON:0001474 ! bone
! A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.

[Term]
id: DOID:12662 ! paracoccidioidomycosis
relationship: has_locus UBERON:0002048 ! lung
! A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.

[Term]
id: DOID:12663 ! blastomycosis
relationship: has_locus UBERON:0002048 ! lung
! A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening.

[Term]
id: DOID:12683 ! vestibular neuronitis
relationship: has_locus UBERON:0003723 ! vestibular nerve
! A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

[Term]
id: DOID:12683 ! vestibular neuronitis
relationship: has_locus UBERON:0001846 ! internal ear
! A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

[Term]
id: DOID:12700 ! hyperprolactinemia
relationship: has_locus UBERON:0000178 ! blood
! An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.

[Term]
id: DOID:12711 ! black piedra
relationship: has_locus UBERON:0000403 ! scalp
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair.

[Term]
id: DOID:12711 ! black piedra
relationship: has_locus UBERON:0010167 ! beard
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair.

[Term]
id: DOID:12711 ! black piedra
relationship: has_locus UBERON:0010169 ! moustache
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair.

[Term]
id: DOID:12711 ! black piedra
relationship: has_locus UBERON:0002074 ! hair shaft
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair.

[Term]
id: DOID:12716 ! newborn respiratory distress syndrome
relationship: has_locus UBERON:0000058 ! duct
! A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

[Term]
id: DOID:12716 ! newborn respiratory distress syndrome
relationship: has_locus UBERON:0002048 ! lung
! A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

[Term]
id: DOID:12716 ! newborn respiratory distress syndrome
relationship: has_locus UBERON:0003215 ! alveolus
! A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

[Term]
id: DOID:12716 ! newborn respiratory distress syndrome
relationship: has_locus UBERON:0007029 ! surface
! A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_locus UBERON:0001474 ! bone
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_locus UBERON:0002418 ! cartilage tissue
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_locus UBERON:0007844 ! cartilaginous element
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_locus UBERON:0001464 ! hip
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_locus UBERON:0001465 ! knee
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_locus UBERON:0001557 ! upper respiratory tract
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_locus UBERON:0001558 ! lower respiratory tract
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_locus UBERON:0000456 ! bodily secretion
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_locus UBERON:0001681 ! nasal bone
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_locus UBERON:0000018 ! compound eye
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_locus UBERON:0000019 ! camera-type eye
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12858 ! Huntington's disease
relationship: has_locus UBERON:0000383 ! musculature of body
! A neurodegenerative disease that has_material_basis_in expansion of CAG repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

[Term]
id: DOID:12858 ! Huntington's disease
relationship: has_locus UBERON:0001015 ! musculature
! A neurodegenerative disease that has_material_basis_in expansion of CAG repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

[Term]
id: DOID:12858 ! Huntington's disease
relationship: has_locus UBERON:0001630 ! muscle organ
! A neurodegenerative disease that has_material_basis_in expansion of CAG repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

[Term]
id: DOID:1289 ! neurodegenerative disease
relationship: has_locus UBERON:0000479 ! tissue
! A central nervous system disease that results_in the progressive deterioration of tissue or organ function or structure, whether due to normal bodily wear or lifestyle choices.

[Term]
id: DOID:1289 ! neurodegenerative disease
relationship: has_locus UBERON:0003103 ! compound organ
! A central nervous system disease that results_in the progressive deterioration of tissue or organ function or structure, whether due to normal bodily wear or lifestyle choices.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
relationship: has_locus UBERON:0010361 ! synostosis
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12965 ! subleukemic leukemia
relationship: has_locus UBERON:0000178 ! blood
! A leukemia that is characterized by the presence of abnormal white blood cells located_in peripheral blood, but in which the total number of white blood cells is normal.

[Term]
id: DOID:12969 ! central nervous system leukemia
relationship: has_locus UBERON:0000955 ! brain
! A hematologic cancer located_in the central nervous system.

[Term]
id: DOID:12969 ! central nervous system leukemia
relationship: has_locus UBERON:0001017 ! central nervous system
! A hematologic cancer located_in the central nervous system.

[Term]
id: DOID:13026 ! lobomycosis
relationship: has_locus UBERON:0011818 ! superficial fascia
! A dermatomycosis that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Lacazia loboi and has_symptom crusty plaques, has_symptom tumors and results_in_formation_of nodular lesions.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0001705 ! nail
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0005273 ! nail bed
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0008198 ! nail plate
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0001308 ! external iliac artery
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0001705 ! nail
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0005441 ! external intercostal muscle
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0005928 ! external naris
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13074 ! tinea unguium
relationship: has_locus UBERON:0001705 ! nail
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0001825 ! paranasal sinus
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0000403 ! scalp
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0000473 ! testis
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0000974 ! neck
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0001684 ! mandible
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0001710 ! lower jaw region
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0001711 ! eyelid
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0001817 ! lacrimal gland
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0002100 ! trunk
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0002356 ! perineum
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0002387 ! foot
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0002387 ! pes
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13078 ! eumycotic mycetoma
relationship: has_locus UBERON:0003278 ! skeleton of lower jaw
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13166 ! allergic bronchopulmonary aspergillosis
relationship: has_locus UBERON:0000912 ! mucus
! An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has_symptom cough, has_symptom wheezing and has_symptom fever.

[Term]
id: DOID:13189 ! gout
relationship: has_locus UBERON:0000982 ! skeletal joint
! An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.

[Term]
id: DOID:13226 ! oculoglandular tularemia
relationship: has_locus UBERON:0000029 ! lymph node
! A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear.

[Term]
id: DOID:13226 ! oculoglandular tularemia
relationship: has_locus UBERON:0001690 ! ear
! A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear.

[Term]
id: DOID:13226 ! oculoglandular tularemia
relationship: has_locus UBERON:0001846 ! internal ear
! A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0000018 ! compound eye
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0000019 ! camera-type eye
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0000165 ! mouth
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0000167 ! oral cavity
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0000456 ! bodily secretion
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_locus UBERON:0001088 ! urine
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:1324 ! lung cancer
relationship: has_locus UBERON:0002048 ! lung
! A respiratory system cancer that is located_in the lung.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_locus UBERON:0001981 ! blood vessel
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_locus UBERON:0000165 ! mouth
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_locus UBERON:0000167 ! oral cavity
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_locus UBERON:0001988 ! feces
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_locus UBERON:0001828 ! gingiva
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_locus UBERON:0001988 ! feces
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_locus UBERON:0000160 ! intestine
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13300 ! Scheuermann's disease
relationship: has_locus UBERON:0006073 ! thoracic region of vertebral column
! An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column.

[Term]
id: DOID:13359 ! Ehlers-Danlos syndrome
relationship: has_locus UBERON:0000982 ! skeletal joint
! A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising.

[Term]
id: DOID:13368 ! tinea profunda
relationship: has_locus UBERON:0000014 ! zone of skin
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton mentagrophytes and results_in_formation_of subcutaneous abscesses.

[Term]
id: DOID:13368 ! tinea profunda
relationship: has_locus UBERON:0002097 ! skin of body
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton mentagrophytes and results_in_formation_of subcutaneous abscesses.

[Term]
id: DOID:13368 ! tinea profunda
relationship: has_locus UBERON:0002199 ! integument
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton mentagrophytes and results_in_formation_of subcutaneous abscesses.

[Term]
id: DOID:13369 ! tinea manuum
relationship: has_locus UBERON:0002398 ! hand
! A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling.

[Term]
id: DOID:13369 ! tinea manuum
relationship: has_locus UBERON:0002398 ! manus
! A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling.

[Term]
id: DOID:13372 ! alpha 1-antitrypsin deficiency
relationship: has_locus UBERON:0000178 ! blood
! A plasma protein metabolism disease that has_material_basis_in  defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.

[Term]
id: DOID:13372 ! alpha 1-antitrypsin deficiency
relationship: has_locus UBERON:0002048 ! lung
! A plasma protein metabolism disease that has_material_basis_in  defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.

[Term]
id: DOID:13374 ! fibrodysplasia ossificans progressiva
relationship: has_locus UBERON:0000043 ! tendon
! .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.

[Term]
id: DOID:13374 ! fibrodysplasia ossificans progressiva
relationship: has_locus UBERON:0001134 ! skeletal muscle tissue
! .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.

[Term]
id: DOID:13374 ! fibrodysplasia ossificans progressiva
relationship: has_locus UBERON:0001475 ! ligament
! .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.

[Term]
id: DOID:13374 ! fibrodysplasia ossificans progressiva
relationship: has_locus UBERON:0008846 ! skeletal ligament
! .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.

[Term]
id: DOID:13374 ! fibrodysplasia ossificans progressiva
relationship: has_locus UBERON:0008982 ! fascia
! .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.

[Term]
id: DOID:13386 ! gastrointestinal anthrax
relationship: has_locus UBERON:0000344 ! mucosa
! An anthrax disease that results_in infection located_in mucosa of gastrointestinal tract, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite.

[Term]
id: DOID:13386 ! gastrointestinal anthrax
relationship: has_locus UBERON:0001555 ! digestive tract
! An anthrax disease that results_in infection located_in mucosa of gastrointestinal tract, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite.

[Term]
id: DOID:13386 ! gastrointestinal anthrax
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! An anthrax disease that results_in infection located_in mucosa of gastrointestinal tract, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0000165 ! mouth
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0000167 ! oral cavity
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0000479 ! tissue
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0001456 ! face
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0002495 ! long bone
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0001474 ! bone
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13431 ! bejel
relationship: has_locus UBERON:0003729 ! mouth mucosa
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13444 ! glanders
relationship: has_locus UBERON:0002048 ! lung
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13444 ! glanders
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13444 ! glanders
relationship: has_locus UBERON:0000479 ! tissue
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
relationship: has_locus UBERON:0000014 ! zone of skin
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
relationship: has_locus UBERON:0000978 ! leg
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
relationship: has_locus UBERON:0002097 ! skin of body
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
relationship: has_locus UBERON:0002199 ! integument
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
relationship: has_locus UBERON:0005895 ! insect leg
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13521 ! tetanus neonatorum
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0000043 ! tendon
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0000383 ! musculature of body
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0000978 ! leg
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0001015 ! musculature
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0001460 ! arm
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0001630 ! muscle organ
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0005895 ! insect leg
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0000018 ! compound eye
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13523 ! loiasis
relationship: has_locus UBERON:0000019 ! camera-type eye
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13533 ! osteopetrosis
relationship: has_locus UBERON:0001474 ! bone
! An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0000018 ! compound eye
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0000019 ! camera-type eye
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0000080 ! mesonephros
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0000948 ! heart
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0000955 ! brain
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0001474 ! bone
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0001555 ! digestive tract
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0002048 ! lung
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0002120 ! pronephros
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0002405 ! immune system
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13564 ! aspergillosis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13565 ! neuroaspergillosis
relationship: has_locus UBERON:0000955 ! brain
! An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion.

[Term]
id: DOID:13565 ! neuroaspergillosis
relationship: has_locus UBERON:0001017 ! central nervous system
! An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion.

[Term]
id: DOID:1362 ! paranasal sinus sarcoma
relationship: has_locus UBERON:0001825 ! paranasal sinus
! A sarcoma and malignant tumor of nasal sinuses that is located_in the paranasal sinus.

[Term]
id: DOID:13622 ! campylobacteriosis
relationship: has_locus UBERON:0000160 ! intestine
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.

[Term]
id: DOID:13775 ! plantar wart
relationship: has_locus UBERON:0002387 ! foot
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13775 ! plantar wart
relationship: has_locus UBERON:0002387 ! pes
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13775 ! plantar wart
relationship: has_locus UBERON:0008338 ! plantar part of foot
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13775 ! plantar wart
relationship: has_locus UBERON:0002387 ! foot
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13775 ! plantar wart
relationship: has_locus UBERON:0002387 ! pes
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13775 ! plantar wart
relationship: has_locus UBERON:0008338 ! plantar part of foot
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_locus UBERON:0000014 ! zone of skin
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_locus UBERON:0002097 ! skin of body
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_locus UBERON:0002199 ! integument
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_locus UBERON:0000177 ! pus
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_locus UBERON:0000912 ! mucus
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_locus UBERON:0001811 ! conjunctiva
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_locus UBERON:0000018 ! compound eye
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_locus UBERON:0000019 ! camera-type eye
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_locus UBERON:0001811 ! conjunctiva
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
relationship: has_locus UBERON:0001811 ! conjunctiva
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13819 ! lymphogranuloma venereum
relationship: has_locus UBERON:0008337 ! inguinal part of abdomen
! A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis.

[Term]
id: DOID:13819 ! lymphogranuloma venereum
relationship: has_locus UBERON:0000029 ! lymph node
! A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis.

[Term]
id: DOID:13867 ! focal labyrinthitis
relationship: has_locus UBERON:0001844 ! cochlea
! A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma.

[Term]
id: DOID:13867 ! focal labyrinthitis
relationship: has_locus UBERON:0001849 ! membranous labyrinth
! A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma.

[Term]
id: DOID:13891 ! bird fancier's lung
relationship: has_locus UBERON:0000174 ! excreta
! An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen.

[Term]
id: DOID:13902 ! white piedra
relationship: has_locus UBERON:0010164 ! collection of hairs
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft.

[Term]
id: DOID:13902 ! white piedra
relationship: has_locus UBERON:0002074 ! hair shaft
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft.

[Term]
id: DOID:1394 ! urinary schistosomiasis
relationship: has_locus UBERON:0001255 ! urinary bladder
! A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

[Term]
id: DOID:1394 ! urinary schistosomiasis
relationship: has_locus UBERON:0001008 ! excretory system
! A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_locus UBERON:0000014 ! zone of skin
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_locus UBERON:0000160 ! intestine
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_locus UBERON:0001008 ! excretory system
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_locus UBERON:0002097 ! skin of body
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_locus UBERON:0002199 ! integument
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:13994 ! cleidocranial dysplasia
relationship: has_locus UBERON:0001105 ! clavicle
! An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in underveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.

[Term]
id: DOID:13994 ! cleidocranial dysplasia
relationship: has_locus UBERON:0003128 ! cranium
! An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in underveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.

[Term]
id: DOID:13994 ! cleidocranial dysplasia
relationship: has_locus UBERON:0003129 ! skull
! An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in underveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.

[Term]
id: DOID:13994 ! cleidocranial dysplasia
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in underveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_locus UBERON:0001089 ! sweat
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14040 ! autoimmune polyendocrine syndrome
relationship: has_locus UBERON:0002405 ! immune system
! An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.

[Term]
id: DOID:14049 ! phaeohyphomycosis
relationship: has_locus UBERON:0000955 ! brain
! A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

[Term]
id: DOID:14049 ! phaeohyphomycosis
relationship: has_locus UBERON:0001179 ! peritoneal cavity
! A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

[Term]
id: DOID:14049 ! phaeohyphomycosis
relationship: has_locus UBERON:0002048 ! lung
! A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

[Term]
id: DOID:14049 ! phaeohyphomycosis
relationship: has_locus UBERON:0011818 ! superficial fascia
! A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

[Term]
id: DOID:14087 ! epicondylitis
relationship: has_locus UBERON:0009978 ! epicondyle
! A bone inflammation disease that results_in inflammation located_in epicondyle.

[Term]
id: DOID:14110 ! anus cancer
relationship: has_locus UBERON:0000931 ! proctodeum
! A gastrointestinal system cancer that is located_in the anus.

[Term]
id: DOID:14110 ! anus cancer
relationship: has_locus UBERON:0001245 ! anus
! A gastrointestinal system cancer that is located_in the anus.

[Term]
id: DOID:14110 ! anus cancer
relationship: has_locus UBERON:0001353 ! anal region
! A gastrointestinal system cancer that is located_in the anus.

[Term]
id: DOID:14150 ! spinal cord lymphoma
relationship: has_locus UBERON:0002240 ! spinal cord
! A CNS lymphoma and malignant neoplasm of spinal cord that is located_in the spinal cord.

[Term]
id: DOID:14239 ! gastrointestinal tularemia
relationship: has_locus UBERON:0001555 ! digestive tract
! A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting.

[Term]
id: DOID:14239 ! gastrointestinal tularemia
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting.

[Term]
id: DOID:14262 ! oral candidiasis
relationship: has_locus UBERON:0000165 ! mouth
! A candidiasis that involves fungal infection of the mucous membrane of the mouth by Candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

[Term]
id: DOID:14262 ! oral candidiasis
relationship: has_locus UBERON:0000167 ! oral cavity
! A candidiasis that involves fungal infection of the mucous membrane of the mouth by Candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

[Term]
id: DOID:14262 ! oral candidiasis
relationship: has_locus UBERON:0000344 ! mucosa
! A candidiasis that involves fungal infection of the mucous membrane of the mouth by Candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

[Term]
id: DOID:14319 ! pleuropneumonia
relationship: has_locus UBERON:0000177 ! pus
! A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria.

[Term]
id: DOID:14330 ! Parkinson's disease
relationship: has_locus UBERON:0000955 ! brain
! A neurodegenerative disease that has_material_basis_in degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.

[Term]
id: DOID:14330 ! Parkinson's disease
relationship: has_locus UBERON:0001017 ! central nervous system
! A neurodegenerative disease that has_material_basis_in degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.

[Term]
id: DOID:14374 ! norwegian scabies
relationship: has_locus UBERON:0000014 ! zone of skin
! A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

[Term]
id: DOID:14374 ! norwegian scabies
relationship: has_locus UBERON:0002097 ! skin of body
! A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

[Term]
id: DOID:14374 ! norwegian scabies
relationship: has_locus UBERON:0002199 ! integument
! A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

[Term]
id: DOID:14374 ! norwegian scabies
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

[Term]
id: DOID:14374 ! norwegian scabies
relationship: has_locus UBERON:0007222 ! late adult stage
! A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

[Term]
id: DOID:1441 ! spinocerebellar ataxia
relationship: has_locus UBERON:0002240 ! spinal cord
! A spinocerebellar degeneration that has_material_basis_in expanded CAG triplet repeats resulting in spinal cord and cerebellum degeneration.

[Term]
id: DOID:14415 ! Legg-Calve-Perthes Disease
relationship: has_locus UBERON:0001486 ! hip joint
! An osteochondrosis that results_in death and fracture located_in hip joint.

[Term]
id: DOID:14415 ! Legg-Calve-Perthes Disease
relationship: has_locus UBERON:0000071 ! death stage
! An osteochondrosis that results_in death and fracture located_in hip joint.

[Term]
id: DOID:1442 ! Alpers syndrome
relationship: has_locus UBERON:0001893 ! telencephalon
! A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.

[Term]
id: DOID:1442 ! Alpers syndrome
relationship: has_locus UBERON:0002020 ! gray matter of neuraxis
! A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.

[Term]
id: DOID:14422 ! dipetalonemiasis
relationship: has_locus UBERON:0000066 ! fully formed stage
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14422 ! dipetalonemiasis
relationship: has_locus UBERON:0000113 ! post-juvenile adult stage
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14422 ! dipetalonemiasis
relationship: has_locus UBERON:0002553 ! anatomical cavity
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14422 ! dipetalonemiasis
relationship: has_locus UBERON:0007023 ! adult organism
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14435 ! chronic tubotympanic suppurative otitis media
relationship: has_locus UBERON:0002364 ! tympanic membrane
! A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections.

[Term]
id: DOID:14435 ! chronic tubotympanic suppurative otitis media
relationship: has_locus UBERON:0001756 ! middle ear
! A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_locus UBERON:0001089 ! sweat
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_locus UBERON:0000071 ! death stage
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_locus UBERON:0002048 ! lung
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14512 ! candidal paronychia
relationship: has_locus UBERON:0001001 ! chitin-based cuticle
! A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury.

[Term]
id: DOID:14512 ! candidal paronychia
relationship: has_locus UBERON:0001705 ! nail
! A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury.

[Term]
id: DOID:14512 ! candidal paronychia
relationship: has_locus UBERON:0003049 ! collagen and cuticulin-based cuticle
! A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury.

[Term]
id: DOID:14512 ! candidal paronychia
relationship: has_locus UBERON:0004882 ! eponychium
! A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury.

[Term]
id: DOID:14512 ! candidal paronychia
relationship: has_locus UBERON:0001705 ! nail
! A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_locus UBERON:0000018 ! compound eye
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_locus UBERON:0000019 ! camera-type eye
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_locus UBERON:0001769 ! iris
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14669 ! acrodysostosis
relationship: has_locus UBERON:0002387 ! foot
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14669 ! acrodysostosis
relationship: has_locus UBERON:0002387 ! pes
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14669 ! acrodysostosis
relationship: has_locus UBERON:0002398 ! hand
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14669 ! acrodysostosis
relationship: has_locus UBERON:0002398 ! manus
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14669 ! acrodysostosis
relationship: has_locus UBERON:0000982 ! skeletal joint
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14705 ! Pfeiffer syndrome
relationship: has_locus UBERON:0003128 ! cranium
! An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14705 ! Pfeiffer syndrome
relationship: has_locus UBERON:0003129 ! skull
! An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14705 ! Pfeiffer syndrome
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14748 ! Sotos syndrome
relationship: has_locus UBERON:0000104 ! life cycle
! An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.

[Term]
id: DOID:14761 ! Greig cephalopolysyndactyly syndrome
relationship: has_locus UBERON:0000033 ! head
! An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.

[Term]
id: DOID:14761 ! Greig cephalopolysyndactyly syndrome
relationship: has_locus UBERON:0001456 ! face
! An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.

[Term]
id: DOID:14761 ! Greig cephalopolysyndactyly syndrome
relationship: has_locus UBERON:0002101 ! limb
! An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.

[Term]
id: DOID:14761 ! Greig cephalopolysyndactyly syndrome
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.

[Term]
id: DOID:14761 ! Greig cephalopolysyndactyly syndrome
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.

[Term]
id: DOID:14768 ! Saethre-Chotzen syndrome
relationship: has_locus UBERON:0003128 ! cranium
! An acrocephalosyndactylia that has_material_basis_in a genetic mutation in the TWIST1 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14768 ! Saethre-Chotzen syndrome
relationship: has_locus UBERON:0003129 ! skull
! An acrocephalosyndactylia that has_material_basis_in a genetic mutation in the TWIST1 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14768 ! Saethre-Chotzen syndrome
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! An acrocephalosyndactylia that has_material_basis_in a genetic mutation in the TWIST1 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0001130 ! vertebral column
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0002101 ! limb
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0002412 ! vertebra
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0003276 ! skeleton of embryo
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0003277 ! skeleton of upper jaw
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0003278 ! skeleton of lower jaw
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0004288 ! skeleton
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:14798 ! Blount's disease
relationship: has_locus UBERON:0000979 ! tibia
! An osteochondrodysplasia that results_in inward turning of lower leg, located_in tibia, which fails to develop normally.

[Term]
id: DOID:14798 ! Blount's disease
relationship: has_locus UBERON:0003131 ! arthropod tibia
! An osteochondrodysplasia that results_in inward turning of lower leg, located_in tibia, which fails to develop normally.

[Term]
id: DOID:14798 ! Blount's disease
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! An osteochondrodysplasia that results_in inward turning of lower leg, located_in tibia, which fails to develop normally.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_locus UBERON:0000948 ! heart
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_locus UBERON:0000955 ! brain
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_locus UBERON:0001474 ! bone
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0000080 ! mesonephros
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0000105 ! life cycle stage
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0000948 ! heart
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0000955 ! brain
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0002048 ! lung
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0002106 ! spleen
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0002107 ! liver
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0002120 ! pronephros
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1496 ! echinococcosis
relationship: has_locus UBERON:0006293 ! spleen primordium
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1498 ! cholera
relationship: has_locus UBERON:0000160 ! intestine
! A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.

[Term]
id: DOID:15 ! reproductive system disease
relationship: has_locus UBERON:0003133 ! reproductive organ
! A disease of anatomical entity that is located_in reproductive system organs.

[Term]
id: DOID:154 ! mixed cell type cancer
relationship: has_locus UBERON:0000479 ! tissue
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from two germinal layers of tissue.

[Term]
id: DOID:1540 ! parathyroid carcinoma
relationship: has_locus UBERON:0001132 ! parathyroid gland
! An endocrine gland cancer located_in the parathyroid glands located in the neck.

[Term]
id: DOID:1562 ! chromoblastomycosis
relationship: has_locus UBERON:0000014 ! zone of skin
! A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

[Term]
id: DOID:1562 ! chromoblastomycosis
relationship: has_locus UBERON:0002097 ! skin of body
! A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

[Term]
id: DOID:1562 ! chromoblastomycosis
relationship: has_locus UBERON:0002199 ! integument
! A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

[Term]
id: DOID:1564 ! fungal infectious disease
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_locus UBERON:0000102 ! lung vasculature
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_locus UBERON:0001443 ! chest
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:16 ! integumentary system disease
relationship: has_locus UBERON:0000026 ! appendage
! A disease of anatomical entity that is located_in the integumentary system  comprising the skin and its appendages.

[Term]
id: DOID:16 ! integumentary system disease
relationship: has_locus UBERON:0002416 ! integumental system
! A disease of anatomical entity that is located_in the integumentary system  comprising the skin and its appendages.

[Term]
id: DOID:1638 ! central nervous system tuberculosis
relationship: has_locus UBERON:0000955 ! brain
! An extrapulmonary tuberculosis that results in formation of tuberculomas located_in brain or located_in spinal cord.

[Term]
id: DOID:1638 ! central nervous system tuberculosis
relationship: has_locus UBERON:0002240 ! spinal cord
! An extrapulmonary tuberculosis that results in formation of tuberculomas located_in brain or located_in spinal cord.

[Term]
id: DOID:1639 ! skeletal tuberculosis
relationship: has_locus UBERON:0001474 ! bone
! An extrapulmonary tuberculosis that results in formation of lesions located_in bone.

[Term]
id: DOID:1642 ! breast adenomyoepithelioma
relationship: has_locus UBERON:0000310 ! breast
! A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells.

[Term]
id: DOID:1664 ! pineoblastoma
relationship: has_locus UBERON:0000955 ! brain
! A pineal gland neoplasm located_in the brain.

[Term]
id: DOID:170 ! endocrine gland cancer
relationship: has_locus UBERON:0000949 ! endocrine system
! An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

[Term]
id: DOID:170 ! endocrine gland cancer
relationship: has_locus UBERON:0003294 ! gland of foregut
! An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

[Term]
id: DOID:170 ! endocrine gland cancer
relationship: has_locus UBERON:0000949 ! endocrine system
! An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

[Term]
id: DOID:170 ! endocrine gland cancer
relationship: has_locus UBERON:0002530 ! gland
! An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_locus UBERON:0000178 ! blood
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_locus UBERON:0000947 ! aorta
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_locus UBERON:0002084 ! heart left ventricle
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_locus UBERON:0002137 ! aortic valve
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_locus UBERON:0001555 ! digestive tract
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_locus UBERON:0001811 ! conjunctiva
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_locus UBERON:0002048 ! lung
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_locus UBERON:0003103 ! compound organ
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_locus UBERON:0000160 ! intestine
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:175 ! vascular cancer
relationship: has_locus UBERON:0001981 ! blood vessel
! A cardiovascular cancer that is located_in blood vessels.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0000161 ! orifice
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0000948 ! heart
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0001191 ! common iliac artery
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0002064 ! common cardinal vein
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0002135 ! mitral valve
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_locus UBERON:0007151 ! leaflets of mitral valve
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:176 ! cardiovascular cancer
relationship: has_locus UBERON:0000948 ! heart
! An organ system cancer that located_in the heart and blood vessels.

[Term]
id: DOID:176 ! cardiovascular cancer
relationship: has_locus UBERON:0001981 ! blood vessel
! An organ system cancer that located_in the heart and blood vessels.

[Term]
id: DOID:1781 ! thyroid cancer
relationship: has_locus UBERON:0001738 ! thyroid cartilage
! An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage.

[Term]
id: DOID:1781 ! thyroid cancer
relationship: has_locus UBERON:0003294 ! gland of foregut
! An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage.

[Term]
id: DOID:1787 ! pericarditis
relationship: has_locus UBERON:0002406 ! pericardial sac
! A heart disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.

[Term]
id: DOID:1787 ! pericarditis
relationship: has_locus UBERON:0002407 ! pericardium
! A heart disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.

[Term]
id: DOID:1790 ! malignant mesothelioma
relationship: has_locus UBERON:0000479 ! tissue
! A cell type cancer that has_material_basis_in meothelial tissue.

[Term]
id: DOID:1791 ! peritoneal carcinoma
relationship: has_locus UBERON:0000916 ! abdomen
! A carcinoma that is located_in the inside of the abdomen.

[Term]
id: DOID:1791 ! peritoneal carcinoma
relationship: has_locus UBERON:0003684 ! abdominal cavity
! A carcinoma that is located_in the inside of the abdomen.

[Term]
id: DOID:1793 ! pancreatic cancer
relationship: has_locus UBERON:0001264 ! pancreas
! An endocrine gland cancer located_in the pancreas.

[Term]
id: DOID:1796 ! pancreas sarcoma
relationship: has_locus UBERON:0001264 ! pancreas
! A sarcoma and malignant neoplasm of pancreas that is located_in the pancreas.

[Term]
id: DOID:18 ! urinary system disease
relationship: has_locus UBERON:0000056 ! ureter
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:18 ! urinary system disease
relationship: has_locus UBERON:0000057 ! urethra
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:18 ! urinary system disease
relationship: has_locus UBERON:0000080 ! mesonephros
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:18 ! urinary system disease
relationship: has_locus UBERON:0001055 ! ureter
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:18 ! urinary system disease
relationship: has_locus UBERON:0001255 ! urinary bladder
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:18 ! urinary system disease
relationship: has_locus UBERON:0002120 ! pronephros
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:180 ! ossifying fibroma
relationship: has_locus UBERON:0000165 ! mouth
! A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

[Term]
id: DOID:180 ! ossifying fibroma
relationship: has_locus UBERON:0000167 ! oral cavity
! A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

[Term]
id: DOID:180 ! ossifying fibroma
relationship: has_locus UBERON:0001828 ! gingiva
! A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

[Term]
id: DOID:1826 ! epilepsy syndrome
relationship: has_locus UBERON:0000955 ! brain
! A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenicnabnormality of the brain that is able to spontaneously gen-nerate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.

[Term]
id: DOID:184 ! bone cancer
relationship: has_locus UBERON:0001474 ! bone
! An musculoskeletal system cancer located_in bone that is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

[Term]
id: DOID:184 ! bone cancer
relationship: has_locus UBERON:0002481 ! bone tissue
! An musculoskeletal system cancer located_in bone that is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

[Term]
id: DOID:184 ! bone cancer
relationship: has_locus UBERON:0001474 ! bone
! An musculoskeletal system cancer located_in bone that is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

[Term]
id: DOID:1858 ! McCune Albright syndrome
relationship: has_locus UBERON:0001474 ! bone
! An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It is caused by mutations in the GNAS1 gene.

[Term]
id: DOID:1862 ! jaw cancer
relationship: has_locus UBERON:0001708 ! jaw
! A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone.

[Term]
id: DOID:1862 ! jaw cancer
relationship: has_locus UBERON:0001708 ! jaw skeleton
! A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone.

[Term]
id: DOID:1862 ! jaw cancer
relationship: has_locus UBERON:0001708 ! jaw
! A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone.

[Term]
id: DOID:1862 ! jaw cancer
relationship: has_locus UBERON:0001708 ! jaw skeleton
! A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_locus UBERON:0002107 ! liver
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1909 ! melanoma
relationship: has_locus UBERON:0000014 ! zone of skin
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:1909 ! melanoma
relationship: has_locus UBERON:0000018 ! compound eye
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:1909 ! melanoma
relationship: has_locus UBERON:0000019 ! camera-type eye
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:1909 ! melanoma
relationship: has_locus UBERON:0000160 ! intestine
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:1909 ! melanoma
relationship: has_locus UBERON:0002097 ! skin of body
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:1909 ! melanoma
relationship: has_locus UBERON:0002199 ! integument
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:192 ! sex cord-gonadal stromal tumor
relationship: has_locus UBERON:0000473 ! testis
! A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis.

[Term]
id: DOID:192 ! sex cord-gonadal stromal tumor
relationship: has_locus UBERON:0000479 ! tissue
! A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis.

[Term]
id: DOID:1920 ! hyperuricemia
relationship: has_locus UBERON:0000178 ! blood
! An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood.

[Term]
id: DOID:1934 ! dysostosis
relationship: has_locus UBERON:0001474 ! bone
! A bone development disease that results_in defective ossification of located_in bone.

[Term]
id: DOID:1947 ! trichomoniasis
relationship: has_locus UBERON:0000165 ! mouth
! A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.

[Term]
id: DOID:1947 ! trichomoniasis
relationship: has_locus UBERON:0000167 ! oral cavity
! A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.

[Term]
id: DOID:1963 ! fallopian tube carcinoma
relationship: has_locus UBERON:0003889 ! fallopian tube
! A fallopian tube cancer that is located_in the fallopian tube.

[Term]
id: DOID:1964 ! fallopian tube cancer
relationship: has_locus UBERON:0003134 ! female reproductive organ
! A female reproductive organ cancer that is located_in fallopian tube.

[Term]
id: DOID:1964 ! fallopian tube cancer
relationship: has_locus UBERON:0003889 ! fallopian tube
! A female reproductive organ cancer that is located_in fallopian tube.

[Term]
id: DOID:1969 ! cerebral palsy
relationship: has_locus UBERON:0000383 ! musculature of body
! A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

[Term]
id: DOID:1969 ! cerebral palsy
relationship: has_locus UBERON:0000955 ! brain
! A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

[Term]
id: DOID:1969 ! cerebral palsy
relationship: has_locus UBERON:0001015 ! musculature
! A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

[Term]
id: DOID:1969 ! cerebral palsy
relationship: has_locus UBERON:0001630 ! muscle organ
! A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

[Term]
id: DOID:1974 ! adenosarcoma
relationship: has_locus UBERON:0006799 ! glandular epithelium
! A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

[Term]
id: DOID:1995 ! rectum sarcoma
relationship: has_locus UBERON:0001052 ! rectum
! A sarcoma and malignant tumor of rectum that is located_in the rectum.

[Term]
id: DOID:1995 ! rectum sarcoma
relationship: has_locus UBERON:0002108 ! small intestine
! A sarcoma and malignant tumor of rectum that is located_in the rectum.

[Term]
id: DOID:1995 ! rectum sarcoma
relationship: has_locus UBERON:0006866 ! terminal part of digestive tract
! A sarcoma and malignant tumor of rectum that is located_in the rectum.

[Term]
id: DOID:2000 ! otosalpingitis
relationship: has_locus UBERON:0000025 ! tube
! A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube.

[Term]
id: DOID:2000 ! otosalpingitis
relationship: has_locus UBERON:0000344 ! mucosa
! A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube.

[Term]
id: DOID:2000 ! otosalpingitis
relationship: has_locus UBERON:0002393 ! pharyngotympanic tube
! A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube.

[Term]
id: DOID:201 ! connective tissue cancer
relationship: has_locus UBERON:0002384 ! connective tissue
! A musculoskeletal system cancer that is located_in connective tissue.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_locus UBERON:0002107 ! liver
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_locus UBERON:0002107 ! liver
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2048 ! autoimmune hepatitis
relationship: has_locus UBERON:0002405 ! immune system
! An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.

[Term]
id: DOID:2048 ! autoimmune hepatitis
relationship: has_locus UBERON:0002107 ! liver
! An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.

[Term]
id: DOID:205 ! hyperostosis
relationship: has_locus UBERON:0001474 ! bone
! A bone remodeling disease that results in an abnormal growth of located_in bone.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0000403 ! scalp
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0000479 ! tissue
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0001705 ! nail
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0000014 ! zone of skin
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0000344 ! mucosa
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0001705 ! nail
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0002097 ! skin of body
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_locus UBERON:0002199 ! integument
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:210 ! heel spur
relationship: has_locus UBERON:0001450 ! calcaneus
! An exostosis that results_in an abnormal growth located_in calcaneus.

[Term]
id: DOID:2122 ! pneumonic tularemia
relationship: has_locus UBERON:0001443 ! chest
! A tularemia that is located_in lungs. The bacteria are transmitted_by breathing dusts or aerosols containing the organisms. The infection has_symptom cough, has_symptom chest has_symptom pain, and has_symptom difficulty breathing.

[Term]
id: DOID:2122 ! pneumonic tularemia
relationship: has_locus UBERON:0002048 ! lung
! A tularemia that is located_in lungs. The bacteria are transmitted_by breathing dusts or aerosols containing the organisms. The infection has_symptom cough, has_symptom chest has_symptom pain, and has_symptom difficulty breathing.

[Term]
id: DOID:2148 ! tuberculous oophoritis
relationship: has_locus UBERON:0000992 ! female gonad
! An urogenital tuberculosis that results_in inflammtion located_in ovary.

[Term]
id: DOID:2149 ! urogenital tuberculosis
relationship: has_locus UBERON:0004122 ! genitourinary system
! An extrapulmonary tuberculosis that is located_in urogenital system.

[Term]
id: DOID:2153 ! ovarian Wilms' cancer
relationship: has_locus UBERON:0000992 ! female gonad
! A malignant neoplasm of ovary and nephroblastoma that is located_in the ovaries.

[Term]
id: DOID:2174 ! ocular cancer
relationship: has_locus UBERON:0000018 ! compound eye
! An organ system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.

[Term]
id: DOID:2174 ! ocular cancer
relationship: has_locus UBERON:0000019 ! camera-type eye
! An organ system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0000177 ! pus
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001191 ! common iliac artery
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001690 ! ear
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001691 ! external ear
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001846 ! internal ear
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001847 ! lobule of pinna
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0002418 ! cartilage tissue
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0007844 ! cartilaginous element
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001352 ! external acoustic meatus
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001691 ! external ear
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0001847 ! lobule of pinna
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0002418 ! cartilage tissue
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_locus UBERON:0007844 ! cartilaginous element
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:2226 ! chronic myeloproliferative disease
relationship: has_locus UBERON:0000178 ! blood
! A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

[Term]
id: DOID:2226 ! chronic myeloproliferative disease
relationship: has_locus UBERON:0002371 ! bone marrow
! A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

[Term]
id: DOID:2228 ! thrombocytosis
relationship: has_locus UBERON:0000178 ! blood
! A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.

[Term]
id: DOID:2247 ! spondylosis
relationship: has_locus UBERON:0002412 ! vertebra
! An bone structure disease that involves degeneration between vertebra located_in vertebral column.

[Term]
id: DOID:2247 ! spondylosis
relationship: has_locus UBERON:0001130 ! vertebral column
! An bone structure disease that involves degeneration between vertebra located_in vertebral column.

[Term]
id: DOID:2256 ! osteochondrodysplasia
relationship: has_locus UBERON:0001474 ! bone
! A bone development disease that results_in defective development of located_in cartilage or located_in bone.

[Term]
id: DOID:2256 ! osteochondrodysplasia
relationship: has_locus UBERON:0002418 ! cartilage tissue
! A bone development disease that results_in defective development of located_in cartilage or located_in bone.

[Term]
id: DOID:2256 ! osteochondrodysplasia
relationship: has_locus UBERON:0007844 ! cartilaginous element
! A bone development disease that results_in defective development of located_in cartilage or located_in bone.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_locus UBERON:0001088 ! urine
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2300 ! spondylolysis
relationship: has_locus UBERON:0006074 ! lumbar region of vertebral column
! A bone structure disease that involves a defect located_in lumbar vertebral column.

[Term]
id: DOID:231 ! motor neuron disease
relationship: has_locus UBERON:0002633 ! motor nucleus of trigeminal nerve
! A neurodegenerative disease that is located_in the motor neurones.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0000955 ! brain
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0003288 ! meninx of midbrain
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0003289 ! meninx of telencephalon
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0003290 ! meninx of diencephalon
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0003291 ! meninx of hindbrain
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0003292 ! meninx of spinal cord
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_locus UBERON:0010743 ! meningeal cluster
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_locus UBERON:0000916 ! abdomen
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_locus UBERON:0003684 ! abdominal cavity
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_locus UBERON:0000059 ! large intestine
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_locus UBERON:0001007 ! digestive system
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2327 ! viral gastritis
relationship: has_locus UBERON:0001007 ! digestive system
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting.

[Term]
id: DOID:2327 ! viral gastritis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting.

[Term]
id: DOID:2340 ! craniosynostosis
relationship: has_locus UBERON:0010361 ! synostosis
! A synostosis that results_in premature fusion located_in skull.

[Term]
id: DOID:2340 ! craniosynostosis
relationship: has_locus UBERON:0003128 ! cranium
! A synostosis that results_in premature fusion located_in skull.

[Term]
id: DOID:2340 ! craniosynostosis
relationship: has_locus UBERON:0003129 ! skull
! A synostosis that results_in premature fusion located_in skull.

[Term]
id: DOID:2340 ! craniosynostosis
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! A synostosis that results_in premature fusion located_in skull.

[Term]
id: DOID:2354 ! myelophthisic anemia
relationship: has_locus UBERON:0002371 ! bone marrow
! A myeloma and anemia that is located_in some people with diseases that affect the bone marrow.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2403 ! aneurysm disease
relationship: has_locus UBERON:0000060 ! anatomical wall
! A vascular disease that is characterized by a localized, blood-filled balloon-like bulge in the wall of a blood vessel.

[Term]
id: DOID:2403 ! aneurysm disease
relationship: has_locus UBERON:0001981 ! blood vessel
! A vascular disease that is characterized by a localized, blood-filled balloon-like bulge in the wall of a blood vessel.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0000018 ! compound eye
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0000019 ! camera-type eye
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0000165 ! mouth
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0000167 ! oral cavity
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0001052 ! rectum
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0001308 ! external iliac artery
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0001690 ! ear
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0001712 ! upper eyelid
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0001826 ! nasal cavity mucosa
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0001846 ! internal ear
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0002108 ! small intestine
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0005441 ! external intercostal muscle
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0005928 ! external naris
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0006866 ! terminal part of digestive tract
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2409 ! rhinosporidiosis
relationship: has_locus UBERON:0000344 ! mucosa
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2449 ! acromegaly
relationship: has_locus UBERON:0002101 ! limb
! A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.

[Term]
id: DOID:2449 ! acromegaly
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.

[Term]
id: DOID:2449 ! acromegaly
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.

[Term]
id: DOID:2473 ! opportunistic mycosis
relationship: has_locus UBERON:0000065 ! respiratory tract
! A fungal infectious disease that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.

[Term]
id: DOID:2473 ! opportunistic mycosis
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A fungal infectious disease that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.

[Term]
id: DOID:2473 ! opportunistic mycosis
relationship: has_locus UBERON:0001004 ! respiratory system
! A fungal infectious disease that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.

[Term]
id: DOID:2476 ! hereditary spastic paraplegia
relationship: has_locus UBERON:0002103 ! hindlimb
! A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.

[Term]
id: DOID:2476 ! hereditary spastic paraplegia
relationship: has_locus UBERON:0010709 ! pelvic complex
! A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.

[Term]
id: DOID:2531 ! hematologic cancer
relationship: has_locus UBERON:0000029 ! lymph node
! An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

[Term]
id: DOID:2531 ! hematologic cancer
relationship: has_locus UBERON:0000178 ! blood
! An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

[Term]
id: DOID:2531 ! hematologic cancer
relationship: has_locus UBERON:0002371 ! bone marrow
! An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

[Term]
id: DOID:2531 ! hematologic cancer
relationship: has_locus UBERON:0002390 ! hematopoietic system
! An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

[Term]
id: DOID:2544 ! extratemporal epilepsy
relationship: has_locus UBERON:0000955 ! brain
! An epilepsy that is located_in an area of the brain other than the temporal lobe.

[Term]
id: DOID:2544 ! extratemporal epilepsy
relationship: has_locus UBERON:0001871 ! temporal lobe
! An epilepsy that is located_in an area of the brain other than the temporal lobe.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
relationship: has_locus UBERON:0001474 ! bone
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:2596 ! larynx cancer
relationship: has_locus UBERON:0001737 ! larynx
! A respiratory system cancer that is located_in the larynx.

[Term]
id: DOID:2615 ! papilloma
relationship: has_locus UBERON:0000483 ! epithelium
! A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue.

[Term]
id: DOID:2615 ! papilloma
relationship: has_locus UBERON:0002384 ! connective tissue
! A cell type benign neoplam that is composed_of epithelial tissue on papillae of vascularized connective tissue.

[Term]
id: DOID:263 ! kidney cancer
relationship: has_locus UBERON:0000080 ! mesonephros
! A urinary system cancer that is located_in the kidney.

[Term]
id: DOID:263 ! kidney cancer
relationship: has_locus UBERON:0002120 ! pronephros
! A urinary system cancer that is located_in the kidney.

[Term]
id: DOID:2632 ! papillary serous adenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A papillary adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies.

[Term]
id: DOID:2661 ! myoepithelioma
relationship: has_locus UBERON:0001820 ! sweat gland
! A carcinoma that is composed_of outgrowths of myoepithelial cells from a sweat gland.

[Term]
id: DOID:268 ! liver angiosarcoma
relationship: has_locus UBERON:0002107 ! liver
! An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver.

[Term]
id: DOID:2683 ! adenofibroma
relationship: has_locus UBERON:0003294 ! gland of foregut
! A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands.

[Term]
id: DOID:270 ! liver sarcoma
relationship: has_locus UBERON:0002107 ! liver
! A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver.

[Term]
id: DOID:2703 ! synovitis
relationship: has_locus UBERON:0002018 ! synovial membrane of synovial joint
! A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.

[Term]
id: DOID:2703 ! synovitis
relationship: has_locus UBERON:0002217 ! synovial joint
! A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.

[Term]
id: DOID:2708 ! mushroom workers' lung
relationship: has_locus UBERON:0002048 ! lung
! An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes.

[Term]
id: DOID:2708 ! mushroom workers' lung
relationship: has_locus UBERON:0003215 ! alveolus
! An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes.

[Term]
id: DOID:2747 ! glycogen storage disease
relationship: has_locus UBERON:0000383 ! musculature of body
! A carbohydrate metabolic disease that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.

[Term]
id: DOID:2747 ! glycogen storage disease
relationship: has_locus UBERON:0001015 ! musculature
! A carbohydrate metabolic disease that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.

[Term]
id: DOID:2747 ! glycogen storage disease
relationship: has_locus UBERON:0001630 ! muscle organ
! A carbohydrate metabolic disease that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.

[Term]
id: DOID:2747 ! glycogen storage disease
relationship: has_locus UBERON:0002107 ! liver
! A carbohydrate metabolic disease that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_locus UBERON:0000080 ! mesonephros
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_locus UBERON:0001013 ! adipose tissue
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_locus UBERON:0002107 ! liver
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_locus UBERON:0002120 ! pronephros
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_locus UBERON:0002107 ! liver
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2752 ! glycogen storage disease II
relationship: has_locus UBERON:0000383 ! musculature of body
! A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to  an accumulation of glycogen in the lysosome.

[Term]
id: DOID:2752 ! glycogen storage disease II
relationship: has_locus UBERON:0001015 ! musculature
! A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to  an accumulation of glycogen in the lysosome.

[Term]
id: DOID:2752 ! glycogen storage disease II
relationship: has_locus UBERON:0001630 ! muscle organ
! A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to  an accumulation of glycogen in the lysosome.

[Term]
id: DOID:2755 ! Mycobacterium avium complex disease
relationship: has_locus UBERON:0001555 ! digestive tract
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.

[Term]
id: DOID:2755 ! Mycobacterium avium complex disease
relationship: has_locus UBERON:0005385 ! nasal cavity respiratory epithelium
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.

[Term]
id: DOID:2755 ! Mycobacterium avium complex disease
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.

[Term]
id: DOID:2775 ! long bone adamantinoma
relationship: has_locus UBERON:0002495 ! long bone
! An adamantinoma that is located_in the long bones and results_in focal epithelial differentiation.

[Term]
id: DOID:2776 ! adamantinoma
relationship: has_locus UBERON:0002495 ! long bone
! A bone cancer that is located_in almost exclusively in the long bones.

[Term]
id: DOID:2784 ! lung sarcoma
relationship: has_locus UBERON:0002048 ! lung
! A sarcoma and malignant neoplasm of lung that is located_in the lung.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_locus UBERON:0002108 ! small intestine
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2797 ! idiopathic interstitial pneumonia
relationship: has_locus UBERON:0008946 ! lung parenchyma
! A pneumonia located_in the lung parenchyma of unknown cause.

[Term]
id: DOID:28 ! endocrine system disease
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

[Term]
id: DOID:28 ! endocrine system disease
relationship: has_locus UBERON:0002368 ! endocrine gland
! A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

[Term]
id: DOID:2810 ! middle lobe syndrome
relationship: has_locus UBERON:0000912 ! mucus
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2810 ! middle lobe syndrome
relationship: has_locus UBERON:0002170 ! upper lobe of right lung
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2810 ! middle lobe syndrome
relationship: has_locus UBERON:0002174 ! middle lobe of right lung
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2843 ! long QT syndrome
relationship: has_locus UBERON:0000948 ! heart
! An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).

[Term]
id: DOID:2871 ! endometrial carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A endometrial cancer that is located_in the tissue lining the uterus.

[Term]
id: DOID:2871 ! endometrial carcinoma
relationship: has_locus UBERON:0000995 ! uterus
! A endometrial cancer that is located_in the tissue lining the uterus.

[Term]
id: DOID:2871 ! endometrial carcinoma
relationship: has_locus UBERON:0006834 ! uterus or analog
! A endometrial cancer that is located_in the tissue lining the uterus.

[Term]
id: DOID:2877 ! larynx sarcoma
relationship: has_locus UBERON:0001737 ! larynx
! A sarcoma and malignant neoplasm of larynx that is located_in the larynx.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0001684 ! mandible
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0001690 ! ear
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0001710 ! lower jaw region
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0001733 ! soft palate
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0001833 ! lip
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0001846 ! internal ear
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0003066 ! pharyngeal arch 2
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0003114 ! pharyngeal arch 3
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0003115 ! pharyngeal arch 4
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0003278 ! skeleton of lower jaw
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2907 ! Goldenhar syndrome
relationship: has_locus UBERON:0004362 ! pharyngeal arch 1
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2914 ! immune system disease
relationship: has_locus UBERON:0002405 ! immune system
! A disease of anatomical entity that is located_in the immune system.

[Term]
id: DOID:2921 ! glomerulonephritis
relationship: has_locus UBERON:0000080 ! mesonephros
! A nephritis that causes inflammation of the glomeruli located_in kidney.

[Term]
id: DOID:2921 ! glomerulonephritis
relationship: has_locus UBERON:0002120 ! pronephros
! A nephritis that causes inflammation of the glomeruli located_in kidney.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_locus UBERON:0007379 ! egg
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_locus UBERON:0007811 ! craniocervical region
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_locus UBERON:0001088 ! urine
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_locus UBERON:0001988 ! feces
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_locus UBERON:0001981 ! blood vessel
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2942 ! bronchiolitis
relationship: has_locus UBERON:0002048 ! lung
! A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.

[Term]
id: DOID:2942 ! bronchiolitis
relationship: has_locus UBERON:0002186 ! bronchiole
! A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_locus UBERON:0000065 ! respiratory tract
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_locus UBERON:0001004 ! respiratory system
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:295 ! eye carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A carcinoma that arises_from the tissues that cover structures located_in the eye.

[Term]
id: DOID:295 ! eye carcinoma
relationship: has_locus UBERON:0000018 ! compound eye
! A carcinoma that arises_from the tissues that cover structures located_in the eye.

[Term]
id: DOID:295 ! eye carcinoma
relationship: has_locus UBERON:0000019 ! camera-type eye
! A carcinoma that arises_from the tissues that cover structures located_in the eye.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_locus UBERON:0000175 ! pleural effusion
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_locus UBERON:0000418 ! tubercle
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_locus UBERON:0005813 ! tubercle
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_locus UBERON:0002048 ! lung
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2962 ! Cockayne syndrome
relationship: has_locus UBERON:0001016 ! nervous system
! An autosomal recessive disease that is caused by  rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.

[Term]
id: DOID:299 ! adenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.

[Term]
id: DOID:3030 ! mucinous adenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin.

[Term]
id: DOID:3042 ! allergic contact dermatitis
relationship: has_locus UBERON:0002405 ! immune system
! A contact dermititis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign.

[Term]
id: DOID:3049 ! Churg-Strauss syndrome
relationship: has_locus UBERON:0001981 ! blood vessel
! A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_locus UBERON:0000160 ! intestine
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3069 ! astrocytoma
relationship: has_locus UBERON:0001893 ! telencephalon
! A malignant glioma that is has_material_basis_in astocyte cells, a type of glial cell, located_in the cerebrum.

[Term]
id: DOID:3070 ! malignant glioma
relationship: has_locus UBERON:0000955 ! brain
! A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.

[Term]
id: DOID:3070 ! malignant glioma
relationship: has_locus UBERON:0001130 ! vertebral column
! A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.

[Term]
id: DOID:3093 ! nervous system cancer
relationship: has_locus UBERON:0000010 ! peripheral nervous system
! An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system.

[Term]
id: DOID:3093 ! nervous system cancer
relationship: has_locus UBERON:0000011 ! parasympathetic nervous system
! An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system.

[Term]
id: DOID:3093 ! nervous system cancer
relationship: has_locus UBERON:0000013 ! sympathetic nervous system
! An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system.

[Term]
id: DOID:3110 ! papillary cystadenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with cysts and papillary endophytic projections.

[Term]
id: DOID:3111 ! cystadenocarcinoma
relationship: has_locus UBERON:0000456 ! bodily secretion
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.

[Term]
id: DOID:3111 ! cystadenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.

[Term]
id: DOID:3112 ! papillary adenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.

[Term]
id: DOID:3113 ! papillary carcinoma
relationship: has_locus UBERON:0002389 ! hand digit
! A carcinoma that is derived_from epithelial cells with finger like projections.

[Term]
id: DOID:3113 ! papillary carcinoma
relationship: has_locus UBERON:0002389 ! manual digit
! A carcinoma that is derived_from epithelial cells with finger like projections.

[Term]
id: DOID:3114 ! serous cystadenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions.

[Term]
id: DOID:3119 ! gastrointestinal system cancer
relationship: has_locus UBERON:0001007 ! digestive system
! An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.

[Term]
id: DOID:3119 ! gastrointestinal system cancer
relationship: has_locus UBERON:0001555 ! digestive tract
! An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.

[Term]
id: DOID:3119 ! gastrointestinal system cancer
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.

[Term]
id: DOID:3119 ! gastrointestinal system cancer
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.

[Term]
id: DOID:3121 ! gallbladder cancer
relationship: has_locus UBERON:0002110 ! gallbladder
! A biliary tract cancer that is located_in the gallbladder.

[Term]
id: DOID:3168 ! squamous cell neoplasm
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities.

[Term]
id: DOID:3168 ! squamous cell neoplasm
relationship: has_locus UBERON:0002553 ! anatomical cavity
! A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_locus UBERON:0000978 ! leg
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_locus UBERON:0005895 ! insect leg
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_locus UBERON:0002240 ! spinal cord
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:3234 ! central nervous system lymphoma
relationship: has_locus UBERON:0000955 ! brain
! A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system.

[Term]
id: DOID:3234 ! central nervous system lymphoma
relationship: has_locus UBERON:0001017 ! central nervous system
! A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_locus UBERON:0001280 ! liver parenchyma
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_locus UBERON:0007196 ! tracheobronchial tree
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3241 ! lipid pneumonia
relationship: has_locus UBERON:0008946 ! lung parenchyma
! An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.

[Term]
id: DOID:3252 ! prostate rhabdomyosarcoma
relationship: has_locus UBERON:0002367 ! prostate gland
! A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:3254 ! bile duct rhabdomyosarcoma
relationship: has_locus UBERON:0002394 ! bile duct
! A rhabdomyosarcoma and sarcoma of bile duct that is located_in the bile duct.

[Term]
id: DOID:3277 ! thymus cancer
relationship: has_locus UBERON:0002370 ! thymus
! An immune system cancer located_in the thymus.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_locus UBERON:0005385 ! nasal cavity respiratory epithelium
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3298 ! vaccinia
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.

[Term]
id: DOID:3298 ! vaccinia
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.

[Term]
id: DOID:3298 ! vaccinia
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.

[Term]
id: DOID:3298 ! vaccinia
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.

[Term]
id: DOID:3303 ! notochordal cancer
relationship: has_locus UBERON:0002328 ! notochord
! An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord.

[Term]
id: DOID:3308 ! embryonal carcinoma
relationship: has_locus UBERON:0000473 ! testis
! An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes.

[Term]
id: DOID:3308 ! embryonal carcinoma
relationship: has_locus UBERON:0000992 ! female gonad
! An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes.

[Term]
id: DOID:3341 ! osteitis fibrosa
relationship: has_locus UBERON:0001474 ! bone
! A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.

[Term]
id: DOID:3342 ! bone inflammation disease
relationship: has_locus UBERON:0001474 ! bone
! A bone disease that results_in inflammation of the located_in bone.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0001009 ! circulatory system
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0001474 ! bone
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0001981 ! blood vessel
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0002418 ! cartilage tissue
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0002465 ! lymphoid system
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0004535 ! cardiovascular system
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0004537 ! blood vasculature
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0006558 ! lymphatic part of lymphoid system
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
relationship: has_locus UBERON:0007844 ! cartilaginous element
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_locus UBERON:0001737 ! larynx
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3449 ! penis carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A penile cancer that is located_in the skin or tissues of the penis.

[Term]
id: DOID:3449 ! penis carcinoma
relationship: has_locus UBERON:0000989 ! penis
! A penile cancer that is located_in the skin or tissues of the penis.

[Term]
id: DOID:345 ! uterine disease
relationship: has_locus UBERON:0000995 ! uterus
! A female reproductive system disease that is located_in the uterus.

[Term]
id: DOID:345 ! uterine disease
relationship: has_locus UBERON:0006834 ! uterus or analog
! A female reproductive system disease that is located_in the uterus.

[Term]
id: DOID:3451 ! skin carcinoma
relationship: has_locus UBERON:0000014 ! zone of skin
! A carcinoma that is located_in tissues of the skin.

[Term]
id: DOID:3451 ! skin carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A carcinoma that is located_in tissues of the skin.

[Term]
id: DOID:3451 ! skin carcinoma
relationship: has_locus UBERON:0002097 ! skin of body
! A carcinoma that is located_in tissues of the skin.

[Term]
id: DOID:3451 ! skin carcinoma
relationship: has_locus UBERON:0002199 ! integument
! A carcinoma that is located_in tissues of the skin.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_locus UBERON:0003103 ! compound organ
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_locus UBERON:0001981 ! blood vessel
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_locus UBERON:0002049 ! vasculature
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3482 ! plague
relationship: has_locus UBERON:0000029 ! lymph node
! A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.

[Term]
id: DOID:3482 ! plague
relationship: has_locus UBERON:0001981 ! blood vessel
! A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.

[Term]
id: DOID:3482 ! plague
relationship: has_locus UBERON:0002048 ! lung
! A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.

[Term]
id: DOID:3482 ! plague
relationship: has_locus UBERON:0002049 ! vasculature
! A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.

[Term]
id: DOID:3482 ! plague
relationship: has_locus UBERON:0002465 ! lymphoid system
! A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0000014 ! zone of skin
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0002097 ! skin of body
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0002199 ! integument
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0000014 ! zone of skin
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0002097 ! skin of body
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0002199 ! integument
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_locus UBERON:0002384 ! connective tissue
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3571 ! liver cancer
relationship: has_locus UBERON:0002107 ! liver
! A gastrointestinal system cancer that is located_in the liver.

[Term]
id: DOID:3603 ! mucinous cystadenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells.

[Term]
id: DOID:3620 ! central nervous system cancer
relationship: has_locus UBERON:0000955 ! brain
! A nervous system cancer that is located_in the central nervous system.

[Term]
id: DOID:3620 ! central nervous system cancer
relationship: has_locus UBERON:0001017 ! central nervous system
! A nervous system cancer that is located_in the central nervous system.

[Term]
id: DOID:3650 ! lactic acidosis
relationship: has_locus UBERON:0000178 ! blood
! An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate.

[Term]
id: DOID:37 ! skin disease
relationship: has_locus UBERON:0000014 ! zone of skin
! An integumentary system disease that is located_in skin.

[Term]
id: DOID:37 ! skin disease
relationship: has_locus UBERON:0002097 ! skin of body
! An integumentary system disease that is located_in skin.

[Term]
id: DOID:37 ! skin disease
relationship: has_locus UBERON:0002199 ! integument
! An integumentary system disease that is located_in skin.

[Term]
id: DOID:381 ! arthropathy
relationship: has_locus UBERON:0000982 ! skeletal joint
! A bone inflammation disease that is located_in joint.

[Term]
id: DOID:3891 ! placental insufficiency
relationship: has_locus UBERON:0001987 ! placenta
! A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

[Term]
id: DOID:3905 ! lung carcinoma
relationship: has_locus UBERON:0002048 ! lung
! A lung cancer that is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.

[Term]
id: DOID:3950 ! adrenal carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland.

[Term]
id: DOID:3950 ! adrenal carcinoma
relationship: has_locus UBERON:0001851 ! cortex
! An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland.

[Term]
id: DOID:3950 ! adrenal carcinoma
relationship: has_locus UBERON:0002369 ! adrenal gland
! An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland.

[Term]
id: DOID:3950 ! adrenal carcinoma
relationship: has_locus UBERON:0005889 ! zygote cortex
! An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland.

[Term]
id: DOID:3953 ! adrenal gland cancer
relationship: has_locus UBERON:0000080 ! mesonephros
! An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.

[Term]
id: DOID:3953 ! adrenal gland cancer
relationship: has_locus UBERON:0002120 ! pronephros
! An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.

[Term]
id: DOID:3953 ! adrenal gland cancer
relationship: has_locus UBERON:0002369 ! adrenal gland
! An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0000029 ! lymph node
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0000955 ! brain
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0001555 ! digestive tract
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0002048 ! lung
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0002406 ! pericardial sac
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0002407 ! pericardium
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:399 ! tuberculosis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:3996 ! urinary system cancer
relationship: has_locus UBERON:0000057 ! urethra
! An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:3996 ! urinary system cancer
relationship: has_locus UBERON:0000080 ! mesonephros
! An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:3996 ! urinary system cancer
relationship: has_locus UBERON:0001255 ! urinary bladder
! An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:3996 ! urinary system cancer
relationship: has_locus UBERON:0002120 ! pronephros
! An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:4007 ! bladder carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A urinary bladder cancer that arises_from tissues of the bladder.

[Term]
id: DOID:4007 ! bladder carcinoma
relationship: has_locus UBERON:0001255 ! urinary bladder
! A urinary bladder cancer that arises_from tissues of the bladder.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0001684 ! mandible
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0001710 ! lower jaw region
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0001716 ! secondary palate
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0001723 ! tongue
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0002397 ! maxilla
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0003278 ! skeleton of lower jaw
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:402 ! oral tuberculosis
relationship: has_locus UBERON:0005620 ! primary palate
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_locus UBERON:0001007 ! digestive system
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:4034 ! fungal gastritis
relationship: has_locus UBERON:0001007 ! digestive system
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by fungal infection in immunocompromised patients.

[Term]
id: DOID:4034 ! fungal gastritis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by fungal infection in immunocompromised patients.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_locus UBERON:0001555 ! digestive tract
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:4045 ! muscle cancer
relationship: has_locus UBERON:0000383 ! musculature of body
! A musculoskeletal system cancer that is located_in muscle.

[Term]
id: DOID:4045 ! muscle cancer
relationship: has_locus UBERON:0001015 ! musculature
! A musculoskeletal system cancer that is located_in muscle.

[Term]
id: DOID:4045 ! muscle cancer
relationship: has_locus UBERON:0001630 ! muscle organ
! A musculoskeletal system cancer that is located_in muscle.

[Term]
id: DOID:4047 ! liver rhabdomyosarcoma
relationship: has_locus UBERON:0002107 ! liver
! A rhabdomyosarcoma and sarcoma of liver that are located_in the liver.

[Term]
id: DOID:4049 ! mediastinum rhabdomyosarcoma
relationship: has_locus UBERON:0003728 ! mediastinum
! A rhabdomyosarcoma and sarcoma of the mediastinum that is located_in the mediastinum and affects children and adolescents.

[Term]
id: DOID:4050 ! mediastinum sarcoma
relationship: has_locus UBERON:0003728 ! mediastinum
! A sarcoma and malignant mediastinal mesenchymnal tumor that is located_in the mediastinum.

[Term]
id: DOID:4053 ! rectum rhabdomyosarcoma
relationship: has_locus UBERON:0001052 ! rectum
! A rhabdomyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:4053 ! rectum rhabdomyosarcoma
relationship: has_locus UBERON:0002108 ! small intestine
! A rhabdomyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:4053 ! rectum rhabdomyosarcoma
relationship: has_locus UBERON:0006866 ! terminal part of digestive tract
! A rhabdomyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:4054 ! prostate sarcoma
relationship: has_locus UBERON:0002367 ! prostate gland
! A sarcoma and malignant neoplasm of prostate that is located_in the prostate.

[Term]
id: DOID:4057 ! gallbladder rhabdomyosarcoma
relationship: has_locus UBERON:0002110 ! gallbladder
! A rhabdomyosarcoma and rhabdomyosarcoma that is located_in the gallbladder.

[Term]
id: DOID:4058 ! gallbladder sarcoma
relationship: has_locus UBERON:0002110 ! gallbladder
! A sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4061 ! testis rhabdomyosarcoma
relationship: has_locus UBERON:0000473 ! testis
! A rhabdomyosarcoma and sarcoma of the testis that is located_in the testis.

[Term]
id: DOID:4062 ! testis sarcoma
relationship: has_locus UBERON:0000473 ! testis
! A sarcoma and malignant neoplasm of testis that is located_in the testis.

[Term]
id: DOID:4064 ! bile duct sarcoma
relationship: has_locus UBERON:0002394 ! bile duct
! A sarcoma and malignant tumor of extrahepatic bile duct that is located_in the bile duct.

[Term]
id: DOID:4066 ! anus rhabdomyosarcoma
relationship: has_locus UBERON:0000931 ! proctodeum
! A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:4066 ! anus rhabdomyosarcoma
relationship: has_locus UBERON:0001245 ! anus
! A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:4066 ! anus rhabdomyosarcoma
relationship: has_locus UBERON:0001353 ! anal region
! A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:4067 ! anus sarcoma
relationship: has_locus UBERON:0000931 ! proctodeum
! A sarcoma and malignant neoplasm of anus that is located_in the anus.

[Term]
id: DOID:4067 ! anus sarcoma
relationship: has_locus UBERON:0001245 ! anus
! A sarcoma and malignant neoplasm of anus that is located_in the anus.

[Term]
id: DOID:4067 ! anus sarcoma
relationship: has_locus UBERON:0001353 ! anal region
! A sarcoma and malignant neoplasm of anus that is located_in the anus.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_locus UBERON:0002107 ! liver
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_locus UBERON:0000161 ! orifice
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_locus UBERON:0000165 ! mouth
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_locus UBERON:0000948 ! heart
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_locus UBERON:0002134 ! tricuspid valve
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4110 ! parasitic ectoparasitic infectious disease
relationship: has_locus UBERON:0007029 ! surface
! A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host.

[Term]
id: DOID:4111 ! cervical adenosarcoma
relationship: has_locus UBERON:0000002 ! uterine cervix
! A cervical carcinosarcoma that is located_in the cervix.

[Term]
id: DOID:4113 ! uterine corpus adenosarcoma
relationship: has_locus UBERON:0000995 ! uterus
! An adenosarcoma and malignant uterine body mixed neoplasm that derives_from the glands that line the uterus.

[Term]
id: DOID:4113 ! uterine corpus adenosarcoma
relationship: has_locus UBERON:0003294 ! gland of foregut
! An adenosarcoma and malignant uterine body mixed neoplasm that derives_from the glands that line the uterus.

[Term]
id: DOID:4113 ! uterine corpus adenosarcoma
relationship: has_locus UBERON:0006834 ! uterus or analog
! An adenosarcoma and malignant uterine body mixed neoplasm that derives_from the glands that line the uterus.

[Term]
id: DOID:4117 ! vaginal adenosarcoma
relationship: has_locus UBERON:0000995 ! uterus
! A vaginal carcinosarcoma derives_from the glands that line the uterus.

[Term]
id: DOID:4117 ! vaginal adenosarcoma
relationship: has_locus UBERON:0003294 ! gland of foregut
! A vaginal carcinosarcoma derives_from the glands that line the uterus.

[Term]
id: DOID:4117 ! vaginal adenosarcoma
relationship: has_locus UBERON:0006834 ! uterus or analog
! A vaginal carcinosarcoma derives_from the glands that line the uterus.

[Term]
id: DOID:4123 ! nail disease
relationship: has_locus UBERON:0001705 ! nail
! An integumentary system disease that is located_in nail.

[Term]
id: DOID:4141 ! intraorbital meningioma
relationship: has_locus UBERON:0003128 ! cranium
! A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance.

[Term]
id: DOID:4141 ! intraorbital meningioma
relationship: has_locus UBERON:0003129 ! skull
! A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance.

[Term]
id: DOID:4141 ! intraorbital meningioma
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance.

[Term]
id: DOID:4141 ! intraorbital meningioma
relationship: has_locus UBERON:0000018 ! compound eye
! A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance.

[Term]
id: DOID:4141 ! intraorbital meningioma
relationship: has_locus UBERON:0000019 ! camera-type eye
! A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_locus UBERON:0001697 ! orbit
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_locus UBERON:0001697 ! orbital region
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_locus UBERON:0001711 ! eyelid
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_locus UBERON:0001825 ! paranasal sinus
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_locus UBERON:0004867 ! orbital cavity
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4153 ! spinal chordoma
relationship: has_locus UBERON:0001130 ! vertebral column
! A chordoma that derives_from the spine.

[Term]
id: DOID:4166 ! syphilis
relationship: has_locus UBERON:0000323 ! late embryo
! A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

[Term]
id: DOID:4166 ! syphilis
relationship: has_locus UBERON:0003907 ! left atrioventricular canal
! A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

[Term]
id: DOID:4166 ! syphilis
relationship: has_locus UBERON:0005613 ! left dorsal aorta
! A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

[Term]
id: DOID:4166 ! syphilis
relationship: has_locus UBERON:0007220 ! late embryonic stage
! A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

[Term]
id: DOID:418 ! systemic scleroderma
relationship: has_locus UBERON:0003103 ! compound organ
! A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.

[Term]
id: DOID:421 ! hair disease
relationship: has_locus UBERON:0001037 ! strand of hair
! An integumentary system disease that is located_in hair.

[Term]
id: DOID:4233 ! clear cell sarcoma
relationship: has_locus UBERON:0000043 ! tendon
! A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

[Term]
id: DOID:4233 ! clear cell sarcoma
relationship: has_locus UBERON:0001019 ! fascicle
! A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

[Term]
id: DOID:4236 ! carcinosarcoma
relationship: has_locus UBERON:0000483 ! epithelium
! MERGED DEFINITION:nTARGET DEFINITION: A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.n--------------------nSOURCE DEFINITION: A mullerian mixed tumor that is composed_of carcinoma of different mC<llerian types and composed_of homologous or heterologous sarcoma-like components.

[Term]
id: DOID:4236 ! carcinosarcoma
relationship: has_locus UBERON:0002384 ! connective tissue
! MERGED DEFINITION:nTARGET DEFINITION: A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.n--------------------nSOURCE DEFINITION: A mullerian mixed tumor that is composed_of carcinoma of different mC<llerian types and composed_of homologous or heterologous sarcoma-like components.

[Term]
id: DOID:4242 ! kidney sarcoma
relationship: has_locus UBERON:0002384 ! connective tissue
! A sarcoma and malignant neoplasm of kidney that is located_in the kidney's connective tissue.

[Term]
id: DOID:4253 ! melorheostosis
relationship: has_locus UBERON:0001439 ! compact bone
! An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex.

[Term]
id: DOID:4257 ! Caffey disease
relationship: has_locus UBERON:0001474 ! bone
! A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability.

[Term]
id: DOID:4257 ! Caffey disease
relationship: has_locus UBERON:0001474 ! bone
! A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability.

[Term]
id: DOID:4258 ! Weissenbacher-ZweymC<ller syndrome
relationship: has_locus UBERON:0002495 ! long bone
! An osteochondrodysplasia that results_in shortened long bones and distinct facial abnormalities.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_locus UBERON:0001308 ! external iliac artery
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_locus UBERON:0005441 ! external intercostal muscle
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_locus UBERON:0005928 ! external naris
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_locus UBERON:0002100 ! trunk
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4336 ! tinea favosa
relationship: has_locus UBERON:0000403 ! scalp
! A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

[Term]
id: DOID:4336 ! tinea favosa
relationship: has_locus UBERON:0001705 ! nail
! A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

[Term]
id: DOID:4336 ! tinea favosa
relationship: has_locus UBERON:0002073 ! hair follicle
! A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

[Term]
id: DOID:4336 ! tinea favosa
relationship: has_locus UBERON:0007029 ! surface
! A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_locus UBERON:0000177 ! pus
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_locus UBERON:0000403 ! scalp
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_locus UBERON:0000403 ! scalp
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_locus UBERON:0001702 ! eyelash
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_locus UBERON:0010163 ! eyebrow
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_locus UBERON:0002107 ! liver
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4442 ! cervical alveolar soft part sarcoma
relationship: has_locus UBERON:0000002 ! uterine cervix
! An alveolar soft part sarcoma and cervical soft tissue tumor and malignant neoplasm of cervix uteri that is located_in the cervix.

[Term]
id: DOID:4451 ! renal carcinoma
relationship: has_locus UBERON:0000178 ! blood
! A carcinoma that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).

[Term]
id: DOID:4451 ! renal carcinoma
relationship: has_locus UBERON:0001287 ! proximal convoluted tubule
! A carcinoma that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).

[Term]
id: DOID:4480 ! achondroplasia
relationship: has_locus UBERON:0002418 ! cartilage tissue
! An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.

[Term]
id: DOID:4480 ! achondroplasia
relationship: has_locus UBERON:0007844 ! cartilaginous element
! An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.

[Term]
id: DOID:4480 ! achondroplasia
relationship: has_locus UBERON:0002495 ! long bone
! An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.

[Term]
id: DOID:4481 ! allergic rhinitis
relationship: has_locus UBERON:0000018 ! compound eye
! A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

[Term]
id: DOID:4481 ! allergic rhinitis
relationship: has_locus UBERON:0000019 ! camera-type eye
! A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

[Term]
id: DOID:4481 ! allergic rhinitis
relationship: has_locus UBERON:0001681 ! nasal bone
! A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

[Term]
id: DOID:4483 ! rhinitis
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4483 ! rhinitis
relationship: has_locus UBERON:0000344 ! mucosa
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4483 ! rhinitis
relationship: has_locus UBERON:0000912 ! mucus
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4483 ! rhinitis
relationship: has_locus UBERON:0001712 ! upper eyelid
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4483 ! rhinitis
relationship: has_locus UBERON:0005385 ! nasal cavity respiratory epithelium
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_locus UBERON:0000065 ! respiratory tract
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_locus UBERON:0001004 ! respiratory system
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_locus UBERON:0000165 ! mouth
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_locus UBERON:0000167 ! oral cavity
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_locus UBERON:0000955 ! brain
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_locus UBERON:0001017 ! central nervous system
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_locus UBERON:0001456 ! face
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_locus UBERON:0002544 ! digit
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4504 ! central nervous system angiosarcoma
relationship: has_locus UBERON:0000955 ! brain
! An angiosarcoma and sarcoma of central nervous system and mesenchymal non-meningothelial tumor of central nervous system that is located_in the central nervous system.

[Term]
id: DOID:4504 ! central nervous system angiosarcoma
relationship: has_locus UBERON:0001017 ! central nervous system
! An angiosarcoma and sarcoma of central nervous system and mesenchymal non-meningothelial tumor of central nervous system that is located_in the central nervous system.

[Term]
id: DOID:4510 ! aorta angiosarcoma
relationship: has_locus UBERON:0000947 ! aorta
! An angiosarcoma that is located_in the aorta.

[Term]
id: DOID:4511 ! breast angiosarcoma
relationship: has_locus UBERON:0000310 ! breast
! An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area.

[Term]
id: DOID:4511 ! breast angiosarcoma
relationship: has_locus UBERON:0009472 ! axilla
! An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area.

[Term]
id: DOID:4513 ! gallbladder angiosarcoma
relationship: has_locus UBERON:0002110 ! gallbladder
! An angiosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4515 ! thyroid sarcoma
relationship: has_locus UBERON:0002046 ! thyroid gland
! A sarcoma and malignant neoplasm of thyroid that is located_in the supporting cells of the thyroid.

[Term]
id: DOID:452 ! pleomorphic adenoma
relationship: has_locus UBERON:0001044 ! salivary gland
! A gastrointestinal benign neoplasm that is a located_in the salivary glands.

[Term]
id: DOID:4524 ! prostate angiosarcoma
relationship: has_locus UBERON:0002367 ! prostate gland
! An angiosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:4525 ! mediastinum angiosarcoma
relationship: has_locus UBERON:0003728 ! mediastinum
! An angiosarcoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:4547 ! adult mesenchymal chondrosarcoma
relationship: has_locus UBERON:0002418 ! cartilage tissue
! An adult sarcoma of soft tissue and mesenchymal chondrosarcoma that is located_in the cartilage.

[Term]
id: DOID:4547 ! adult mesenchymal chondrosarcoma
relationship: has_locus UBERON:0007844 ! cartilaginous element
! An adult sarcoma of soft tissue and mesenchymal chondrosarcoma that is located_in the cartilage.

[Term]
id: DOID:4606 ! bile duct cancer
relationship: has_locus UBERON:0002394 ! bile duct
! A biliary tract cancer that is located_in the bile duct.

[Term]
id: DOID:4607 ! biliary tract cancer
relationship: has_locus UBERON:0002394 ! bile duct
! A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0000033 ! head
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0000978 ! leg
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0000982 ! skeletal joint
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0001460 ! arm
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0002495 ! long bone
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4624 ! Ollier disease
relationship: has_locus UBERON:0005895 ! insect leg
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4653 ! intraocular retinoblastoma
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A retinoblastoma that is located_in the eye and has not spread to other parts of the body.

[Term]
id: DOID:4692 ! endophthalmitis
relationship: has_locus UBERON:0000019 ! camera-type eye
! Endophthalmitis is a infectious disease consisting of an uncommon infection with Inflammation of the inside of the eye with the infection caused by bacteria, fungi or protozoa that have entered the eye during a surgical procedure, as the result of an injury or less commonly by traveling through the bloodstream to the eyeball.

[Term]
id: DOID:4692 ! endophthalmitis
relationship: has_locus UBERON:0010230 ! eyeball of camera-type eye
! Endophthalmitis is a infectious disease consisting of an uncommon infection with Inflammation of the inside of the eye with the infection caused by bacteria, fungi or protozoa that have entered the eye during a surgical procedure, as the result of an injury or less commonly by traveling through the bloodstream to the eyeball.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_locus UBERON:0001021 ! nerve
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_locus UBERON:0001762 ! nasal concha
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_locus UBERON:0001826 ! nasal cavity mucosa
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_locus UBERON:0003294 ! gland of foregut
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4744 ! placenta accreta
relationship: has_locus UBERON:0001295 ! endometrium
! A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

[Term]
id: DOID:4744 ! placenta accreta
relationship: has_locus UBERON:0001296 ! myometrium
! A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

[Term]
id: DOID:4744 ! placenta accreta
relationship: has_locus UBERON:0001987 ! placenta
! A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

[Term]
id: DOID:4765 ! pulmonary blastoma
relationship: has_locus UBERON:0000060 ! anatomical wall
! An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children.

[Term]
id: DOID:4765 ! pulmonary blastoma
relationship: has_locus UBERON:0000479 ! tissue
! An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children.

[Term]
id: DOID:4765 ! pulmonary blastoma
relationship: has_locus UBERON:0002048 ! lung
! An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children.

[Term]
id: DOID:4765 ! pulmonary blastoma
relationship: has_locus UBERON:0002224 ! thoracic cavity
! An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children.

[Term]
id: DOID:4766 ! embryoma
relationship: has_locus UBERON:0000923 ! germ layer
! A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells.

[Term]
id: DOID:4769 ! pleuropulmonary blastoma
relationship: has_locus UBERON:0002048 ! lung
! A pulmonary blastoma that derives_from the lung or pleural cavity.

[Term]
id: DOID:4769 ! pleuropulmonary blastoma
relationship: has_locus UBERON:0002402 ! pleural cavity
! A pulmonary blastoma that derives_from the lung or pleural cavity.

[Term]
id: DOID:4837 ! Gorham's disease
relationship: has_locus UBERON:0001474 ! bone
! A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.

[Term]
id: DOID:4837 ! Gorham's disease
relationship: has_locus UBERON:0001981 ! blood vessel
! A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.

[Term]
id: DOID:4866 ! adenoid cystic carcinoma
relationship: has_locus UBERON:0000058 ! duct
! A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

[Term]
id: DOID:4866 ! adenoid cystic carcinoma
relationship: has_locus UBERON:0003103 ! compound organ
! A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_locus UBERON:0000029 ! lymph node
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_locus UBERON:0002465 ! lymphoid system
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
relationship: has_locus UBERON:0000383 ! musculature of body
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
relationship: has_locus UBERON:0001015 ! musculature
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
relationship: has_locus UBERON:0001630 ! muscle organ
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4905 ! pancreatic carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A pancreas cancer that is located_in cells found in the tissues of the pancreas.

[Term]
id: DOID:4905 ! pancreatic carcinoma
relationship: has_locus UBERON:0001264 ! pancreas
! A pancreas cancer that is located_in cells found in the tissues of the pancreas.

[Term]
id: DOID:4907 ! small intestine carcinoma
relationship: has_locus UBERON:0002108 ! small intestine
! A carcinoma that is located_in the small intestine.

[Term]
id: DOID:4908 ! anal carcinoma
relationship: has_locus UBERON:0000931 ! proctodeum
! A anus cancer that is located_in the anus.

[Term]
id: DOID:4908 ! anal carcinoma
relationship: has_locus UBERON:0001245 ! anus
! A anus cancer that is located_in the anus.

[Term]
id: DOID:4908 ! anal carcinoma
relationship: has_locus UBERON:0001353 ! anal region
! A anus cancer that is located_in the anus.

[Term]
id: DOID:4917 ! villous adenocarcinoma
relationship: has_locus UBERON:0000479 ! tissue
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, with villous architecture.

[Term]
id: DOID:4929 ! tubular adenocarcinoma
relationship: has_locus UBERON:0003891 ! stroma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

[Term]
id: DOID:4929 ! tubular adenocarcinoma
relationship: has_locus UBERON:0011079 ! angular bone
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

[Term]
id: DOID:4939 ! ureter carcinoma
relationship: has_locus UBERON:0000056 ! ureter
! An ureter cancer that is located_in the ureter.

[Term]
id: DOID:4939 ! ureter carcinoma
relationship: has_locus UBERON:0001055 ! ureter
! An ureter cancer that is located_in the ureter.

[Term]
id: DOID:4948 ! gallbladder carcinoma
relationship: has_locus UBERON:0000479 ! tissue
! A carcinoma that is located_in the tissues of the gallbladder.

[Term]
id: DOID:4948 ! gallbladder carcinoma
relationship: has_locus UBERON:0002110 ! gallbladder
! A carcinoma that is located_in the tissues of the gallbladder.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_locus UBERON:0000383 ! musculature of body
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_locus UBERON:0001015 ! musculature
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_locus UBERON:0001630 ! muscle organ
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_locus UBERON:0000383 ! musculature of body
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_locus UBERON:0001015 ! musculature
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_locus UBERON:0001630 ! muscle organ
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_locus UBERON:0001988 ! feces
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4960 ! bone marrow cancer
relationship: has_locus UBERON:0002371 ! bone marrow
! A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow.

[Term]
id: DOID:4962 ! pericardial tuberculosis
relationship: has_locus UBERON:0002406 ! pericardial sac
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4962 ! pericardial tuberculosis
relationship: has_locus UBERON:0002407 ! pericardium
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4971 ! myelofibrosis
relationship: has_locus UBERON:0002371 ! bone marrow
! A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue.

[Term]
id: DOID:4971 ! myelofibrosis
relationship: has_locus UBERON:0002371 ! bone marrow
! A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue.

[Term]
id: DOID:4972 ! myelodysplastic myeloproliferative cancer
relationship: has_locus UBERON:0002371 ! bone marrow
! A bone marrow cancer that is located_in the bone marrow and results_in the production of too many white blood cells. The cancer possess both dysplastic and proliferative features but are not properly classified as either.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_locus UBERON:0000065 ! respiratory tract
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_locus UBERON:0001004 ! respiratory system
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_locus UBERON:0002360 ! meninx
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_locus UBERON:0001988 ! feces
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4997 ! Camurati-Engelmann disease
relationship: has_locus UBERON:0002495 ! long bone
! An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_locus UBERON:0001437 ! epiphysis
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_locus UBERON:0001905 ! pineal body
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:50 ! thyroid gland disease
relationship: has_locus UBERON:0002046 ! thyroid gland
! An endocrine system disease that is located_in the thyroid.

[Term]
id: DOID:5032 ! pineal gland cancer
relationship: has_locus UBERON:0002368 ! endocrine gland
! An endocrine gland located_in the pineal gland located in the brain.

[Term]
id: DOID:5032 ! pineal gland cancer
relationship: has_locus UBERON:0000955 ! brain
! An endocrine gland located_in the pineal gland located in the brain.

[Term]
id: DOID:5041 ! esophageal cancer
relationship: has_locus UBERON:0001043 ! esophagus
! A gastrointestinal system cancer that is located_in the esophagus.

[Term]
id: DOID:5074 ! malignant ependymoma
relationship: has_locus UBERON:0000955 ! brain
! A malignant glioma that is derived from ependymal cells, a type of glial cell, located_in ventricle lining within the central part of the brain.

[Term]
id: DOID:5090 ! sternum cancer
relationship: has_locus UBERON:0000975 ! sternum
! A bone cancer and neoplasm of chest wall and sternal disorder that is located_in the sternum.

[Term]
id: DOID:5090 ! sternum cancer
relationship: has_locus UBERON:0003130 ! arthropod sternum
! A bone cancer and neoplasm of chest wall and sternal disorder that is located_in the sternum.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0001043 ! esophagus
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0001191 ! common iliac artery
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0002048 ! lung
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0002064 ! common cardinal vein
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0002224 ! thoracic cavity
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0003126 ! trachea
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0003127 ! open tracheal system trachea
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5093 ! thoracic cancer
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5154 ! borna disease
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.

[Term]
id: DOID:5154 ! borna disease
relationship: has_locus UBERON:0001017 ! central nervous system
! A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.

[Term]
id: DOID:5154 ! borna disease
relationship: has_locus UBERON:0000176 ! oronasal secretion
! A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_locus UBERON:0000383 ! musculature of body
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_locus UBERON:0000479 ! tissue
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_locus UBERON:0000995 ! uterus
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_locus UBERON:0001015 ! musculature
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_locus UBERON:0001630 ! muscle organ
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_locus UBERON:0006834 ! uterus or analog
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5190 ! cervical Wilms' tumor
relationship: has_locus UBERON:0000002 ! uterine cervix
! A nephroblastoma and malignant cervical mixed epithelial and mesenchymal neoplasm that is located_in the cervix.

[Term]
id: DOID:5259 ! colon leiomyosarcoma
relationship: has_locus UBERON:0001155 ! colon
! A leiomyosarcoma and sarcoma of colon that is located_in the colon.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0000029 ! lymph node
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0002405 ! immune system
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0001913 ! milk
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0001968 ! semen
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_locus UBERON:0004691 ! bulbourethral gland secretion
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:5260 ! colon sarcoma
relationship: has_locus UBERON:0001155 ! colon
! A sarcoma and malignant tumor of colon that is located_in the colon.

[Term]
id: DOID:5262 ! heart sarcoma
relationship: has_locus UBERON:0000948 ! heart
! A sarcoma and malignant neoplasm of heart that is located_in the heart.

[Term]
id: DOID:5265 ! lung leiomyosarcoma
relationship: has_locus UBERON:0002048 ! lung
! A leiomyosarcoma and sarcoma of lung that is located_in the lung.

[Term]
id: DOID:5267 ! anus leiomyosarcoma
relationship: has_locus UBERON:0000931 ! proctodeum
! A leiomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:5267 ! anus leiomyosarcoma
relationship: has_locus UBERON:0001245 ! anus
! A leiomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:5267 ! anus leiomyosarcoma
relationship: has_locus UBERON:0001353 ! anal region
! A leiomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:5272 ! small intestinal sarcoma
relationship: has_locus UBERON:0002108 ! small intestine
! A sarcoma and malignant tumor of small intestine that is located_in the small intestine.

[Term]
id: DOID:5275 ! gallbladder leiomyosarcoma
relationship: has_locus UBERON:0002110 ! gallbladder
! A leiomyosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:5282 ! prostate leiomyosarcoma
relationship: has_locus UBERON:0002367 ! prostate gland
! A prostate sarcoma that is located_in the prostate.

[Term]
id: DOID:5287 ! kidney leiomyosarcoma
relationship: has_locus UBERON:0000080 ! mesonephros
! A leiomyosarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5287 ! kidney leiomyosarcoma
relationship: has_locus UBERON:0002120 ! pronephros
! A leiomyosarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5288 ! larynx leiomyosarcoma
relationship: has_locus UBERON:0001737 ! larynx
! A leimyosarcoma and sarcoma of the larynx that is located_in the larynx.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
relationship: has_locus UBERON:0000953 ! visceral muscle
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
relationship: has_locus UBERON:0000995 ! uterus
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
relationship: has_locus UBERON:0001135 ! smooth muscle tissue
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
relationship: has_locus UBERON:0006834 ! uterus or analog
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5292 ! mediastinum leiomyosarcoma
relationship: has_locus UBERON:0000953 ! visceral muscle
! A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels.

[Term]
id: DOID:5292 ! mediastinum leiomyosarcoma
relationship: has_locus UBERON:0001135 ! smooth muscle tissue
! A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels.

[Term]
id: DOID:5293 ! extrahepatic bile duct leiomyosarcoma
relationship: has_locus UBERON:0002107 ! liver
! A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver.

[Term]
id: DOID:5293 ! extrahepatic bile duct leiomyosarcoma
relationship: has_locus UBERON:0002394 ! bile duct
! A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver.

[Term]
id: DOID:5296 ! liver leiomyosarcoma
relationship: has_locus UBERON:0002107 ! liver
! A leiomyosarcoma and sarcoma of liver that is located_in the liver.

[Term]
id: DOID:5297 ! rectum leiomyosarcoma
relationship: has_locus UBERON:0001052 ! rectum
! A leimyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:5297 ! rectum leiomyosarcoma
relationship: has_locus UBERON:0002108 ! small intestine
! A leimyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:5297 ! rectum leiomyosarcoma
relationship: has_locus UBERON:0006866 ! terminal part of digestive tract
! A leimyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:53 ! pituitary gland disease
relationship: has_locus UBERON:0000007 ! pituitary gland
! An endocrine system disease that is located_in the pituitary gland.

[Term]
id: DOID:5313 ! vulvar alveolar soft part sarcoma
relationship: has_locus UBERON:0000474 ! female reproductive system
! An alveolar soft part sarcoma and vulvar sarcoma that is located_in the vulva.

[Term]
id: DOID:5313 ! vulvar alveolar soft part sarcoma
relationship: has_locus UBERON:0000997 ! mammalian vulva
! An alveolar soft part sarcoma and vulvar sarcoma that is located_in the vulva.

[Term]
id: DOID:5362 ! focal epithelial hyperplasia
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity.

[Term]
id: DOID:5362 ! focal epithelial hyperplasia
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity.

[Term]
id: DOID:5362 ! focal epithelial hyperplasia
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity.

[Term]
id: DOID:5362 ! focal epithelial hyperplasia
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity.

[Term]
id: DOID:5381 ! bile duct adenoma
relationship: has_locus UBERON:0003891 ! stroma
! An adenoma and biliary tract cancer that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma.

[Term]
id: DOID:5381 ! bile duct adenoma
relationship: has_locus UBERON:0002394 ! bile duct
! An adenoma and biliary tract cancer that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma.

[Term]
id: DOID:5390 ! clear cell adenoma
relationship: has_locus UBERON:0000992 ! female gonad
! An adenoma that is composed_of cells with a clear cytoplasm located_in ovary.

[Term]
id: DOID:5398 ! lipoadenoma
relationship: has_locus UBERON:0001013 ! adipose tissue
! An adenoma that is composed_of adipose tissue.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0001130 ! vertebral column
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0002101 ! limb
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0002355 ! pelvis
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0003128 ! cranium
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0003129 ! skull
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0010323 ! cranial skeletal system
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0001901 ! epithelium of trachea
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0001951 ! epithelium of nasopharynx
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0002340 ! epithelium of main bronchus
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003229 ! epithelium of elbow
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003230 ! epithelium of carpal region
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003231 ! epithelium of hip
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003232 ! epithelium of knee
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003233 ! epithelium of shoulder
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003235 ! epithelium of upper jaw
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003236 ! epithelium of lower jaw
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003238 ! epithelium of superior semicircular canal
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003239 ! epithelium of posterior semicircular canal
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003240 ! epithelium of lateral semicircular canal
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003241 ! epithelium of utricle
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003242 ! epithelium of saccule
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003243 ! epithelium of cochlear duct
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003244 ! epithelium of mammary gland
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003246 ! epithelium of endolymphatic sac
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003247 ! epithelium of forearm
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003248 ! epithelium of footplate
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0003249 ! epithelium of otic placode
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0005384 ! nasal cavity epithelium
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0006957 ! submandibular gland primordium epithelium
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5438 ! extrahepatic bile duct adenoma
relationship: has_locus UBERON:0002394 ! bile duct
! A bile duct ademona and neoplasm of extrahepatic bile duct that are composed_of papillary, tubular, or combined tubulopapillary structures lined by dysplastic epithelium.

[Term]
id: DOID:5488 ! mediastinum synovial sarcoma
relationship: has_locus UBERON:0003728 ! mediastinum
! A sarcoma of the mediastinum and synovial sarcoma that is located_in the mediastinum.

[Term]
id: DOID:5501 ! Pediculus humanus capitis infestation
relationship: has_locus UBERON:0001836 ! saliva
! A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

[Term]
id: DOID:5501 ! Pediculus humanus capitis infestation
relationship: has_locus UBERON:0000178 ! blood
! A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

[Term]
id: DOID:5501 ! Pediculus humanus capitis infestation
relationship: has_locus UBERON:0000403 ! scalp
! A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

[Term]
id: DOID:5501 ! Pediculus humanus capitis infestation
relationship: has_locus UBERON:0001037 ! strand of hair
! A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

[Term]
id: DOID:5517 ! stomach carcinoma
relationship: has_locus UBERON:0000945 ! stomach
! A stomach cancer that is located_in the stomach.

[Term]
id: DOID:5546 ! femoral cancer
relationship: has_locus UBERON:0000981 ! femur
! A bone cancer that is located_in the femur.

[Term]
id: DOID:5559 ! mediastinal cancer
relationship: has_locus UBERON:0003728 ! mediastinum
! A thoracic cancer that is located_in the mediastinum.

[Term]
id: DOID:5612 ! spinal cancer
relationship: has_locus UBERON:0000310 ! breast
! A bone cancer and central nervous system neoplasm and spinal disease that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

[Term]
id: DOID:5612 ! spinal cancer
relationship: has_locus UBERON:0002240 ! spinal cord
! A bone cancer and central nervous system neoplasm and spinal disease that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

[Term]
id: DOID:5612 ! spinal cancer
relationship: has_locus UBERON:0002367 ! prostate gland
! A bone cancer and central nervous system neoplasm and spinal disease that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

[Term]
id: DOID:5696 ! larynx liposarcoma
relationship: has_locus UBERON:0001737 ! larynx
! A liposarcoma and sarcoma of the larynx that is located_in the larynx.

[Term]
id: DOID:5699 ! kidney liposarcoma
relationship: has_locus UBERON:0000080 ! mesonephros
! A liposarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5699 ! kidney liposarcoma
relationship: has_locus UBERON:0002120 ! pronephros
! A liposarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5713 ! mediastinum liposarcoma
relationship: has_locus UBERON:0003728 ! mediastinum
! A liposarcoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:5772 ! central nervous system hematologic cancer
relationship: has_locus UBERON:0000955 ! brain
! A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system.

[Term]
id: DOID:5772 ! central nervous system hematologic cancer
relationship: has_locus UBERON:0001017 ! central nervous system
! A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system.

[Term]
id: DOID:5815 ! cerebral lymphoma
relationship: has_locus UBERON:0000955 ! brain
! A CNS lymphoma and malignant cerebral lymphoma that affects the lymph cells and derives_from the brain.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_locus UBERON:0001191 ! common iliac artery
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_locus UBERON:0002048 ! lung
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_locus UBERON:0003215 ! alveolus
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5875 ! retroperitoneal cancer
relationship: has_locus UBERON:0000916 ! abdomen
! An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

[Term]
id: DOID:5875 ! retroperitoneal cancer
relationship: has_locus UBERON:0002358 ! peritoneum
! An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

[Term]
id: DOID:5875 ! retroperitoneal cancer
relationship: has_locus UBERON:0003684 ! abdominal cavity
! An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

[Term]
id: DOID:5875 ! retroperitoneal cancer
relationship: has_locus UBERON:0003693 ! retroperitoneal space
! An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

[Term]
id: DOID:594 ! panic disorder
relationship: has_locus UBERON:0000948 ! heart
! An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

[Term]
id: DOID:5983 ! kidney osteogenic sarcoma
relationship: has_locus UBERON:0000080 ! mesonephros
! A sarcoma of kidney and extraosseous osteosarcoma that is located_in the kidney.

[Term]
id: DOID:5983 ! kidney osteogenic sarcoma
relationship: has_locus UBERON:0002120 ! pronephros
! A sarcoma of kidney and extraosseous osteosarcoma that is located_in the kidney.

[Term]
id: DOID:6000 ! congestive heart failure
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A heart disease that is characterized by any structural or functional cardiacdisorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body.

[Term]
id: DOID:6000 ! congestive heart failure
relationship: has_locus UBERON:0000948 ! heart
! A heart disease that is characterized by any structural or functional cardiacdisorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body.

[Term]
id: DOID:6000 ! congestive heart failure
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A heart disease that is characterized by any structural or functional cardiacdisorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body.

[Term]
id: DOID:6037 ! spindle cell intraocular melanoma
relationship: has_locus UBERON:0001768 ! vascular layer of eyeball
! An intraocular malanoma and malignant spindle cell melanoma that derives_from melanocytes in the uveal tract that results_in_formation_of spindle-shaped cells.

[Term]
id: DOID:6043 ! ciliary body spindle cell melanoma
relationship: has_locus UBERON:0001775 ! ciliary body
! A malignant melanoma of ciliary body and spindle intraocular melanoma that is located_in the ciliary body.

[Term]
id: DOID:6132 ! bronchitis
relationship: has_locus UBERON:0002185 ! bronchus
! A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.

[Term]
id: DOID:6132 ! bronchitis
relationship: has_locus UBERON:0000912 ! mucus
! A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.

[Term]
id: DOID:6190 ! rectum Kaposi's sarcoma
relationship: has_locus UBERON:0001052 ! rectum
! A sarcoma of the rectum that results_in lesions that are located_in the rectum.

[Term]
id: DOID:6190 ! rectum Kaposi's sarcoma
relationship: has_locus UBERON:0002108 ! small intestine
! A sarcoma of the rectum that results_in lesions that are located_in the rectum.

[Term]
id: DOID:6190 ! rectum Kaposi's sarcoma
relationship: has_locus UBERON:0006866 ! terminal part of digestive tract
! A sarcoma of the rectum that results_in lesions that are located_in the rectum.

[Term]
id: DOID:6209 ! malignant mediastinum hemangiopericytoma
relationship: has_locus UBERON:0003728 ! mediastinum
! A hemangiopericytoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:6313 ! clivus chondroid chordoma
relationship: has_locus UBERON:0004108 ! clivus of occipital bone
! A chondroid chordoma and chordoma of the clivus that is located_in the clivus.

[Term]
id: DOID:6322 ! tibial adamantinoma
relationship: has_locus UBERON:0000979 ! tibia
! An adamantinoma of long bone that is located_in the tibia.

[Term]
id: DOID:6322 ! tibial adamantinoma
relationship: has_locus UBERON:0003131 ! arthropod tibia
! An adamantinoma of long bone that is located_in the tibia.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0000178 ! blood
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0000178 ! blood
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0001191 ! common iliac artery
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0001913 ! milk
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0001968 ! semen
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0004691 ! bulbourethral gland secretion
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:646 ! viral encephalitis
relationship: has_locus UBERON:0000955 ! brain
! An encephalitis that involves inflammation of the brain caused by viral infection.

[Term]
id: DOID:6495 ! adult myxoid chondrosarcoma
relationship: has_locus UBERON:0003037 ! septum
! An adult sarcoma of soft tissue and myxoid chondrosarcoma that is composed_of multiple lobules of chondroblast-like cells, arranged in cords and strands, embedded in a myxoid stroma, and separated by fibrous septa.

[Term]
id: DOID:6495 ! adult myxoid chondrosarcoma
relationship: has_locus UBERON:0003891 ! stroma
! An adult sarcoma of soft tissue and myxoid chondrosarcoma that is composed_of multiple lobules of chondroblast-like cells, arranged in cords and strands, embedded in a myxoid stroma, and separated by fibrous septa.

[Term]
id: DOID:6495 ! adult myxoid chondrosarcoma
relationship: has_locus UBERON:0009911 ! lobule
! An adult sarcoma of soft tissue and myxoid chondrosarcoma that is composed_of multiple lobules of chondroblast-like cells, arranged in cords and strands, embedded in a myxoid stroma, and separated by fibrous septa.

[Term]
id: DOID:657 ! adenoma
relationship: has_locus UBERON:0000483 ! epithelium
! A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.

[Term]
id: DOID:657 ! adenoma
relationship: has_locus UBERON:0003294 ! gland of foregut
! A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.

[Term]
id: DOID:6676 ! Froelich's syndrome
relationship: has_locus UBERON:0001898 ! hypothalamus
! A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus.

[Term]
id: DOID:6676 ! Froelich's syndrome
relationship: has_locus UBERON:0003937 ! sex gland
! A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0001705 ! nail
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0007774 ! secondary dentition
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0000014 ! zone of skin
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0001037 ! strand of hair
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0001091 ! calcareous tooth
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0001705 ! nail
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0002097 ! skin of body
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0002199 ! integument
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_locus UBERON:0003672 ! dentition
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
relationship: has_locus UBERON:0000029 ! lymph node
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
relationship: has_locus UBERON:0002106 ! spleen
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
relationship: has_locus UBERON:0002107 ! liver
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
relationship: has_locus UBERON:0006293 ! spleen primordium
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
relationship: has_locus UBERON:0002405 ! immune system
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_locus UBERON:0000978 ! leg
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_locus UBERON:0001473 ! lymphatic vessel
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_locus UBERON:0004536 ! lymph vasculature
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_locus UBERON:0005895 ! insect leg
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6725 ! spinal stenosis
relationship: has_locus UBERON:0001475 ! ligament
! A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.

[Term]
id: DOID:6725 ! spinal stenosis
relationship: has_locus UBERON:0008846 ! skeletal ligament
! A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.

[Term]
id: DOID:6725 ! spinal stenosis
relationship: has_locus UBERON:0002240 ! spinal cord
! A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.

[Term]
id: DOID:6741 ! bilateral breast cancer
relationship: has_locus UBERON:0000310 ! breast
! A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

[Term]
id: DOID:6759 ! bone lymphoma
relationship: has_locus UBERON:0001474 ! bone
! A bone cancer and lymphoma by site that results_in lymphoma starting in the bone.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
relationship: has_locus UBERON:0000479 ! tissue
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
relationship: has_locus UBERON:0000982 ! skeletal joint
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:680 ! tauopathy
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.

[Term]
id: DOID:680 ! tauopathy
relationship: has_locus UBERON:0000955 ! brain
! A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.

[Term]
id: DOID:6804 ! colon Kaposi sarcoma
relationship: has_locus UBERON:0001155 ! colon
! A sarcoma of colon that is located_in the colon.

[Term]
id: DOID:6880 ! small bowel fibrosarcoma
relationship: has_locus UBERON:0002108 ! small intestine
! A fibrosarcoma of soft tissue and small intestinal sarcoma that is located_in the small bowel.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_locus UBERON:0001264 ! pancreas
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_locus UBERON:0002048 ! lung
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_locus UBERON:0002107 ! liver
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_locus UBERON:0003688 ! omentum
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_locus UBERON:0001242 ! intestinal mucosa
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
relationship: has_locus UBERON:0002106 ! spleen
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
relationship: has_locus UBERON:0006293 ! spleen primordium
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:712 ! refractory hematologic cancer
relationship: has_locus UBERON:0000178 ! blood
! A hematologic cancer that is located_in the blood or bone marrow that doesn't respond to treatment.

[Term]
id: DOID:712 ! refractory hematologic cancer
relationship: has_locus UBERON:0002371 ! bone marrow
! A hematologic cancer that is located_in the blood or bone marrow that doesn't respond to treatment.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
relationship: has_locus UBERON:0000014 ! zone of skin
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
relationship: has_locus UBERON:0000029 ! lymph node
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
relationship: has_locus UBERON:0001474 ! bone
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
relationship: has_locus UBERON:0002097 ! skin of body
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
relationship: has_locus UBERON:0002107 ! liver
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
relationship: has_locus UBERON:0002199 ! integument
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0001130 ! vertebral column
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0001464 ! hip
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0001708 ! jaw
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0001708 ! jaw skeleton
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0003252 ! rib cage
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0000982 ! skeletal joint
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0001130 ! vertebral column
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_locus UBERON:0002355 ! pelvis
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7148 ! rheumatoid arthritis
relationship: has_locus UBERON:0000479 ! tissue
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7148 ! rheumatoid arthritis
relationship: has_locus UBERON:0000982 ! skeletal joint
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7152 ! prostate stromal sarcoma
relationship: has_locus UBERON:0002367 ! prostate gland
! A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located_in the prostate.

[Term]
id: DOID:7188 ! autoimmune thyroiditis
relationship: has_locus UBERON:0000479 ! tissue
! An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.

[Term]
id: DOID:7188 ! autoimmune thyroiditis
relationship: has_locus UBERON:0002405 ! immune system
! An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.

[Term]
id: DOID:7188 ! autoimmune thyroiditis
relationship: has_locus UBERON:0002046 ! thyroid gland
! An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.

[Term]
id: DOID:731 ! urinary system benign neoplasm
relationship: has_locus UBERON:0000057 ! urethra
! An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:731 ! urinary system benign neoplasm
relationship: has_locus UBERON:0000080 ! mesonephros
! An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:731 ! urinary system benign neoplasm
relationship: has_locus UBERON:0001255 ! urinary bladder
! An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:731 ! urinary system benign neoplasm
relationship: has_locus UBERON:0002120 ! pronephros
! An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:7328 ! iris spindle cell melanoma
relationship: has_locus UBERON:0001769 ! iris
! A malignant melanoma of iris and spindle cell intraocular melanoma that is located_in the iris.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_locus UBERON:0001043 ! esophagus
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:734 ! urethra cancer
relationship: has_locus UBERON:0000057 ! urethra
! An urinary tract cancer that derives_from the tissues of the urethra.

[Term]
id: DOID:734 ! urethra cancer
relationship: has_locus UBERON:0000479 ! tissue
! An urinary tract cancer that derives_from the tissues of the urethra.

[Term]
id: DOID:7426 ! cutaneous anthrax
relationship: has_locus UBERON:0000014 ! zone of skin
! An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center.

[Term]
id: DOID:7426 ! cutaneous anthrax
relationship: has_locus UBERON:0002097 ! skin of body
! An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center.

[Term]
id: DOID:7426 ! cutaneous anthrax
relationship: has_locus UBERON:0002199 ! integument
! An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_locus UBERON:0000014 ! zone of skin
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_locus UBERON:0001555 ! digestive tract
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_locus UBERON:0002048 ! lung
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_locus UBERON:0002097 ! skin of body
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_locus UBERON:0002199 ! integument
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7489 ! Osgood-Schlatter's disease
relationship: has_locus UBERON:0000979 ! tibia
! A bone inflammation disease that involves rupture of the growth plate in children located_in tibia.

[Term]
id: DOID:7489 ! Osgood-Schlatter's disease
relationship: has_locus UBERON:0003131 ! arthropod tibia
! A bone inflammation disease that involves rupture of the growth plate in children located_in tibia.

[Term]
id: DOID:754 ! bladder tuberculosis
relationship: has_locus UBERON:0000383 ! musculature of body
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:754 ! bladder tuberculosis
relationship: has_locus UBERON:0001015 ! musculature
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:754 ! bladder tuberculosis
relationship: has_locus UBERON:0001255 ! urinary bladder
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:754 ! bladder tuberculosis
relationship: has_locus UBERON:0001256 ! wall of urinary bladder
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:754 ! bladder tuberculosis
relationship: has_locus UBERON:0001630 ! muscle organ
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000989 ! penis
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000057 ! urethra
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000165 ! mouth
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000167 ! oral cavity
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000341 ! throat
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000931 ! proctodeum
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000995 ! uterus
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0001245 ! anus
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0001353 ! anal region
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0003889 ! fallopian tube
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0006834 ! uterus or analog
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000165 ! mouth
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000167 ! oral cavity
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000931 ! proctodeum
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000989 ! penis
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0000996 ! vagina
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0001245 ! anus
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7551 ! gonorrhea
relationship: has_locus UBERON:0001353 ! anal region
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7615 ! sarcomatosis
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body.

[Term]
id: DOID:768 ! retinoblastoma
relationship: has_locus UBERON:0000966 ! retina
! A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.

[Term]
id: DOID:77 ! gastrointestinal system disease
relationship: has_locus UBERON:0001555 ! digestive tract
! A disease of anatomical entity that is located_in the gastrointestinal tract.

[Term]
id: DOID:77 ! gastrointestinal system disease
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A disease of anatomical entity that is located_in the gastrointestinal tract.

[Term]
id: DOID:771 ! retinal cell cancer
relationship: has_locus UBERON:0000966 ! retina
! A malignant neoplasm that derives_from the retina.

[Term]
id: DOID:780 ! placenta disease
relationship: has_locus UBERON:0001987 ! placenta
! A uterine disease that is located_in the placenta.

[Term]
id: DOID:7849 ! dendritic cell sarcoma
relationship: has_locus UBERON:0000029 ! lymph node
! A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes.

[Term]
id: DOID:8022 ! liver fibrosarcoma
relationship: has_locus UBERON:0002107 ! liver
! A fibrosarcoma of soft tissue and sarcoma of liver that is located_in the liver.

[Term]
id: DOID:8125 ! osteochondrosis
relationship: has_locus UBERON:0001474 ! bone
! An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone.

[Term]
id: DOID:813 ! septic arthritis
relationship: has_locus UBERON:0000982 ! skeletal joint
! An arthritis that involves infection by a pathogen located_in joint.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_locus UBERON:0001474 ! bone
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_locus UBERON:0002418 ! cartilage tissue
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_locus UBERON:0007844 ! cartilaginous element
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:827 ! ureter tuberculosis
relationship: has_locus UBERON:0000056 ! ureter
! An urogenital tuberculosis that is located_in ureter resulting in ureteral strictures.

[Term]
id: DOID:827 ! ureter tuberculosis
relationship: has_locus UBERON:0001055 ! ureter
! An urogenital tuberculosis that is located_in ureter resulting in ureteral strictures.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0000310 ! breast
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0000468 ! multi-cellular organism
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0000989 ! penis
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0001461 ! elbow
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0001465 ! knee
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0001467 ! shoulder
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0001712 ! upper eyelid
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0002027 ! stratum corneum of epidermis
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8295 ! scabies
relationship: has_locus UBERON:0004452 ! carpal region
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:833 ! auditory system cancer
relationship: has_locus UBERON:0003103 ! compound organ
! An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs.

[Term]
id: DOID:833 ! auditory system cancer
relationship: has_locus UBERON:0001690 ! ear
! An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs.

[Term]
id: DOID:833 ! auditory system cancer
relationship: has_locus UBERON:0001846 ! internal ear
! An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_locus UBERON:0000912 ! mucus
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_locus UBERON:0001154 ! appendix
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_locus UBERON:0001988 ! feces
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_locus UBERON:0001007 ! digestive system
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_locus UBERON:0001154 ! appendix
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_locus UBERON:0005409 ! gastrointestinal system
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8398 ! osteoarthritis
relationship: has_locus UBERON:0002418 ! cartilage tissue
! An arthritis that has_material_basis_in worn out cartilage located_in joint.

[Term]
id: DOID:8398 ! osteoarthritis
relationship: has_locus UBERON:0007844 ! cartilaginous element
! An arthritis that has_material_basis_in worn out cartilage located_in joint.

[Term]
id: DOID:8398 ! osteoarthritis
relationship: has_locus UBERON:0000982 ! skeletal joint
! An arthritis that has_material_basis_in worn out cartilage located_in joint.

[Term]
id: DOID:84 ! osteochondritis dissecans
relationship: has_locus UBERON:0001437 ! epiphysis
! An ischemic bone disease that results_in necrosis located_in epiphysis.

[Term]
id: DOID:84 ! osteochondritis dissecans
relationship: has_locus UBERON:0001905 ! pineal body
! An ischemic bone disease that results_in necrosis located_in epiphysis.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_locus UBERON:0002048 ! lung
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_locus UBERON:0002186 ! bronchiole
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_locus UBERON:0003215 ! alveolus
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0000018 ! compound eye
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0000019 ! camera-type eye
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0000955 ! brain
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0003907 ! left atrioventricular canal
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0003908 ! right atrioventricular canal
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0005388 ! photoreceptor array
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0005613 ! left dorsal aorta
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_locus UBERON:0005622 ! right dorsal aorta
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8469 ! influenza
relationship: has_locus UBERON:0000065 ! respiratory tract
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8469 ! influenza
relationship: has_locus UBERON:0000072 ! segment of respiratory tract
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8469 ! influenza
relationship: has_locus UBERON:0001004 ! respiratory system
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8469 ! influenza
relationship: has_locus UBERON:0000176 ! oronasal secretion
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8478 ! actinomycosis
relationship: has_locus UBERON:0001825 ! paranasal sinus
! A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

[Term]
id: DOID:8478 ! actinomycosis
relationship: has_locus UBERON:0000344 ! mucosa
! A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

[Term]
id: DOID:8478 ! actinomycosis
relationship: has_locus UBERON:0000479 ! tissue
! A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

[Term]
id: DOID:848 ! arthritis
relationship: has_locus UBERON:0000982 ! skeletal joint
! A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint.

[Term]
id: DOID:8484 ! maple bark strippers' lung
relationship: has_locus UBERON:0002048 ! lung
! An opportunistic mycosis that is located_in lungs caused by inhalation of fungal spores while stripping the bark from maple logs, has_material_basis_in Cryptostroma corticale.

[Term]
id: DOID:8488 ! polyhydramnios
relationship: has_locus UBERON:0000173 ! amniotic fluid
! A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

[Term]
id: DOID:8502 ! bullous skin disease
relationship: has_locus UBERON:0000014 ! zone of skin
! An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested.

[Term]
id: DOID:8502 ! bullous skin disease
relationship: has_locus UBERON:0002097 ! skin of body
! An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested.

[Term]
id: DOID:8502 ! bullous skin disease
relationship: has_locus UBERON:0002199 ! integument
! An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested.

[Term]
id: DOID:8504 ! impetigo
relationship: has_locus UBERON:0001191 ! common iliac artery
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8504 ! impetigo
relationship: has_locus UBERON:0002064 ! common cardinal vein
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8504 ! impetigo
relationship: has_locus UBERON:0004879 ! marginal zone of embryo
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8504 ! impetigo
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_locus UBERON:0000948 ! heart
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_locus UBERON:0002048 ! lung
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_locus UBERON:0002080 ! heart right ventricle
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_locus UBERON:0000948 ! heart
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8533 ! hypopharynx cancer
relationship: has_locus UBERON:0001051 ! hypopharynx
! A pharynx cancer that is located_in the hypopharynx.

[Term]
id: DOID:8533 ! hypopharynx cancer
relationship: has_locus UBERON:0003132 ! arthropod hypopharynx
! A pharynx cancer that is located_in the hypopharynx.

[Term]
id: DOID:8536 ! herpes zoster
relationship: has_locus UBERON:0006134 ! nerve fiber
! A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.

[Term]
id: DOID:8545 ! malignant hyperthermia
relationship: has_locus UBERON:0001134 ! skeletal muscle tissue
! A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.

[Term]
id: DOID:8566 ! herpes simplex
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

[Term]
id: DOID:8566 ! herpes simplex
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

[Term]
id: DOID:8566 ! herpes simplex
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

[Term]
id: DOID:8566 ! herpes simplex
relationship: has_locus UBERON:0003133 ! reproductive organ
! A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

[Term]
id: DOID:8566 ! herpes simplex
relationship: has_locus UBERON:0006314 ! bodily fluid
! A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_locus UBERON:0000165 ! mouth
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_locus UBERON:0000167 ! oral cavity
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_locus UBERON:0000341 ! throat
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_locus UBERON:0001042 ! chordate pharynx
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8607 ! herpetic whitlow
relationship: has_locus UBERON:0001463 ! manual digit 1
! A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes.

[Term]
id: DOID:8607 ! herpetic whitlow
relationship: has_locus UBERON:0001466 ! foot digit
! A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes.

[Term]
id: DOID:8607 ! herpetic whitlow
relationship: has_locus UBERON:0001466 ! pedal digit
! A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes.

[Term]
id: DOID:8618 ! oral cavity cancer
relationship: has_locus UBERON:0000165 ! mouth
! A gastrointestinal system cancer that is located_in the oral cavity.

[Term]
id: DOID:8618 ! oral cavity cancer
relationship: has_locus UBERON:0000167 ! oral cavity
! A gastrointestinal system cancer that is located_in the oral cavity.

[Term]
id: DOID:8622 ! measles
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8622 ! measles
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8622 ! measles
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8622 ! measles
relationship: has_locus UBERON:0000176 ! oronasal secretion
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8622 ! measles
relationship: has_locus UBERON:0001968 ! semen
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:863 ! nervous system disease
relationship: has_locus UBERON:0000010 ! peripheral nervous system
! A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:863 ! nervous system disease
relationship: has_locus UBERON:0000011 ! parasympathetic nervous system
! A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:863 ! nervous system disease
relationship: has_locus UBERON:0000013 ! sympathetic nervous system
! A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:863 ! nervous system disease
relationship: has_locus UBERON:0000955 ! brain
! A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:863 ! nervous system disease
relationship: has_locus UBERON:0001017 ! central nervous system
! A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:8632 ! Kaposi's sarcoma
relationship: has_locus UBERON:0002042 ! endothelium of lymphatic vessel
! A connective tissue cancer  that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).

[Term]
id: DOID:8632 ! Kaposi's sarcoma
relationship: has_locus UBERON:0000178 ! blood
! A connective tissue cancer  that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).

[Term]
id: DOID:8659 ! chickenpox
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_locus UBERON:0000456 ! bodily secretion
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8687 ! skin carcinoma in situ
relationship: has_locus UBERON:0000479 ! tissue
! A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues.

[Term]
id: DOID:870 ! neuropathy
relationship: has_locus UBERON:0001021 ! nerve
! A nervous system disease that is located_in nerves or nerve cells.

[Term]
id: DOID:8704 ! genital herpes
relationship: has_locus UBERON:0000990 ! reproductive system
! A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.

[Term]
id: DOID:8704 ! genital herpes
relationship: has_locus UBERON:0001052 ! rectum
! A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.

[Term]
id: DOID:8704 ! genital herpes
relationship: has_locus UBERON:0002108 ! small intestine
! A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.

[Term]
id: DOID:8704 ! genital herpes
relationship: has_locus UBERON:0006866 ! terminal part of digestive tract
! A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.

[Term]
id: DOID:8725 ! vascular dementia
relationship: has_locus UBERON:0000955 ! brain
! A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

[Term]
id: DOID:8725 ! vascular dementia
relationship: has_locus UBERON:0001981 ! blood vessel
! A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_locus UBERON:0002386 ! forelimb zeugopod
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:8731 ! carotid body cancer
relationship: has_locus UBERON:0001530 ! common carotid artery plus branches
! A cardiovascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery.

[Term]
id: DOID:8731 ! carotid body cancer
relationship: has_locus UBERON:0010197 ! trunk of common carotid artery
! A cardiovascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0002100 ! trunk
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0002386 ! forelimb zeugopod
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0000355 ! pharyngeal mucosa
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:8736 ! smallpox
relationship: has_locus UBERON:0001681 ! nasal bone
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:874 ! bacterial pneumonia
relationship: has_locus UBERON:0002048 ! lung
! A pneumonia involving inflammation of the lungs caused by bacteria.

[Term]
id: DOID:8761 ! megakaryocytic leukemia
relationship: has_locus UBERON:0000178 ! blood
! A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

[Term]
id: DOID:8761 ! megakaryocytic leukemia
relationship: has_locus UBERON:0002371 ! bone marrow
! A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0000989 ! penis
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0001460 ! arm
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0002389 ! hand digit
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0002389 ! manual digit
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0002398 ! hand
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0002398 ! manus
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0003822 ! forelimb stylopod
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8778 ! Crohn's disease
relationship: has_locus UBERON:0000160 ! intestine
! An intestinal disease that involves inflammation located_in intestine.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0002100 ! trunk
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0002101 ! limb
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_locus UBERON:0000176 ! oronasal secretion
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8792 ! eye carcinoma in situ
relationship: has_locus UBERON:0000479 ! tissue
! A carcinoma in situ that is characterized by the spread of cancer in the eye and the lack of invasion of surrounding tissues.

[Term]
id: DOID:8867 ! molluscum contagiosum
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8867 ! molluscum contagiosum
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8867 ! molluscum contagiosum
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8867 ! molluscum contagiosum
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8867 ! molluscum contagiosum
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8867 ! molluscum contagiosum
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0001191 ! common iliac artery
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0000014 ! zone of skin
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0002097 ! skin of body
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0002199 ! integument
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0007029 ! surface
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0000014 ! zone of skin
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0002097 ! skin of body
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8912 ! tinea nigra
relationship: has_locus UBERON:0002199 ! integument
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8913 ! dermatophytosis
relationship: has_locus UBERON:0000403 ! scalp
! A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source.

[Term]
id: DOID:8913 ! dermatophytosis
relationship: has_locus UBERON:0001705 ! nail
! A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source.

[Term]
id: DOID:8941 ! seborrheic infantile dermatitis
relationship: has_locus UBERON:0000403 ! scalp
! A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

[Term]
id: DOID:8941 ! seborrheic infantile dermatitis
relationship: has_locus UBERON:0007380 ! dermal scale
! A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

[Term]
id: DOID:8941 ! seborrheic infantile dermatitis
relationship: has_locus UBERON:0000403 ! scalp
! A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

[Term]
id: DOID:8956 ! cowpox
relationship: has_locus UBERON:0000014 ! zone of skin
! A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.

[Term]
id: DOID:8956 ! cowpox
relationship: has_locus UBERON:0002097 ! skin of body
! A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.

[Term]
id: DOID:8956 ! cowpox
relationship: has_locus UBERON:0002199 ! integument
! A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.

[Term]
id: DOID:8956 ! cowpox
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.

[Term]
id: DOID:8970 ! subacute sclerosing panencephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Measles virus which is immune resistant (which can be a result of a mutation of the virus itself).

[Term]
id: DOID:90 ! degenerative disc disease
relationship: has_locus UBERON:0001827 ! lacrimal gland secretion
! A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.

[Term]
id: DOID:90 ! degenerative disc disease
relationship: has_locus UBERON:0001827 ! tear
! A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.

[Term]
id: DOID:90 ! degenerative disc disease
relationship: has_locus UBERON:0001066 ! intervertebral disk
! A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.

[Term]
id: DOID:9060 ! pityriasis versicolor
relationship: has_locus UBERON:0007380 ! dermal scale
! A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

[Term]
id: DOID:9060 ! pityriasis versicolor
relationship: has_locus UBERON:0000014 ! zone of skin
! A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

[Term]
id: DOID:9060 ! pityriasis versicolor
relationship: has_locus UBERON:0002097 ! skin of body
! A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

[Term]
id: DOID:9060 ! pityriasis versicolor
relationship: has_locus UBERON:0002199 ! integument
! A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_locus UBERON:0000014 ! zone of skin
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_locus UBERON:0002097 ! skin of body
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_locus UBERON:0002199 ! integument
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_locus UBERON:0000014 ! zone of skin
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_locus UBERON:0002097 ! skin of body
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_locus UBERON:0002199 ! integument
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9113 ! granuloma inguinale
relationship: has_locus UBERON:0000344 ! mucosa
! A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers.

[Term]
id: DOID:9113 ! granuloma inguinale
relationship: has_locus UBERON:0001018 ! axon tract
! A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers.

[Term]
id: DOID:9123 ! eczema herpeticum
relationship: has_locus UBERON:0000029 ! lymph node
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9123 ! eczema herpeticum
relationship: has_locus UBERON:0000014 ! zone of skin
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9123 ! eczema herpeticum
relationship: has_locus UBERON:0002097 ! skin of body
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9123 ! eczema herpeticum
relationship: has_locus UBERON:0002199 ! integument
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_locus UBERON:0002107 ! liver
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_locus UBERON:0002371 ! bone marrow
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_locus UBERON:0003103 ! compound organ
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9153 ! variola minor
relationship: has_locus UBERON:0000014 ! zone of skin
! A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:9153 ! variola minor
relationship: has_locus UBERON:0002097 ! skin of body
! A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:9153 ! variola minor
relationship: has_locus UBERON:0002199 ! integument
! A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0000344 ! mucosa
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0001557 ! upper respiratory tract
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0000479 ! tissue
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0001681 ! nasal bone
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0001824 ! mucosa of larynx
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0004530 ! bony projection
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_locus UBERON:0009292 ! embryonic nasal process
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9159 ! gas gangrene
relationship: has_locus UBERON:0000479 ! tissue
! A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.

[Term]
id: DOID:9159 ! gas gangrene
relationship: has_locus UBERON:0002385 ! muscle tissue
! A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_locus UBERON:0000178 ! blood
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_locus UBERON:0000955 ! brain
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_locus UBERON:0002048 ! lung
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_locus UBERON:0002107 ! liver
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_locus UBERON:0003103 ! compound organ
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9201 ! lichen planus
relationship: has_locus UBERON:0000014 ! zone of skin
! A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known.

[Term]
id: DOID:9201 ! lichen planus
relationship: has_locus UBERON:0001723 ! tongue
! A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known.

[Term]
id: DOID:9201 ! lichen planus
relationship: has_locus UBERON:0002097 ! skin of body
! A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known.

[Term]
id: DOID:9201 ! lichen planus
relationship: has_locus UBERON:0002199 ! integument
! A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known.

[Term]
id: DOID:9201 ! lichen planus
relationship: has_locus UBERON:0003729 ! mouth mucosa
! A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_locus UBERON:0000165 ! mouth
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_locus UBERON:0000167 ! oral cavity
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_locus UBERON:0001690 ! ear
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_locus UBERON:0001846 ! internal ear
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_locus UBERON:0001456 ! face
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_locus UBERON:0001647 ! facial nerve
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_locus UBERON:0002101 ! limb
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_locus UBERON:0005896 ! jointed/prehensile appendage
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_locus UBERON:0010707 ! appendage girdle complex
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9250 ! acrocallosal syndrome
relationship: has_locus UBERON:0002633 ! motor nucleus of trigeminal nerve
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9254 ! mast-cell leukemia
relationship: has_locus UBERON:0000178 ! blood
! A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood.

[Term]
id: DOID:9254 ! mast-cell leukemia
relationship: has_locus UBERON:0000479 ! tissue
! A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
relationship: has_locus UBERON:0000341 ! throat
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
relationship: has_locus UBERON:0001557 ! upper respiratory tract
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
relationship: has_locus UBERON:0001681 ! nasal bone
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
relationship: has_locus UBERON:0001728 ! nasopharynx
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
relationship: has_locus UBERON:0002393 ! pharyngotympanic tube
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_locus UBERON:0000071 ! death stage
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_locus UBERON:0001088 ! urine
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_locus UBERON:0000178 ! blood
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_locus UBERON:0001088 ! urine
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_locus UBERON:0001359 ! cerebrospinal fluid
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9305 ! splenic tuberculosis
relationship: has_locus UBERON:0002106 ! spleen
! An abdominal tuberculosis that results_in formation of granulomas or abscesses located_in spleen.

[Term]
id: DOID:9305 ! splenic tuberculosis
relationship: has_locus UBERON:0006293 ! spleen primordium
! An abdominal tuberculosis that results_in formation of granulomas or abscesses located_in spleen.

[Term]
id: DOID:931 ! monieziasis
relationship: has_locus UBERON:0001191 ! common iliac artery
! A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep.

[Term]
id: DOID:931 ! monieziasis
relationship: has_locus UBERON:0002064 ! common cardinal vein
! A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep.

[Term]
id: DOID:931 ! monieziasis
relationship: has_locus UBERON:0005599 ! common dorsal aorta
! A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep.

[Term]
id: DOID:9370 ! exophthalmos
relationship: has_locus UBERON:0001697 ! orbit
! An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

[Term]
id: DOID:9370 ! exophthalmos
relationship: has_locus UBERON:0001697 ! orbital region
! An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

[Term]
id: DOID:9370 ! exophthalmos
relationship: has_locus UBERON:0004867 ! orbital cavity
! An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

[Term]
id: DOID:9392 ! tracheitis
relationship: has_locus UBERON:0000341 ! throat
! A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions.

[Term]
id: DOID:9392 ! tracheitis
relationship: has_locus UBERON:0000456 ! bodily secretion
! A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions.

[Term]
id: DOID:9392 ! tracheitis
relationship: has_locus UBERON:0001042 ! chordate pharynx
! A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions.

[Term]
id: DOID:9395 ! croup
relationship: has_locus UBERON:0001004 ! respiratory system
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9395 ! croup
relationship: has_locus UBERON:0001737 ! larynx
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9395 ! croup
relationship: has_locus UBERON:0002185 ! bronchus
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9395 ! croup
relationship: has_locus UBERON:0003126 ! trachea
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9395 ! croup
relationship: has_locus UBERON:0003127 ! open tracheal system trachea
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9463 ! otitis externa
relationship: has_locus UBERON:0001352 ! external acoustic meatus
! An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection.

[Term]
id: DOID:9463 ! otitis externa
relationship: has_locus UBERON:0001691 ! external ear
! An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0000315 ! subarachnoid space
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0002360 ! meninx
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0001016 ! nervous system
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0003288 ! meninx of midbrain
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0003289 ! meninx of telencephalon
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0003290 ! meninx of diencephalon
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0003291 ! meninx of hindbrain
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0003292 ! meninx of spinal cord
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_locus UBERON:0010743 ! meningeal cluster
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_locus UBERON:0001088 ! urine
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9538 ! multiple myeloma
relationship: has_locus UBERON:0002371 ! bone marrow
! A myeloma that is located_in the plasma cells in bone marrow.

[Term]
id: DOID:9553 ! adrenal gland disease
relationship: has_locus UBERON:0002369 ! adrenal gland
! An endocrine system disease that is located_in the adrenal gland.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0000060 ! anatomical wall
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0002185 ! bronchus
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0002186 ! bronchiole
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0000060 ! anatomical wall
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0002048 ! lung
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0009856 ! sac
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_locus UBERON:0010168 ! collection of eyelashes
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_locus UBERON:0000978 ! leg
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_locus UBERON:0003823 ! hindlimb zeugopod
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_locus UBERON:0005895 ! insect leg
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_locus UBERON:0000955 ! brain
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_locus UBERON:0000160 ! intestine
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_locus UBERON:0000160 ! intestine
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_locus UBERON:0000383 ! musculature of body
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_locus UBERON:0001015 ! musculature
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_locus UBERON:0001630 ! muscle organ
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9667 ! placental abruption
relationship: has_locus UBERON:0000995 ! uterus
! A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

[Term]
id: DOID:9667 ! placental abruption
relationship: has_locus UBERON:0006834 ! uterus or analog
! A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

[Term]
id: DOID:9681 ! cervical incompetence
relationship: has_locus UBERON:0000002 ! uterine cervix
! A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_locus UBERON:0000004 ! olfactory apparatus
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_locus UBERON:0000945 ! stomach
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9733 ! renal tuberculosis
relationship: has_locus UBERON:0000080 ! mesonephros
! An urogenital tuberculosis that results_in formation of granulomas located_in kidney.

[Term]
id: DOID:9733 ! renal tuberculosis
relationship: has_locus UBERON:0002120 ! pronephros
! An urogenital tuberculosis that results_in formation of granulomas located_in kidney.

[Term]
id: DOID:9744 ! type 1 diabetes mellitus
relationship: has_locus UBERON:0001264 ! pancreas
! A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.

[Term]
id: DOID:9765 ! emphysematous cholecystitis
relationship: has_locus UBERON:0011818 ! superficial fascia
! Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues.

[Term]
id: DOID:9765 ! emphysematous cholecystitis
relationship: has_locus UBERON:0002110 ! gallbladder
! Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues.

[Term]
id: DOID:9778 ! irritable bowel syndrome
relationship: has_locus UBERON:0000160 ! intestine
! A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

[Term]
id: DOID:9786 ! bulbar polio
relationship: has_locus UBERON:0001988 ! feces
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty speaking, has_symptom difficulty swallowing, and has_symptom difficulty chewing.

[Term]
id: DOID:9801 ! tuberculous peritonitis
relationship: has_locus UBERON:0000418 ! tubercle
! A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation.

[Term]
id: DOID:9801 ! tuberculous peritonitis
relationship: has_locus UBERON:0002358 ! peritoneum
! A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation.

[Term]
id: DOID:9801 ! tuberculous peritonitis
relationship: has_locus UBERON:0005813 ! tubercle
! A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation.

[Term]
id: DOID:9808 ! Goodpasture syndrome
relationship: has_locus UBERON:0002048 ! lung
! An autoimmune disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung.

[Term]
id: DOID:9828 ! neonatal abstinence syndrome
relationship: has_locus UBERON:0000995 ! uterus
! A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment.

[Term]
id: DOID:9856 ! congenital syphilis
relationship: has_locus UBERON:0000323 ! late embryo
! A syphilis that results_in a multisystem infection in the fetus via the placenta.

[Term]
id: DOID:9856 ! congenital syphilis
relationship: has_locus UBERON:0001987 ! placenta
! A syphilis that results_in a multisystem infection in the fetus via the placenta.

[Term]
id: DOID:9856 ! congenital syphilis
relationship: has_locus UBERON:0007220 ! late embryonic stage
! A syphilis that results_in a multisystem infection in the fetus via the placenta.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_locus UBERON:0002137 ! aortic valve
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_locus UBERON:0003710 ! vasa vasorum
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_locus UBERON:0000947 ! aorta
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_locus UBERON:0001496 ! ascending aorta
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9909 ! hordeolum
relationship: has_locus UBERON:0001821 ! sebaceous gland
! Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

[Term]
id: DOID:9909 ! hordeolum
relationship: has_locus UBERON:0010168 ! collection of eyelashes
! Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_locus UBERON:0000178 ! blood
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_locus UBERON:0001088 ! urine
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_locus UBERON:0001713 ! lower eyelid
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_locus UBERON:0001733 ! soft palate
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_locus UBERON:0007311 ! sputum
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:9931 ! Waterhouse-Friderichsen syndrome
relationship: has_locus UBERON:0002360 ! meninx
! A meningococcal meningitis described as an adrenal gland hypofunction disease functionally, resulting from a meningococcal infection caused by the bacterium Neisseria meningitidis, which is characterized by hemorrhages in the adrenal glands, usually observed in severe cases of meningitis. Infection can also be caused by Streptococcus pneumoniae infection. Staphylococcus aureus has recently also been implicated in pediatric WFS. The symptoms include fever, rigors, vomiting, headache, rash, hypotension and septic shock.

[Term]
id: DOID:9931 ! Waterhouse-Friderichsen syndrome
relationship: has_locus UBERON:0002369 ! adrenal gland
! A meningococcal meningitis described as an adrenal gland hypofunction disease functionally, resulting from a meningococcal infection caused by the bacterium Neisseria meningitidis, which is characterized by hemorrhages in the adrenal glands, usually observed in severe cases of meningitis. Infection can also be caused by Streptococcus pneumoniae infection. Staphylococcus aureus has recently also been implicated in pediatric WFS. The symptoms include fever, rigors, vomiting, headache, rash, hypotension and septic shock.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_locus UBERON:0000323 ! late embryo
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_locus UBERON:0001988 ! feces
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_locus UBERON:0007220 ! late embryonic stage
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9988 ! tertiary neurosyphilis
relationship: has_locus UBERON:0000955 ! brain
! A tertiary syphilis that results_in infection located_in brain or located_in spinal cord.

[Term]
id: DOID:9988 ! tertiary neurosyphilis
relationship: has_locus UBERON:0002240 ! spinal cord
! A tertiary syphilis that results_in infection located_in brain or located_in spinal cord.