do-bridge-has_phenotype-HP.obo

[Term]
id: DOID:0050012 ! chikungunya
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.

[Term]
id: DOID:0050012 ! chikungunya
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.

[Term]
id: DOID:0050025 ! human granulocytic anaplasmosis
relationship: has_phenotype HP:0001945 ! Fever
! An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050025 ! human granulocytic anaplasmosis
relationship: has_phenotype HP:0002315 ! Headache
! An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050026 ! human monocytic ehrlichiosis
relationship: has_phenotype HP:0001945 ! Fever
! An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050026 ! human monocytic ehrlichiosis
relationship: has_phenotype HP:0002315 ! Headache
! An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050035 ! African tick-bite fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash.

[Term]
id: DOID:0050041 ! Astrakhan spotted fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp caspia, which is trasnmitted_by ticks (Rhipicephalus pumilio and Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050042 ! Indian tick typhus
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp indica, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050043 ! Israeli tick typhus
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050046 ! Far Eastern spotted fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy.

[Term]
id: DOID:0050050 ! Japanese spotted fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities.

[Term]
id: DOID:0050051 ! Rickettsia parkeri spotted fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia parkeri, which is transmitted_by Gulf Coast tick (Amblyomma maculatum). The infection has_symptom fever, has_symptom headache, has_symptom eschar, and has_symptom rash.

[Term]
id: DOID:0050051 ! Rickettsia parkeri spotted fever
relationship: has_phenotype HP:0002315 ! Headache
! A spotted fever that has_material_basis_in Rickettsia parkeri, which is transmitted_by Gulf Coast tick (Amblyomma maculatum). The infection has_symptom fever, has_symptom headache, has_symptom eschar, and has_symptom rash.

[Term]
id: DOID:0050052 ! Rocky Mountain spotted fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia rickettsii, which is transmitted_by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, and has_symptom maculopapular rash progressing into papular or petechial rash.

[Term]
id: DOID:0050052 ! Rocky Mountain spotted fever
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A spotted fever that has_material_basis_in Rickettsia rickettsii, which is transmitted_by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, and has_symptom maculopapular rash progressing into papular or petechial rash.

[Term]
id: DOID:0050052 ! Rocky Mountain spotted fever
relationship: has_phenotype HP:0002315 ! Headache
! A spotted fever that has_material_basis_in Rickettsia rickettsii, which is transmitted_by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, and has_symptom maculopapular rash progressing into papular or petechial rash.

[Term]
id: DOID:0050068 ! pestis minor
relationship: has_phenotype HP:0001945 ! Fever
! A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration.

[Term]
id: DOID:0050068 ! pestis minor
relationship: has_phenotype HP:0002315 ! Headache
! A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration.

[Term]
id: DOID:0050068 ! pestis minor
relationship: has_phenotype HP:0002840 ! Lymphadenitis
! A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration.

[Term]
id: DOID:0050073 ! invasive aspergillosis
relationship: has_phenotype HP:0002488 ! Acute leukemia
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050073 ! invasive aspergillosis
relationship: has_phenotype HP:0002090 ! Pneumonia
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050084 ! rhinotracheitis
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050116 ! tinea imbricata
relationship: has_phenotype HP:0000006 ! Autosomal dominant inheritance
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype HP:0001250 ! Seizures
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
relationship: has_phenotype HP:0001876 ! Pancytopenia
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
relationship: has_phenotype HP:0001945 ! Fever
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050125 ! dengue shock syndrome
relationship: has_phenotype HP:0000978 ! Bruising susceptibility
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050125 ! dengue shock syndrome
relationship: has_phenotype HP:0002615 ! Hypotension
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_phenotype HP:0002019 ! Constipation
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_phenotype HP:0004789 ! Lactose intolerance
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_phenotype HP:0002014 ! Diarrhea
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050131 ! motility-related diarrhea
relationship: has_phenotype HP:0002014 ! Diarrhea
! Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
relationship: has_phenotype HP:0003003 ! Colon cancer
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
relationship: has_phenotype HP:0002014 ! Diarrhea
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050140 ! acute diarrhea
relationship: has_phenotype HP:0002014 ! Diarrhea
! A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

[Term]
id: DOID:0050147 ! otomycosis
relationship: has_phenotype HP:0000989 ! Pruritus
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050152 ! aspiration pneumonia
relationship: has_phenotype HP:0002015 ! Dysphagia
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050152 ! aspiration pneumonia
relationship: has_phenotype HP:0011009 ! Acute
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050152 ! aspiration pneumonia
relationship: has_phenotype HP:0002789 ! Tachypnea
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype HP:0001824 ! Weight loss
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype HP:0001945 ! Fever
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype HP:0003674 ! Onset
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype HP:0100699 ! Scarring
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050167 ! autoimmune polyendocrine syndrome type 1
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.

[Term]
id: DOID:0050168 ! autoimmune polyendocrine syndrome type 2
relationship: has_phenotype HP:0001425 ! Heterogeneous
! An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
relationship: has_phenotype HP:0001254 ! Lethargy
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
relationship: has_phenotype HP:0001945 ! Fever
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
relationship: has_phenotype HP:0002329 ! Drowsiness
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0001250 ! Seizures
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
relationship: has_phenotype HP:0001873 ! Thrombocytopenia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
relationship: has_phenotype HP:0001882 ! Leukopenia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0000132 ! Menorrhagia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0000421 ! Epistaxis
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002039 ! Anorexia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002248 ! Hematemesis
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002249 ! Melena
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002309 ! Weakness
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050199 ! Whitewater Arroyo hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050199 ! Whitewater Arroyo hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050199 ! Whitewater Arroyo hemorrhagic fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0000622 ! Blurred vision
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0002018 ! Nausea
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0002615 ! Hypotension
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0003418 ! Back pain
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype HP:0011009 ! Acute
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0000083 ! Renal failure
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0002013 ! Vomiting
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0002018 ! Nausea
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0002315 ! Headache
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0003326 ! Myalgia
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0003418 ! Back pain
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype HP:0011029 ! Internal hemorrhage
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype HP:0006562 ! Viral hepatitis
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype HP:0002018 ! Nausea
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype HP:0001254 ! Lethargy
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype HP:0001945 ! Fever
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype HP:0002013 ! Vomiting
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype HP:0002014 ! Diarrhea
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype HP:0002018 ! Nausea
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype HP:0001250 ! Seizures
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype HP:0002018 ! Nausea
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype HP:0002063 ! Rigidity
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050246 ! granulomatous amebic encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

[Term]
id: DOID:0050253 ! mesocestoidiasis
relationship: has_phenotype HP:0002013 ! Vomiting
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050253 ! mesocestoidiasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050253 ! mesocestoidiasis
relationship: has_phenotype HP:0002018 ! Nausea
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0001824 ! Weight loss
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0001945 ! Fever
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0002013 ! Vomiting
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0002018 ! Nausea
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0002019 ! Constipation
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_phenotype HP:0000618 ! Blindness
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050266 ! tungiasis
relationship: has_phenotype HP:0011123 ! Inflammatory abnormality of the skin
! A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_phenotype HP:0001482 ! Subcutaneous nodules
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050278 ! basidiobolomycosis
relationship: has_phenotype HP:0011010 ! Chronic
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050279 ! conidiobolomycosis
relationship: has_phenotype HP:0001482 ! Subcutaneous nodules
! An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.

[Term]
id: DOID:0050279 ! conidiobolomycosis
relationship: has_phenotype HP:0011010 ! Chronic
! An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype HP:0001824 ! Weight loss
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype HP:0001903 ! Anemia
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype HP:0001945 ! Fever
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype HP:0001873 ! Thrombocytopenia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype HP:0000622 ! Blurred vision
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype HP:0000651 ! Diplopia
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype HP:0001260 ! Dysarthria
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype HP:0001618 ! Dysphonia
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype HP:0002015 ! Dysphagia
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype HP:0000508 ! Ptosis
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype HP:0001254 ! Lethargy
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype HP:0001324 ! Muscle weakness
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype HP:0002019 ! Constipation
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050383 ! typhoidal tularemia
relationship: has_phenotype HP:0001824 ! Weight loss
! A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss.

[Term]
id: DOID:0050383 ! typhoidal tularemia
relationship: has_phenotype HP:0001945 ! Fever
! A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss.

[Term]
id: DOID:0050383 ! typhoidal tularemia
relationship: has_phenotype HP:0003326 ! Myalgia
! A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss.

[Term]
id: DOID:0050398 ! Carrion's Disease
relationship: has_phenotype HP:0011009 ! Acute
! A primary bacterial infectious disease that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

[Term]
id: DOID:0050398 ! Carrion's Disease
relationship: has_phenotype HP:0011010 ! Chronic
! A primary bacterial infectious disease that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
relationship: has_phenotype HP:0003003 ! Colon cancer
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050432 ! Asperger syndrome
relationship: has_phenotype HP:0000729 ! Autism spectrum disorder
! An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_phenotype HP:0000006 ! Autosomal dominant inheritance
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_phenotype HP:0004308 ! Ventricular arrhythmia
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_phenotype HP:0000347 ! Micrognathia
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050445 ! X-linked hypophosphatemia
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! A metal metabolism disorder that results from the inactivation of hormone-like substances (phosphatonins) that promote phosphate excretion which has_material_basis_in a X-linked mutation in the PHEX gene.

[Term]
id: DOID:0050473 ! Alstrom syndrome
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.

[Term]
id: DOID:0050473 ! Alstrom syndrome
relationship: has_phenotype HP:0000556 ! Retinal dystrophy
! An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.

[Term]
id: DOID:0050473 ! Alstrom syndrome
relationship: has_phenotype HP:0000618 ! Blindness
! An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.

[Term]
id: DOID:0050480 ! epidemic typhus
relationship: has_phenotype HP:0003326 ! Myalgia
! A typhus that has_material_basis_in Rickettsia prowazekii, which is transmitted_by human body louse (Pediculus humanus corporis). The infection has_symptom high fever, has_symptom cough, has_symptom rash, has_symptom severe muscle pain, has_symptom chills, has_symptom falling blood pressure, has_symptom stupor, has_symptom sensitivity to light, and has_symptom delirium.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype HP:0001945 ! Fever
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype HP:0002013 ! Vomiting
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype HP:0002018 ! Nausea
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype HP:0002315 ! Headache
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype HP:0003326 ! Myalgia
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050484 ! aneruptive fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia helvetica, which is transmitted_by ticks (Ixodes sp). The infection has_symptom fever, has_symptom headache, has_symptom myalgia.

[Term]
id: DOID:0050484 ! aneruptive fever
relationship: has_phenotype HP:0002315 ! Headache
! A spotted fever that has_material_basis_in Rickettsia helvetica, which is transmitted_by ticks (Ixodes sp). The infection has_symptom fever, has_symptom headache, has_symptom myalgia.

[Term]
id: DOID:0050484 ! aneruptive fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A spotted fever that has_material_basis_in Rickettsia helvetica, which is transmitted_by ticks (Ixodes sp). The infection has_symptom fever, has_symptom headache, has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype HP:0002039 ! Anorexia
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0000238 ! Hydrocephalus
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0001249 ! Intellectual disability
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0001250 ! Seizures
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0001287 ! Meningitis
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0001508 ! Failure to thrive
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_phenotype HP:0011010 ! Chronic
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_phenotype HP:0000737 ! Irritability
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_phenotype HP:0001254 ! Lethargy
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_phenotype HP:0002315 ! Headache
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_phenotype HP:0100785 ! Insomnia
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0000622 ! Blurred vision
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0001977 ! Thrombosis
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0002309 ! Weakness
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0002315 ! Headache
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0002354 ! Memory impairment
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0003470 ! Paralysis
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0003677 ! Slow progression
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0007147 ! Urinary or fecal incontinence
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype HP:0100785 ! Insomnia
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_phenotype HP:0003470 ! Paralysis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_phenotype HP:0003470 ! Paralysis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050515 ! paralytic poliomyelitis
relationship: has_phenotype HP:0011009 ! Acute
! A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:0050516 ! O'nyong'nyong fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.

[Term]
id: DOID:0050516 ! O'nyong'nyong fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.

[Term]
id: DOID:0050516 ! O'nyong'nyong fever
relationship: has_phenotype HP:0002840 ! Lymphadenitis
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.

[Term]
id: DOID:0050517 ! Barmah Forest virus disease
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050517 ! Barmah Forest virus disease
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050518 ! Ross River fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050518 ! Ross River fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype HP:0002039 ! Anorexia
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype HP:0000083 ! Renal failure
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype HP:0000093 ! Proteinuria
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype HP:0000967 ! Petechiae
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype HP:0001387 ! Joint stiffness
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype HP:0003621 ! Juvenile onset
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype HP:0009125 ! Lipodystrophy
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype HP:0009473 ! Joint contractures involving the joints of the hand
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050573 ! 2-hydroxyglutaric aciduria
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage.

[Term]
id: DOID:0050576 ! Senior-Loken syndrome
relationship: has_phenotype HP:0000090 ! Nephronophthisis
! An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease.

[Term]
id: DOID:0050576 ! Senior-Loken syndrome
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease.

[Term]
id: DOID:0050578 ! occult macular dystrophy
relationship: has_phenotype HP:0000608 ! Macular degeneration
! A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.

[Term]
id: DOID:0050578 ! occult macular dystrophy
relationship: has_phenotype HP:0000572 ! Visual loss
! A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype HP:0001880 ! Eosinophilia
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype HP:0001945 ! Fever
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype HP:0002255 ! Bloody diarrhea
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050600 ! ABCD syndrome
relationship: has_phenotype HP:0001022 ! Albinism
! An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB).

[Term]
id: DOID:0050600 ! ABCD syndrome
relationship: has_phenotype HP:0008538 ! Sensorineural deafness
! An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB).

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype HP:0000668 ! Hypodontia
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype HP:0001000 ! Abnormality of skin pigmentation
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype HP:0001480 ! Freckling
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype HP:0002164 ! Nail dysplasia
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype HP:0003187 ! Breast hypoplasia
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype HP:0008070 ! Sparse hair
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050631 ! Allan-Herndon-Dudley syndrome
relationship: has_phenotype HP:0001249 ! Intellectual disability
! An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.

[Term]
id: DOID:0050631 ! Allan-Herndon-Dudley syndrome
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.

[Term]
id: DOID:0050650 ! familial atrial fibrillation
relationship: has_phenotype HP:0000006 ! Autosomal dominant inheritance
! A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
relationship: has_phenotype HP:0100021 ! Cerebral paralysis
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_phenotype HP:0001252 ! Muscular hypotonia
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_phenotype HP:0100021 ! Cerebral paralysis
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_phenotype HP:0001252 ! Muscular hypotonia
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_phenotype HP:0001276 ! Hypertonia
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_phenotype HP:0100021 ! Cerebral paralysis
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050673 ! mixed cerebral palsy
relationship: has_phenotype HP:0100021 ! Cerebral paralysis
! A cerebral palsy that is caused by injury to both the pyramidal and extra pyramidal areas of the brain, which results in both the tight muscle tone and the involuntary movements. The individual have difficulty with speaking and swallowing.

[Term]
id: DOID:0050708 ! early onset absence epilepsy
relationship: has_phenotype HP:0011147 ! Typical absence seizures
! A childhood electroclinical syndrome characterized by the occurrance of typical absence seizures startign between the age of four and ten years.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype HP:0001252 ! Muscular hypotonia
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype HP:0001254 ! Lethargy
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype HP:0002014 ! Diarrhea
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype HP:0002022 ! Feeding difficulties
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype HP:0003202 ! Amyotrophy
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050711 ! aceruloplasminemia
relationship: has_phenotype HP:0000819 ! Diabetes mellitus
! An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.

[Term]
id: DOID:0050711 ! aceruloplasminemia
relationship: has_phenotype HP:0002344 ! Progressive neurologic deterioration
! An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.

[Term]
id: DOID:0050714 ! alcaptonuria
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! An organic acidemia that has_material_basis_in an autosomal recessive mutation in the HGD (homogentisate 1,2-dioxygenase gene ) gene affecting the production of the homogentisate 1,2-dioxygenase enzyme resulting in the accumulation of homogentisic acid in the blood.

[Term]
id: DOID:0050715 ! methylmalonic aciduria and homocystinuria type cblC
relationship: has_phenotype HP:0002912 ! Methylmalonic acidemia
! A methylmalonic acidemia that has_material_basis_in deficiency in synthesis of both AdoCbl and MeCbl (cblC) and is characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl), which results in decreased activity of the respective enzymes methylmalonyl-CoA mutase.

[Term]
id: DOID:0050716 ! methylmalonic aciduria and homocystinuria type cblD
relationship: has_phenotype HP:0002156 ! Homocystinuria
! A methylmalonic aciduria that is characterized by combined homocystinuria and methylmalonic aciduria and deficiency of MCM and MS activities.

[Term]
id: DOID:0050716 ! methylmalonic aciduria and homocystinuria type cblD
relationship: has_phenotype HP:0002912 ! Methylmalonic acidemia
! A methylmalonic aciduria that is characterized by combined homocystinuria and methylmalonic aciduria and deficiency of MCM and MS activities.

[Term]
id: DOID:0050716 ! methylmalonic aciduria and homocystinuria type cblD
relationship: has_phenotype HP:0002912 ! Methylmalonic acidemia
! A methylmalonic aciduria that is characterized by combined homocystinuria and methylmalonic aciduria and deficiency of MCM and MS activities.

[Term]
id: DOID:0050717 ! methylmalonic aciduria and homocystinuria type cblF
relationship: has_phenotype HP:0002912 ! Methylmalonic acidemia
! A methylmalonic acidemia that is characterized by the accumulation of cobalamin in lysosomes which is then unable to synthesize the cofactors adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl).

[Term]
id: DOID:0050725 ! tyrosinemia type II
relationship: has_phenotype HP:0000491 ! Keratitis
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050725 ! tyrosinemia type II
relationship: has_phenotype HP:0000972 ! Palmoplantar hyperkeratosis
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050725 ! tyrosinemia type II
relationship: has_phenotype HP:0001249 ! Intellectual disability
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050725 ! tyrosinemia type II
relationship: has_phenotype HP:0003231 ! Hypertyrosinemia
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050726 ! tyrosinemia type I
relationship: has_phenotype HP:0003231 ! Hypertyrosinemia
! A tyrosinemia that has_material_basis_in deficiency of the enzyme fumarylacetoacetate hydrolase resulting in an increase in fumarylacetoacetate which inhibits previous steps in tyrosine degradation leading to an accumulation of tyrosine in the body.

[Term]
id: DOID:0050727 ! tyrosinemia type III
relationship: has_phenotype HP:0003231 ! Hypertyrosinemia
! A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine.

[Term]
id: DOID:0050734 ! congenital intrinsic factor deficiency
relationship: has_phenotype HP:0001889 ! Megaloblastic anemia
! A vitamin B12 deficiency that is characterized by megaloblastic anemia due to the absence of gastric intrinsic factor which results in abnormal vitamin B12 absorption.

[Term]
id: DOID:0050734 ! congenital intrinsic factor deficiency
relationship: has_phenotype HP:0100502 ! Vitamin B12 deficiency
! A vitamin B12 deficiency that is characterized by megaloblastic anemia due to the absence of gastric intrinsic factor which results in abnormal vitamin B12 absorption.

[Term]
id: DOID:0050740 ! Qazi Markouizos syndrome
relationship: has_phenotype HP:0001252 ! Muscular hypotonia
! A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation.

[Term]
id: DOID:0050740 ! Qazi Markouizos syndrome
relationship: has_phenotype HP:0005832 ! Dysharmonic delayed bone age
! A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation.

[Term]
id: DOID:0060002 ! C1 inhibitor deficiency
relationship: has_phenotype HP:0004431 ! Complement deficiency
! A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue.

[Term]
id: DOID:0060013 ! gamma chain deficiency
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.

[Term]
id: DOID:0060013 ! gamma chain deficiency
relationship: has_phenotype HP:0004430 ! Severe combined immunodeficiency
! A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.

[Term]
id: DOID:0060016 ! CD3delta deficiency
relationship: has_phenotype HP:0004430 ! Severe combined immunodeficiency
! A severe combined immunodeficiency that is characterized by the absence of T cells but normal numbers of B cells. CD3D is essential for T cell development.

[Term]
id: DOID:0060017 ! CD3epsilon deficiency
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex.

[Term]
id: DOID:0060017 ! CD3epsilon deficiency
relationship: has_phenotype HP:0002721 ! Immunodeficiency
! A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex.

[Term]
id: DOID:0060017 ! CD3epsilon deficiency
relationship: has_phenotype HP:0004430 ! Severe combined immunodeficiency
! A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex.

[Term]
id: DOID:0060018 ! CD3gamma deficiency
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected.

[Term]
id: DOID:0060018 ! CD3gamma deficiency
relationship: has_phenotype HP:0002721 ! Immunodeficiency
! A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected.

[Term]
id: DOID:0060018 ! CD3gamma deficiency
relationship: has_phenotype HP:0004430 ! Severe combined immunodeficiency
! A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype HP:0001427 ! Mitochondrial inheritance
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype HP:0000777 ! Abnormality of the thymus
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype HP:0001888 ! Lymphopenia
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype HP:0005541 ! Congenital agranulocytosis
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype HP:0004430 ! Severe combined immunodeficiency
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060021 ! DNA ligase IV deficiency
relationship: has_phenotype HP:0001510 ! Growth delay
! A combined T cell and B cell immunodeficiency that is caused by a mutatino in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.

[Term]
id: DOID:0060021 ! DNA ligase IV deficiency
relationship: has_phenotype HP:0002721 ! Immunodeficiency
! A combined T cell and B cell immunodeficiency that is caused by a mutatino in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.

[Term]
id: DOID:0060022 ! CD40 ligand deficiency
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.

[Term]
id: DOID:0060022 ! CD40 ligand deficiency
relationship: has_phenotype HP:0002721 ! Immunodeficiency
! A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.

[Term]
id: DOID:0060025 ! immunoglobulin alpha deficiency
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! A B cell deficiency that is an autosomal recessive disorder caused by mutation in the IgA (CD79 alpha) antigen receptor.

[Term]
id: DOID:0060041 ! autism spectrum disorder
relationship: has_phenotype HP:0000729 ! Autism spectrum disorder
! A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.

[Term]
id: DOID:0060062 ! familial juvenile hyperuricemic nephropathy
relationship: has_phenotype HP:0001997 ! Gout
! A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease.

[Term]
id: DOID:0060062 ! familial juvenile hyperuricemic nephropathy
relationship: has_phenotype HP:0002149 ! Hyperuricemia
! A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease.

[Term]
id: DOID:0060067 ! Pearson syndrome
relationship: has_phenotype HP:0001924 ! Sideroblastic anemia
! A mitochondrial disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.

[Term]
id: DOID:0060158 ! acquired metabolic disease
relationship: has_phenotype HP:0002024 ! Malabsorption
! A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

[Term]
id: DOID:0060161 ! Kennedy's disease
relationship: has_phenotype HP:0003560 ! Muscular dystrophy
! A spinal muscular dystrophy that has_material_basis_in an X-linked recessive mutation of the androgen receptor.

[Term]
id: DOID:0060162 ! dentatorubral-pallidoluysian atrophy
relationship: has_phenotype HP:0002503 ! Spinocerebellar tract degeneration
! A spinocerebellar degeneration that has_material_basis_in an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein.

[Term]
id: DOID:0060166 ! bipolar ll disorder
relationship: has_phenotype HP:0007302 ! Bipolar affective disorder
! A bipolar disorder that is characterized by at least one hypomanic episode and at least one major depressive episode; with this disorder, depressive episodes are more frequent and more intense than manic episodes.

[Term]
id: DOID:0060170 ! generalized epilepsy with febrile seizures plus
relationship: has_phenotype HP:0002069 ! Generalized tonic-clonic seizures
! A generalized epilepsy that is characterized by febrile seizures often with accessory afebrile generalized tonic-clonic seizures with childhood onset.

[Term]
id: DOID:0060170 ! generalized epilepsy with febrile seizures plus
relationship: has_phenotype HP:0002373 ! Febrile seizures
! A generalized epilepsy that is characterized by febrile seizures often with accessory afebrile generalized tonic-clonic seizures with childhood onset.

[Term]
id: DOID:0060170 ! generalized epilepsy with febrile seizures plus
relationship: has_phenotype HP:0003621 ! Juvenile onset
! A generalized epilepsy that is characterized by febrile seizures often with accessory afebrile generalized tonic-clonic seizures with childhood onset.

[Term]
id: DOID:0060171 ! Dravet Syndrome
relationship: has_phenotype HP:0002373 ! Febrile seizures
! An epilepsy that is characterized by frequent febrile seizures with onset before 1 year.

[Term]
id: DOID:0060172 ! juvenile absence epilepsy
relationship: has_phenotype HP:0011147 ! Typical absence seizures
! An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_phenotype HP:0001269 ! Hemiparesis
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_phenotype HP:0001289 ! Confusion
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_phenotype HP:0002309 ! Weakness
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_phenotype HP:0002329 ! Drowsiness
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_phenotype HP:0002077 ! Migraine with aura
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype HP:0000252 ! Microcephaly
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype HP:0000318 ! Long, narrow facies
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype HP:0004322 ! Short stature
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype HP:0008734 ! Decreased testicular size
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype HP:0001249 ! Intellectual disability
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0080020 ! Jansen's metaphyseal chondrodysplasia
relationship: has_phenotype HP:0100255 ! Metaphyseal dysplasia
! A metaphyseal dysplasia that has_material_basis_in mutation in PTH receptor which results_in short-limbed dwarfism.

[Term]
id: DOID:0080020 ! Jansen's metaphyseal chondrodysplasia
relationship: has_phenotype HP:0003505 ! Disproportionate short limb dwarfism
! A metaphyseal dysplasia that has_material_basis_in mutation in PTH receptor which results_in short-limbed dwarfism.

[Term]
id: DOID:0080021 ! Schmid metaphyseal chondrodysplasia
relationship: has_phenotype HP:0100255 ! Metaphyseal dysplasia
! A metaphyseal dysplasia that results_in dwarfism and bowed legs.

[Term]
id: DOID:0080021 ! Schmid metaphyseal chondrodysplasia
relationship: has_phenotype HP:0001516 ! Dwarfism
! A metaphyseal dysplasia that results_in dwarfism and bowed legs.

[Term]
id: DOID:0080022 ! McKusick type metaphyseal dysplasia
relationship: has_phenotype HP:0100255 ! Metaphyseal dysplasia
! A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair.

[Term]
id: DOID:0080022 ! McKusick type metaphyseal dysplasia
relationship: has_phenotype HP:0003505 ! Disproportionate short limb dwarfism
! A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair.

[Term]
id: DOID:0080022 ! McKusick type metaphyseal dysplasia
relationship: has_phenotype HP:0008070 ! Sparse hair
! A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_phenotype HP:0000926 ! Platyspondyly
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0002651 ! Spondyloepimetaphyseal dysplasia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0000768 ! Pectus carinatum
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0000924 ! Abnormality of the musculoskeletal system
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0000926 ! Platyspondyly
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0001762 ! Talipes equinovarus
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0002650 ! Scoliosis
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0002812 ! Coxa vara
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0002939 ! Lordosis
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype HP:0004322 ! Short stature
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080030 ! spondyloepimetaphyseal dysplasia, Missouri type
relationship: has_phenotype HP:0002651 ! Spondyloepimetaphyseal dysplasia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities.

[Term]
id: DOID:0080030 ! spondyloepimetaphyseal dysplasia, Missouri type
relationship: has_phenotype HP:0002970 ! Genu varum
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities.

[Term]
id: DOID:0080030 ! spondyloepimetaphyseal dysplasia, Missouri type
relationship: has_phenotype HP:0004566 ! Pear-shaped vertebrae
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities.

[Term]
id: DOID:0080032 ! craniodiaphyseal dysplasia
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_phenotype HP:0100774 ! Hyperostosis
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_phenotype HP:0001548 ! Overgrowth
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080037 ! Worth's syndrome
relationship: has_phenotype HP:0100774 ! Hyperostosis
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080037 ! Worth's syndrome
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080038 ! pycnodysostosis
relationship: has_phenotype HP:0001516 ! Dwarfism
! An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.

[Term]
id: DOID:0080038 ! pycnodysostosis
relationship: has_phenotype HP:0011002 ! Osteopetrosis
! An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.

[Term]
id: DOID:0080039 ! axial osteomalacia
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that results_in coarsening located_in trabecular bone.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_phenotype HP:0000774 ! Narrow chest
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_phenotype HP:0008867 ! Dwarfism, short-trunk, short-limbed
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080044 ! hypochondrogenesis
relationship: has_phenotype HP:0001789 ! Hydrops fetalis
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_phenotype HP:0000272 ! Malar hypoplasia
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_phenotype HP:0001516 ! Dwarfism
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_phenotype HP:0001524 ! Short trunk
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080049 ! acromesomelic dysplasia
relationship: has_phenotype HP:0003027 ! Mesomelia
! An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism.

[Term]
id: DOID:0080049 ! acromesomelic dysplasia
relationship: has_phenotype HP:0010884 ! Acromelia
! An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism.

[Term]
id: DOID:0080050 ! acromesomelic dysplasia, Maroteaux type
relationship: has_phenotype HP:0001516 ! Dwarfism
! An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb.

[Term]
id: DOID:0080052 ! acromesomelic dysplasia, Grebe type
relationship: has_phenotype HP:0002983 ! Micromelia
! An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_phenotype HP:0001513 ! Obesity
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_phenotype HP:0004322 ! Short stature
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080055 ! achondrogenesis type IB
relationship: has_phenotype HP:0000023 ! Inguinal hernia
! An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen.

[Term]
id: DOID:0080056 ! achondrogenesis type II
relationship: has_phenotype HP:0001789 ! Hydrops fetalis
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:0080056 ! achondrogenesis type II
relationship: has_phenotype HP:0011220 ! Prominent forehead
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_phenotype HP:0000802 ! Impotence
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_phenotype HP:0002066 ! Gait ataxia
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_phenotype HP:0003401 ! Paresthesia
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10027 ! tabes dorsalis
relationship: has_phenotype HP:0100963 ! Hyperaesthesia
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10035 ! asymptomatic neurosyphilis
relationship: has_phenotype HP:0001287 ! Meningitis
! A tertiary neurosyphilis that results_in mild meningitis.

[Term]
id: DOID:10039 ! late congenital syphilis
relationship: has_phenotype HP:0000648 ! Optic atrophy
! A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has_symptom gummatous ulcers, has_symptom periosteal lesions, has_symptom paresis, has_symptom tabes, has_symptom optic atrophy, has_symptom interstitial keratitis, has_symptom sensorineural deafness, and has_symptom dental deformities.

[Term]
id: DOID:10039 ! late congenital syphilis
relationship: has_phenotype HP:0008538 ! Sensorineural deafness
! A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has_symptom gummatous ulcers, has_symptom periosteal lesions, has_symptom paresis, has_symptom tabes, has_symptom optic atrophy, has_symptom interstitial keratitis, has_symptom sensorineural deafness, and has_symptom dental deformities.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype HP:0001824 ! Weight loss
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype HP:0002013 ! Vomiting
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype HP:0100502 ! Vitamin B12 deficiency
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10192 ! pleomorphic lipoma
relationship: has_phenotype HP:0001012 ! Lipomas
! A lipoma that is characterized by floret giant cells with overlapping nuclei.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_phenotype HP:0100614 ! Myositis
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10242 ! ehrlichiosis
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash.

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0001370 ! Rheumatoid arthritis
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0001733 ! Pancreatitis
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0002090 ! Pneumonia
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0002102 ! Pleuritis
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0002204 ! Pulmonary embolism
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0002725 ! Systemic lupus erythematosus
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype HP:0002102 ! Pleuritis
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10250 ! louping ill
relationship: has_phenotype HP:0001254 ! Lethargy
! A viral infectious disease that results_in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted_by sheep tick, Ixodes ricinus. The infection has_symptom lethargy, has_symptom muscle pains, has_symptom fever, and has_symptom focal neurological signs.

[Term]
id: DOID:10250 ! louping ill
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted_by sheep tick, Ixodes ricinus. The infection has_symptom lethargy, has_symptom muscle pains, has_symptom fever, and has_symptom focal neurological signs.

[Term]
id: DOID:10264 ! mumps
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10264 ! mumps
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10316 ! pneumoconiosis
relationship: has_phenotype HP:0006530 ! Interstitial pulmonary disease
! An interstitial lung disease that is caused by the inhalation of dust.

[Term]
id: DOID:10326 ! Caplan's syndrome
relationship: has_phenotype HP:0001370 ! Rheumatoid arthritis
! A pneumoconiosis that results_in humans that also have rheumatoid arthritis.

[Term]
id: DOID:10398 ! pneumonic plague
relationship: has_phenotype HP:0001945 ! Fever
! A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype HP:0001945 ! Fever
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype HP:0002315 ! Headache
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype HP:0003326 ! Myalgia
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype HP:0011110 ! Tonsillitis
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10457 ! Legionnaires' disease
relationship: has_phenotype HP:0001945 ! Fever
! A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

[Term]
id: DOID:10457 ! Legionnaires' disease
relationship: has_phenotype HP:0002090 ! Pneumonia
! A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10459 ! common cold
relationship: has_phenotype HP:0011009 ! Acute
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10533 ! viral pneumonia
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.

[Term]
id: DOID:10567 ! late yaws
relationship: has_phenotype HP:0000962 ! Hyperkeratosis
! A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

[Term]
id: DOID:10573 ! osteomalacia
relationship: has_phenotype HP:0100512 ! Vitamin D deficiency
! A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.

[Term]
id: DOID:10579 ! leukodystrophy
relationship: has_phenotype HP:0007313 ! Cerebral degeneration
! A cerebral degeneration characterized by dysfunction of the white matter of the brain.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_phenotype HP:0002202 ! Pleural effusion
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:1060 ! Hartnup disease
relationship: has_phenotype HP:0003355 ! Aminoaciduria
! An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.

[Term]
id: DOID:10600 ! chronic tic disorder
relationship: has_phenotype HP:0100035 ! Phonic tics
! A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_phenotype HP:0002014 ! Diarrhea
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_phenotype HP:0002017 ! Nausea and vomiting
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_phenotype HP:0002019 ! Constipation
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10609 ! rickets
relationship: has_phenotype HP:0100512 ! Vitamin D deficiency
! A bone remodeling disease that has_material_basis_in a vitamin D deficiency in children which results_in softening and deformity located_in bone.

[Term]
id: DOID:10632 ! Wolfram syndrome
relationship: has_phenotype HP:0000404 ! Deafness
! A genetic disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).

[Term]
id: DOID:10632 ! Wolfram syndrome
relationship: has_phenotype HP:0000648 ! Optic atrophy
! A genetic disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).

[Term]
id: DOID:10632 ! Wolfram syndrome
relationship: has_phenotype HP:0000819 ! Diabetes mellitus
! A genetic disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).

[Term]
id: DOID:10632 ! Wolfram syndrome
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! A genetic disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype HP:0000712 ! Emotional lability
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype HP:0001289 ! Confusion
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype HP:0000726 ! Dementia
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype HP:0001289 ! Confusion
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype HP:0002185 ! Neurofibrillary tangles
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype HP:0002354 ! Memory impairment
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10755 ! petrositis
relationship: has_phenotype HP:0002754 ! Osteomyelitis
! An osteomyelitis that has_material_basis_in infection located_in petrous part of temporal bone.

[Term]
id: DOID:10773 ! bubonic plague
relationship: has_phenotype HP:0001945 ! Fever
! A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration.

[Term]
id: DOID:10784 ! Queensland tick typhus
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.

[Term]
id: DOID:10784 ! Queensland tick typhus
relationship: has_phenotype HP:0002315 ! Headache
! A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.

[Term]
id: DOID:10784 ! Queensland tick typhus
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.

[Term]
id: DOID:10784 ! Queensland tick typhus
relationship: has_phenotype HP:0003326 ! Myalgia
! A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.

[Term]
id: DOID:1082 ! dirofilariasis
relationship: has_phenotype HP:0001482 ! Subcutaneous nodules
! A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype HP:0001250 ! Seizures
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0002309 ! Weakness
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype HP:0002329 ! Drowsiness
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype HP:0002039 ! Anorexia
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype HP:0002309 ! Weakness
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10844 ! Japanese encephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10844 ! Japanese encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10844 ! Japanese encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_phenotype HP:0000988 ! Skin rash
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_phenotype HP:0004396 ! Poor appetite
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10882 ! epidemic pleurodynia
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache.

[Term]
id: DOID:10882 ! epidemic pleurodynia
relationship: has_phenotype HP:0002102 ! Pleuritis
! A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache.

[Term]
id: DOID:10882 ! epidemic pleurodynia
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache.

[Term]
id: DOID:10883 ! herpangina
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10887 ! lepromatous leprosy
relationship: has_phenotype HP:0001596 ! Alopecia
! A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

[Term]
id: DOID:10887 ! lepromatous leprosy
relationship: has_phenotype HP:0100964 ! Hypoaesthesia
! A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

[Term]
id: DOID:10921 ! Siberian tick typhus
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia sibirica, which is transmitted_by ticks (Dermacentor nuttalli, Dermacentor marginatus and Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash.

[Term]
id: DOID:10936 ! schizoid personality disorder
relationship: has_phenotype HP:0000741 ! Apathy
! A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world.

[Term]
id: DOID:10983 ! Alport syndrome
relationship: has_phenotype HP:0000099 ! Glomerulonephritis
! A monogenic disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss.

[Term]
id: DOID:11055 ! pasteurellosis
relationship: has_phenotype HP:0001649 ! Tachycardia
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11055 ! pasteurellosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11055 ! pasteurellosis
relationship: has_phenotype HP:0002090 ! Pneumonia
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11055 ! pasteurellosis
relationship: has_phenotype HP:0002829 ! Arthralgia
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype HP:0001064 ! Diaphoresis
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype HP:0001945 ! Fever
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype HP:0002039 ! Anorexia
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype HP:0002315 ! Headache
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype HP:0002829 ! Arthralgia
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype HP:0003326 ! Myalgia
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype HP:0002309 ! Weakness
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype HP:0002829 ! Arthralgia
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype HP:0003418 ! Back pain
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11100 ! Q fever
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11100 ! Q fever
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11100 ! Q fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11100 ! Q fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11101 ! trench fever
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11103 ! rickettsialpox
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash.

[Term]
id: DOID:11103 ! rickettsialpox
relationship: has_phenotype HP:0002315 ! Headache
! A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash.

[Term]
id: DOID:11103 ! rickettsialpox
relationship: has_phenotype HP:0003326 ! Myalgia
! A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash.

[Term]
id: DOID:11104 ! spotted fever
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

[Term]
id: DOID:11104 ! spotted fever
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

[Term]
id: DOID:11119 ! Gilles de la Tourette syndrome
relationship: has_phenotype HP:0100034 ! Motor tics
! A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.

[Term]
id: DOID:1114 ! esophagus sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of esophagus that is_located in the esophagus.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
relationship: has_phenotype HP:0000613 ! Photophobia
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11258 ! cat-scratch disease
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A primary bacterial infectious disease that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.

[Term]
id: DOID:11258 ! cat-scratch disease
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype HP:0000713 ! Agitation
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype HP:0000739 ! Anxiety
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11262 ! ornithosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.

[Term]
id: DOID:11262 ! ornithosis
relationship: has_phenotype HP:0002090 ! Pneumonia
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.

[Term]
id: DOID:11262 ! ornithosis
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype HP:0000083 ! Renal failure
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype HP:0000093 ! Proteinuria
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype HP:0000967 ! Petechiae
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11285 ! tick paralysis
relationship: has_phenotype HP:0000969 ! Edema
! A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage.

[Term]
id: DOID:11285 ! tick paralysis
relationship: has_phenotype HP:0011009 ! Acute
! A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage.

[Term]
id: DOID:11320 ! Kyasanur forest disease
relationship: has_phenotype HP:0001944 ! Dehydration
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11320 ! Kyasanur forest disease
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11320 ! Kyasanur forest disease
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11320 ! Kyasanur forest disease
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11337 ! Lemierre's syndrome
relationship: has_phenotype HP:0001945 ! Fever
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11337 ! Lemierre's syndrome
relationship: has_phenotype HP:0001974 ! Leukocytosis
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11337 ! Lemierre's syndrome
relationship: has_phenotype HP:0011110 ! Tonsillitis
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11337 ! Lemierre's syndrome
relationship: has_phenotype HP:0100806 ! Sepsis
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11339 ! pneumocystosis
relationship: has_phenotype HP:0001945 ! Fever
! An opportunistic mycosis that is located_in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has_symptom nonproductive cough, has_symptom shortness of breath, and has_symptom fever.

[Term]
id: DOID:11360 ! Phlebotomus fever
relationship: has_phenotype HP:0001649 ! Tachycardia
! A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia.

[Term]
id: DOID:11360 ! Phlebotomus fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype HP:0100598 ! Pulmonary edema
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype HP:0002090 ! Pneumonia
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype HP:0002093 ! Respiratory insufficiency
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype HP:0002835 ! Aspiration
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype HP:0100806 ! Sepsis
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11405 ! diphtheria
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:1156 ! pseudogout
relationship: has_phenotype HP:0001369 ! Arthritis
! An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0001624 ! Stillbirth
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0002013 ! Vomiting
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0002018 ! Nausea
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype HP:0003418 ! Back pain
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:1166 ! palindromic rheumatism
relationship: has_phenotype HP:0001369 ! Arthritis
! A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype HP:0000618 ! Blindness
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype HP:0000964 ! Eczema
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype HP:0000989 ! Pruritus
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype HP:0001482 ! Subcutaneous nodules
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_phenotype HP:0000988 ! Skin rash
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11760 ! Kohler's disease
relationship: has_phenotype HP:0010885 ! Aseptic necrosis
! An osteochondrosis that results_in death and collapse located_in navicular bone of foot.

[Term]
id: DOID:11812 ! bladder sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of urinary bladder that is located_in the bladder.

[Term]
id: DOID:11838 ! penis sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of penis that is located_in the penis.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:12002 ! trachea sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant tumor of trachea that is located_in the trachea.

[Term]
id: DOID:12096 ! sodoku disease
relationship: has_phenotype HP:0002829 ! Arthralgia
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:1210 ! optic neuritis
relationship: has_phenotype HP:0000572 ! Visual loss
! An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_phenotype HP:0002633 ! Vasculitis
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_phenotype HP:0002960 ! Autoimmunity
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12134 ! factor VIII deficiency
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.

[Term]
id: DOID:12134 ! factor VIII deficiency
relationship: has_phenotype HP:0003125 ! Factor VIII deficiency
! An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.

[Term]
id: DOID:12140 ! Chagas disease
relationship: has_phenotype HP:0002013 ! Vomiting
! A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

[Term]
id: DOID:12148 ! alveolar echinococcosis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12177 ! common variable immunodeficiency
relationship: has_phenotype HP:0004313 ! Hypogammaglobulinemia
! A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).

[Term]
id: DOID:12179 ! tinea corporis
relationship: has_phenotype HP:0000988 ! Skin rash
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_phenotype HP:0002653 ! Bone pain
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12205 ! dengue disease
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
relationship: has_phenotype HP:0001873 ! Thrombocytopenia
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0000031 ! Epididymitis
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0000962 ! Hyperkeratosis
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0001004 ! Lymphedema
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0001945 ! Fever
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0002840 ! Lymphadenitis
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0011009 ! Acute
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype HP:0011010 ! Chronic
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12275 ! cutaneous diphtheria
relationship: has_phenotype HP:0000999 ! Pyoderma
! A pyoderma that is a milder form of diphtheria restricted to the skin producing shallow skin ulcers is caused by direct physical contact of indivduals infected with Corynebacterium diphtheriae as the bacteria releases the diphtheria toxin.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype HP:0000967 ! Petechiae
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype HP:0003418 ! Back pain
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_phenotype HP:0001262 ! Somnolence
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_phenotype HP:0003470 ! Paralysis
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_phenotype HP:0100786 ! Hypersomnia
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_phenotype HP:0001287 ! Meningitis
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_phenotype HP:0002960 ! Autoimmunity
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12323 ! cough variant asthma
relationship: has_phenotype HP:0011010 ! Chronic
! An asthma that is characterized by chronic nonproductive cough without shortness of breath.

[Term]
id: DOID:12323 ! cough variant asthma
relationship: has_phenotype HP:0002099 ! Asthma
! An asthma that is characterized by chronic nonproductive cough without shortness of breath.

[Term]
id: DOID:12341 ! retroperitoneal sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12385 ! shigellosis
relationship: has_phenotype HP:0002255 ! Bloody diarrhea
! A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

[Term]
id: DOID:12386 ! balantidiasis
relationship: has_phenotype HP:0002255 ! Bloody diarrhea
! A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.

[Term]
id: DOID:12386 ! balantidiasis
relationship: has_phenotype HP:0002018 ! Nausea
! A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.

[Term]
id: DOID:12386 ! balantidiasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_phenotype HP:0001510 ! Growth delay
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_phenotype HP:0002035 ! Rectal prolapse
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:12522 ! bagassosis
relationship: has_phenotype HP:0001945 ! Fever
! An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

[Term]
id: DOID:12522 ! bagassosis
relationship: has_phenotype HP:0002309 ! Weakness
! An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12683 ! vestibular neuronitis
relationship: has_phenotype HP:0002017 ! Nausea and vomiting
! A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_phenotype HP:0002829 ! Arthralgia
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_phenotype HP:0002098 ! Respiratory distress
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:12783 ! migraine without aura
relationship: has_phenotype HP:0002076 ! Migraine
! A migraine that is characterized by migraine headaches that are not accompanied by an aura.

[Term]
id: DOID:12783 ! migraine without aura
relationship: has_phenotype HP:0002076 ! Migraine
! A migraine that is characterized by migraine headaches that are not accompanied by an aura.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_phenotype HP:0001903 ! Anemia
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_phenotype HP:0002584 ! Intestinal bleeding
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_phenotype HP:0004395 ! Malnutrition
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12849 ! autistic disorder
relationship: has_phenotype HP:0000750 ! Delayed speech and language development
! An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

[Term]
id: DOID:12849 ! autistic disorder
relationship: has_phenotype HP:0003674 ! Onset
! An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

[Term]
id: DOID:12849 ! autistic disorder
relationship: has_phenotype HP:0000729 ! Autism spectrum disorder
! An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
relationship: has_phenotype HP:0001159 ! Syndactyly
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
relationship: has_phenotype HP:0001363 ! Craniosynostosis
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12965 ! subleukemic leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that is characterized by the presence of abnormal white blood cells located_in peripheral blood, but in which the total number of white blood cells is normal.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype HP:0001945 ! Fever
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype HP:0001649 ! Tachycardia
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype HP:0002789 ! Tachypnea
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype HP:0001945 ! Fever
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype HP:0001649 ! Tachycardia
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype HP:0002789 ! Tachypnea
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13166 ! allergic bronchopulmonary aspergillosis
relationship: has_phenotype HP:0001945 ! Fever
! An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has_symptom cough, has_symptom wheezing and has_symptom fever.

[Term]
id: DOID:13189 ! gout
relationship: has_phenotype HP:0001369 ! Arthritis
! An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13238 ! Haverhill fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_phenotype HP:0000554 ! Uveitis
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype HP:0001744 ! Splenomegaly
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype HP:0001882 ! Leukopenia
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype HP:0002014 ! Diarrhea
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_phenotype HP:0000132 ! Menorrhagia
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype HP:0002013 ! Vomiting
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype HP:0002018 ! Nausea
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype HP:0002239 ! Gastrointestinal hemorrhage
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13300 ! Scheuermann's disease
relationship: has_phenotype HP:0010885 ! Aseptic necrosis
! An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column.

[Term]
id: DOID:13352 ! ego-dystonic sexual orientation
relationship: has_phenotype HP:0000739 ! Anxiety
! A gender identity disorder that is characterized by having a sexual orientation or an attraction that is at odds with one's idealized self-image, causing anxiety and a desire to change one's orientation or become more comfortable with one's sexual orientation.

[Term]
id: DOID:13366 ! Stiff-Person syndrome
relationship: has_phenotype HP:0002063 ! Rigidity
! A movement disease that is of unknown etiology characterized by progressive rigidity.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype HP:0001744 ! Splenomegaly
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype HP:0001945 ! Fever
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype HP:0002315 ! Headache
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype HP:0003326 ! Myalgia
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13444 ! glanders
relationship: has_phenotype HP:0000975 ! Hyperhidrosis
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13444 ! glanders
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13444 ! glanders
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13444 ! glanders
relationship: has_phenotype HP:0100749 ! Chest pain
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13450 ! coccidioidomycosis
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.

[Term]
id: DOID:13450 ! coccidioidomycosis
relationship: has_phenotype HP:0001369 ! Arthritis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.

[Term]
id: DOID:13450 ! coccidioidomycosis
relationship: has_phenotype HP:0100749 ! Chest pain
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.

[Term]
id: DOID:13487 ! childhood disintegrative disease
relationship: has_phenotype HP:0003584 ! Late onset
! A pervasive developmental disease that is a rare condition characterized by late onset (>3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress.

[Term]
id: DOID:13523 ! loiasis
relationship: has_phenotype HP:0011010 ! Chronic
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13533 ! osteopetrosis
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.

[Term]
id: DOID:1362 ! paranasal sinus sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant tumor of nasal sinuses that is located_in the paranasal sinus.

[Term]
id: DOID:13622 ! campylobacteriosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.

[Term]
id: DOID:13622 ! campylobacteriosis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13867 ! focal labyrinthitis
relationship: has_phenotype HP:0000265 ! Mastoiditis
! A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma.

[Term]
id: DOID:13867 ! focal labyrinthitis
relationship: has_phenotype HP:0009797 ! Cholesteatoma
! A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma.

[Term]
id: DOID:13891 ! bird fancier's lung
relationship: has_phenotype HP:0001945 ! Fever
! An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen.

[Term]
id: DOID:13891 ! bird fancier's lung
relationship: has_phenotype HP:0002094 ! Dyspnea
! An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype HP:0000790 ! Hematuria
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype HP:0001945 ! Fever
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype HP:0002018 ! Nausea
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype HP:0003326 ! Myalgia
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype HP:0001744 ! Splenomegaly
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype HP:0001824 ! Weight loss
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype HP:0001945 ! Fever
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype HP:0002309 ! Weakness
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype HP:0002315 ! Headache
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14042 ! bipolar I disorder
relationship: has_phenotype HP:0007302 ! Bipolar affective disorder
! A bipolar disorder that is characterized by at least one manic or mixed episode.

[Term]
id: DOID:14095 ! boutonneuse fever
relationship: has_phenotype HP:0001945 ! Fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype HP:0000707 ! Abnormality of the nervous system
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype HP:0001945 ! Fever
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype HP:0002013 ! Vomiting
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype HP:0002014 ! Diarrhea
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype HP:0002315 ! Headache
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype HP:0002615 ! Hypotension
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14179 ! Bruton-type agammaglobulinemia
relationship: has_phenotype HP:0002721 ! Immunodeficiency
! A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

[Term]
id: DOID:14239 ! gastrointestinal tularemia
relationship: has_phenotype HP:0001945 ! Fever
! A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting.

[Term]
id: DOID:14239 ! gastrointestinal tularemia
relationship: has_phenotype HP:0002013 ! Vomiting
! A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting.

[Term]
id: DOID:14256 ! adult-onset Still's disease
relationship: has_phenotype HP:0001369 ! Arthritis
! An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

[Term]
id: DOID:14319 ! pleuropneumonia
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria.

[Term]
id: DOID:14320 ! generalized anxiety disorder
relationship: has_phenotype HP:0000739 ! Anxiety
! An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

[Term]
id: DOID:1441 ! spinocerebellar ataxia
relationship: has_phenotype HP:0002503 ! Spinocerebellar tract degeneration
! A spinocerebellar degeneration that has_material_basis_in expanded CAG triplet repeats resulting in spinal cord and cerebellum degeneration.

[Term]
id: DOID:14415 ! Legg-Calve-Perthes Disease
relationship: has_phenotype HP:0010885 ! Aseptic necrosis
! An osteochondrosis that results_in death and fracture located_in hip joint.

[Term]
id: DOID:1442 ! Alpers syndrome
relationship: has_phenotype HP:0007313 ! Cerebral degeneration
! A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.

[Term]
id: DOID:14435 ! chronic tubotympanic suppurative otitis media
relationship: has_phenotype HP:0000405 ! Conductive hearing impairment
! A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections.

[Term]
id: DOID:14453 ! farmer's lung
relationship: has_phenotype HP:0001945 ! Fever
! An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

[Term]
id: DOID:14456 ! Brucella melitensis brucellosis
relationship: has_phenotype HP:0001945 ! Fever
! A brucellosis that involves an infection caused by Brucella melitensis [NCBITaxon:29459] in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain.

[Term]
id: DOID:14456 ! Brucella melitensis brucellosis
relationship: has_phenotype HP:0002039 ! Anorexia
! A brucellosis that involves an infection caused by Brucella melitensis [NCBITaxon:29459] in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain.

[Term]
id: DOID:14456 ! Brucella melitensis brucellosis
relationship: has_phenotype HP:0003418 ! Back pain
! A brucellosis that involves an infection caused by Brucella melitensis [NCBITaxon:29459] in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain.

[Term]
id: DOID:14456 ! Brucella melitensis brucellosis
relationship: has_phenotype HP:0009763 ! Limb pain
! A brucellosis that involves an infection caused by Brucella melitensis [NCBITaxon:29459] in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_phenotype HP:0001824 ! Weight loss
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_phenotype HP:0001945 ! Fever
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_phenotype HP:0002315 ! Headache
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_phenotype HP:0002829 ! Arthralgia
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_phenotype HP:0003326 ! Myalgia
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype HP:0002113 ! Pulmonary infiltrates
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype HP:0100598 ! Pulmonary edema
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_phenotype HP:0002667 ! Nephroblastoma (Wilms tumor)
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_phenotype HP:0000526 ! Aniridia
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_phenotype HP:0001249 ! Intellectual disability
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_phenotype HP:0002667 ! Nephroblastoma (Wilms tumor)
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14669 ! acrodysostosis
relationship: has_phenotype HP:0001249 ! Intellectual disability
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14764 ! Larsen syndrome
relationship: has_phenotype HP:0001373 ! Joint dislocation
! An autosomal dominant disease that is characterized by large-joint dislocations and characteristic craniofacial abnormalities.

[Term]
id: DOID:14780 ! KBG syndrome
relationship: has_phenotype HP:0001249 ! Intellectual disability
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
relationship: has_phenotype HP:0000252 ! Microcephaly
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
relationship: has_phenotype HP:0001510 ! Growth delay
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
relationship: has_phenotype HP:0002053 ! Receding chin
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0001025 ! Urticaria
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0001880 ! Eosinophilia
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0001945 ! Fever
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0002105 ! Hemoptysis
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0100749 ! Chest pain
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype HP:0100845 ! Anaphylactic shock
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1498 ! cholera
relationship: has_phenotype HP:0002013 ! Vomiting
! A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.

[Term]
id: DOID:1498 ! cholera
relationship: has_phenotype HP:0011009 ! Acute
! A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.

[Term]
id: DOID:1562 ! chromoblastomycosis
relationship: has_phenotype HP:0011010 ! Chronic
! A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

[Term]
id: DOID:1583 ! laryngeal tuberculosis
relationship: has_phenotype HP:0001609 ! Hoarse voice
! A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

[Term]
id: DOID:1583 ! laryngeal tuberculosis
relationship: has_phenotype HP:0002015 ! Dysphagia
! A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_phenotype HP:0001945 ! Fever
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_phenotype HP:0001974 ! Leukocytosis
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_phenotype HP:0002789 ! Tachypnea
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_phenotype HP:0001650 ! Aortic valve stenosis
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_phenotype HP:0001650 ! Aortic valve stenosis
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1731 ! histoplasmosis
relationship: has_phenotype HP:0002315 ! Headache
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype HP:0001824 ! Weight loss
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype HP:0001944 ! Dehydration
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype HP:0001945 ! Fever
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype HP:0002017 ! Nausea and vomiting
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_phenotype HP:0001718 ! Mitral stenosis
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_phenotype HP:0002564 ! Cardiac malformation
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_phenotype HP:0001718 ! Mitral stenosis
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1759 ! American histoplasmosis
relationship: has_phenotype HP:0002315 ! Headache
! A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.

[Term]
id: DOID:1787 ! pericarditis
relationship: has_phenotype HP:0100749 ! Chest pain
! A heart disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.

[Term]
id: DOID:1796 ! pancreas sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of pancreas that is located_in the pancreas.

[Term]
id: DOID:180 ! ossifying fibroma
relationship: has_phenotype HP:0001548 ! Overgrowth
! A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

[Term]
id: DOID:1825 ! childhood absence epilepsy
relationship: has_phenotype HP:0002121 ! Absence seizures
! A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.

[Term]
id: DOID:1825 ! childhood absence epilepsy
relationship: has_phenotype HP:0011007 ! Age of onset
! A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.

[Term]
id: DOID:1826 ! epilepsy syndrome
relationship: has_phenotype HP:0001250 ! Seizures
! A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenicnabnormality of the brain that is able to spontaneously gen-nerate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1974 ! adenosarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

[Term]
id: DOID:1995 ! rectum sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant tumor of rectum that is located_in the rectum.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0001254 ! Lethargy
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0001262 ! Somnolence
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype HP:0002039 ! Anorexia
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_phenotype HP:0001425 ! Heterogeneous
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_phenotype HP:0100699 ! Scarring
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:2153 ! ovarian Wilms' cancer
relationship: has_phenotype HP:0002667 ! Nephroblastoma (Wilms tumor)
! A malignant neoplasm of ovary and nephroblastoma that is located_in the ovaries.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_phenotype HP:0001945 ! Fever
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:2224 ! hemorrhagic thrombocythemia
relationship: has_phenotype HP:0001894 ! Thrombocytosis
! A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets.

[Term]
id: DOID:2224 ! hemorrhagic thrombocythemia
relationship: has_phenotype HP:0011010 ! Chronic
! A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets.

[Term]
id: DOID:2272 ! vulvovaginal candidiasis
relationship: has_phenotype HP:0010783 ! Erythema
! A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_phenotype HP:0000952 ! Jaundice
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_phenotype HP:0002240 ! Hepatomegaly
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_phenotype HP:0003326 ! Myalgia
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_phenotype HP:0002090 ! Pneumonia
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_phenotype HP:0100658 ! Cellulitis
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype HP:0002013 ! Vomiting
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype HP:0002018 ! Nausea
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2327 ! viral gastritis
relationship: has_phenotype HP:0002017 ! Nausea and vomiting
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting.

[Term]
id: DOID:2327 ! viral gastritis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting.

[Term]
id: DOID:2354 ! myelophthisic anemia
relationship: has_phenotype HP:0001903 ! Anemia
! A myeloma and anemia that is located_in some people with diseases that affect the bone marrow.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype HP:0001259 ! Coma
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype HP:0001289 ! Confusion
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype HP:0001324 ! Muscle weakness
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2366 ! West Nile fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2366 ! West Nile fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2366 ! West Nile fever
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2366 ! West Nile fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2476 ! hereditary spastic paraplegia
relationship: has_phenotype HP:0001257 ! Spasticity
! A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.

[Term]
id: DOID:2476 ! hereditary spastic paraplegia
relationship: has_phenotype HP:0010550 ! Paraplegia
! A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.

[Term]
id: DOID:2571 ! Langerhans-cell histiocytosis
relationship: has_phenotype HP:0006530 ! Interstitial pulmonary disease
! A disease of metabolism and histiocytic and dendritic cell cancer and histiocytosis and interstitial lung disease that results_in the proliferation of Langerhans cells.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
relationship: has_phenotype HP:0000518 ! Cataract
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
relationship: has_phenotype HP:0001250 ! Seizures
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
relationship: has_phenotype HP:0002968 ! Rhizomelic shortening
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:270 ! liver sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver.

[Term]
id: DOID:2710 ! sick building syndrome
relationship: has_phenotype HP:0002315 ! Headache
! An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_phenotype HP:0002240 ! Hepatomegaly
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2784 ! lung sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of lung that is located_in the lung.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype HP:0001824 ! Weight loss
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype HP:0001903 ! Anemia
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2797 ! idiopathic interstitial pneumonia
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia located_in the lung parenchyma of unknown cause.

[Term]
id: DOID:2810 ! middle lobe syndrome
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2841 ! asthma
relationship: has_phenotype HP:0000739 ! Anxiety
! A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptomrecurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

[Term]
id: DOID:2841 ! asthma
relationship: has_phenotype HP:0002205 ! Recurrent respiratory infections
! A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptomrecurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

[Term]
id: DOID:2843 ! long QT syndrome
relationship: has_phenotype HP:0001664 ! Torsade de pointes
! An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).

[Term]
id: DOID:2843 ! long QT syndrome
relationship: has_phenotype HP:0001721 ! Irregular heart beat
! An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).

[Term]
id: DOID:2877 ! larynx sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of larynx that is located_in the larynx.

[Term]
id: DOID:2921 ! glomerulonephritis
relationship: has_phenotype HP:0000123 ! Nephritis
! A nephritis that causes inflammation of the glomeruli located_in kidney.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype HP:0001824 ! Weight loss
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype HP:0001903 ! Anemia
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype HP:0002240 ! Hepatomegaly
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2942 ! bronchiolitis
relationship: has_phenotype HP:0001945 ! Fever
! A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_phenotype HP:0001945 ! Fever
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_phenotype HP:0002202 ! Pleural effusion
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2962 ! Cockayne syndrome
relationship: has_phenotype HP:0000992 ! Cutaneous photosensitivity
! An autosomal recessive disease that is caused by  rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.

[Term]
id: DOID:2962 ! Cockayne syndrome
relationship: has_phenotype HP:0001517 ! Growth failure
! An autosomal recessive disease that is caused by  rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.

[Term]
id: DOID:2988 ! antiphospholipid syndrome
relationship: has_phenotype HP:0004420 ! Arterial thrombosis
! An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).

[Term]
id: DOID:2988 ! antiphospholipid syndrome
relationship: has_phenotype HP:0002960 ! Autoimmunity
! An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).

[Term]
id: DOID:3049 ! Churg-Strauss syndrome
relationship: has_phenotype HP:0002099 ! Asthma
! A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.

[Term]
id: DOID:3049 ! Churg-Strauss syndrome
relationship: has_phenotype HP:0002239 ! Gastrointestinal hemorrhage
! A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0001662 ! Bradycardia
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0002019 ! Constipation
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0002039 ! Anorexia
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype HP:0002315 ! Headache
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3109 ! idiopathic CD4-positive T-lymphocytopenia
relationship: has_phenotype HP:0001888 ! Lymphopenia
! A lymphopenia that is caused by a reduction of CD4+ T lymphocytes.

[Term]
id: DOID:3162 ! malignant spindle cell melanoma
relationship: has_phenotype HP:0002861 ! Malignant melanoma
! A melanoma that is most commonly located_in sun-exposed skin and results_in_formation_ of spindle-like shaped cells that have a high recurrence rate even with treatment.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_phenotype HP:0002309 ! Weakness
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_phenotype HP:0003552 ! Muscle stiffness
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:3234 ! central nervous system lymphoma
relationship: has_phenotype HP:0002665 ! Lymphoma
! A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype HP:0001250 ! Seizures
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype HP:0002452 ! Cerebrovascular accident
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype HP:0002098 ! Respiratory distress
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype HP:0002789 ! Tachypnea
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype HP:0002835 ! Aspiration
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3241 ! lipid pneumonia
relationship: has_phenotype HP:0002835 ! Aspiration
! An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.

[Term]
id: DOID:3241 ! lipid pneumonia
relationship: has_phenotype HP:0002835 ! Aspiration
! An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.

[Term]
id: DOID:3252 ! prostate rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:3254 ! bile duct rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of bile duct that is located_in the bile duct.

[Term]
id: DOID:3264 ! subacute leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity.

[Term]
id: DOID:3264 ! subacute leukemia
relationship: has_phenotype HP:0005558 ! Chronic leukemia
! A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity.

[Term]
id: DOID:3264 ! subacute leukemia
relationship: has_phenotype HP:0011009 ! Acute
! A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3298 ! vaccinia
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.

[Term]
id: DOID:3310 ! atopic dermatitis
relationship: has_phenotype HP:0000964 ! Eczema
! A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.

[Term]
id: DOID:3341 ! osteitis fibrosa
relationship: has_phenotype HP:0000843 ! Hyperparathyroidism
! A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.

[Term]
id: DOID:3341 ! osteitis fibrosa
relationship: has_phenotype HP:0000752 ! Hyperactivity
! A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_phenotype HP:0001609 ! Hoarse voice
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_phenotype HP:0001686 ! Loss of voice
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3459 ! breast carcinoma
relationship: has_phenotype HP:0003002 ! Breast carcinoma
! A breast cancer that derives_from breast tissue.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_phenotype HP:0001945 ! Fever
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
relationship: has_phenotype HP:0100658 ! Cellulitis
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3764 ! Denys-Drash syndrome
relationship: has_phenotype HP:0000037 ! Male pseudohermaphroditism
! An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).

[Term]
id: DOID:3764 ! Denys-Drash syndrome
relationship: has_phenotype HP:0001967 ! Diffuse mesangial sclerosis
! An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).

[Term]
id: DOID:3764 ! Denys-Drash syndrome
relationship: has_phenotype HP:0002667 ! Nephroblastoma (Wilms tumor)
! An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).

[Term]
id: DOID:3905 ! lung carcinoma
relationship: has_phenotype HP:0001824 ! Weight loss
! A lung cancer that is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.

[Term]
id: DOID:3905 ! lung carcinoma
relationship: has_phenotype HP:0002105 ! Hemoptysis
! A lung cancer that is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_phenotype HP:0002013 ! Vomiting
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_phenotype HP:0002018 ! Nausea
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype HP:0001824 ! Weight loss
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype HP:0001945 ! Fever
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype HP:0002013 ! Vomiting
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype HP:0002018 ! Nausea
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype HP:0002039 ! Anorexia
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:4047 ! liver rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of liver that are located_in the liver.

[Term]
id: DOID:4049 ! mediastinum rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the mediastinum that is located_in the mediastinum and affects children and adolescents.

[Term]
id: DOID:4050 ! mediastinum sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant mediastinal mesenchymnal tumor that is located_in the mediastinum.

[Term]
id: DOID:4053 ! rectum rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:4054 ! prostate sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of prostate that is located_in the prostate.

[Term]
id: DOID:4057 ! gallbladder rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and rhabdomyosarcoma that is located_in the gallbladder.

[Term]
id: DOID:4058 ! gallbladder sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4061 ! testis rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the testis that is located_in the testis.

[Term]
id: DOID:4062 ! testis sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of testis that is located_in the testis.

[Term]
id: DOID:4064 ! bile duct sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant tumor of extrahepatic bile duct that is located_in the bile duct.

[Term]
id: DOID:4066 ! anus rhabdomyosarcoma
relationship: has_phenotype HP:0002859 ! Rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:4067 ! anus sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of anus that is located_in the anus.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype HP:0000952 ! Jaundice
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype HP:0001824 ! Weight loss
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype HP:0001945 ! Fever
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype HP:0002039 ! Anorexia
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_phenotype HP:0001718 ! Mitral stenosis
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_phenotype HP:0006685 ! Endocardial fibrosis
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
relationship: has_phenotype HP:0100584 ! Endocarditis
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_phenotype HP:0000520 ! Proptosis
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4151 ! skull base chordoma
relationship: has_phenotype HP:0010762 ! Chordoma
! A chordoma that is located_in the skull base.

[Term]
id: DOID:4152 ! chondroid chordoma
relationship: has_phenotype HP:0010762 ! Chordoma
! A chordoma that histologically derives_from chordoma, derives_from chondroma, and derives_from chondrosarcoma.

[Term]
id: DOID:4152 ! chondroid chordoma
relationship: has_phenotype HP:0006765 ! Chondrosarcoma
! A chordoma that histologically derives_from chordoma, derives_from chondroma, and derives_from chondrosarcoma.

[Term]
id: DOID:4152 ! chondroid chordoma
relationship: has_phenotype HP:0010762 ! Chordoma
! A chordoma that histologically derives_from chordoma, derives_from chondroma, and derives_from chondrosarcoma.

[Term]
id: DOID:4153 ! spinal chordoma
relationship: has_phenotype HP:0010762 ! Chordoma
! A chordoma that derives_from the spine.

[Term]
id: DOID:418 ! systemic scleroderma
relationship: has_phenotype HP:0100324 ! Scleroderma
! A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.

[Term]
id: DOID:4233 ! clear cell sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

[Term]
id: DOID:4235 ! spindle cell sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy.

[Term]
id: DOID:4242 ! kidney sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of kidney that is located_in the kidney's connective tissue.

[Term]
id: DOID:4253 ! melorheostosis
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex.

[Term]
id: DOID:4257 ! Caffey disease
relationship: has_phenotype HP:0000737 ! Irritability
! A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability.

[Term]
id: DOID:4257 ! Caffey disease
relationship: has_phenotype HP:0000737 ! Irritability
! A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype HP:0002014 ! Diarrhea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype HP:0002309 ! Weakness
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0002014 ! Diarrhea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype HP:0100749 ! Chest pain
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4336 ! tinea favosa
relationship: has_phenotype HP:0100699 ! Scarring
! A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_phenotype HP:0001596 ! Alopecia
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype HP:0002829 ! Arthralgia
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4480 ! achondroplasia
relationship: has_phenotype HP:0001516 ! Dwarfism
! An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype HP:0001945 ! Fever
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype HP:0002013 ! Vomiting
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype HP:0002014 ! Diarrhea
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype HP:0002018 ! Nausea
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype HP:0002090 ! Pneumonia
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_phenotype HP:0000113 ! Polycystic kidney dysplasia
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
relationship: has_phenotype HP:0001417 ! X-linked inheritance
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4514 ! thyroid angiosarcoma
relationship: has_phenotype HP:0000853 ! Goiter
! A thyroid sarcoma and angiosarcoma that results_in a high prevalence of iodine-deficient goiter.

[Term]
id: DOID:4515 ! thyroid sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of thyroid that is located_in the supporting cells of the thyroid.

[Term]
id: DOID:4647 ! trilateral retinoblastoma
relationship: has_phenotype HP:0009919 ! Retinoblastoma
! A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region.

[Term]
id: DOID:4653 ! intraocular retinoblastoma
relationship: has_phenotype HP:0009919 ! Retinoblastoma
! A retinoblastoma that is located_in the eye and has not spread to other parts of the body.

[Term]
id: DOID:4837 ! Gorham's disease
relationship: has_phenotype HP:0002797 ! Osteolysis
! A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.

[Term]
id: DOID:4885 ! Colorado tick fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.

[Term]
id: DOID:4885 ! Colorado tick fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.

[Term]
id: DOID:4885 ! Colorado tick fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_phenotype HP:0001824 ! Weight loss
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_phenotype HP:0001945 ! Fever
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
relationship: has_phenotype HP:0001336 ! Myoclonus
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_phenotype HP:0001324 ! Muscle weakness
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_phenotype HP:0003326 ! Myalgia
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_phenotype HP:0010535 ! Sleep apnea
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype HP:0011009 ! Acute
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4962 ! pericardial tuberculosis
relationship: has_phenotype HP:0001698 ! Pericardial effusion
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4962 ! pericardial tuberculosis
relationship: has_phenotype HP:0005132 ! Pericardial constriction
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4962 ! pericardial tuberculosis
relationship: has_phenotype HP:0011010 ! Chronic
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype HP:0000388 ! Otitis media
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype HP:0001287 ! Meningitis
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype HP:0002090 ! Pneumonia
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype HP:0002586 ! Peritonitis
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype HP:0100584 ! Endocarditis
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_phenotype HP:0001945 ! Fever
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_phenotype HP:0002315 ! Headache
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4997 ! Camurati-Engelmann disease
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.

[Term]
id: DOID:4997 ! Camurati-Engelmann disease
relationship: has_phenotype HP:0011001 ! Increased bone mineral density
! An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_phenotype HP:0000219 ! Thin upper lip vermilion
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_phenotype HP:0002209 ! Sparse scalp hair
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_phenotype HP:0004322 ! Short stature
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:5052 ! melioidosis
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.

[Term]
id: DOID:5052 ! melioidosis
relationship: has_phenotype HP:0002098 ! Respiratory distress
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.

[Term]
id: DOID:5052 ! melioidosis
relationship: has_phenotype HP:0100749 ! Chest pain
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5183 ! hereditary Wilms' tumor
relationship: has_phenotype HP:0002667 ! Nephroblastoma (Wilms tumor)
! A nephroblastoma that results_in either bilateral disease or a family history of Wilms' tumour.

[Term]
id: DOID:5190 ! cervical Wilms' tumor
relationship: has_phenotype HP:0002667 ! Nephroblastoma (Wilms tumor)
! A nephroblastoma and malignant cervical mixed epithelial and mesenchymal neoplasm that is located_in the cervix.

[Term]
id: DOID:5204 ! fructose-1,6-bisphosphatase deficiency
relationship: has_phenotype HP:0001942 ! Metabolic acidosis
! A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.

[Term]
id: DOID:5204 ! fructose-1,6-bisphosphatase deficiency
relationship: has_phenotype HP:0001943 ! Hypoglycemia
! A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.

[Term]
id: DOID:5259 ! colon leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and sarcoma of colon that is located_in the colon.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_phenotype HP:0002014 ! Diarrhea
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:5260 ! colon sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant tumor of colon that is located_in the colon.

[Term]
id: DOID:5262 ! heart sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant neoplasm of heart that is located_in the heart.

[Term]
id: DOID:5265 ! lung leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and sarcoma of lung that is located_in the lung.

[Term]
id: DOID:5272 ! small intestinal sarcoma
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and malignant tumor of small intestine that is located_in the small intestine.

[Term]
id: DOID:5275 ! gallbladder leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:5287 ! kidney leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5292 ! mediastinum leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels.

[Term]
id: DOID:5293 ! extrahepatic bile duct leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver.

[Term]
id: DOID:5296 ! liver leiomyosarcoma
relationship: has_phenotype HP:0100243 ! Leiomyosarcoma
! A leiomyosarcoma and sarcoma of liver that is located_in the liver.

[Term]
id: DOID:5501 ! Pediculus humanus capitis infestation
relationship: has_phenotype HP:0000737 ! Irritability
! A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

[Term]
id: DOID:5524 ! adenoid squamous cell carcinoma
relationship: has_phenotype HP:0002860 ! Squamous cell carcinoma
! A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

[Term]
id: DOID:5621 ! histiocytic and dendritic cell cancer
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma and hematologic cancer that derives_from follicular lymphoma.

[Term]
id: DOID:5810 ! adenosine deaminase deficiency
relationship: has_phenotype HP:0004430 ! Severe combined immunodeficiency
! A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP.

[Term]
id: DOID:5813 ! purine nucleoside phosphorylase deficiency
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder caused by a mutaion in the PNP gene and characterized mainly by decreased T-cell function.

[Term]
id: DOID:5822 ! gray zone lymphoma
relationship: has_phenotype HP:0002665 ! Lymphoma
! A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_phenotype HP:0000975 ! Hyperhidrosis
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_phenotype HP:0001945 ! Fever
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:594 ! panic disorder
relationship: has_phenotype HP:0001962 ! Palpitations
! An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

[Term]
id: DOID:594 ! panic disorder
relationship: has_phenotype HP:0100749 ! Chest pain
! An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

[Term]
id: DOID:6004 ! aleukemic leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that arises from changes in the tissues forming white blood cells and characterized by a normal or decreased number of white blood cells in the circulating blood.

[Term]
id: DOID:6132 ! bronchitis
relationship: has_phenotype HP:0001945 ! Fever
! A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.

[Term]
id: DOID:6364 ! migraine
relationship: has_phenotype HP:0002018 ! Nausea
! A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

[Term]
id: DOID:6364 ! migraine
relationship: has_phenotype HP:0002315 ! Headache
! A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

[Term]
id: DOID:646 ! viral encephalitis
relationship: has_phenotype HP:0002383 ! Encephalitis
! An encephalitis that involves inflammation of the brain caused by viral infection.

[Term]
id: DOID:6676 ! Froelich's syndrome
relationship: has_phenotype HP:0001263 ! Global developmental delay
! A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus.

[Term]
id: DOID:6676 ! Froelich's syndrome
relationship: has_phenotype HP:0001513 ! Obesity
! A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus.

[Term]
id: DOID:6678 ! tooth and nail syndrome
relationship: has_phenotype HP:0000668 ! Hypodontia
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype HP:0001004 ! Lymphedema
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype HP:0001394 ! Cirrhosis
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype HP:0001396 ! Cholestasis
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6741 ! bilateral breast cancer
relationship: has_phenotype HP:0003002 ! Breast carcinoma
! A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

[Term]
id: DOID:6741 ! bilateral breast cancer
relationship: has_phenotype HP:0003002 ! Breast carcinoma
! A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

[Term]
id: DOID:6759 ! bone lymphoma
relationship: has_phenotype HP:0002665 ! Lymphoma
! A bone cancer and lymphoma by site that results_in lymphoma starting in the bone.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
relationship: has_phenotype HP:0001370 ! Rheumatoid arthritis
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
relationship: has_phenotype HP:0002960 ! Autoimmunity
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:680 ! tauopathy
relationship: has_phenotype HP:0002185 ! Neurofibrillary tangles
! A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_phenotype HP:0002017 ! Nausea and vomiting
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:7033 ! anisakiasis
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:7148 ! rheumatoid arthritis
relationship: has_phenotype HP:0001369 ! Arthritis
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7148 ! rheumatoid arthritis
relationship: has_phenotype HP:0002960 ! Autoimmunity
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_phenotype HP:0001824 ! Weight loss
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_phenotype HP:0001945 ! Fever
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_phenotype HP:0002015 ! Dysphagia
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_phenotype HP:0100749 ! Chest pain
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype HP:0001945 ! Fever
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype HP:0002018 ! Nausea
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype HP:0002255 ! Bloody diarrhea
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype HP:0004396 ! Poor appetite
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype HP:0200042 ! skin ulcer
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7615 ! sarcomatosis
relationship: has_phenotype HP:0100242 ! Sarcoma
! A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body.

[Term]
id: DOID:768 ! retinoblastoma
relationship: has_phenotype HP:0003006 ! Neuroblastoma
! A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.

[Term]
id: DOID:813 ! septic arthritis
relationship: has_phenotype HP:0001369 ! Arthritis
! An arthritis that involves infection by a pathogen located_in joint.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_phenotype HP:0002257 ! Chronic rhinitis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_phenotype HP:0001945 ! Fever
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_phenotype HP:0002013 ! Vomiting
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_phenotype HP:0002018 ! Nausea
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8398 ! osteoarthritis
relationship: has_phenotype HP:0001369 ! Arthritis
! An arthritis that has_material_basis_in worn out cartilage located_in joint.

[Term]
id: DOID:840 ! cork-handlers' disease
relationship: has_phenotype HP:0001945 ! Fever
! An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia.

[Term]
id: DOID:840 ! cork-handlers' disease
relationship: has_phenotype HP:0002094 ! Dyspnea
! An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_phenotype HP:0001824 ! Weight loss
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_phenotype HP:0001945 ! Fever
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_phenotype HP:0006530 ! Interstitial pulmonary disease
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:8461 ! Aicardi syndrome
relationship: has_phenotype HP:0007858 ! Chorioretinal lacunae
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8469 ! influenza
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8469 ! influenza
relationship: has_phenotype HP:0002309 ! Weakness
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:848 ! arthritis
relationship: has_phenotype HP:0002829 ! Arthralgia
! A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint.

[Term]
id: DOID:8502 ! bullous skin disease
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested.

[Term]
id: DOID:8504 ! impetigo
relationship: has_phenotype HP:0000999 ! Pyoderma
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8506 ! bullous pemphigoid
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! An autoimmune disease of skin and connective tissue characterized by large blisters.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_phenotype HP:0001635 ! Congestive heart failure
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8536 ! herpes zoster
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.

[Term]
id: DOID:8536 ! herpes zoster
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.

[Term]
id: DOID:8536 ! herpes zoster
relationship: has_phenotype HP:0003401 ! Paresthesia
! A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.

[Term]
id: DOID:8536 ! herpes zoster
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype HP:0001744 ! Splenomegaly
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_phenotype HP:0011009 ! Acute
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8607 ! herpetic whitlow
relationship: has_phenotype HP:0001945 ! Fever
! A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes.

[Term]
id: DOID:8622 ! measles
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8622 ! measles
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype HP:0002018 ! Nausea
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype HP:0002039 ! Anorexia
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8704 ! genital herpes
relationship: has_phenotype HP:0001945 ! Fever
! A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.

[Term]
id: DOID:8725 ! vascular dementia
relationship: has_phenotype HP:0000726 ! Dementia
! A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:874 ! bacterial pneumonia
relationship: has_phenotype HP:0002090 ! Pneumonia
! A pneumonia involving inflammation of the lungs caused by bacteria.

[Term]
id: DOID:8761 ! megakaryocytic leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

[Term]
id: DOID:8781 ! rubella
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8941 ! seborrheic infantile dermatitis
relationship: has_phenotype HP:0001051 ! Seborrheic dermatitis
! A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

[Term]
id: DOID:90 ! degenerative disc disease
relationship: has_phenotype HP:0001944 ! Dehydration
! A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.

[Term]
id: DOID:9060 ! pityriasis versicolor
relationship: has_phenotype HP:0011010 ! Chronic
! A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_phenotype HP:0010783 ! Erythema
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_phenotype HP:0000737 ! Irritability
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_phenotype HP:0001945 ! Fever
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9113 ! granuloma inguinale
relationship: has_phenotype HP:0003249 ! Genital ulcers
! A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers.

[Term]
id: DOID:9123 ! eczema herpeticum
relationship: has_phenotype HP:0001945 ! Fever
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9123 ! eczema herpeticum
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_phenotype HP:0001824 ! Weight loss
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_phenotype HP:0001945 ! Fever
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
relationship: has_phenotype HP:0011010 ! Chronic
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9159 ! gas gangrene
relationship: has_phenotype HP:0008066 ! Abnormal blistering of the skin
! A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.

[Term]
id: DOID:9159 ! gas gangrene
relationship: has_phenotype HP:0100806 ! Sepsis
! A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_phenotype HP:0002583 ! Colitis
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype HP:0000360 ! Tinnitus
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype HP:0002321 ! Vertigo
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype HP:0003470 ! Paralysis
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_phenotype HP:0001789 ! Hydrops fetalis
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_phenotype HP:0010442 ! Polydactyly
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9250 ! acrocallosal syndrome
relationship: has_phenotype HP:0001249 ! Intellectual disability
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9250 ! acrocallosal syndrome
relationship: has_phenotype HP:0001274 ! Agenesis of corpus callosum
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9250 ! acrocallosal syndrome
relationship: has_phenotype HP:0010442 ! Polydactyly
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9250 ! acrocallosal syndrome
relationship: has_phenotype HP:0000007 ! Autosomal recessive inheritance
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9254 ! mast-cell leukemia
relationship: has_phenotype HP:0001909 ! Leukemia
! A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype HP:0001250 ! Seizures
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype HP:0001276 ! Hypertonia
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype HP:0002013 ! Vomiting
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype HP:0010864 ! Intellectual disability, severe
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9360 ! intrinsic asthma
relationship: has_phenotype HP:0000739 ! Anxiety
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9360 ! intrinsic asthma
relationship: has_phenotype HP:0002099 ! Asthma
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9360 ! intrinsic asthma
relationship: has_phenotype HP:0002883 ! Hyperventilation
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9395 ! croup
relationship: has_phenotype HP:0000969 ! Edema
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9415 ! allergic asthma
relationship: has_phenotype HP:0002099 ! Asthma
! An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.

[Term]
id: DOID:9471 ! meningitis
relationship: has_phenotype HP:0001287 ! Meningitis
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
relationship: has_phenotype HP:0001287 ! Meningitis
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0000093 ! Proteinuria
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0000509 ! Conjunctivitis
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0002013 ! Vomiting
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0002014 ! Diarrhea
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0002027 ! Abdominal pain
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype HP:0003418 ! Back pain
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9551 ! smoldering myeloma
relationship: has_phenotype HP:0006775 ! Multiple myeloma
! A multiple myeloma that is a slow growing type of myeloma in which abnormal plasma cells results_in too much of a single type of monoclonal antibody.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype HP:0002205 ! Recurrent respiratory infections
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype HP:0002721 ! Immunodeficiency
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype HP:0100526 ! Neoplasia of the lungs
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype HP:0011010 ! Chronic
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype HP:0002110 ! Bronchiectasis
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_phenotype HP:0000613 ! Photophobia
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype HP:0002013 ! Vomiting
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype HP:0002014 ! Diarrhea
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype HP:0002018 ! Nausea
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype HP:0002309 ! Weakness
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype HP:0002013 ! Vomiting
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype HP:0002014 ! Diarrhea
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype HP:0002315 ! Headache
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype HP:0002716 ! Lymphadenopathy
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype HP:0002829 ! Arthralgia
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype HP:0010783 ! Erythema
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9643 ! babesiosis
relationship: has_phenotype HP:0001878 ! Hemolytic anemia
! A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

[Term]
id: DOID:9643 ! babesiosis
relationship: has_phenotype HP:0001903 ! Anemia
! A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_phenotype HP:0000952 ! Jaundice
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_phenotype HP:0003326 ! Myalgia
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9744 ! type 1 diabetes mellitus
relationship: has_phenotype HP:0000819 ! Diabetes mellitus
! A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.

[Term]
id: DOID:9808 ! Goodpasture syndrome
relationship: has_phenotype HP:0000099 ! Glomerulonephritis
! An autoimmune disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung.

[Term]
id: DOID:9808 ! Goodpasture syndrome
relationship: has_phenotype HP:0002960 ! Autoimmunity
! An autoimmune disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_phenotype HP:0011010 ! Chronic
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_phenotype HP:0002617 ! Aneurysm
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9909 ! hordeolum
relationship: has_phenotype HP:0010606 ! Hordeolum
! Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_phenotype HP:0001945 ! Fever
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
relationship: has_phenotype HP:0002315 ! Headache
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:9931 ! Waterhouse-Friderichsen syndrome
relationship: has_phenotype HP:0001287 ! Meningitis
! A meningococcal meningitis described as an adrenal gland hypofunction disease functionally, resulting from a meningococcal infection caused by the bacterium Neisseria meningitidis, which is characterized by hemorrhages in the adrenal glands, usually observed in severe cases of meningitis. Infection can also be caused by Streptococcus pneumoniae infection. Staphylococcus aureus has recently also been implicated in pediatric WFS. The symptoms include fever, rigors, vomiting, headache, rash, hypotension and septic shock.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype HP:0001433 ! Hepatosplenomegaly
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype HP:0001882 ! Leukopenia
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype HP:0001903 ! Anemia
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype HP:0001945 ! Fever
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype HP:0003326 ! Myalgia
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.