do-bridge-has_phenotype-MP.obo

[Term]
id: DOID:0050025 ! human granulocytic anaplasmosis
relationship: has_phenotype MP:0002899 ! fatigue
! An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050026 ! human monocytic ehrlichiosis
relationship: has_phenotype MP:0002899 ! fatigue
! An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050041 ! Astrakhan spotted fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia conorii subsp caspia, which is trasnmitted_by ticks (Rhipicephalus pumilio and Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050042 ! Indian tick typhus
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia conorii subsp indica, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050043 ! Israeli tick typhus
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050046 ! Far Eastern spotted fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy.

[Term]
id: DOID:0050047 ! Flinders Island spotted fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia honei, which is transmitted_by cayenne ticks (Amblyomma cajennense). The infection has_symptom mild spotted fever, has_symptom eschar and has_symptom adenopathy.

[Term]
id: DOID:0050050 ! Japanese spotted fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities.

[Term]
id: DOID:0050068 ! pestis minor
relationship: has_phenotype MP:0003865 ! lymph node inflammation
! A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration.

[Term]
id: DOID:0050073 ! invasive aspergillosis
relationship: has_phenotype MP:0001914 ! hemorrhage
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050073 ! invasive aspergillosis
relationship: has_phenotype MP:0001861 ! lung inflammation
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050084 ! rhinotracheitis
relationship: has_phenotype MP:0001852 ! conjunctivitis
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050084 ! rhinotracheitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype MP:0002064 ! seizures
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
relationship: has_phenotype MP:0005152 ! pancytopenia
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050125 ! dengue shock syndrome
relationship: has_phenotype MP:0001596 ! hypotension
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_phenotype MP:0003267 ! constipation
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
relationship: has_phenotype MP:0005036 ! diarrhea
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050131 ! motility-related diarrhea
relationship: has_phenotype MP:0005036 ! diarrhea
! Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
relationship: has_phenotype MP:0005036 ! diarrhea
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050134 ! cutaneous mycosis
relationship: has_phenotype MP:0001212 ! skin lesions
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050140 ! acute diarrhea
relationship: has_phenotype MP:0005036 ! diarrhea
! A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

[Term]
id: DOID:0050145 ! adenoiditis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050147 ! otomycosis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050148 ! laryngotracheitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.

[Term]
id: DOID:0050152 ! aspiration pneumonia
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050152 ! aspiration pneumonia
relationship: has_phenotype MP:0003158 ! dysphagia
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050152 ! aspiration pneumonia
relationship: has_phenotype MP:0005426 ! tachypnea
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype MP:0001263 ! weight loss
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
relationship: has_phenotype MP:0002899 ! fatigue
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050158 ! respiratory bronchiolitis-associated interstitial lung disease
relationship: has_phenotype MP:0002499 ! chronic inflammation
! A idiopathic interstitial pneumonia which involves bronchiolocentric alveolar macrophage accumulation, mild bronchiolar fibrosis and chronic inflammation. Respiratory bronchiolitis is a histopathologic lesion found in cigarette smokers and is characterized by the presence of pigmented intralumenal macrophages within first- and second-order respiratory bronchioles.

[Term]
id: DOID:0050158 ! respiratory bronchiolitis-associated interstitial lung disease
relationship: has_phenotype MP:0003045 ! fibrosis
! A idiopathic interstitial pneumonia which involves bronchiolocentric alveolar macrophage accumulation, mild bronchiolar fibrosis and chronic inflammation. Respiratory bronchiolitis is a histopathologic lesion found in cigarette smokers and is characterized by the presence of pigmented intralumenal macrophages within first- and second-order respiratory bronchioles.

[Term]
id: DOID:0050160 ! inhalation anthrax
relationship: has_phenotype MP:0001954 ! respiratory distress
! An anthrax disease that results_in infection located_in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
relationship: has_phenotype MP:0005202 ! lethargy
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype MP:0000745 ! tremors
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype MP:0002064 ! seizures
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050179 ! Powassan encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
relationship: has_phenotype MP:0000221 ! decreased leukocyte cell number
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
relationship: has_phenotype MP:0003179 ! decreased platelet cell number
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype MP:0000746 ! weakness
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype MP:0000947 ! convulsive seizures
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype MP:0003261 ! hematemesis
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
relationship: has_phenotype MP:0003292 ! melena
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype MP:0002843 ! decreased systemic arterial blood pressure
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype MP:0003259 ! nausea
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
relationship: has_phenotype MP:0006149 ! blurred vision
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype MP:0001634 ! internal hemorrhage
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype MP:0003259 ! nausea
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype MP:0003260 ! vomiting
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050201 ! nephropathia epidemica
relationship: has_phenotype MP:0003606 ! kidney failure
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050202 ! lujo hemorrhagic fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that results_in infection, has_material_basis_in Lujo virus, which has_symptom bleeding.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype MP:0000611 ! jaundice
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype MP:0002899 ! fatigue
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype MP:0003259 ! nausea
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype MP:0003259 ! nausea
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype MP:0003260 ! vomiting
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype MP:0005036 ! diarrhea
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050211 ! swine influenza
relationship: has_phenotype MP:0005202 ! lethargy
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype MP:0002064 ! seizures
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype MP:0003259 ! nausea
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
relationship: has_phenotype MP:0003260 ! vomiting
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050246 ! granulomatous amebic encephalitis
relationship: has_phenotype MP:0001641 ! death
! A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

[Term]
id: DOID:0050253 ! mesocestoidiasis
relationship: has_phenotype MP:0003259 ! nausea
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050253 ! mesocestoidiasis
relationship: has_phenotype MP:0003260 ! vomiting
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050253 ! mesocestoidiasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype MP:0001263 ! weight loss
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype MP:0003259 ! nausea
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype MP:0003260 ! vomiting
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype MP:0003267 ! constipation
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050254 ! acanthocephaliasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_phenotype MP:0001641 ! death
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050259 ! baylisascariasis
relationship: has_phenotype MP:0002001 ! blindness
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050266 ! tungiasis
relationship: has_phenotype MP:0004947 ! skin inflammation
! A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype MP:0001212 ! skin lesions
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype MP:0001263 ! weight loss
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050288 ! penicilliosis
relationship: has_phenotype MP:0001577 ! anemia
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype MP:0003179 ! decreased platelet cell number
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050339 ! commensal bacterial infectious disease
relationship: has_phenotype MP:0001924 ! infertility
! A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype MP:0003158 ! dysphagia
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype MP:0006149 ! blurred vision
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050352 ! foodborne botulism
relationship: has_phenotype MP:0006150 ! double vision
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype MP:0000747 ! muscle weakness
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype MP:0001344 ! blepharoptosis
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype MP:0003267 ! constipation
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050354 ! infant botulism
relationship: has_phenotype MP:0005202 ! lethargy
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050383 ! typhoidal tularemia
relationship: has_phenotype MP:0001263 ! weight loss
! A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_phenotype MP:0002639 ! micrognathia
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_phenotype MP:0004592 ! small mandible
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
relationship: has_phenotype MP:0006253 ! clinodactyly
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050473 ! Alstrom syndrome
relationship: has_phenotype MP:0002001 ! blindness
! An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.

[Term]
id: DOID:0050473 ! Alstrom syndrome
relationship: has_phenotype MP:0004740 ! sensorineural hearing loss
! An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype MP:0003259 ! nausea
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050481 ! endemic typhus
relationship: has_phenotype MP:0003260 ! vomiting
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
relationship: has_phenotype MP:0002899 ! fatigue
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype MP:0001212 ! skin lesions
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype MP:0001848 ! choroid inflammation
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype MP:0001891 ! hydroencephaly
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050488 ! early congenital syphilis
relationship: has_phenotype MP:0002064 ! seizures
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
relationship: has_phenotype MP:0005202 ! lethargy
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0000746 ! weakness
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0000753 ! paralysis
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0005048 ! thrombosis
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0005150 ! cachexia
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0006149 ! blurred vision
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0009434 ! paraparesis
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050513 ! spinal polio
relationship: has_phenotype MP:0000753 ! paralysis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
relationship: has_phenotype MP:0000753 ! paralysis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050515 ! paralytic poliomyelitis
relationship: has_phenotype MP:0000743 ! muscle spasm
! A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:0050516 ! O'nyong'nyong fever
relationship: has_phenotype MP:0003865 ! lymph node inflammation
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.

[Term]
id: DOID:0050521 ! Oropouche fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype MP:0003606 ! kidney failure
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
relationship: has_phenotype MP:0008816 ! petechiae
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050523 ! adult T-cell leukemia
relationship: has_phenotype MP:0001212 ! skin lesions
! A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype MP:0001190 ! reddish skin
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype MP:0001212 ! skin lesions
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050553 ! JMP syndrome
relationship: has_phenotype MP:0011174 ! lipodystrophy
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050576 ! Senior-Loken syndrome
relationship: has_phenotype MP:0005150 ! cachexia
! An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype MP:0005011 ! increased eosinophil cell number
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050601 ! ADULT syndrome
relationship: has_phenotype MP:0000416 ! sparse hair
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_phenotype MP:0000745 ! tremors
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
relationship: has_phenotype MP:0004144 ! hypotonia
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_phenotype MP:0004143 ! hypertonia
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
relationship: has_phenotype MP:0004144 ! hypotonia
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype MP:0002269 ! muscular atrophy
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype MP:0005036 ! diarrhea
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
relationship: has_phenotype MP:0005202 ! lethargy
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050740 ! Qazi Markouizos syndrome
relationship: has_phenotype MP:0004144 ! hypotonia
! A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation.

[Term]
id: DOID:0060000 ! infective endocarditis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection.

[Term]
id: DOID:0060013 ! gamma chain deficiency
relationship: has_phenotype MP:0002536 ! severe combined immunodeficiency disease
! A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.

[Term]
id: DOID:0060017 ! CD3epsilon deficiency
relationship: has_phenotype MP:0001791 ! immunodeficiency
! A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex.

[Term]
id: DOID:0060018 ! CD3gamma deficiency
relationship: has_phenotype MP:0001791 ! immunodeficiency
! A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype MP:0001823 ! thymus hypoplasia
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype MP:0005016 ! decreased lymphocyte cell number
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060020 ! reticular dysgenesis
relationship: has_phenotype MP:0002536 ! severe combined immunodeficiency disease
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060021 ! DNA ligase IV deficiency
relationship: has_phenotype MP:0001791 ! immunodeficiency
! A combined T cell and B cell immunodeficiency that is caused by a mutatino in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.

[Term]
id: DOID:0060022 ! CD40 ligand deficiency
relationship: has_phenotype MP:0001791 ! immunodeficiency
! A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.

[Term]
id: DOID:0060024 ! lambda 5 deficiency
relationship: has_phenotype MP:0002539 ! B cell deficiency
! A B cell deficiency that is caused by mutations in the IGLL1 gene. Lambda 5 mutations an cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.

[Term]
id: DOID:0060025 ! immunoglobulin alpha deficiency
relationship: has_phenotype MP:0002539 ! B cell deficiency
! A B cell deficiency that is an autosomal recessive disorder caused by mutation in the IgA (CD79 alpha) antigen receptor.

[Term]
id: DOID:0060027 ! B cell linker protein deficiency
relationship: has_phenotype MP:0002539 ! B cell deficiency
! A hypobammaglobulinemia that is a B cell deficiency caused by a mutation a cytoplasmic linker or adaptor protein that plays a critical role in B cell development, the B cell linker protein (BLNK) gene. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. The BLNK gene is associated with intracellular calcium mobilization, essential for cell activation.

[Term]
id: DOID:0060062 ! familial juvenile hyperuricemic nephropathy
relationship: has_phenotype MP:0008821 ! increased blood uric acid level
! A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease.

[Term]
id: DOID:0060169 ! benign familial infantile epilepsy
relationship: has_phenotype MP:0000947 ! convulsive seizures
! An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
relationship: has_phenotype MP:0000746 ! weakness
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype MP:0000433 ! microcephaly
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype MP:0001147 ! small testis
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0060179 ! Renpenning syndrome
relationship: has_phenotype MP:0001255 ! decreased body height
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0080022 ! McKusick type metaphyseal dysplasia
relationship: has_phenotype MP:0000416 ! sparse hair
! A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
relationship: has_phenotype MP:0011175 ! platyspondylia
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype MP:0000161 ! scoliosis
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype MP:0000162 ! lordosis
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype MP:0000576 ! clubfoot
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype MP:0001255 ! decreased body height
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
relationship: has_phenotype MP:0011175 ! platyspondylia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080032 ! craniodiaphyseal dysplasia
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
relationship: has_phenotype MP:0009877 ! exostosis
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080037 ! Worth's syndrome
relationship: has_phenotype MP:0009877 ! exostosis
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080037 ! Worth's syndrome
relationship: has_phenotype MP:0000062 ! increased bone mineral density
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080038 ! pycnodysostosis
relationship: has_phenotype MP:0000067 ! osteopetrosis
! An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.

[Term]
id: DOID:0080039 ! axial osteomalacia
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that results_in coarsening located_in trabecular bone.

[Term]
id: DOID:0080043 ! achondrogenesis
relationship: has_phenotype MP:0001641 ! death
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080044 ! hypochondrogenesis
relationship: has_phenotype MP:0002192 ! hydrops fetalis
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen.

[Term]
id: DOID:0080045 ! Kniest dysplasia
relationship: has_phenotype MP:0001258 ! decreased body length
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080052 ! acromesomelic dysplasia, Grebe type
relationship: has_phenotype MP:0008736 ! micromelia
! An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_phenotype MP:0001255 ! decreased body height
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
relationship: has_phenotype MP:0001261 ! obese
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080055 ! achondrogenesis type IB
relationship: has_phenotype MP:0006077 ! inguinal hernia
! An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen.

[Term]
id: DOID:0080056 ! achondrogenesis type II
relationship: has_phenotype MP:0002192 ! hydrops fetalis
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:10039 ! late congenital syphilis
relationship: has_phenotype MP:0000754 ! paresis
! A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has_symptom gummatous ulcers, has_symptom periosteal lesions, has_symptom paresis, has_symptom tabes, has_symptom optic atrophy, has_symptom interstitial keratitis, has_symptom sensorineural deafness, and has_symptom dental deformities.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype MP:0001263 ! weight loss
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype MP:0003260 ! vomiting
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10075 ! diphyllobothriasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia.

[Term]
id: DOID:10159 ! osteonecrosis
relationship: has_phenotype MP:0001651 ! necrosis
! An ischemic bone disease that results_in necrosis located_in bone.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_phenotype MP:0004510 ! myositis
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:10223 ! dermatomyositis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:1024 ! leprosy
relationship: has_phenotype MP:0001212 ! skin lesions
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:10242 ! ehrlichiosis
relationship: has_phenotype MP:0002899 ! fatigue
! A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash.

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype MP:0001799 ! Viral
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype MP:0001861 ! lung inflammation
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype MP:0001869 ! pancreas inflammation
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype MP:0003561 ! rheumatoid arthritis
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
relationship: has_phenotype MP:0009275 ! bruising
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10250 ! louping ill
relationship: has_phenotype MP:0005202 ! lethargy
! A viral infectious disease that results_in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted_by sheep tick, Ixodes ricinus. The infection has_symptom lethargy, has_symptom muscle pains, has_symptom fever, and has_symptom focal neurological signs.

[Term]
id: DOID:10264 ! mumps
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10326 ! Caplan's syndrome
relationship: has_phenotype MP:0003561 ! rheumatoid arthritis
! A pneumoconiosis that results_in humans that also have rheumatoid arthritis.

[Term]
id: DOID:10371 ! yaws
relationship: has_phenotype MP:0001212 ! skin lesions
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype MP:0001794 ! Bacterial
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype MP:0001799 ! Viral
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10456 ! tonsillitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10457 ! Legionnaires' disease
relationship: has_phenotype MP:0001861 ! lung inflammation
! A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

[Term]
id: DOID:10458 ! legionellosis
relationship: has_phenotype MP:0005036 ! diarrhea
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10459 ! common cold
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10516 ! malignant otitis externa
relationship: has_phenotype MP:0002055 ! Diabetes
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10533 ! viral pneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.

[Term]
id: DOID:10567 ! late yaws
relationship: has_phenotype MP:0001242 ! hyperkeratosis
! A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

[Term]
id: DOID:106 ! pleural tuberculosis
relationship: has_phenotype MP:0010334 ! pleural effusion
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:1060 ! Hartnup disease
relationship: has_phenotype MP:0003311 ! aminoaciduria
! An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_phenotype MP:0003267 ! constipation
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10608 ! celiac disease
relationship: has_phenotype MP:0005036 ! diarrhea
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10632 ! Wolfram syndrome
relationship: has_phenotype MP:0001967 ! deafness
! A genetic disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).

[Term]
id: DOID:10652 ! Alzheimer's disease
relationship: has_phenotype MP:0003214 ! neurofibrillary tangles
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10755 ! petrositis
relationship: has_phenotype MP:0005190 ! osteomyelitis
! An osteomyelitis that has_material_basis_in infection located_in petrous part of temporal bone.

[Term]
id: DOID:10784 ! Queensland tick typhus
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype MP:0002064 ! seizures
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype MP:0000746 ! weakness
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype MP:0000746 ! weakness
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10844 ! Japanese encephalitis
relationship: has_phenotype MP:0000745 ! tremors
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10844 ! Japanese encephalitis
relationship: has_phenotype MP:0000947 ! convulsive seizures
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_phenotype MP:0000745 ! tremors
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_phenotype MP:0000947 ! convulsive seizures
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
relationship: has_phenotype MP:0001208 ! blistering
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10882 ! epidemic pleurodynia
relationship: has_phenotype MP:0001651 ! necrosis
! A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache.

[Term]
id: DOID:10887 ! lepromatous leprosy
relationship: has_phenotype MP:0000414 ! alopecia
! A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

[Term]
id: DOID:10921 ! Siberian tick typhus
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia sibirica, which is transmitted_by ticks (Dermacentor nuttalli, Dermacentor marginatus and Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash.

[Term]
id: DOID:10983 ! Alport syndrome
relationship: has_phenotype MP:0002743 ! glomerulonephritis
! A monogenic disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss.

[Term]
id: DOID:11055 ! pasteurellosis
relationship: has_phenotype MP:0001861 ! lung inflammation
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11055 ! pasteurellosis
relationship: has_phenotype MP:0002626 ! increased heart rate
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
relationship: has_phenotype MP:0002899 ! fatigue
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype MP:0000746 ! weakness
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
relationship: has_phenotype MP:0002899 ! fatigue
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11104 ! spotted fever
relationship: has_phenotype MP:0002899 ! fatigue
! A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

[Term]
id: DOID:1114 ! esophagus sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of esophagus that is_located in the esophagus.

[Term]
id: DOID:1116 ! pertussis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

[Term]
id: DOID:11193 ! syndactyly
relationship: has_phenotype MP:0000566 ! synostosis
! A synostosis that results_in the fusion of two or more digits.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
relationship: has_phenotype MP:0006167 ! eyelid edema
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11260 ! rabies
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11262 ! ornithosis
relationship: has_phenotype MP:0001861 ! lung inflammation
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype MP:0003606 ! kidney failure
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
relationship: has_phenotype MP:0008816 ! petechiae
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11285 ! tick paralysis
relationship: has_phenotype MP:0001785 ! edema
! A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage.

[Term]
id: DOID:11285 ! tick paralysis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage.

[Term]
id: DOID:11285 ! tick paralysis
relationship: has_phenotype MP:0001914 ! hemorrhage
! A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage.

[Term]
id: DOID:11302 ! cercarial dermatitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has_symptom skin reddening, has_symptom skin itching, in the water or immediately after emerging and has_symptom itchy, raised papules, occur within hours of infection.

[Term]
id: DOID:11320 ! Kyasanur forest disease
relationship: has_phenotype MP:0001429 ! dehydration
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11320 ! Kyasanur forest disease
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11336 ! rhinoscleroma
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11337 ! Lemierre's syndrome
relationship: has_phenotype MP:0000218 ! increased leukocyte cell number
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11337 ! Lemierre's syndrome
relationship: has_phenotype MP:0005044 ! sepsis
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11339 ! pneumocystosis
relationship: has_phenotype MP:0001954 ! respiratory distress
! An opportunistic mycosis that is located_in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has_symptom nonproductive cough, has_symptom shortness of breath, and has_symptom fever.

[Term]
id: DOID:11360 ! Phlebotomus fever
relationship: has_phenotype MP:0002626 ! increased heart rate
! A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype MP:0003828 ! pulmonary edema
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype MP:0001861 ! lung inflammation
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype MP:0001953 ! respiratory failure
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype MP:0002296 ! aspiration
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
relationship: has_phenotype MP:0005044 ! sepsis
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11450 ! allergic cutaneous vasculitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

[Term]
id: DOID:11549 ! Adie syndrome
relationship: has_phenotype MP:0005163 ! cyclopia
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:1156 ! pseudogout
relationship: has_phenotype MP:0002993 ! arthritis
! An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype MP:0003259 ! nausea
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype MP:0003260 ! vomiting
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:11573 ! listeriosis
relationship: has_phenotype MP:0005036 ! diarrhea
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:1166 ! palindromic rheumatism
relationship: has_phenotype MP:0002993 ! arthritis
! A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype MP:0001194 ! dermatitis
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11678 ! onchocerciasis
relationship: has_phenotype MP:0002001 ! blindness
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11729 ! Lyme disease
relationship: has_phenotype MP:0002899 ! fatigue
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11760 ! Kohler's disease
relationship: has_phenotype MP:0001641 ! death
! An osteochondrosis that results_in death and collapse located_in navicular bone of foot.

[Term]
id: DOID:11812 ! bladder sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of urinary bladder that is located_in the bladder.

[Term]
id: DOID:11838 ! penis sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of penis that is located_in the penis.

[Term]
id: DOID:11917 ! tinea cruris
relationship: has_phenotype MP:0001208 ! blistering
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:11991 ! osteopoikilosis
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:12002 ! trachea sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant tumor of trachea that is located_in the trachea.

[Term]
id: DOID:1210 ! optic neuritis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
relationship: has_phenotype MP:0001864 ! vasculitis
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12140 ! Chagas disease
relationship: has_phenotype MP:0003260 ! vomiting
! A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12177 ! common variable immunodeficiency
relationship: has_phenotype MP:0001805 ! decreased IgG level
! A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).

[Term]
id: DOID:12205 ! dengue disease
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
relationship: has_phenotype MP:0003179 ! decreased platelet cell number
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype MP:0001242 ! hyperkeratosis
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype MP:0003390 ! lymphedema
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype MP:0003865 ! lymph node inflammation
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12211 ! filarial elephantiasis
relationship: has_phenotype MP:0010141 ! lymphangitis
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
relationship: has_phenotype MP:0008816 ! petechiae
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_phenotype MP:0000753 ! paralysis
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_phenotype MP:0005456 ! weight gain
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12294 ! atypical depressive disorder
relationship: has_phenotype MP:0009710 ! anhedonia
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12323 ! cough variant asthma
relationship: has_phenotype MP:0001954 ! respiratory distress
! An asthma that is characterized by chronic nonproductive cough without shortness of breath.

[Term]
id: DOID:12341 ! retroperitoneal sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12375 ! bronchopneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12386 ! balantidiasis
relationship: has_phenotype MP:0003259 ! nausea
! A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_phenotype MP:0000493 ! rectal prolapse
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:1252 ! trichuriasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:12522 ! bagassosis
relationship: has_phenotype MP:0000746 ! weakness
! An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12549 ! hepatitis A
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12663 ! blastomycosis
relationship: has_phenotype MP:0001212 ! skin lesions
! A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening.

[Term]
id: DOID:12683 ! vestibular neuronitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
relationship: has_phenotype MP:0002899 ! fatigue
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
relationship: has_phenotype MP:0001954 ! respiratory distress
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:12841 ! ancylostomiasis
relationship: has_phenotype MP:0001577 ! anemia
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12858 ! Huntington's disease
relationship: has_phenotype MP:0003224 ! neuron degeneration
! A neurodegenerative disease that has_material_basis_in expansion of CAG repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
relationship: has_phenotype MP:0000566 ! synostosis
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
relationship: has_phenotype MP:0000081 ! premature suture closure
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
relationship: has_phenotype MP:0000564 ! syndactyly
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12965 ! subleukemic leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that is characterized by the presence of abnormal white blood cells located_in peripheral blood, but in which the total number of white blood cells is normal.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype MP:0002626 ! increased heart rate
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
relationship: has_phenotype MP:0005426 ! tachypnea
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype MP:0002626 ! increased heart rate
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
relationship: has_phenotype MP:0005426 ! tachypnea
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13166 ! allergic bronchopulmonary aspergillosis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has_symptom cough, has_symptom wheezing and has_symptom fever.

[Term]
id: DOID:13189 ! gout
relationship: has_phenotype MP:0002993 ! arthritis
! An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.

[Term]
id: DOID:13226 ! oculoglandular tularemia
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_phenotype MP:0002499 ! chronic inflammation
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13241 ! Behcet's disease
relationship: has_phenotype MP:0005515 ! uveitis
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype MP:0000221 ! decreased leukocyte cell number
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype MP:0000691 ! enlarged spleen
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:13258 ! typhoid fever
relationship: has_phenotype MP:0005036 ! diarrhea
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:1328 ! Rift Valley fever
relationship: has_phenotype MP:0003261 ! hematemesis
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype MP:0000465 ! gastrointestinal hemorrhage
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype MP:0003259 ! nausea
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13282 ! intestinal tuberculosis
relationship: has_phenotype MP:0003260 ! vomiting
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13359 ! Ehlers-Danlos syndrome
relationship: has_phenotype MP:0009275 ! bruising
! A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype MP:0000691 ! enlarged spleen
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13371 ! scrub typhus
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13450 ! coccidioidomycosis
relationship: has_phenotype MP:0001852 ! conjunctivitis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.

[Term]
id: DOID:13450 ! coccidioidomycosis
relationship: has_phenotype MP:0002993 ! arthritis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.

[Term]
id: DOID:13521 ! tetanus neonatorum
relationship: has_phenotype MP:0000743 ! muscle spasm
! A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion.

[Term]
id: DOID:13523 ! loiasis
relationship: has_phenotype MP:0003045 ! fibrosis
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13533 ! osteopetrosis
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.

[Term]
id: DOID:1362 ! paranasal sinus sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant tumor of nasal sinuses that is located_in the paranasal sinus.

[Term]
id: DOID:13622 ! campylobacteriosis
relationship: has_phenotype MP:0005036 ! diarrhea
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_phenotype MP:0002038 ! carcinoma
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
relationship: has_phenotype MP:0009704 ! skin squamous cell carcinoma
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13819 ! lymphogranuloma venereum
relationship: has_phenotype MP:0010141 ! lymphangitis
! A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis.

[Term]
id: DOID:13891 ! bird fancier's lung
relationship: has_phenotype MP:0001954 ! respiratory distress
! An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen.

[Term]
id: DOID:1394 ! urinary schistosomiasis
relationship: has_phenotype MP:0003045 ! fibrosis
! A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype MP:0003259 ! nausea
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:1395 ! schistosomiasis
relationship: has_phenotype MP:0005161 ! hematuria
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype MP:0000691 ! enlarged spleen
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype MP:0000746 ! weakness
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
relationship: has_phenotype MP:0001263 ! weight loss
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14068 ! blackwater fever
relationship: has_phenotype MP:0003606 ! kidney failure
! A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

[Term]
id: DOID:14087 ! epicondylitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A bone inflammation disease that results_in inflammation located_in epicondyle.

[Term]
id: DOID:14095 ! boutonneuse fever
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype MP:0001596 ! hypotension
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype MP:0003260 ! vomiting
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14115 ! toxic shock syndrome
relationship: has_phenotype MP:0005036 ! diarrhea
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14179 ! Bruton-type agammaglobulinemia
relationship: has_phenotype MP:0001791 ! immunodeficiency
! A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

[Term]
id: DOID:14179 ! Bruton-type agammaglobulinemia
relationship: has_phenotype MP:0002539 ! B cell deficiency
! A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

[Term]
id: DOID:14239 ! gastrointestinal tularemia
relationship: has_phenotype MP:0003260 ! vomiting
! A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting.

[Term]
id: DOID:14256 ! adult-onset Still's disease
relationship: has_phenotype MP:0002993 ! arthritis
! An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

[Term]
id: DOID:14319 ! pleuropneumonia
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria.

[Term]
id: DOID:14319 ! pleuropneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria.

[Term]
id: DOID:14415 ! Legg-Calve-Perthes Disease
relationship: has_phenotype MP:0001641 ! death
! An osteochondrosis that results_in death and fracture located_in hip joint.

[Term]
id: DOID:1442 ! Alpers syndrome
relationship: has_phenotype MP:0000947 ! convulsive seizures
! A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.

[Term]
id: DOID:14422 ! dipetalonemiasis
relationship: has_phenotype MP:0001651 ! necrosis
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14422 ! dipetalonemiasis
relationship: has_phenotype MP:0003045 ! fibrosis
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14435 ! chronic tubotympanic suppurative otitis media
relationship: has_phenotype MP:0004739 ! conductive hearing loss
! A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
relationship: has_phenotype MP:0001263 ! weight loss
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype MP:0001641 ! death
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype MP:0003828 ! pulmonary edema
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
relationship: has_phenotype MP:0005039 ! hypoxia
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14515 ! WAGR syndrome
relationship: has_phenotype MP:0005261 ! aniridia
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14687 ! diastrophic dysplasia
relationship: has_phenotype MP:0000164 ! abnormal cartilage development
! An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
relationship: has_phenotype MP:0000433 ! microcephaly
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:1495 ! cystic echinococcosis
relationship: has_phenotype MP:0005011 ! increased eosinophil cell number
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1498 ! cholera
relationship: has_phenotype MP:0003260 ! vomiting
! A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.

[Term]
id: DOID:1562 ! chromoblastomycosis
relationship: has_phenotype MP:0001212 ! skin lesions
! A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

[Term]
id: DOID:1583 ! laryngeal tuberculosis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

[Term]
id: DOID:1583 ! laryngeal tuberculosis
relationship: has_phenotype MP:0003158 ! dysphagia
! A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_phenotype MP:0000218 ! increased leukocyte cell number
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1584 ! acute chest syndrome
relationship: has_phenotype MP:0005426 ! tachypnea
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_phenotype MP:0006117 ! aortic valve stenosis
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1712 ! aortic valve stenosis
relationship: has_phenotype MP:0006117 ! aortic valve stenosis
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype MP:0001263 ! weight loss
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1733 ! cryptosporidiosis
relationship: has_phenotype MP:0001429 ! dehydration
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1749 ! squamous cell carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that derives_from squamous epithelial cells.

[Term]
id: DOID:1754 ! mitral valve stenosis
relationship: has_phenotype MP:0006122 ! mitral valve stenosis
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1787 ! pericarditis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A heart disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.

[Term]
id: DOID:1791 ! peritoneal carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is located_in the inside of the abdomen.

[Term]
id: DOID:1796 ! pancreas sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of pancreas that is located_in the pancreas.

[Term]
id: DOID:1800 ! neuroendocrine carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that derives_from neuroendocrine cells.

[Term]
id: DOID:1825 ! childhood absence epilepsy
relationship: has_phenotype MP:0003216 ! absence seizures
! A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.

[Term]
id: DOID:1826 ! epilepsy syndrome
relationship: has_phenotype MP:0000947 ! convulsive seizures
! A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenicnabnormality of the brain that is able to spontaneously gen-nerate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.

[Term]
id: DOID:1826 ! epilepsy syndrome
relationship: has_phenotype MP:0002064 ! seizures
! A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenicnabnormality of the brain that is able to spontaneously gen-nerate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1883 ! hepatitis C
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1974 ! adenosarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

[Term]
id: DOID:1995 ! rectum sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant tumor of rectum that is located_in the rectum.

[Term]
id: DOID:2000 ! otosalpingitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A eustachian tube disorder which involves inflammation of the mucous membrane of the cartilagenous portion of the eustachian tube caused by acute nasopharyngitis, infection from some pathogenic microbes or trauma of the tube.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2043 ! hepatitis B
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype MP:0004924 ! abnormal behavior
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype MP:0005202 ! lethargy
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2047 ! hepatitis D
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2048 ! autoimmune hepatitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
relationship: has_phenotype MP:0001212 ! skin lesions
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:206 ! hereditary multiple exostoses
relationship: has_phenotype MP:0009877 ! exostosis
! An exostosis that has_material_basis_in a mutation on the genes EXT1, EXT2 and EXT3 which results_in multiple bony spurs throughout a child's growth.

[Term]
id: DOID:210 ! heel spur
relationship: has_phenotype MP:0009877 ! exostosis
! An exostosis that results_in an abnormal growth located_in calcaneus.

[Term]
id: DOID:222 ! perichondritis of auricle
relationship: has_phenotype MP:0001794 ! Bacterial
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:2224 ! hemorrhagic thrombocythemia
relationship: has_phenotype MP:0005505 ! increased platelet cell number
! A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets.

[Term]
id: DOID:2226 ! chronic myeloproliferative disease
relationship: has_phenotype MP:0009440 ! myeloma
! A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

[Term]
id: DOID:2228 ! thrombocytosis
relationship: has_phenotype MP:0009440 ! myeloma
! A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.

[Term]
id: DOID:2272 ! vulvovaginal candidiasis
relationship: has_phenotype MP:0001190 ! reddish skin
! A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_phenotype MP:0000599 ! enlarged liver
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2297 ! leptospirosis
relationship: has_phenotype MP:0000611 ! jaundice
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2312 ! nocardiosis
relationship: has_phenotype MP:0001861 ! lung inflammation
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype MP:0003259 ! nausea
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype MP:0003260 ! vomiting
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype MP:0005036 ! diarrhea
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2326 ! gastroenteritis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2340 ! craniosynostosis
relationship: has_phenotype MP:0000566 ! synostosis
! A synostosis that results_in premature fusion located_in skull.

[Term]
id: DOID:2354 ! myelophthisic anemia
relationship: has_phenotype MP:0001577 ! anemia
! A myeloma and anemia that is located_in some people with diseases that affect the bone marrow.

[Term]
id: DOID:2354 ! myelophthisic anemia
relationship: has_phenotype MP:0009440 ! myeloma
! A myeloma and anemia that is located_in some people with diseases that affect the bone marrow.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype MP:0000745 ! tremors
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype MP:0000747 ! muscle weakness
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype MP:0000947 ! convulsive seizures
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2365 ! West Nile encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2366 ! West Nile fever
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2366 ! West Nile fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2476 ! hereditary spastic paraplegia
relationship: has_phenotype MP:0004143 ! hypertonia
! A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
relationship: has_phenotype MP:0001304 ! cataracts
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
relationship: has_phenotype MP:0002064 ! seizures
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:2583 ! agammaglobulinemia
relationship: has_phenotype MP:0002539 ! B cell deficiency
! A B cell deficiency that is caused by a reduction in all types of gamma globulins.

[Term]
id: DOID:265 ! spleen angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results_in a nonhematolymphoid malignant neoplasm of the spleen.

[Term]
id: DOID:2661 ! myoepithelioma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is composed_of outgrowths of myoepithelial cells from a sweat gland.

[Term]
id: DOID:2671 ! transitional cell carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that derives_from transitional epithelial cells.

[Term]
id: DOID:268 ! liver angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver.

[Term]
id: DOID:270 ! liver sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver.

[Term]
id: DOID:2703 ! synovitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.

[Term]
id: DOID:2708 ! mushroom workers' lung
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes.

[Term]
id: DOID:2749 ! glycogen storage disease I
relationship: has_phenotype MP:0000599 ! enlarged liver
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2784 ! lung sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of lung that is located_in the lung.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype MP:0001263 ! weight loss
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype MP:0001577 ! anemia
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2797 ! idiopathic interstitial pneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia located_in the lung parenchyma of unknown cause.

[Term]
id: DOID:2810 ! middle lobe syndrome
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2810 ! middle lobe syndrome
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2841 ! asthma
relationship: has_phenotype MP:0002499 ! chronic inflammation
! A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptomrecurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

[Term]
id: DOID:2841 ! asthma
relationship: has_phenotype MP:0001954 ! respiratory distress
! A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptomrecurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

[Term]
id: DOID:2843 ! long QT syndrome
relationship: has_phenotype MP:0001636 ! irregular heartbeat
! An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).

[Term]
id: DOID:2877 ! larynx sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of larynx that is located_in the larynx.

[Term]
id: DOID:2921 ! glomerulonephritis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A nephritis that causes inflammation of the glomeruli located_in kidney.

[Term]
id: DOID:2921 ! glomerulonephritis
relationship: has_phenotype MP:0001859 ! kidney inflammation
! A nephritis that causes inflammation of the glomeruli located_in kidney.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype MP:0001394 ! circling
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype MP:0001852 ! conjunctivitis
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2929 ! Newcastle disease
relationship: has_phenotype MP:0001954 ! respiratory distress
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype MP:0000599 ! enlarged liver
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype MP:0000691 ! enlarged spleen
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype MP:0001263 ! weight loss
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2934 ! aleutian mink disease
relationship: has_phenotype MP:0001577 ! anemia
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2942 ! bronchiolitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.

[Term]
id: DOID:2942 ! bronchiolitis
relationship: has_phenotype MP:0001954 ! respiratory distress
! A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
relationship: has_phenotype MP:0005039 ! hypoxia
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:295 ! eye carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that arises_from the tissues that cover structures located_in the eye.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_phenotype MP:0003045 ! fibrosis
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
relationship: has_phenotype MP:0010334 ! pleural effusion
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2962 ! Cockayne syndrome
relationship: has_phenotype MP:0001999 ! photosensitivity
! An autosomal recessive disease that is caused by  rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.

[Term]
id: DOID:2962 ! Cockayne syndrome
relationship: has_phenotype MP:0003786 ! premature aging
! An autosomal recessive disease that is caused by  rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.

[Term]
id: DOID:299 ! adenocarcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.

[Term]
id: DOID:3025 ! acinar cell carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells.

[Term]
id: DOID:3030 ! mucinous adenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin.

[Term]
id: DOID:3049 ! Churg-Strauss syndrome
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.

[Term]
id: DOID:3049 ! Churg-Strauss syndrome
relationship: has_phenotype MP:0000465 ! gastrointestinal hemorrhage
! A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype MP:0003267 ! constipation
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3055 ! paratyphoid fever
relationship: has_phenotype MP:0005333 ! decreased heart rate
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3093 ! nervous system cancer
relationship: has_phenotype MP:0008912 ! nervous
! An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system.

[Term]
id: DOID:3109 ! idiopathic CD4-positive T-lymphocytopenia
relationship: has_phenotype MP:0005016 ! decreased lymphocyte cell number
! A lymphopenia that is caused by a reduction of CD4+ T lymphocytes.

[Term]
id: DOID:3111 ! cystadenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.

[Term]
id: DOID:3112 ! papillary adenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.

[Term]
id: DOID:3113 ! papillary carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is derived_from epithelial cells with finger like projections.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_phenotype MP:0000746 ! weakness
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:321 ! tropical spastic paraparesis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype MP:0002064 ! seizures
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype MP:0001954 ! respiratory distress
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype MP:0002296 ! aspiration
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
relationship: has_phenotype MP:0005426 ! tachypnea
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3241 ! lipid pneumonia
relationship: has_phenotype MP:0002296 ! aspiration
! An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.

[Term]
id: DOID:3241 ! lipid pneumonia
relationship: has_phenotype MP:0002296 ! aspiration
! An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.

[Term]
id: DOID:3252 ! prostate rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:3254 ! bile duct rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of bile duct that is located_in the bile duct.

[Term]
id: DOID:3264 ! subacute leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity.

[Term]
id: DOID:3292 ! monkeypox
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3310 ! atopic dermatitis
relationship: has_phenotype MP:0001194 ! dermatitis
! A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.

[Term]
id: DOID:3341 ! osteitis fibrosa
relationship: has_phenotype MP:0003432 ! increased activity of parathyroid
! A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.

[Term]
id: DOID:3341 ! osteitis fibrosa
relationship: has_phenotype MP:0001399 ! hyperactivity
! A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.

[Term]
id: DOID:3342 ! bone inflammation disease
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A bone disease that results_in inflammation of the located_in bone.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_phenotype MP:0001794 ! Bacterial
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_phenotype MP:0001799 ! Viral
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3437 ! laryngitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3451 ! skin carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is located_in tissues of the skin.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_phenotype MP:0001914 ! hemorrhage
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3481 ! septicemic plague
relationship: has_phenotype MP:0001794 ! Bacterial
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3493 ! signet ring cell adenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance.

[Term]
id: DOID:3764 ! Denys-Drash syndrome
relationship: has_phenotype MP:0002789 ! male pseudohermaphroditism
! An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).

[Term]
id: DOID:3905 ! lung carcinoma
relationship: has_phenotype MP:0001263 ! weight loss
! A lung cancer that is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_phenotype MP:0003259 ! nausea
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:4033 ! bacterial gastritis
relationship: has_phenotype MP:0003260 ! vomiting
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype MP:0001263 ! weight loss
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype MP:0003259 ! nausea
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
relationship: has_phenotype MP:0003260 ! vomiting
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:4047 ! liver rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of liver that are located_in the liver.

[Term]
id: DOID:4049 ! mediastinum rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the mediastinum that is located_in the mediastinum and affects children and adolescents.

[Term]
id: DOID:4050 ! mediastinum sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant mediastinal mesenchymnal tumor that is located_in the mediastinum.

[Term]
id: DOID:4053 ! rectum rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:4054 ! prostate sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of prostate that is located_in the prostate.

[Term]
id: DOID:4057 ! gallbladder rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and rhabdomyosarcoma that is located_in the gallbladder.

[Term]
id: DOID:4058 ! gallbladder sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4061 ! testis rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the testis that is located_in the testis.

[Term]
id: DOID:4062 ! testis sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of testis that is located_in the testis.

[Term]
id: DOID:4064 ! bile duct sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant tumor of extrahepatic bile duct that is located_in the bile duct.

[Term]
id: DOID:4066 ! anus rhabdomyosarcoma
relationship: has_phenotype MP:0002036 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:4067 ! anus sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of anus that is located_in the anus.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype MP:0000611 ! jaundice
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:407 ! hepatic tuberculosis
relationship: has_phenotype MP:0001263 ! weight loss
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:4143 ! orbital cancer
relationship: has_phenotype MP:0002750 ! exophthalmos
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4159 ! skin cancer
relationship: has_phenotype MP:0002096 ! abnormal skin condition/ morphology
! An organ system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.

[Term]
id: DOID:418 ! systemic scleroderma
relationship: has_phenotype MP:0003045 ! fibrosis
! A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.

[Term]
id: DOID:4233 ! clear cell sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

[Term]
id: DOID:4235 ! spindle cell sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy.

[Term]
id: DOID:4236 ! carcinosarcoma
relationship: has_phenotype MP:0002038 ! carcinoma
! MERGED DEFINITION:nTARGET DEFINITION: A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.n--------------------nSOURCE DEFINITION: A mullerian mixed tumor that is composed_of carcinoma of different mC<llerian types and composed_of homologous or heterologous sarcoma-like components.

[Term]
id: DOID:4242 ! kidney sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of kidney that is located_in the kidney's connective tissue.

[Term]
id: DOID:4253 ! melorheostosis
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype MP:0000746 ! weakness
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
relationship: has_phenotype MP:0005036 ! diarrhea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype MP:0001914 ! hemorrhage
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
relationship: has_phenotype MP:0005036 ! diarrhea
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4337 ! tinea capitis
relationship: has_phenotype MP:0000414 ! alopecia
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4411 ! hepatitis E
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4451 ! renal carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).

[Term]
id: DOID:4468 ! clear cell adenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm.

[Term]
id: DOID:4481 ! allergic rhinitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

[Term]
id: DOID:4481 ! allergic rhinitis
relationship: has_phenotype MP:0001867 ! rhinitis
! A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

[Term]
id: DOID:4483 ! rhinitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype MP:0001861 ! lung inflammation
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype MP:0003259 ! nausea
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype MP:0003260 ! vomiting
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4492 ! avian influenza
relationship: has_phenotype MP:0005036 ! diarrhea
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4504 ! central nervous system angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and sarcoma of central nervous system and mesenchymal non-meningothelial tumor of central nervous system that is located_in the central nervous system.

[Term]
id: DOID:4510 ! aorta angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma that is located_in the aorta.

[Term]
id: DOID:4511 ! breast angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area.

[Term]
id: DOID:4513 ! gallbladder angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4514 ! thyroid angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! A thyroid sarcoma and angiosarcoma that results_in a high prevalence of iodine-deficient goiter.

[Term]
id: DOID:4515 ! thyroid sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of thyroid that is located_in the supporting cells of the thyroid.

[Term]
id: DOID:4517 ! skin angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and hemangioma of skin and malignant skin vascular tumor and sarcoma of skin that is located_in the skin and results_in an enlarged bruise (a blue-black nodule) and an unhealed ulceration.

[Term]
id: DOID:4517 ! skin angiosarcoma
relationship: has_phenotype MP:0009275 ! bruising
! An angiosarcoma and hemangioma of skin and malignant skin vascular tumor and sarcoma of skin that is located_in the skin and results_in an enlarged bruise (a blue-black nodule) and an unhealed ulceration.

[Term]
id: DOID:4524 ! prostate angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:4525 ! mediastinum angiosarcoma
relationship: has_phenotype MP:0003667 ! hemangiosarcoma
! An angiosarcoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:4531 ! mucoepidermoid carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

[Term]
id: DOID:4647 ! trilateral retinoblastoma
relationship: has_phenotype MP:0006310 ! retinoblastoma
! A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region.

[Term]
id: DOID:4653 ! intraocular retinoblastoma
relationship: has_phenotype MP:0006310 ! retinoblastoma
! A retinoblastoma that is located_in the eye and has not spread to other parts of the body.

[Term]
id: DOID:4692 ! endophthalmitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! Endophthalmitis is a infectious disease consisting of an uncommon infection with Inflammation of the inside of the eye with the infection caused by bacteria, fungi or protozoa that have entered the eye during a surgical procedure, as the result of an injury or less commonly by traveling through the bloodstream to the eyeball.

[Term]
id: DOID:4692 ! endophthalmitis
relationship: has_phenotype MP:0003665 ! endophthalmitis
! Endophthalmitis is a infectious disease consisting of an uncommon infection with Inflammation of the inside of the eye with the infection caused by bacteria, fungi or protozoa that have entered the eye during a surgical procedure, as the result of an injury or less commonly by traveling through the bloodstream to the eyeball.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4731 ! atrophic rhinitis
relationship: has_phenotype MP:0001867 ! rhinitis
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4838 ! myoepithelial carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that derives_from myoepithelial cells.

[Term]
id: DOID:4866 ! adenoid cystic carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

[Term]
id: DOID:4885 ! Colorado tick fever
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_phenotype MP:0001263 ! weight loss
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4889 ! lymph node tuberculosis
relationship: has_phenotype MP:0002899 ! fatigue
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
relationship: has_phenotype MP:0000243 ! myoclonus
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
relationship: has_phenotype MP:0005424 ! jerky movement
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4903 ! granular cell carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that derives_from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

[Term]
id: DOID:4905 ! pancreatic carcinoma
relationship: has_phenotype MP:0009153 ! increased pancreas tumor incidence
! A pancreas cancer that is located_in cells found in the tissues of the pancreas.

[Term]
id: DOID:4907 ! small intestine carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is located_in the small intestine.

[Term]
id: DOID:4917 ! villous adenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, with villous architecture.

[Term]
id: DOID:4929 ! tubular adenocarcinoma
relationship: has_phenotype MP:0009308 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

[Term]
id: DOID:4948 ! gallbladder carcinoma
relationship: has_phenotype MP:0002038 ! carcinoma
! A carcinoma that is located_in the tissues of the gallbladder.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
relationship: has_phenotype MP:0000747 ! muscle weakness
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype MP:0000743 ! muscle spasm
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4953 ! poliomyelitis
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4962 ! pericardial tuberculosis
relationship: has_phenotype MP:0005312 ! pericardial effusion
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4971 ! myelofibrosis
relationship: has_phenotype MP:0009440 ! myeloma
! A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype MP:0001852 ! conjunctivitis
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4974 ! actinobacillosis
relationship: has_phenotype MP:0001861 ! lung inflammation
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_phenotype MP:0000743 ! muscle spasm
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_phenotype MP:0002899 ! fatigue
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
relationship: has_phenotype MP:0003260 ! vomiting
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4997 ! Camurati-Engelmann disease
relationship: has_phenotype MP:0005422 ! osteosclerosis
! An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.

[Term]
id: DOID:4997 ! Camurati-Engelmann disease
relationship: has_phenotype MP:0000062 ! increased bone mineral density
! An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_phenotype MP:0009877 ! exostosis
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
relationship: has_phenotype MP:0001255 ! decreased body height
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:5052 ! melioidosis
relationship: has_phenotype MP:0001954 ! respiratory distress
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5204 ! fructose-1,6-bisphosphatase deficiency
relationship: has_phenotype MP:0000189 ! hypoglycemia
! A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.

[Term]
id: DOID:5259 ! colon leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of colon that is located_in the colon.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
relationship: has_phenotype MP:0005036 ! diarrhea
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:5260 ! colon sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant tumor of colon that is located_in the colon.

[Term]
id: DOID:5262 ! heart sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant neoplasm of heart that is located_in the heart.

[Term]
id: DOID:5265 ! lung leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of lung that is located_in the lung.

[Term]
id: DOID:5272 ! small intestinal sarcoma
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and malignant tumor of small intestine that is located_in the small intestine.

[Term]
id: DOID:5275 ! gallbladder leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:5287 ! kidney leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5292 ! mediastinum leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels.

[Term]
id: DOID:5293 ! extrahepatic bile duct leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver.

[Term]
id: DOID:5296 ! liver leiomyosarcoma
relationship: has_phenotype MP:0002035 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of liver that is located_in the liver.

[Term]
id: DOID:5408 ! Paget's disease of bone
relationship: has_phenotype MP:0001399 ! hyperactivity
! A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs.

[Term]
id: DOID:5524 ! adenoid squamous cell carcinoma
relationship: has_phenotype MP:0004241 ! acantholysis
! A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

[Term]
id: DOID:5524 ! adenoid squamous cell carcinoma
relationship: has_phenotype MP:0004207 ! squamous cell carcinoma
! A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

[Term]
id: DOID:5583 ! lung giant cell carcinoma
relationship: has_phenotype MP:0008714 ! lung carcinoma
! A lung carcinoma that is located_in large undifferentiated cells.

[Term]
id: DOID:5621 ! histiocytic and dendritic cell cancer
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma and hematologic cancer that derives_from follicular lymphoma.

[Term]
id: DOID:5621 ! histiocytic and dendritic cell cancer
relationship: has_phenotype MP:0009317 ! follicular lymphoma
! A sarcoma and hematologic cancer that derives_from follicular lymphoma.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:594 ! panic disorder
relationship: has_phenotype MP:0001954 ! respiratory distress
! An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

[Term]
id: DOID:6004 ! aleukemic leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that arises from changes in the tissues forming white blood cells and characterized by a normal or decreased number of white blood cells in the circulating blood.

[Term]
id: DOID:6132 ! bronchitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.

[Term]
id: DOID:6132 ! bronchitis
relationship: has_phenotype MP:0001954 ! respiratory distress
! A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.

[Term]
id: DOID:6364 ! migraine
relationship: has_phenotype MP:0003259 ! nausea
! A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

[Term]
id: DOID:646 ! viral encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An encephalitis that involves inflammation of the brain caused by viral infection.

[Term]
id: DOID:646 ! viral encephalitis
relationship: has_phenotype MP:0001847 ! brain inflammation
! An encephalitis that involves inflammation of the brain caused by viral infection.

[Term]
id: DOID:6676 ! Froelich's syndrome
relationship: has_phenotype MP:0001261 ! obese
! A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype MP:0000610 ! cholestasis
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype MP:0003045 ! fibrosis
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype MP:0003046 ! liver cirrhosis
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6691 ! Aagenaes syndrome
relationship: has_phenotype MP:0003390 ! lymphedema
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
relationship: has_phenotype MP:0003561 ! rheumatoid arthritis
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:680 ! tauopathy
relationship: has_phenotype MP:0003214 ! neurofibrillary tangles
! A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:7147 ! ankylosing spondylitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7148 ! rheumatoid arthritis
relationship: has_phenotype MP:0002993 ! arthritis
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7188 ! autoimmune thyroiditis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_phenotype MP:0001263 ! weight loss
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7332 ! esophageal tuberculosis
relationship: has_phenotype MP:0003158 ! dysphagia
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype MP:0001954 ! respiratory distress
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7427 ! anthrax disease
relationship: has_phenotype MP:0003259 ! nausea
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:754 ! bladder tuberculosis
relationship: has_phenotype MP:0003045 ! fibrosis
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:7615 ! sarcomatosis
relationship: has_phenotype MP:0002032 ! sarcoma
! A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body.

[Term]
id: DOID:768 ! retinoblastoma
relationship: has_phenotype MP:0002039 ! neuroblastoma
! A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.

[Term]
id: DOID:8125 ! osteochondrosis
relationship: has_phenotype MP:0001651 ! necrosis
! An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone.

[Term]
id: DOID:813 ! septic arthritis
relationship: has_phenotype MP:0002993 ! arthritis
! An arthritis that involves infection by a pathogen located_in joint.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_phenotype MP:0001914 ! hemorrhage
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
relationship: has_phenotype MP:0001867 ! rhinitis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_phenotype MP:0003259 ! nausea
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8337 ! appendicitis
relationship: has_phenotype MP:0003260 ! vomiting
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8398 ! osteoarthritis
relationship: has_phenotype MP:0002993 ! arthritis
! An arthritis that has_material_basis_in worn out cartilage located_in joint.

[Term]
id: DOID:84 ! osteochondritis dissecans
relationship: has_phenotype MP:0001651 ! necrosis
! An ischemic bone disease that results_in necrosis located_in epiphysis.

[Term]
id: DOID:840 ! cork-handlers' disease
relationship: has_phenotype MP:0001954 ! respiratory distress
! An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_phenotype MP:0001263 ! weight loss
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_phenotype MP:0001954 ! respiratory distress
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:8469 ! influenza
relationship: has_phenotype MP:0000746 ! weakness
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8478 ! actinomycosis
relationship: has_phenotype MP:0002500 ! granulomatous inflammation
! A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

[Term]
id: DOID:8504 ! impetigo
relationship: has_phenotype MP:0001212 ! skin lesions
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_phenotype MP:0002842 ! increased systemic arterial blood pressure
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8515 ! cor pulmonale
relationship: has_phenotype MP:0006138 ! congestive heart failure
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype MP:0000691 ! enlarged spleen
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype MP:0002899 ! fatigue
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8568 ! infectious mononucleosis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8596 ! scarlet fever
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8622 ! measles
relationship: has_phenotype MP:0001852 ! conjunctivitis
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:8659 ! chickenpox
relationship: has_phenotype MP:0003259 ! nausea
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:8729 ! milker's nodule
relationship: has_phenotype MP:0010141 ! lymphangitis
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:874 ! bacterial pneumonia
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A pneumonia involving inflammation of the lungs caused by bacteria.

[Term]
id: DOID:874 ! bacterial pneumonia
relationship: has_phenotype MP:0001861 ! lung inflammation
! A pneumonia involving inflammation of the lungs caused by bacteria.

[Term]
id: DOID:8761 ! megakaryocytic leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

[Term]
id: DOID:8778 ! Crohn's disease
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An intestinal disease that involves inflammation located_in intestine.

[Term]
id: DOID:8781 ! rubella
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8781 ! rubella
relationship: has_phenotype MP:0001852 ! conjunctivitis
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8941 ! seborrheic infantile dermatitis
relationship: has_phenotype MP:0009792 ! seborrheic dermatitis
! A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

[Term]
id: DOID:90 ! degenerative disc disease
relationship: has_phenotype MP:0001429 ! dehydration
! A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_phenotype MP:0001190 ! reddish skin
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_phenotype MP:0001651 ! necrosis
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9063 ! Ritter's disease
relationship: has_phenotype MP:0001208 ! blistering
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_phenotype MP:0000691 ! enlarged spleen
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9146 ! visceral leishmaniasis
relationship: has_phenotype MP:0001263 ! weight loss
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9159 ! gas gangrene
relationship: has_phenotype MP:0005044 ! sepsis
! A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_phenotype MP:0002816 ! colitis
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9181 ! amebiasis
relationship: has_phenotype MP:0005036 ! diarrhea
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype MP:0003741 ! tinnitus
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype MP:0000753 ! paralysis
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9210 ! geniculate herpes zoster
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_phenotype MP:0000562 ! polydactyly
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
relationship: has_phenotype MP:0002192 ! hydrops fetalis
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9250 ! acrocallosal syndrome
relationship: has_phenotype MP:0000562 ! polydactyly
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9254 ! mast-cell leukemia
relationship: has_phenotype MP:0002026 ! leukemia
! A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype MP:0001641 ! death
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype MP:0002064 ! seizures
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype MP:0003260 ! vomiting
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9269 ! maple syrup urine disease
relationship: has_phenotype MP:0004143 ! hypertonia
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9317 ! lymphangitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A disease of lympoid system that results in inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning.

[Term]
id: DOID:9360 ! intrinsic asthma
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9360 ! intrinsic asthma
relationship: has_phenotype MP:0001954 ! respiratory distress
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9360 ! intrinsic asthma
relationship: has_phenotype MP:0002320 ! hyperventilation
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9392 ! tracheitis
relationship: has_phenotype MP:0001799 ! Viral
! A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions.

[Term]
id: DOID:9395 ! croup
relationship: has_phenotype MP:0001785 ! edema
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9395 ! croup
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9415 ! allergic asthma
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.

[Term]
id: DOID:9415 ! allergic asthma
relationship: has_phenotype MP:0001954 ! respiratory distress
! An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.

[Term]
id: DOID:9463 ! otitis externa
relationship: has_phenotype MP:0001794 ! Bacterial
! An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection.

[Term]
id: DOID:9463 ! otitis externa
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection.

[Term]
id: DOID:9471 ! meningitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype MP:0001852 ! conjunctivitis
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype MP:0003260 ! vomiting
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9537 ! Lassa fever
relationship: has_phenotype MP:0005036 ! diarrhea
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9538 ! multiple myeloma
relationship: has_phenotype MP:0009440 ! myeloma
! A myeloma that is located_in the plasma cells in bone marrow.

[Term]
id: DOID:9551 ! smoldering myeloma
relationship: has_phenotype MP:0009440 ! myeloma
! A multiple myeloma that is a slow growing type of myeloma in which abnormal plasma cells results_in too much of a single type of monoclonal antibody.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9563 ! bronchiectasis
relationship: has_phenotype MP:0011012 ! bronchiectasis
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype MP:0000746 ! weakness
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype MP:0003259 ! nausea
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype MP:0003260 ! vomiting
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:96 ! staphyloenterotoxemia
relationship: has_phenotype MP:0005036 ! diarrhea
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype MP:0000702 ! enlarged lymph nodes
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype MP:0001190 ! reddish skin
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype MP:0003260 ! vomiting
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9640 ! sarcocystosis
relationship: has_phenotype MP:0005036 ! diarrhea
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9643 ! babesiosis
relationship: has_phenotype MP:0001585 ! hemolytic anemia
! A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

[Term]
id: DOID:9643 ! babesiosis
relationship: has_phenotype MP:0001577 ! anemia
! A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

[Term]
id: DOID:9682 ! yellow fever
relationship: has_phenotype MP:0000611 ! jaundice
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9765 ! emphysematous cholecystitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues.

[Term]
id: DOID:9778 ! irritable bowel syndrome
relationship: has_phenotype MP:0009247 ! meteorism
! A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

[Term]
id: DOID:9801 ! tuberculous peritonitis
relationship: has_phenotype MP:0005150 ! cachexia
! A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation.

[Term]
id: DOID:9801 ! tuberculous peritonitis
relationship: has_phenotype MP:0001845 ! abnormal inflammatory response
! A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation.

[Term]
id: DOID:9808 ! Goodpasture syndrome
relationship: has_phenotype MP:0002743 ! glomerulonephritis
! An autoimmune disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung.

[Term]
id: DOID:9880 ! cardiovascular syphilis
relationship: has_phenotype MP:0003279 ! aneurysm
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype MP:0000221 ! decreased leukocyte cell number
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9965 ! toxoplasmosis
relationship: has_phenotype MP:0001577 ! anemia
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.