do-bridge-is_a-DOID.obo

[Term]
id: DOID:0001816 ! angiosarcoma
is_a: DOID:175 ! vascular cancer
! A malignant vascular tumor that results_in rapidly proliferating, extensively infiltrating anaplastic cells derived_from blood vessels and derived_from the lining of irregular blood-filled spaces.

[Term]
id: DOID:0050012 ! chikungunya
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash.

[Term]
id: DOID:0050025 ! human granulocytic anaplasmosis
is_a: DOID:10242 ! ehrlichiosis
! An ehrlichiosis that results_in infection located_in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted_by lone start tick (Amblyomma americanum ). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050026 ! human monocytic ehrlichiosis
is_a: DOID:10242 ! ehrlichiosis
! An ehrlichiosis that results_in infection located_in monocyte or located_in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted_by black-legged tick (Ixodes scapularis), transmitted_by western black-legged tick (Ixodes pacificus) or transmitted_by castor bean tick (Ixodes ricinus,). The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue, has_symptom fever and has_symptom rash.

[Term]
id: DOID:0050035 ! African tick-bite fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash.

[Term]
id: DOID:0050041 ! Astrakhan spotted fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp caspia, which is trasnmitted_by ticks (Rhipicephalus pumilio and Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050042 ! Indian tick typhus
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp indica, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050043 ! Israeli tick typhus
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp israelensis, which is transmitted_by ticks (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash on extremities.

[Term]
id: DOID:0050046 ! Far Eastern spotted fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy.

[Term]
id: DOID:0050047 ! Flinders Island spotted fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia honei, which is transmitted_by cayenne ticks (Amblyomma cajennense). The infection has_symptom mild spotted fever, has_symptom eschar and has_symptom adenopathy.

[Term]
id: DOID:0050050 ! Japanese spotted fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities.

[Term]
id: DOID:0050051 ! Rickettsia parkeri spotted fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia parkeri, which is transmitted_by Gulf Coast tick (Amblyomma maculatum). The infection has_symptom fever, has_symptom headache, has_symptom eschar, and has_symptom rash.

[Term]
id: DOID:0050052 ! Rocky Mountain spotted fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia rickettsii, which is transmitted_by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, and has_symptom maculopapular rash progressing into papular or petechial rash.

[Term]
id: DOID:0050059 ! oropharyngeal anthrax
is_a: DOID:13386 ! gastrointestinal anthrax
! A gastrointestinal anthrax that results_in infection located_in mucosa of oropharynx, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite.

[Term]
id: DOID:0050061 ! erysipeloid
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin.

[Term]
id: DOID:0050068 ! pestis minor
is_a: DOID:10773 ! bubonic plague
! A bubonic plague that results_in a benign form of bubonic plague, has_symptom fever, has_symptom lymphadenitis, has_symptom headache and has_symptom prostration.

[Term]
id: DOID:0050072 ! adiaspiromycosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens.

[Term]
id: DOID:0050073 ! invasive aspergillosis
is_a: DOID:13564 ! aspergillosis
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050073 ! invasive aspergillosis
is_a: DOID:552 ! pneumonia
! An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage.

[Term]
id: DOID:0050084 ! rhinotracheitis
is_a: DOID:974 ! upper respiratory tract disease
! An upper respiratory tract disease involving inflammation of the nasal cavities and trachea caused by feline herpesvirus 1, of the family Herpesviridae in cats and especially young kittens that is characterized by sneezing, conjunctivitis with discharge, and nasal discharges.

[Term]
id: DOID:0050096 ! tinea barbae
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in fungal infection which effects horny layer of epidermis of the bearded areas located_in face or located_in neck, has_material_basis_in Trichophyton mentagrophytes or has_material_basis_in Trichophyton verrucosum, which also effects hair, and effects nail and has_symptom inflammatory kerion-like plaques, and results_in_formation_of noninflammatory superficial perifollicular pustules.

[Term]
id: DOID:0050097 ! ectothrix infectious disease
is_a: DOID:4337 ! tinea capitis
! A tinea capitis that results_in fungal infection located_in cuticle of hair, has_material_basis_in Microsporum canis, has_material_basis_in Microsporum gypseum, has_material_basis_in Trichophyton equinum, and has_material_basis_in Trichophyton verrucosum, which produce arthroconidia on the exterior of the hair shaft.

[Term]
id: DOID:0050105 ! endothrix infectious disease
is_a: DOID:4337 ! tinea capitis
! A tinea capitis that results_in fungal infection located_in hair, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which produce arthroconidia within the hair shaft only.

[Term]
id: DOID:0050116 ! tinea imbricata
is_a: DOID:12179 ! tinea corporis
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition.

[Term]
id: DOID:0050118 ! La Crosse encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis.

[Term]
id: DOID:0050120 ! hemophagocytic lymphohistiocytosis
is_a: DOID:75 ! lymphatic system disease
! A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages.

[Term]
id: DOID:0050125 ! dengue shock syndrome
is_a: DOID:12205 ! dengue disease
! A dengue disease that involves the most severe form of dengue fever, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom easy bruising, has_symptom blood spots, has_symptom bleeding gums, and has_symptom nosebleeds. It is accompanied by circulatory collapse, involves hypotension, narrow pulse pressure (less than or equal to 20mm Hg), or frank shock. The shock occurs after two to six days of symptoms, followed by collapse, weak pulse, and blueness around the mouth.

[Term]
id: DOID:0050130 ! osmotic diarrhea
is_a: DOID:0050130 ! osmotic diarrhea
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
is_a: DOID:10608 ! celiac disease
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050130 ! osmotic diarrhea
is_a: DOID:2985 ! chronic rejection of renal transplant
! Osmotic diarrhea is a dirrhea where diarrhea occurs when too much water is drawn into the bowels. This can be the result of maldigestion (e.g., pancreatic disease or Coeliac disease), in which the nutrients are left in the lumen to pull in water. Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels). In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel. A person who does not have lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.

[Term]
id: DOID:0050131 ! motility-related diarrhea
is_a: DOID:0050131 ! motility-related diarrhea
! Motility-related diarrhea is a diarrhea which is caused by the rapid movement of food through the intestines (hypermotility). If the food moves too quickly through the GI tract, there is not enough time for sufficient nutrients and water to be absorbed.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
is_a: DOID:0050117 ! disease by infectious agent
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
is_a: DOID:13250 ! diarrhea
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050132 ! inflammatory diarrhea
is_a: DOID:2985 ! chronic rejection of renal transplant
! A gastrointestinal system infectious disease involving diarrhea that occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids. It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases. It can also be caused by tuberculosis, colon cancer, and enteritis.

[Term]
id: DOID:0050133 ! superficial mycosis
is_a: DOID:1564 ! fungal infectious disease
! A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host.

[Term]
id: DOID:0050134 ! cutaneous mycosis
is_a: DOID:1564 ! fungal infectious disease
! A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions.

[Term]
id: DOID:0050135 ! subcutaneous mycosis
is_a: DOID:1564 ! fungal infectious disease
! A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma.

[Term]
id: DOID:0050136 ! systemic mycosis
is_a: DOID:1564 ! fungal infectious disease
! A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs.

[Term]
id: DOID:0050140 ! acute diarrhea
is_a: DOID:13250 ! diarrhea
! A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.

[Term]
id: DOID:0050141 ! intestinal botulism
is_a: DOID:11976 ! botulism
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins.

[Term]
id: DOID:0050143 ! asymptomatic dengue
is_a: DOID:12205 ! dengue disease
! A dengue disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has no manifestations of symptoms.

[Term]
id: DOID:0050145 ! adenoiditis
is_a: DOID:1205 ! hypersensitivity reaction type I disease
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050145 ! adenoiditis
is_a: DOID:974 ! upper respiratory tract disease
! An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has_symptom pain, has_symptom redness, has_symptom swelling, and has_symptom difficulty swallowing.

[Term]
id: DOID:0050147 ! otomycosis
is_a: DOID:9463 ! otitis externa
! A otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans.

[Term]
id: DOID:0050148 ! laryngotracheitis
is_a: DOID:974 ! upper respiratory tract disease
! An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe.

[Term]
id: DOID:0050152 ! aspiration pneumonia
is_a: DOID:874 ! bacterial pneumonia
! A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough.

[Term]
id: DOID:0050157 ! cryptogenic organizing pneumonia
is_a: DOID:2797 ! ideopathic interstitial pneumonia
! A idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope.

[Term]
id: DOID:0050158 ! respiratory bronchiolitis-associated interstitial lung disease
is_a: DOID:2797 ! ideopathic interstitial pneumonia
! A idiopathic interstitial pneumonia which involves bronchiolocentric alveolar macrophage accumulation, mild bronchiolar fibrosis and chronic inflammation. Respiratory bronchiolitis is a histopathologic lesion found in cigarette smokers and is characterized by the presence of pigmented intralumenal macrophages within first- and second-order respiratory bronchioles.

[Term]
id: DOID:0050158 ! respiratory bronchiolitis-associated interstitial lung disease
is_a: DOID:2942 ! bronchiolitis
! A idiopathic interstitial pneumonia which involves bronchiolocentric alveolar macrophage accumulation, mild bronchiolar fibrosis and chronic inflammation. Respiratory bronchiolitis is a histopathologic lesion found in cigarette smokers and is characterized by the presence of pigmented intralumenal macrophages within first- and second-order respiratory bronchioles.

[Term]
id: DOID:0050160 ! inhalation anthrax
is_a: DOID:7427 ! anthrax disease
! An anthrax disease that results_in infection located_in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches.

[Term]
id: DOID:0050166 ! tuberculous salpingitis
is_a: DOID:2149 ! urogenital tuberculosis
! An urogenital tuberculosis that results_in formation of granulomas located_in fallopian tube.

[Term]
id: DOID:0050167 ! autoimmune polyendocrine syndrome type 1
is_a: DOID:14040 ! autoimmune polyendocrine syndrome
! An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.

[Term]
id: DOID:0050168 ! autoimmune polyendocrine syndrome type 2
is_a: DOID:14040 ! autoimmune polyendocrine syndrome
! An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene.

[Term]
id: DOID:0050174 ! Kunjin encephalitis
is_a: DOID:2365 ! West Nile encephalitis
! A West Nile encephalitis that results_in infection located_in brain, has_material_basis_in Kunjin virus, a subtype of West Nile Virus, which is transmitted_by Culex annulirostris mosquito bite. The infection has_symptom fever, has_symptom rigor, has_symptom headache, has_symptom confusion, and has_symptom lethargy.

[Term]
id: DOID:0050175 ! tick-borne encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis.

[Term]
id: DOID:0050179 ! Powassan encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Powassan virus, which is transmitted_by Ixodes and transmitted_by Dermacentor species of ticks. The infection has_symptom headache, has_symptom fever, has_symptom vomiting, has_symptom stiff neck, has_symptom sleepiness, has_symptom breathing distress, has_symptom tremors, has_symptom confusion, has_symptom seizures, has_symptom paralysis, and has_symptom coma.

[Term]
id: DOID:0050185 ! erythema multiforme
is_a: DOID:37 ! skin disease
! A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050194 ! Argentine hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050195 ! Bolivian hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Machupo virus, which is transmitted_by vesper mouse, Calomys callosus. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom myalgia, has_symptom arthralgia, has_symptom bleeding from the oral and nasal mucosa, and has_symptom bleeding from the bronchopulmonary, gastrointestinal and genitourinary tracts.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050196 ! Venezuelan hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050197 ! Brazilian hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Sabia virus, which is transmitted_by rodents. The infection has_symptom fever, has_symptom eye redness, has_symptom fatigue, has_symptom dizziness, has_symptom muscle aches, has_symptom loss of strength, and has_symptom bleeding under the skin, internal organs, or from body orifices like the mouth, eyes or ears.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050198 ! Chapare hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Chapare virus. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom shock, and has_symptom bleeding.

[Term]
id: DOID:0050199 ! Whitewater Arroyo hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050199 ! Whitewater Arroyo hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Whitewater Arroyo virus, which is transmitted_by white-throated woodrats (Neotoma albigula). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, and has_symptom hemorrhagic manifestations.

[Term]
id: DOID:0050200 ! Korean hemorrhagic fever
is_a: DOID:11266 ! hemorrhagic fever with renal syndrome
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload.

[Term]
id: DOID:0050201 ! nephropathia epidemica
is_a: DOID:11266 ! hemorrhagic fever with renal syndrome
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Puumala virus, which is transmitted_by bank vole, Clethrionomys glareolus. The infection has_symptom headache, has_symptom nausea, has_symptom back pain, has_symptom vomiting, has_symptom myalgia, has_symptom abdominal pain, has_symptom internal hemorrhage, and has_symptom renal failure.

[Term]
id: DOID:0050202 ! lujo hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Lujo virus, which has_symptom bleeding.

[Term]
id: DOID:0050204 ! Epstein-Barr virus hepatitis
is_a: DOID:1884 ! viral hepatitis
! A viral hepatitis that results_in inflammation, located_in liver, has_material_basis_in Human herpesvirus 4 and has_symptom headache, has_symptom fatigue, has_symptom fever, has_symptom abdominal pain, has_symptom nausea, and has_symptom jaundice.

[Term]
id: DOID:0050211 ! swine influenza
is_a: DOID:8469 ! influenza
! An influenza that results_in infection located_in respiratory tract of pigs and humans, has_material_basis_in Influenza C virus, or has_material_basis_in Influenza A virus subtypes (H1N1, H1N2, H3N1, H3N2, and H2N3), which are transmitted_by direct contact with infected pigs. The infection in humans has_symptom fever, has_symptom lethargy, has_symptom lack of appetite, has_symptom coughing, has_symptom runny nose, has_symptom sore throat, has_symptom nausea, has_symptom vomiting, and has_symptom diarrhea.

[Term]
id: DOID:0050218 ! polycystic echinococcosis
is_a: DOID:1496 ! echinococcosis
! An echinococcosis that is caused by the larvae of Echinococcus vogeli or Echinococcus oligarthrus, which infect the liver.

[Term]
id: DOID:0050242 ! primary amebic meningoencephalitis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma.

[Term]
id: DOID:0050246 ! granulomatous amebic encephalitis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death.

[Term]
id: DOID:0050253 ! mesocestoidiasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves parasitic cestode infection caused by Mesocestoides lineatus resulting in nausea, diarrhea, abdominal discomfort and vomiting.

[Term]
id: DOID:0050254 ! acanthocephaliasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves infection of the intestine caused by thorny-headed worms Macracanthorhynchus or Moniliformis moniliformis. The infection has_symptom abdominal pain, has_symptom distension, has_symptom fever, has_symptom decreased appetite, has_symptom nausea, has_symptom vomiting, has_symptom weight loss, has_symptom diarrhea, and has_symptom constipation or has_symptom bloody stools.

[Term]
id: DOID:0050259 ! baylisascariasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine caused by the larvae of Baylisascaris procyonis, which can invade the spinal cord, brain, and eye of humans, resulting in permanent neurologic damage, blindness, or death.

[Term]
id: DOID:0050266 ! tungiasis
is_a: DOID:37 ! skin disease
! A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

[Term]
id: DOID:0050266 ! tungiasis
is_a: DOID:4110 ! parasitic ectoparasitic infectious disease
! A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo.

[Term]
id: DOID:0050278 ! basidiobolomycosis
is_a: DOID:0050135 ! subcutaneous mycosis
! A subcutaneous mycosis that involves a chronic inflammatory or granulomatous fungal infection of the subcutaneous tissue of the limbs, chest, back or buttocks caused by Basidiobolus ranarum. Lesions appear as subcutaneous nodules which develop into massive, firm, indurated, painless swellings which are freely movable over the underlying muscle, but are attached to the skin which may become hyperpigmented but not ulcerated.

[Term]
id: DOID:0050279 ! conidiobolomycosis
is_a: DOID:0050135 ! subcutaneous mycosis
! An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions.

[Term]
id: DOID:0050288 ! penicilliosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that has_material_basis_in Penicillium marneffei, results_in systemic infection and has_symptom fever, has_symptom anemia, has_symptom weight loss, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom respiratory signs, and has_symptom skin lesions.

[Term]
id: DOID:0050290 ! trichosporonosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body.

[Term]
id: DOID:0050292 ! primary systemic mycosis
is_a: DOID:0050136 ! systemic mycosis
! A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050308 ! Alkhurma hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Alkhurma hemorrhagic fever virus, which is transmitted_by Ornithodoros savignyi tick bite, transmitted_by ingestion of unpasteurized camel milk, or transmitted_by entry via skin wound. The infection has_symptom headache, has_symptom joint pain, has_symptom muscle pain, has_symptom vomiting, has_symptom thrombocytopenia, and has_symptom hemorrhagic fever.

[Term]
id: DOID:0050325 ! genetic disorder
is_a: DOID:0060035 ! medical disorder
! A medical disorder that is an illness caused by abnormalities in genes or chromosomes.

[Term]
id: DOID:0050331 ! LADD syndrome
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that is characterized by abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes.

[Term]
id: DOID:0050338 ! primary bacterial infectious disease
is_a: DOID:104 ! bacterial infectious disease
! A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread.

[Term]
id: DOID:0050339 ! commensal bacterial infectious disease
is_a: DOID:104 ! bacterial infectious disease
! A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder.

[Term]
id: DOID:0050340 ! opportunistic bacterial infectious disease
is_a: DOID:104 ! bacterial infectious disease
! A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised.

[Term]
id: DOID:0050352 ! foodborne botulism
is_a: DOID:11976 ! botulism
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted_by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has_symptom blurred vision, has_symptom diplopia, has_symptom dysarthria, has_symptom dysphonia, has_symptom dysphagia and has_symptom descending muscle paralysis.

[Term]
id: DOID:0050353 ! wound botulism
is_a: DOID:11976 ! botulism
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted_by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

[Term]
id: DOID:0050354 ! infant botulism
is_a: DOID:11976 ! botulism
! A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness.

[Term]
id: DOID:0050382 ! glandular tularemia
is_a: DOID:2123 ! tularemia
! A tularemia that results_in swelling of regional lymph glands.

[Term]
id: DOID:0050383 ! typhoidal tularemia
is_a: DOID:2123 ! tularemia
! A tularemia that results_in bacteremia and has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom malaise, and has_symptom weight loss.

[Term]
id: DOID:0050398 ! Carrion's Disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed.

[Term]
id: DOID:0050424 ! familial adenomatous polyposis
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that is caused by mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer.

[Term]
id: DOID:0050432 ! Asperger syndrome
is_a: DOID:0060041 ! autism spectrum disorder
! An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

[Term]
id: DOID:0050434 ! Andersen-Tawil syndrome
is_a: DOID:225 ! syndrome
! A long QY syndrome that has_material_basis_in autosomal dominant inheritance of a mutation in the KCNJ2 gene which disrupts the rhythm of the heart's lower chambers (ventricular arrhythmia) and results_in an unusually small lower jaw (micrognathia), low-set ears, and an abnormal curvature of the fingers called clinodactyly.

[Term]
id: DOID:0050445 ! X-linked hypophosphatemia
is_a: DOID:896 ! metal metabolism disorder
! A metal metabolism disorder that results from the inactivation of hormone-like substances (phosphatonins) that promote phosphate excretion which has_material_basis_in a X-linked mutation in the PHEX gene.

[Term]
id: DOID:0050456 ! Buruli ulcer disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin.

[Term]
id: DOID:0050463 ! campomelic dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur.

[Term]
id: DOID:0050473 ! Alstrom syndrome
is_a: DOID:0080003 ! autosomal recessive disease
! An autosomal recessive disease that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene.

[Term]
id: DOID:0050480 ! epidemic typhus
is_a: DOID:11256 ! typhus
! A typhus that has_material_basis_in Rickettsia prowazekii, which is transmitted_by human body louse (Pediculus humanus corporis). The infection has_symptom high fever, has_symptom cough, has_symptom rash, has_symptom severe muscle pain, has_symptom chills, has_symptom falling blood pressure, has_symptom stupor, has_symptom sensitivity to light, and has_symptom delirium.

[Term]
id: DOID:0050481 ! endemic typhus
is_a: DOID:11256 ! typhus
! A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted_by fleas (Xenopsylla cheopis). The infection has_symptom headache, has_symptom fever, has_symptom chills, has_symptom myalgia, has_symptom nausea, has_symptom vomiting, has_symptom cough and has_symptom rash.

[Term]
id: DOID:0050484 ! aneruptive fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia helvetica, which is transmitted_by ticks (Ixodes sp). The infection has_symptom fever, has_symptom headache, has_symptom myalgia.

[Term]
id: DOID:0050485 ! sennetsu fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia.

[Term]
id: DOID:0050488 ! early congenital syphilis
is_a: DOID:9856 ! congenital syphilis
! A congenital syphilis that is manifested during the first 3 months of life. The infection has_symptom skin lesions, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom failure to thrive, has_symptom blood-stained nasal discharge, has_symptom perioral fissures, has_symptom meningitis, has_symptom choroiditis, has_symptom hydrocephalus, has_symptom seizures, has_symptom intellectual disability, has_symptom osteochondritis, and has_symptom pseudoparalysis.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
is_a: DOID:10554 ! meningoencephalitis
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050490 ! parenchymatous neurosyphilis
is_a: DOID:9988 ! tertiary neurosyphilis
! A tertiary neurosyphilis that results when chronic meningoencephalitis causes destruction of cortical parenchyma. The infection has_symptom irritability, has_symptom difficulty concentrating, has_symptom deterioration of memory, has_symptom defective judgment, has_symptom headaches, has_symptom insomnia, has_symptom fatigue, and has_symptom lethargy.

[Term]
id: DOID:0050491 ! meningovascular neurosyphilis
is_a: DOID:9988 ! tertiary neurosyphilis
! A tertiary neurosyphilis that results_in inflammation located_in arteries of the brain or located_in arteries of spinal cord. The infection has_symptom headache, has_symptom neck stiffness, has_symptom dizziness, has_symptom behavioral abnormalities, has_symptom poor concentration, has_symptom memory loss, has_symptom lassitude, has_symptom insomnia, has_symptom blurred vision, has_symptom weakness and wasting of shoulder-girdle and arm muscles, has_symptom slowly progressive leg weakness with urinary or fecal incontinence or both, and has_symptom paralysis of the legs due to thrombosis of spinal arteries.

[Term]
id: DOID:0050495 ! exanthema subitum
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck.

[Term]
id: DOID:0050508 ! variola major
is_a: DOID:8736 ! smallpox
! A smallpox that results_in severe infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:0050513 ! spinal polio
is_a: DOID:0050515 ! paralytic poliomyelitis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050514 ! bulbospinal polio
is_a: DOID:0050515 ! paralytic poliomyelitis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem or located_in motor neurons of spinal cord, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty swallowing, and has_symptom paralysis of arms and legs.

[Term]
id: DOID:0050515 ! paralytic poliomyelitis
is_a: DOID:4953 ! poliomyelitis
! A poliomyelitis that results_in destruction located_in motor neurons of central nervous system, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom loss of reflexes, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:0050516 ! O'nyong'nyong fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in O'nyong-nyong virus, which is transmitted_by Anopheles gambiae, and transmitted_by Anopheles funestus mosquitoes. The infection has_symptom fever, has_symptom arthralgia, has_symptom rash, and has_symptom lymphadenitis.

[Term]
id: DOID:0050517 ! Barmah Forest virus disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Barmah Forest virus, which is transmitted_by mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050518 ! Ross River fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in joint, has_material_basis_in Ross River virus, which is transmitted_by Culex, and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom arthralgia, and has_symptom rash.

[Term]
id: DOID:0050521 ! Oropouche fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Oropouche virus, which is transmitted_by biting midge, Culicoides paraensis. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom anorexia, has_symptom muscle pain, has_symptom joint pain, and has_symptom vomiting.

[Term]
id: DOID:0050522 ! Balkan hemorrhagic fever
is_a: DOID:11266 ! hemorrhagic fever with renal syndrome
! A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Dobrava-Belgrade virus , which is transmitted_by yellow-necked field mouse, Apodemus flavicollis. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:0050523 ! adult T-cell leukemia
is_a: DOID:715 ! T-cell leukemia
! A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions.

[Term]
id: DOID:0050524 ! maturity-onset diabetes of the young
is_a: DOID:630 ! genetic disease
! A genetic disease that has_material_basis_in mutations in the MODY genes disrupting insulin production.

[Term]
id: DOID:0050527 ! familial hypertriglyceridemia
is_a: DOID:3146 ! lipid metabolism disorder
! A lipid metabolism disorder characterized by elevated triglyceride levels as a result of excess hepatic production of VLDL or heterozygous LPL deficiency.

[Term]
id: DOID:0050553 ! JMP syndrome
is_a: DOID:4 ! disease
! An autosomal receessive disease that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy.

[Term]
id: DOID:0050563 ! nonsyndromic deafness
is_a: DOID:2742 ! auditory system disease
! An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms.

[Term]
id: DOID:0050568 ! spondylocostal dysostosis
is_a: DOID:1934 ! dysostosis
! A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together.

[Term]
id: DOID:0050573 ! 2-hydroxyglutaric aciduria
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage.

[Term]
id: DOID:0050576 ! Senior-Loken syndrome
is_a: DOID:630 ! genetic disease
! An autosomal recessive genetic disease characterized by progressive wasting of the filtering unit of the kidney (nephronophthisis), with or without medullary cystic renal disease, and progressive eye disease.

[Term]
id: DOID:0050578 ! occult macular dystrophy
is_a: DOID:4448 ! macular degeneration
! A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings.

[Term]
id: DOID:0050584 ! gummatous syphilis
is_a: DOID:8200 ! tertiary syphilis
! A tertiary syphilis that is characterized by granulomatous lesions, called gummas, which are characterized by a center of necrotic tissue with a rubbery texture. They form in the liver, bones, and testes but may affect any organ.

[Term]
id: DOID:0050596 ! taeniasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that has_material_basis_in Taenia solium or has_material_basis_in Taenia saginata, which are transmitted_by ingestion of undercooked contaminated meat.

[Term]
id: DOID:0050597 ! intestinal schistosomiasis
is_a: DOID:1395 ! schistosomiasis
! A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia.

[Term]
id: DOID:0050599 ! abdominal tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas.

[Term]
id: DOID:0050600 ! ABCD syndrome
is_a: DOID:0080003 ! autosomal recessive disease
! An autosomal recessive disease that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB).

[Term]
id: DOID:0050601 ! ADULT syndrome
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63

[Term]
id: DOID:0050615 ! respiratory system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract.

[Term]
id: DOID:0050619 ! paranasal sinus cancer
is_a: DOID:0050615 ! respiratory system cancer
! A respiratory system cancer that is located_in the paranasal sinuses.

[Term]
id: DOID:0050621 ! respiratory system benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in the respiratory system which extends from the nasal sinuses to the diaphragm.

[Term]
id: DOID:0050622 ! reproductive organ benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in reproductive system organs.

[Term]
id: DOID:0050624 ! gastrointestinal system benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm located_in gastrointestinal tract organs.

[Term]
id: DOID:0050631 ! Allan-Herndon-Dudley syndrome
is_a: DOID:4 ! disease
! An X-linked disease that is caused by mutation in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement.

[Term]
id: DOID:0050650 ! familial atrial fibrillation
is_a: DOID:10273 ! heart conduction disease
! A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes.

[Term]
id: DOID:0050669 ! spastic cerebral palsy
is_a: DOID:1969 ! cerebral palsy
! A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements.

[Term]
id: DOID:0050670 ! ataxic cerebral palsy
is_a: DOID:1969 ! cerebral palsy
! A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing.

[Term]
id: DOID:0050672 ! dyskinetic cerebral palsy
is_a: DOID:1969 ! cerebral palsy
! A cerebral palsy that is caused by damage to the extrapyramidal motor system and/or pyramidal tract and to the basal ganglia, which results in mixed muscle tone (hypertonia and hypotonia). The individuals have trouble holding themselves in an upright, steady position for sitting or walking, and often show involuntary motions.

[Term]
id: DOID:0050673 ! mixed cerebral palsy
is_a: DOID:1969 ! cerebral palsy
! A cerebral palsy that is caused by injury to both the pyramidal and extra pyramidal areas of the brain, which results in both the tight muscle tone and the involuntary movements. The individual have difficulty with speaking and swallowing.

[Term]
id: DOID:0050700 ! cardiomyopathy
is_a: DOID:114 ! heart disease
! A heart disease that is characterized by deterioration of the funciton of the heart muscle.

[Term]
id: DOID:0050708 ! early onset absence epilepsy
is_a: DOID:225 ! syndrome
! A childhood electroclinical syndrome characterized by the occurrance of typical absence seizures startign between the age of four and ten years.

[Term]
id: DOID:0050710 ! 3-Methylcrotonyl-CoA carboxylase deficiency
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that has_material_basis_in mutations in the MCCC1 and MCCC2 genes causing inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy.

[Term]
id: DOID:0050711 ! aceruloplasminemia
is_a: DOID:2351 ! iron metabolism disease
! An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus.

[Term]
id: DOID:0050712 ! AGAT deficiency
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that has_material_basis_in a mutation in the GATM gene resulting in deficiency of arginine:glycine amidinotransferase which then limits creatine synthesis.

[Term]
id: DOID:0050713 ! fatal infantile encephalocardiomyopathy
is_a: DOID:700 ! mitochondrial metabolism disease
! A mitochondrial metabolism disease that has_material_basis_in a mutation in the SCO2 gene which encodes a COX assembly factor and results in deficiency of cytochrome c oxidase.

[Term]
id: DOID:0050714 ! alcaptonuria
is_a: DOID:0060159 ! organic acidemia
! An organic acidemia that has_material_basis_in an autosomal recessive mutation in the HGD (homogentisate 1,2-dioxygenase gene ) gene affecting the production of the homogentisate 1,2-dioxygenase enzyme resulting in the accumulation of homogentisic acid in the blood.

[Term]
id: DOID:0050715 ! methylmalonic aciduria and homocystinuria type cblC
is_a: DOID:14749 ! methylmalonic acidemia
! A methylmalonic acidemia that has_material_basis_in deficiency in synthesis of both AdoCbl and MeCbl (cblC) and is characterized by decreased levels of the coenzymes adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl), which results in decreased activity of the respective enzymes methylmalonyl-CoA mutase.

[Term]
id: DOID:0050716 ! methylmalonic aciduria and homocystinuria type cblD
is_a: DOID:14749 ! methylmalonic acidemia
! A methylmalonic aciduria that is characterized by combined homocystinuria and methylmalonic aciduria and deficiency of MCM and MS activities.

[Term]
id: DOID:0050717 ! methylmalonic aciduria and homocystinuria type cblF
is_a: DOID:14749 ! methylmalonic acidemia
! A methylmalonic acidemia that is characterized by the accumulation of cobalamin in lysosomes which is then unable to synthesize the cofactors adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl).

[Term]
id: DOID:0050720 ! ornithine translocase deficiency
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood.

[Term]
id: DOID:0050721 ! serine deficiency
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine.

[Term]
id: DOID:0050725 ! tyrosinemia type II
is_a: DOID:9275 ! tyrosinemia
! A tyrosinemia that has_material_basis_in deficiency of hepatic tyrosine aminotransferase located_in the liver and is characterized by keratitis, painful palmoplantar hyperkeratosis, mental retardation, and elevated serum tyrosine levels.

[Term]
id: DOID:0050726 ! tyrosinemia type I
is_a: DOID:9275 ! tyrosinemia
! A tyrosinemia that has_material_basis_in deficiency of the enzyme fumarylacetoacetate hydrolase resulting in an increase in fumarylacetoacetate which inhibits previous steps in tyrosine degradation leading to an accumulation of tyrosine in the body.

[Term]
id: DOID:0050727 ! tyrosinemia type III
is_a: DOID:9275 ! tyrosinemia
! A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine.

[Term]
id: DOID:0050729 ! neutral lipid storage disease
is_a: DOID:9455 ! lipid storage disease
! A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues.

[Term]
id: DOID:0050730 ! coenzyme Q10 deficiency disease
is_a: DOID:700 ! mitochondrial metabolism disease
! A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis.

[Term]
id: DOID:0050734 ! congenital intrinsic factor deficiency
is_a: DOID:8459 ! vitamin B 12 deficiency
! A vitamin B12 deficiency that is characterized by megaloblastic anemia due to the absence of gastric intrinsic factor which results in abnormal vitamin B12 absorption.

[Term]
id: DOID:0050740 ! Qazi Markouizos syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by hypotonia, congenital fiber type disproportion and dysharmonic skeletal maturation.

[Term]
id: DOID:0050747 ! lymphoplasmacytic lymphoma
is_a: DOID:707 ! B-cell lymphocytic neoplasm
! A B-cell lymphocytic neoplasm characterized by an uncontrolled increase of B-cells.

[Term]
id: DOID:0060000 ! infective endocarditis
is_a: DOID:114 ! heart disease
! A heart disease involving inflammation of the endocardium (inner layer of the heart) caused by bacterial infection.

[Term]
id: DOID:0060002 ! C1 inhibitor deficiency
is_a: DOID:626 ! complement deficiency
! A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue.

[Term]
id: DOID:0060013 ! gamma chain deficiency
is_a: DOID:627 ! severe combined immunodeficiency
! A severe combined immunodeficiency that is a X-linked SCID caused by mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells.

[Term]
id: DOID:0060016 ! CD3delta deficiency
is_a: DOID:627 ! severe combined immunodeficiency
! A severe combined immunodeficiency that is characterized by the absence of T cells but normal numbers of B cells. CD3D is essential for T cell development.

[Term]
id: DOID:0060017 ! CD3epsilon deficiency
is_a: DOID:627 ! severe combined immunodeficiency
! A severe combined immunodeficiency that is an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3epsilon chain precursors. Patients with CD3epsilon deficiency have a severe defect in the expression of the T-cell receptor CD3-complex.

[Term]
id: DOID:0060018 ! CD3gamma deficiency
is_a: DOID:627 ! severe combined immunodeficiency
! A severe combined immunodeficiency an autosomal recessive immunodeficiency caused by mutations in the gene coding for T-cell surface glycoprotein CD3gamma chain precursors. Patients with CD3gamma deficiency have a severe defect in the expression of the T-cell receptor CD3-complex. Affected patients have decreased T-cell numbers and function; B cells are variably affected.

[Term]
id: DOID:0060020 ! reticular dysgenesis
is_a: DOID:627 ! severe combined immunodeficiency
! A severe combined immunodeficiency that is the most severe form of SCID and is caused by mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.

[Term]
id: DOID:0060021 ! DNA ligase IV deficiency
is_a: DOID:628 ! combined T cell and B cell immunodeficiency
! A combined T cell and B cell immunodeficiency that is caused by a mutatino in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.

[Term]
id: DOID:0060022 ! CD40 ligand deficiency
is_a: DOID:628 ! combined T cell and B cell immunodeficiency
! A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.

[Term]
id: DOID:0060023 ! CD40 deficiency
is_a: DOID:628 ! combined T cell and B cell immunodeficiency
! A combined T cell and B cell immunodeficiency that is caused by mutation in TNFRSF5 resulting in type 3 hyper-IgM immunodeficiency characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.

[Term]
id: DOID:0060024 ! lambda 5 deficiency
is_a: DOID:2115 ! B cell deficiency
! A B cell deficiency that is caused by mutations in the IGLL1 gene. Lambda 5 mutations an cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.

[Term]
id: DOID:0060025 ! immunoglobulin alpha deficiency
is_a: DOID:2115 ! B cell deficiency
! A B cell deficiency that is an autosomal recessive disorder caused by mutation in the IgA (CD79 alpha) antigen receptor.

[Term]
id: DOID:0060027 ! B cell linker protein deficiency
is_a: DOID:2115 ! B cell deficiency
! A hypobammaglobulinemia that is a B cell deficiency caused by a mutation a cytoplasmic linker or adaptor protein that plays a critical role in B cell development, the B cell linker protein (BLNK) gene. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. The BLNK gene is associated with intracellular calcium mobilization, essential for cell activation.

[Term]
id: DOID:0060040 ! pervasive developmental disorder
is_a: DOID:0060037 ! developmental disorder of mental health
! A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors.

[Term]
id: DOID:0060041 ! autism spectrum disorder
is_a: DOID:0060040 ! pervasive developmental disorder
! A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.

[Term]
id: DOID:0060053 ! peripheral neuropathy
is_a: DOID:870 ! neuropathy
! A neuropathy that is located_in nerves of the peripheral nervous system.

[Term]
id: DOID:0060062 ! familial juvenile hyperuricemic nephropathy
is_a: DOID:557 ! kidney disease
! A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease.

[Term]
id: DOID:0060067 ! Pearson syndrome
is_a: DOID:0080013 ! mitochondrial disease
! A mitochondrial disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction.

[Term]
id: DOID:0060073 ! lymphatic system cancer
is_a: DOID:0060083 ! immune system cancer
! An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue.

[Term]
id: DOID:0060083 ! immune system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system.

[Term]
id: DOID:0060089 ! endocrine organ benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

[Term]
id: DOID:0060091 ! cardiovascular organ benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system.

[Term]
id: DOID:0060092 ! immune system organ benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm located_in the immune system organs.

[Term]
id: DOID:0060099 ! musculoskeletal system benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in the muscular and skeletal organs.

[Term]
id: DOID:0060100 ! musculoskeletal system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the muscular and skeltal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs.

[Term]
id: DOID:0060115 ! nervous system benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:0060116 ! sensory system cancer
is_a: DOID:3093 ! nervous system cancer
! A nervous system cancer that is located_in the sensory system.

[Term]
id: DOID:0060117 ! peritoneal benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in the serous membrane lining the abdominal cavity or coelom.

[Term]
id: DOID:0060119 ! pharynx cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the pharyx.

[Term]
id: DOID:0060122 ! integumentary system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer that is located_in the skin, hair and nails.

[Term]
id: DOID:0060124 ! skeletal system cancer
is_a: DOID:0060100 ! musculoskeletal system cancer
! A musculoskeletal system cancer that is located_in the skeletal system.

[Term]
id: DOID:0060158 ! acquired metabolic disease
is_a: DOID:0014667 ! disease of metabolism
! A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

[Term]
id: DOID:0060161 ! Kennedy's disease
is_a: DOID:9884 ! muscular dystrophy
! A spinal muscular dystrophy that has_material_basis_in an X-linked recessive mutation of the androgen receptor.

[Term]
id: DOID:0060162 ! dentatorubral-pallidoluysian atrophy
is_a: DOID:2478 ! spinocerebellar degeneration
! A spinocerebellar degeneration that has_material_basis_in an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein.

[Term]
id: DOID:0060164 ! pain disorder
is_a: DOID:4737 ! somatoform disorder
! A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress.

[Term]
id: DOID:0060165 ! Kleine-Levin syndrome
is_a: DOID:8619 ! recurrent hypersomnia
! A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior.

[Term]
id: DOID:0060166 ! bipolar ll disorder
is_a: DOID:3312 ! bipolar disorder
! A bipolar disorder that is characterized by at least one hypomanic episode and at least one major depressive episode; with this disorder, depressive episodes are more frequent and more intense than manic episodes.

[Term]
id: DOID:0060169 ! benign familial infantile epilepsy
is_a: DOID:225 ! syndrome
! An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months.

[Term]
id: DOID:0060171 ! Dravet Syndrome
is_a: DOID:1826 ! epilepsy
! An epilepsy that is characterized by frequent febrile seizures with onset before 1 year.

[Term]
id: DOID:0060172 ! juvenile absence epilepsy
is_a: DOID:225 ! syndrome
! An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures.

[Term]
id: DOID:0060173 ! Timothy syndrome
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form caused by mutations in a transcript variant of CACNA1C.

[Term]
id: DOID:0060174 ! GABA aminotransferase deficiency
is_a: DOID:0060176 ! gamma-amino butyric acid metabolism disorder
! A gamma-amino butyric acid metabolism disorder that is characterized by a defect in the gene coding for gamma-aminobutyrate transaminase, which is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.

[Term]
id: DOID:0060175 ! succinic semialdehyde dehydrogenase deficiency
is_a: DOID:0060176 ! gamma-amino butyric acid metabolism disorder
! A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid.

[Term]
id: DOID:0060176 ! gamma-amino butyric acid metabolism disorder
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway.

[Term]
id: DOID:0060177 ! homocarnosinosis
is_a: DOID:0060176 ! gamma-amino butyric acid metabolism disorder
! A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine.

[Term]
id: DOID:0060178 ! familial hemiplegic migraine
is_a: DOID:10024 ! migraine with aura
! A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness.

[Term]
id: DOID:0060179 ! Renpenning syndrome
is_a: DOID:1059 ! intellectual disability
! An intellectual disability that is characterized by small head size (microcephaly), long narrow face, short stature, small testes, and intellectual deficit which follows X-linked inheritance and presents most often in males.

[Term]
id: DOID:0070003 ! blastoma
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from precursor cells called blast cells.

[Term]
id: DOID:0080005 ! bone remodeling disease
is_a: DOID:0080001 ! bone disease
! A bone disease that results_in formation or resorption abnormalities located_in bone.

[Term]
id: DOID:0080006 ! bone development disease
is_a: DOID:0080001 ! bone disease
! A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage.

[Term]
id: DOID:0080007 ! bone deterioration disease
is_a: DOID:0080010 ! bone structure disease
! A bone structure disease that results_in change or damage of structure located_in bone.

[Term]
id: DOID:0080008 ! ischemic bone disease
is_a: DOID:0080001 ! bone disease
! A bone disease that results_in an interruption of blood supply located_in bone.

[Term]
id: DOID:0080010 ! bone structure disease
is_a: DOID:0080001 ! bone disease
! A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure.

[Term]
id: DOID:0080018 ! dysbaric osteonecrosis
is_a: DOID:0080008 ! ischemic bone disease
! An ischemic bone disease the has_material_basis_in nitrogen embolization located_in bone.

[Term]
id: DOID:0080019 ! metaphyseal dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results_in thinning and the tendency to fracture located_in bone.

[Term]
id: DOID:0080020 ! Jansen's metaphyseal chondrodysplasia
is_a: DOID:0080019 ! metaphyseal dysplasia
! A metaphyseal dysplasia that has_material_basis_in mutation in PTH receptor which results_in short-limbed dwarfism.

[Term]
id: DOID:0080021 ! Schmid metaphyseal chondrodysplasia
is_a: DOID:0080019 ! metaphyseal dysplasia
! A metaphyseal dysplasia that results_in dwarfism and bowed legs.

[Term]
id: DOID:0080022 ! McKusick type metaphyseal dysplasia
is_a: DOID:0080019 ! metaphyseal dysplasia
! A metaphyseal dysplasia that results_in short-limbed dwarfism and fine sparse hair.

[Term]
id: DOID:0080026 ! otospondylomegaepiphyseal dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results from mutations in the COL11A2 gene which results_in enlargement of the located_in epiphysis in located_in hand and located_in foot, distinct facial features, platyspondyly and hearing loss.

[Term]
id: DOID:0080027 ! spondyloepimetaphyseal dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results_in abnormalities of the located_in vertebral column, located_in epiphysis, located_in metaphysis.

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
is_a: DOID:0080027 ! spondyloepimetaphyseal dysplasia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080028 ! spondyloepimetaphyseal dysplasia, Strudwick type
is_a: DOID:5684 ! sponastrime dysplasia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the COL2A1 gene which results_in short stature and multiple skeletal abnormalities (lordosis, scoliosis, flattened vertebrae, pectus carinatum, coxa vara, clubfoot, and abnormal epiphyses or metaphyses).

[Term]
id: DOID:0080030 ! spondyloepimetaphyseal dysplasia, Missouri type
is_a: DOID:0080027 ! spondyloepimetaphyseal dysplasia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities.

[Term]
id: DOID:0080030 ! spondyloepimetaphyseal dysplasia, Missouri type
is_a: DOID:5684 ! sponastrime dysplasia
! A spondyloepimetaphyseal dysplasia that has_material_basis_in mutations in the MMP13 gene which results_in a pear-shaped vertebrae, abnormal metaphyseal changes, and genu varum deformities.

[Term]
id: DOID:0080031 ! fibrous dysplasia
is_a: DOID:0080005 ! bone remodeling disease
! A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue.

[Term]
id: DOID:0080032 ! craniodiaphyseal dysplasia
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that results_in increased calcium concentration located_in skull which decreases the size of cranium foramina and cervical spinal canal.

[Term]
id: DOID:0080033 ! craniometaphyseal dysplasia
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that has_material_basis_in mutations in the ANKH gene which results_in progressive thickening located_in skull and abnormally shaped ends of long bones in the limbs.

[Term]
id: DOID:0080036 ! SOST-related sclerosing bone dysplasia
is_a: DOID:205 ! hyperostosis
! A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull.

[Term]
id: DOID:0080037 ! Worth's syndrome
is_a: DOID:205 ! hyperostosis
! A hyperostosis that has_material_basis_in a mutation in the LRP5 gene which results_in increased bone density and bony structures located_in palate.

[Term]
id: DOID:0080038 ! pycnodysostosis
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges.

[Term]
id: DOID:0080039 ! axial osteomalacia
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that results_in coarsening located_in trabecular bone.

[Term]
id: DOID:0080041 ! hypochondroplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism.

[Term]
id: DOID:0080043 ! achondrogenesis
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period.

[Term]
id: DOID:0080044 ! hypochondrogenesis
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which affects bone growth and results_in a small body, hydrops fetalis, and abnormal ossification located_in vertebral column or located_in pelvis. The disease has_symptom enlarged abdomen.

[Term]
id: DOID:0080045 ! Kniest dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face.

[Term]
id: DOID:0080047 ! pseudoachondroplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism.

[Term]
id: DOID:0080049 ! acromesomelic dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb Dwarfism.

[Term]
id: DOID:0080050 ! acromesomelic dysplasia, Maroteaux type
is_a: DOID:0080049 ! acromesomelic dysplasia
! An acromesomelic dysplasia that has_material_basis_in mutation in NPR-B receptor which results_in severe dwarfism, abnormalities of the located_in vertebral column and shortening of middle and distal segments in the located_in limb.

[Term]
id: DOID:0080051 ! acromesomelic dysplasia, Hunter-Thompson type
is_a: DOID:0080049 ! acromesomelic dysplasia
! An acromesomelic dysplasia that has_material_basis_in mutation in AMDH gene which results_in normal axial skeleton but fused bones in the located_in hand or located_in foot.

[Term]
id: DOID:0080052 ! acromesomelic dysplasia, Grebe type
is_a: DOID:0080049 ! acromesomelic dysplasia
! An acromesomelic dysplasia that has_material_basis_in mutation in CDMP-1 which results_in micromelia, absence of middle and proximal phalanges and some metacarpal and metatarsal bones.

[Term]
id: DOID:0080053 ! Albright's hereditary osteodystrophy
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in lack of responsiveness to parathyroid hormone which results_in shortening and widening of long bones of the located_in hand or located_in foot along with short stature, obesity, and rounded face.

[Term]
id: DOID:0080054 ! achondrogenesis type IA
is_a: DOID:0080043 ! achondrogenesis
! An achondrogenesis that results_in abnormal ossification of the located_in vertebral column or located_in spine.

[Term]
id: DOID:0080055 ! achondrogenesis type IB
is_a: DOID:0080043 ! achondrogenesis
! An achondrogenesis that has_material_basis_in mutation in the SLC26A2 gene which results_in umbilical or inguinal hernia and a prominent rounded abdomen.

[Term]
id: DOID:0080056 ! achondrogenesis type II
is_a: DOID:0080043 ! achondrogenesis
! An achondrogenesis that has_material_basis_in mutations in the COL2A1 gene which results_in underdeveloped lungs, hydrops fetalis,a prominent forehead and abnormal ossification of the located_in vertebral column or located_in pelvis.

[Term]
id: DOID:100 ! intestinal infectious disease
is_a: DOID:5295 ! intestinal disease
! An intestinal disease that involves intestinal infection caused by viruses, bacteria, fungi and parasites.

[Term]
id: DOID:10027 ! tabes dorsalis
is_a: DOID:9988 ! tertiary neurosyphilis
! A tertiary neurosyphilis that results_in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has_symptom intense, stabbing pain in the back and legs that recurs irregularly, has_symptom gait ataxia, has_symptom hyperesthesia, has_symptom paresthesia, has_symptom loss of bladder sensation leading to urine retention, has_symptom erectile dysfunction.

[Term]
id: DOID:10035 ! asymptomatic neurosyphilis
is_a: DOID:9988 ! tertiary neurosyphilis
! A tertiary neurosyphilis that results_in mild meningitis.

[Term]
id: DOID:10039 ! late congenital syphilis
is_a: DOID:9856 ! congenital syphilis
! A congenital syphilis that occurs in children at or greater than two years of age who acquired the infection trans-placentally. The infection has_symptom gummatous ulcers, has_symptom periosteal lesions, has_symptom paresis, has_symptom tabes, has_symptom optic atrophy, has_symptom interstitial keratitis, has_symptom sensorineural deafness, and has_symptom dental deformities.

[Term]
id: DOID:10113 ! trypanosomiasis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans.

[Term]
id: DOID:10154 ! small intestine cancer
is_a: DOID:10155 ! intestinal cancer
! An intestinal cancer that is located_in the small intestine.

[Term]
id: DOID:10155 ! intestinal cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the intestine.

[Term]
id: DOID:10159 ! osteonecrosis
is_a: DOID:0080008 ! ischemic bone disease
! An ischemic bone disease that results_in necrosis located_in bone.

[Term]
id: DOID:1019 ! osteomyelitis
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow.

[Term]
id: DOID:10192 ! pleomorphic lipoma
is_a: DOID:3315 ! lipoma
! A lipoma that is characterized by floret giant cells with overlapping nuclei.

[Term]
id: DOID:10205 ! axillary lipoma
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm located_in the axilla, an area directly under the arm and shoulder joint composed_of adipose tissue.

[Term]
id: DOID:1022 ! pinta disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Treponema carateum, which is transmitted_by contact with skin and mucous membrane of an infected person. The infection has_symptom pruritic plaque, which slowly enlarges and becomes pigmented and hyperkeratotic.

[Term]
id: DOID:10223 ! dermatomyositis
is_a: DOID:633 ! myositis
! A myositis that results_in inflammation located_in muscle or located_in skin. The disease may result from either a viral infection or an autoimmune reaction.

[Term]
id: DOID:1024 ! leprosy
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage.

[Term]
id: DOID:10242 ! ehrlichiosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash.

[Term]
id: DOID:10247 ! pleurisy
is_a: DOID:0050117 ! disease by infectious agent
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
is_a: DOID:10247 ! pleurisy
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10247 ! pleurisy
is_a: DOID:162 ! cancer
! A lower respiratory infectious disease involving inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. Major causes of pleurisy include cancer, drug reactions, infection with parasites such as amoeba or flukes, injury such as a rib fracture or bruise, irritants that reach the pleura from the airways such as asbestos, lung infarction caused by pulmonary embolism, pancreatitis, pneumonia, rheumatoid arthritis, systemic lupus erythematosus, tuberculosis and viral pleuritis. The inflamed pleural layers rub against each other every time the lungs expand to breathe in air. This can cause sharp pain with breathing (also called pleuritic chest pain).

[Term]
id: DOID:10250 ! louping ill
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted_by sheep tick, Ixodes ricinus. The infection has_symptom lethargy, has_symptom muscle pains, has_symptom fever, and has_symptom focal neurological signs.

[Term]
id: DOID:10264 ! mumps
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in salivary gland, has_material_basis_in Mumps virus, which is transmitted_by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted_by contaminated fomites. The infection has_symptom fever, has_symptom headache, has_symptom muscle aches, has_symptom tiredness, has_symptom loss of appetite, has_symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face.

[Term]
id: DOID:10316 ! pneumoconiosis
is_a: DOID:3082 ! interstitial lung disease
! An interstitial lung disease that is caused by the inhalation of dust.

[Term]
id: DOID:10322 ! berylliosis
is_a: DOID:10316 ! pneumoconiosis
! A pneumoconiosis that involves allergic response located_in lungs caused by inhalation of beryllium compounds.

[Term]
id: DOID:10326 ! Caplan's syndrome
is_a: DOID:10316 ! pneumoconiosis
! A pneumoconiosis that results_in humans that also have rheumatoid arthritis.

[Term]
id: DOID:10371 ! yaws
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in skin, located_in joint or located_in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has_symptom skin lesions.

[Term]
id: DOID:10398 ! pneumonic plague
is_a: DOID:3482 ! plague
! A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing.

[Term]
id: DOID:104 ! bacterial infectious disease
is_a: DOID:0050117 ! disease by infectious agent
! A disease by infectious agent that results_in infection, has_material_basis_in Bacteria.

[Term]
id: DOID:10426 ! Klippel-Feil syndrome
is_a: DOID:759 ! congenital disorder
! A congenital disorder that has_material_basis_in abnormal segementation of the vertebra during fetal development which results_in fusion located_in cervical vertebra.

[Term]
id: DOID:10456 ! tonsillitis
is_a: DOID:10456 ! tonsillitis
! An upper respiratory tract disease which involves inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat (which may be experienced as referred pain to the ears), painful/difficult swallowing, coughing, headache, myalgia (muscle aches), fever and chills. Tonsillitis is characterized by signs of red, swollen tonsils which may have a purulent exudative coating of white patches (i.e. pus). Swelling of the cheeks and neck may occur.

[Term]
id: DOID:10457 ! Legionnaires' disease
is_a: DOID:10458 ! legionellosis
! A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough.

[Term]
id: DOID:10458 ! legionellosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea.

[Term]
id: DOID:10459 ! common cold
is_a: DOID:974 ! upper respiratory tract disease
! An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus.

[Term]
id: DOID:10516 ! malignant otitis externa
is_a: DOID:9463 ! otitis externa
! A otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

[Term]
id: DOID:10518 ! beach ear
is_a: DOID:9463 ! otitis externa
! A otitis externa which is a microbial infection that occurs suddenly, rapidly worsens, and becomes very painful and alarming. It is caused by swimming in polluted water, scratching the ear or inside the ear and object stuck in the ear. It is occasionally associated with middle ear infection or upper respiratory infections such as colds.

[Term]
id: DOID:10533 ! viral pneumonia
is_a: DOID:552 ! pneumonia
! A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus.

[Term]
id: DOID:10534 ! stomach cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the stomach.

[Term]
id: DOID:10567 ! late yaws
is_a: DOID:10371 ! yaws
! A yaws that appears after five years of the initial infection and is characterized by disabling consequences of the nose, bones and palmar/plantar hyperkeratosis.

[Term]
id: DOID:10573 ! osteomalacia
is_a: DOID:0080005 ! bone remodeling disease
! A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone.

[Term]
id: DOID:10579 ! leukodystrophy
is_a: DOID:1443 ! cerebral degeneration
! A cerebral degeneration characterized by dysfunction of the white matter of the brain.

[Term]
id: DOID:106 ! pleural tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that results_in lymphocyte-predominant exudative pleural effusion, located_in pleura. This results from an allergic response to tuberculoprotein causing the permeabiltity of the pleural vasculature to alter leading to a sub-pleural caseous focus rupture into the pleural sac.

[Term]
id: DOID:1060 ! Hartnup disease
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that iis caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum.

[Term]
id: DOID:10600 ! chronic tic disorder
is_a: DOID:2769 ! tic disorder
! A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

[Term]
id: DOID:10608 ! celiac disease
is_a: DOID:3044 ! food allergy
! A food allergy that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite.

[Term]
id: DOID:10609 ! rickets
is_a: DOID:0080005 ! bone remodeling disease
! A bone remodeling disease that has_material_basis_in a vitamin D deficiency in children which results_in softening and deformity located_in bone.

[Term]
id: DOID:10632 ! Wolfram syndrome
is_a: DOID:630 ! genetic disease
! A genetic disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the gene encoding wolframin (WFS1).

[Term]
id: DOID:10652 ! Alzheimer's disease
is_a: DOID:1307 ! dementia
! A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.

[Term]
id: DOID:10755 ! petrositis
is_a: DOID:1019 ! osteomyelitis
! An osteomyelitis that has_material_basis_in infection located_in petrous part of temporal bone.

[Term]
id: DOID:10773 ! bubonic plague
is_a: DOID:3482 ! plague
! A plague that results_in infection located_in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has_symptom enlarged, tender lymph nodes, has_symptom fever, has_symptom chills and has_symptom prostration.

[Term]
id: DOID:10784 ! Queensland tick typhus
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy.

[Term]
id: DOID:10811 ! nasal cavity cancer
is_a: DOID:0050615 ! respiratory system cancer
! A respiratory system cancer that is located_in the nasal cavity.

[Term]
id: DOID:1082 ! dirofilariasis
is_a: DOID:1080 ! filariasis
! A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

[Term]
id: DOID:10841 ! Eastern equine encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted_by Aedes, transmitted_by Coquillettidia, and transmitted_by Culex species of mosquitoes. The infection has_symptom sudden onset of headache, has_symptom high fever, has_symptom chills, has_symptom vomiting, has_symptom disorientation, has_symptom seizures, and has_symptom coma.

[Term]
id: DOID:10842 ! Murray Valley encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness.

[Term]
id: DOID:10843 ! Western equine encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness.

[Term]
id: DOID:10844 ! Japanese encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis.

[Term]
id: DOID:10845 ! St. Louis encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis.

[Term]
id: DOID:10881 ! hand, foot and mouth disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet.

[Term]
id: DOID:10882 ! epidemic pleurodynia
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in necrosis located_in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has_symptom severe chest pain, has_symptom fever, has_symptom malaise, has_symptom pleuritis, and has_symptom headache.

[Term]
id: DOID:10883 ! herpangina
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted_by ingestion of food contaminated with feces, transmitted_by contact with pharyngeal secretions, or transmitted_by droplet spread of oronasal secretions. The infection has_symptom fever, has_symptom sore throat, and has_symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars.

[Term]
id: DOID:10887 ! lepromatous leprosy
is_a: DOID:1024 ! leprosy
! A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas.

[Term]
id: DOID:10919 ! transsexualism
is_a: DOID:1234 ! gender identity disorder
! A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex.

[Term]
id: DOID:10921 ! Siberian tick typhus
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia sibirica, which is transmitted_by ticks (Dermacentor nuttalli, Dermacentor marginatus and Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom regional adenopathy, and has_symptom maculopapular rash.

[Term]
id: DOID:10930 ! borderline personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods.

[Term]
id: DOID:10931 ! dependent personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that is characterized by a pervasive psychological dependence on other people.

[Term]
id: DOID:10932 ! obsessive-compulsive personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency.

[Term]
id: DOID:10936 ! schizoid personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world.

[Term]
id: DOID:10938 ! paranoid personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others.

[Term]
id: DOID:1094 ! attention deficit hyperactivity disorder
is_a: DOID:0060038 ! specific developmental disorder
! A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age.

[Term]
id: DOID:10983 ! Alport syndrome
is_a: DOID:0050177 ! monogenic disease
! A monogenic disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss.

[Term]
id: DOID:11042 ! Felty's syndrome
is_a: DOID:225 ! syndrome
! A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia.

[Term]
id: DOID:11054 ! urinary bladder cancer
is_a: DOID:3996 ! urinary system cancer
! An urinary system cancer that results_in malignant growth located_in the urinary bladder.

[Term]
id: DOID:11055 ! pasteurellosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia.

[Term]
id: DOID:11060 ! placenta praevia
is_a: DOID:780 ! placenta disease
! A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix.

[Term]
id: DOID:1107 ! esophageal carcinoma
is_a: DOID:5041 ! esophageal cancer
! A esophageal cancer that is located_in the esophagus.

[Term]
id: DOID:11076 ! Brucella suis brucellosis
is_a: DOID:11077 ! brucellosis
! A brucellosis that involves an infection caused by Brucella suis [NCBITaxon:29461] in swine and humans. The disease has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom diaphoresis, has_symptom arthralgia, has_symptom myalgia, has_symptom headache, has_symptom anorexia, and has_symptom fatigue.

[Term]
id: DOID:11077 ! brucellosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue.

[Term]
id: DOID:11080 ! myiasis
is_a: DOID:4110 ! parasitic ectoparasitic infectious disease
! A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue.

[Term]
id: DOID:11100 ! Q fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia.

[Term]
id: DOID:11101 ! trench fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted_by body lice (Pediculus humanus corporis). The infection has_symptom relapsing fever, has_symptom headache, has_symptom shin pain, and has_symptom soreness of the muscles of the legs and back.

[Term]
id: DOID:11103 ! rickettsialpox
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia akari, which is transmitted_by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, and has_symptom papulovesicular rash.

[Term]
id: DOID:11104 ! spotted fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, located_in endothelial cell of artery or located_in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted_by ticks and mites. The infection has_symptom fever, has_symptom headache, has_symptom fatigue, has_symptom muscle aches, and has_symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

[Term]
id: DOID:11119 ! Gilles de la Tourette syndrome
is_a: DOID:2769 ! tic disorder
! A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year.

[Term]
id: DOID:1114 ! esophagus sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of esophagus that is_located in the esophagus.

[Term]
id: DOID:1115 ! sarcoma
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic mesoderm.

[Term]
id: DOID:1116 ! pertussis
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop).

[Term]
id: DOID:11165 ! common wart
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body.

[Term]
id: DOID:11168 ! anogenital venereal wart
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts.

[Term]
id: DOID:11186 ! allescheriosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Pseudallescheria boydii, which results_in_formation_of abscesses.

[Term]
id: DOID:11193 ! syndactyly
is_a: DOID:11971 ! synostosis
! A synostosis that results_in the fusion of two or more digits.

[Term]
id: DOID:11227 ! acute hemorrhagic conjunctivitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted_by contaminated fomites or transmitted_by contact with contaminated hands. The infection has_symptom vascular dilation, has_symptom eyelid edema, has_symptom photophobia, has_symptom redness of the eyes, has_symptom watering of the eye, has_symptom conjunctival congestion, and has_symptom superficial punctate epithelial keratitis.

[Term]
id: DOID:11239 ! appendix cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the appendix.

[Term]
id: DOID:11256 ! typhus
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that refers to a group of diseases, located_in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted_by lice, transmitted_by fleas, and transmitted_by mites.

[Term]
id: DOID:11258 ! cat-scratch disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain.

[Term]
id: DOID:11260 ! rabies
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain or located_in spinal cord, has_material_basis_in Rabies virus, which is transmitted_by bite of an infected animal, or transmitted_by contact of mucous membranes with saliva of an infected animal. The infection has_symptom fever, has_symptom headache, has_symptom prickling or itching sensation at the site of bite, has_symptom anxiety, has_symptom confusion, has_symptom agitation, has_symptom delirium, has_symptom difficulty swallowing, has_symptom hydrophobia, and has_symptom paralysis.

[Term]
id: DOID:11262 ! ornithosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia.

[Term]
id: DOID:11265 ! trachoma
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11266 ! hemorrhagic fever with renal syndrome
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, located_in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade virus, has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted_by rodents. The infection has_symptom headache, has_symptom fever, has_symptom muscle pains, has_symptom facial flush, has_symptom petechiae, has_symptom hemorrhagic features, has_symptom proteinuria, and has_symptom renal failure.

[Term]
id: DOID:11285 ! tick paralysis
is_a: DOID:4109 ! tick infestation
! A tick infestation that is characterized by an acute, ascending, flaccid motor paralysis, which is caused by the introduction of a neurotoxin into humans during attachment and feeding by the females of several tick species such as Dermacentor andersoni, Dermacentor variabilis, Amblyomma americanum, Amblyomma maculatum, Ixodes scapularis, Ixodes pacificus, Ixodes holocyclus, Rhipicephalus sanguineus and Otobius megnini. The symptoms include local inflammation, edema and hemorrhage.

[Term]
id: DOID:11289 ! ventilation pneumonitis
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis caused by inhalation of antigens from thermophilic actinomycetes species growing in air conditioners and humidifiers. Fungi like Aureobasidium sp and Candida albicans that survive in the contaminated water in humidifiers and air conditioners are also known to cause the disease.

[Term]
id: DOID:11302 ! cercarial dermatitis
is_a: DOID:1395 ! schistosomiasis
! A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has_symptom skin reddening, has_symptom skin itching, in the water or immediately after emerging and has_symptom itchy, raised papules, occur within hours of infection.

[Term]
id: DOID:11315 ! African histoplasmosis
is_a: DOID:1731 ! histoplasmosis
! A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and results_in_formation_of nodules, results_in_formation_of ulcers and results_in_formation_of osteolytic bone lesions.

[Term]
id: DOID:11320 ! Kyasanur forest disease
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11320 ! Kyasanur forest disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted_by Haemaphysalis spinigera tick bite. The infection has_symptom fever, has_symptom headache, has_symptom stiffness of the neck, has_symptom severe muscle pain, has_symptom cough, has_symptom dehydration, and has_symptom bleeding problems.

[Term]
id: DOID:11336 ! rhinoscleroma
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

[Term]
id: DOID:11337 ! Lemierre's syndrome
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that is characterized by systemic sepsis, ulcerative or necrotic lesions and multisystem abscesses caused by Fusobacterium necrophorum. The disease often first presents as a severe tonsillitis or pharyngitis with high-grade fever and chills together with leukocytosis, cervical pain and neck swelling.

[Term]
id: DOID:11339 ! pneumocystosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that is located_in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has_symptom nonproductive cough, has_symptom shortness of breath, and has_symptom fever.

[Term]
id: DOID:11360 ! Phlebotomus fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted_by Phlebotomus papatasi sandfly. The infection has_symptom fever, has_symptom severe frontal headaches, has_symptom muscle ache, has_symptom joint aches, has_symptom flushing of the face, and has_symptom tachycardia.

[Term]
id: DOID:11385 ! expressive language disorder
is_a: DOID:93 ! language disorder
! A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits.

[Term]
id: DOID:11387 ! epidural abscess
is_a: DOID:11387 ! epidural abscess
! Epidural abscess is a CNS abscess characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine. The abscess causes swelling in the area. Epidural abscess is a rare disorder caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). This infectious disease is called an intracranial epidural abscess if it is inside the skull area, or a spinal epidural abscess if it is found in the spine area. Nine out of 10 cases are located in the spine.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
is_a: DOID:11162 ! respiratory failure
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11394 ! adult respiratory distress syndrome
is_a: DOID:552 ! pneumonia
! A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia.

[Term]
id: DOID:11405 ! diphtheria
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys.

[Term]
id: DOID:11450 ! allergic cutaneous vasculitis
is_a: DOID:9809 ! hypersensitivity vasculitis
! A hypersensitivity vasculitis that results_in inflammation of small blood vessels, characterized clinically by palpable purpura, which is a slightly elevated purpuric rash over one or more areas of the skin.

[Term]
id: DOID:11476 ! osteoporosis
is_a: DOID:0080011 ! bone resorption disease
! A bone resorption disease that has_material_basis_in a drop in estrogen or testosterone which results_in the thinning of bone tissue and loss of bone mineral density.

[Term]
id: DOID:11516 ! hypertensive heart disease
is_a: DOID:114 ! heart disease
! A heart disease that is caused by high blood presure.

[Term]
id: DOID:11549 ! Adie syndrome
is_a: DOID:0060052 ! neurological disorder
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:11549 ! Adie syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is a neurological disorder affecting the pupil of the eye and the autonomic nervous system. It is characterized by one eye with a pupil that is larger than normal and constricts slowly in bright light (tonic pupil), along with the absence of deep tendon reflexes, usually in the Achilles tendon.

[Term]
id: DOID:11558 ! acute allergic serous otitis media
is_a: DOID:11557 ! acute serous otitis media
! A acute serous otitis media caused by an allergen.

[Term]
id: DOID:1156 ! pseudogout
is_a: DOID:848 ! arthritis
! An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint.

[Term]
id: DOID:11573 ! listeriosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth.

[Term]
id: DOID:1166 ! palindromic rheumatism
is_a: DOID:225 ! syndrome
! A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

[Term]
id: DOID:1166 ! palindromic rheumatism
is_a: DOID:848 ! arthritis
! A syndrome that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms.

[Term]
id: DOID:11678 ! onchocerciasis
is_a: DOID:1080 ! filariasis
! A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy.

[Term]
id: DOID:11702 ! dysgammaglobulinemia
is_a: DOID:6025 ! selective immunoglobulin deficiency disease
! A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins.

[Term]
id: DOID:11729 ! Lyme disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system.

[Term]
id: DOID:11750 ! Bordetella parapertussis whooping cough
is_a: DOID:1116 ! pertussis
! A pertussis that is a milder disease caused by the bacterium Bordetella parapertussis. The disease has_symptom coughing, has_symptom sneezing, or has_symptom runny nose .

[Term]
id: DOID:11760 ! Kohler's disease
is_a: DOID:8125 ! osteochondrosis
! An osteochondrosis that results_in death and collapse located_in navicular bone of foot.

[Term]
id: DOID:118 ! pericardial effusion
is_a: DOID:114 ! heart disease
! A heart disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

[Term]
id: DOID:11812 ! bladder sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of urinary bladder that is located_in the bladder.

[Term]
id: DOID:11819 ! ureter cancer
is_a: DOID:3996 ! urinary system cancer
! A urinary system cancer that is located_in the ureter.

[Term]
id: DOID:11838 ! penis sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of penis that is located_in the penis.

[Term]
id: DOID:11917 ! tinea cruris
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

[Term]
id: DOID:1192 ! peripheral nervous system neoplasm
is_a: DOID:3093 ! nervous system cancer
! A nervous system cancer that is located_in the peripheral nervous system.

[Term]
id: DOID:11920 ! tracheal cancer
is_a: DOID:0050615 ! respiratory system cancer
! A respiratory system cancer that is located_in the trachea.

[Term]
id: DOID:11971 ! synostosis
is_a: DOID:1934 ! dysostosis
! A dysostosis that results_in abnormal fusing of adjacent bones.

[Term]
id: DOID:11976 ! botulism
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located_in neuromuscular junction, resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F.

[Term]
id: DOID:11990 ! ulceroglandular tularemia
is_a: DOID:2123 ! tularemia
! A tularemia that results_in painful regional lymphadenopathy and an ulcerated skin lesion.

[Term]
id: DOID:11991 ! osteopoikilosis
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that results_in numerous bone islands located_in skeleton.

[Term]
id: DOID:12002 ! trachea sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant tumor of trachea that is located_in the trachea.

[Term]
id: DOID:12053 ! cryptococcosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii.

[Term]
id: DOID:12096 ! sodoku disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Spirillum minus, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom relapsing fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:1210 ! optic neuritis
is_a: DOID:1891 ! optic nerve disease
! An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision.

[Term]
id: DOID:12119 ! hemosiderosis
is_a: DOID:2351 ! iron metabolism disease
! An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload.

[Term]
id: DOID:12129 ! bulimia nervosa
is_a: DOID:8670 ! eating disorder
! An eating disorder characterized by the restraining of food intake for a period of time followed by an over intake or binging period that results in feelings of guilt and low self-esteem.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
is_a: DOID:417 ! hypersensitivity reaction type II disease
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12132 ! Wegener's granulomatosis
is_a: DOID:865 ! vasculitis
! An autoimmune disease that is a vasculitis that is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels.

[Term]
id: DOID:12134 ! factor VIII deficiency
is_a: DOID:4 ! disease
! An X-linked disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.

[Term]
id: DOID:12140 ! Chagas disease
is_a: DOID:10113 ! trypanosomiasis
! A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis.

[Term]
id: DOID:12148 ! alveolar echinococcosis
is_a: DOID:1496 ! echinococcosis
! An echinococcosis that is caused by the larvae of Echinococcus multilocularis affecting the liver as a slow growing, destructive tumor, with abdominal pain, biliary obstruction, and occasionally metastatic lesions into the lungs and brain.

[Term]
id: DOID:12155 ! lymphocytic choriomeningitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in brain, or located_in meninges, or located_in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has_symptom fever, has_symptom lack of appetite, has_symptom headache, has_symptom muscle aches, has_symptom malaise, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:12177 ! common variable immunodeficiency
is_a: DOID:2583 ! agammaglobulinemia
! A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).

[Term]
id: DOID:12179 ! tinea corporis
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in fungal infection located_in skin, limited to the stratum corneum of the epidermis, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, and has_symptom red colored skin rash. The border of the rash lesions look scaly.

[Term]
id: DOID:12205 ! dengue disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom severe headache, has_symptom severe pain behind the eyes, has_symptom joint pain, has_symptom muscle and bone pain, has_symptom rash, and has_symptom mild bleeding.

[Term]
id: DOID:12206 ! dengue hemorrhagic fever
is_a: DOID:12205 ! dengue disease
! A dengue disease that occurs when a person experiences a second infection with a heterologous Dengue virus serotype, which is transmitted_by Aedes mosquito bite. The infection has_symptom hemorrhagic lesions of the skin, has_symptom thrombocytopenia, has_symptom reduction in the fluid part of the blood, and has_symptom high fever.

[Term]
id: DOID:12211 ! filarial elephantiasis
is_a: DOID:1080 ! filariasis
! A filariasis that is characterized by the thickening of the skin and underlying tissues, especially in the legs, male genitals and female breasts, caused by thread-like parasitic worms Wuchereria bancrofti, Brugia malayi or Brugia timori, which inhabit the lymphatics. These nematodes are transmitted by mosquitoes. Acute symptoms include fever, lymphadenitis, lymphangitis, funiculitis, and epididymitis. Chronic symptoms include abscesses, hyperkeratosis, polyarthritis, hydroceles, lymphedema, and elephantiasis.

[Term]
id: DOID:12215 ! oligohydramnios
is_a: DOID:780 ! placenta disease
! A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion.

[Term]
id: DOID:12252 ! Cushing's syndrome
is_a: DOID:3947 ! adrenal gland hyperfunction
! An adrenal gland hyperfunction that is caused by overactivity of the adrenal cortex caused by a tumor of the pituitary gland.

[Term]
id: DOID:12259 ! hemophilia B
is_a: DOID:2214 ! inherited blood coagulation disease
! An inherited blood coagulation disease that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait.

[Term]
id: DOID:12275 ! cutaneous diphtheria
is_a: DOID:11405 ! diphtheria
! A pyoderma that is a milder form of diphtheria restricted to the skin producing shallow skin ulcers is caused by direct physical contact of indivduals infected with Corynebacterium diphtheriae as the bacteria releases the diphtheria toxin.

[Term]
id: DOID:12275 ! cutaneous diphtheria
is_a: DOID:4223 ! pyoderma
! A pyoderma that is a milder form of diphtheria restricted to the skin producing shallow skin ulcers is caused by direct physical contact of indivduals infected with Corynebacterium diphtheriae as the bacteria releases the diphtheria toxin.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12287 ! Crimean-Congo hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine.

[Term]
id: DOID:12294 ! atypical depressive disorder
is_a: DOID:3324 ! mood disorder
! A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.

[Term]
id: DOID:12297 ! Vogt-Koyanagi-Harada disease
is_a: DOID:417 ! hypersensitivity reaction type II disease
! An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis.

[Term]
id: DOID:12323 ! cough variant asthma
is_a: DOID:2841 ! asthma
! An asthma that is characterized by chronic nonproductive cough without shortness of breath.

[Term]
id: DOID:12341 ! retroperitoneal sarcoma
is_a: DOID:1115 ! sarcoma
! A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space.

[Term]
id: DOID:12347 ! osteogenesis imperfecta
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue.

[Term]
id: DOID:12361 ! Graves' disease
is_a: DOID:0060005 ! autoimmune disease of endocrine system
! An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland.

[Term]
id: DOID:12365 ! malaria
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

[Term]
id: DOID:12375 ! bronchopneumonia
is_a: DOID:552 ! pneumonia
! A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

[Term]
id: DOID:12377 ! spinal muscular atrophy
is_a: DOID:231 ! motor neuron disease
! A motor neuron disease that is_a degenerative neuromuscular disease characterized by motor neuron degeration.

[Term]
id: DOID:12385 ! shigellosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces.

[Term]
id: DOID:12386 ! balantidiasis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease involving infection caused by Balantidium coli. The trophozoites are capable of attacking the intestinal epithelium, creating ulcers and causing bloody diarrhea. The infectiou has_symptom cramping, has_symptom abdominal pain, has_symptom nausea and has_symptom foul breath.

[Term]
id: DOID:12403 ! tinea pedis
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot.

[Term]
id: DOID:12474 ! capillariasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species.

[Term]
id: DOID:1251 ! tuberculous epididymitis
is_a: DOID:2149 ! urogenital tuberculosis
! An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling.

[Term]
id: DOID:1252 ! trichuriasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation.

[Term]
id: DOID:12522 ! bagassosis
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis that is an industrial disease characterized by cough, difficult breathing, chills, fever, and prolonged weakness caused by the inhalation of the dust of bagasse containing thermophilic actinomycetes.

[Term]
id: DOID:12549 ! hepatitis A
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:12662 ! paracoccidioidomycosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis.

[Term]
id: DOID:12663 ! blastomycosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening.

[Term]
id: DOID:12683 ! vestibular neuronitis
is_a: DOID:0050117 ! disease by infectious agent
! A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent.

[Term]
id: DOID:12700 ! hyperprolactinemia
is_a: DOID:0060158 ! acquired metabolic disease
! An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood.

[Term]
id: DOID:12711 ! black piedra
is_a: DOID:0050133 ! superficial mycosis
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Piedraia hortae, an ascomycetous fungus forming hard black nodules on the shafts of the scalp, beard, moustache and pubic hair.

[Term]
id: DOID:12716 ! newborn respiratory distress syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is characterized as a respiratory disorder that occurs in newborn premature infants and is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts.

[Term]
id: DOID:12721 ! multiple epiphyseal dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results_in irregular ossification centers of the located_in hip or located_in knee. The disease has_symptom fatigue, has_symptom joint pain.

[Term]
id: DOID:1273 ! respiratory syncytial virus infectious disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress.

[Term]
id: DOID:12783 ! migraine without aura
is_a: DOID:6364 ! migraine
! A migraine that is characterized by migraine headaches that are not accompanied by an aura.

[Term]
id: DOID:12841 ! ancylostomiasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition.

[Term]
id: DOID:12849 ! autistic disorder
is_a: DOID:0060041 ! autism spectrum disorder
! An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

[Term]
id: DOID:12858 ! Huntington's disease
is_a: DOID:1289 ! neurodegenerative disease
! A neurodegenerative disease that has_material_basis_in expansion of CAG repeats resulting in neuron degeneration affecting muscle coordination, cognitive abilities.

[Term]
id: DOID:1289 ! neurodegenerative disease
is_a: DOID:331 ! central nervous system disease
! A central nervous system disease that results_in the progressive deterioration of tissue or organ function or structure, whether due to normal bodily wear or lifestyle choices.

[Term]
id: DOID:12919 ! Plasmodium ovale malaria
is_a: DOID:12365 ! malaria
! A malaria characaterized as a relatively mild form caused by a parasite Plasmodium ovale, which is characterized by tertian chills and febrile paroxysms, and that ends spontaneously.

[Term]
id: DOID:12960 ! acrocephalosyndactylia
is_a: DOID:11971 ! synostosis
! A synostosis that results_in craniosynostosis and syndactyly.

[Term]
id: DOID:12965 ! subleukemic leukemia
is_a: DOID:1240 ! leukemia
! A leukemia that is characterized by the presence of abnormal white blood cells located_in peripheral blood, but in which the total number of white blood cells is normal.

[Term]
id: DOID:12969 ! central nervous system leukemia
is_a: DOID:2531 ! hematologic cancer
! A hematologic cancer located_in the central nervous system.

[Term]
id: DOID:12978 ! Plasmodium vivax malaria
is_a: DOID:12365 ! malaria
! A malaria that is caused by the protozoan parasite Plasmodium vivax, which induces paroxysms at 48-hour intervals.

[Term]
id: DOID:13026 ! lobomycosis
is_a: DOID:1563 ! dermatomycosis
! A dermatomycosis that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Lacazia loboi and has_symptom crusty plaques, has_symptom tumors and results_in_formation_of nodular lesions.

[Term]
id: DOID:13027 ! transient global amnesia
is_a: DOID:10914 ! amnestic disorder
! An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories.

[Term]
id: DOID:13034 ! relapsing fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse.

[Term]
id: DOID:13035 ! louse-borne relapsing fever
is_a: DOID:13034 ! relapsing fever
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia recurrentis, which is transmitted_by body louse (Pediculus humanus). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13036 ! tick-borne relapsing fever
is_a: DOID:13034 ! relapsing fever
! A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13074 ! tinea unguium
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

[Term]
id: DOID:13078 ! eumycotic mycetoma
is_a: DOID:1563 ! dermatomycosis
! A dermatomycosis that effects skin and subcutaneous tissue located_in foot, located_in trunk, located_in buttocks, located_in eyelids, located_in lacrimal glands, located_in paranasal sinuses, located_in mandible, located_in scalp, located_in neck, located_in perineum, or located_in testes and has_symptom sinus discharge and result_in_formation_of nodules.

[Term]
id: DOID:13166 ! allergic bronchopulmonary aspergillosis
is_a: DOID:13564 ! aspergillosis
! An aspergillosis that involves an allergic reaction due to the spores of Aspergillus moulds (A. fumigatus), which colonizes the mucus in the airways causing inflammation. The disease has_symptom cough, has_symptom wheezing and has_symptom fever.

[Term]
id: DOID:13189 ! gout
is_a: DOID:848 ! arthritis
! An arthritis that has_material_basis_in uric acid crystal deposits located_in joint.

[Term]
id: DOID:13226 ! oculoglandular tularemia
is_a: DOID:2123 ! tularemia
! A tularemia that results_in inflammation of eye and swelling of lymph glands in front of the ear.

[Term]
id: DOID:13238 ! Haverhill fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Streptobacillus moniliformis, which is transmitted_by contact with urine or secretions from the mouth, eye, or nose of an infected animal or transmitted_by bite of an infected animal, especially rat. The infection has_symptom chills, has_symptom fever, has_symptom rash and has_symptom joint pain.

[Term]
id: DOID:1324 ! lung cancer
is_a: DOID:0050615 ! respiratory system cancer
! A respiratory system cancer that is located_in the lung.

[Term]
id: DOID:13241 ! Behcet's disease
is_a: DOID:0060051 ! autoimmune disease of cardiovascular system
! An autoimmune disease of cardiovascular system that causes chronic inflammation in blood vessels throughout the body leading to ulcerations on the mouth and sometimes the genitals, notorious for causing hypopyon uveitis.

[Term]
id: DOID:13258 ! typhoid fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia.

[Term]
id: DOID:1328 ! Rift Valley fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites.

[Term]
id: DOID:13282 ! intestinal tuberculosis
is_a: DOID:404 ! gastrointestinal tuberculosis
! A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:13300 ! Scheuermann's disease
is_a: DOID:8125 ! osteochondrosis
! An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column.

[Term]
id: DOID:13352 ! ego-dystonic sexual orientation
is_a: DOID:1234 ! gender identity disorder
! A gender identity disorder that is characterized by having a sexual orientation or an attraction that is at odds with one's idealized self-image, causing anxiety and a desire to change one's orientation or become more comfortable with one's sexual orientation.

[Term]
id: DOID:13359 ! Ehlers-Danlos syndrome
is_a: DOID:854 ! collagen disease
! A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising.

[Term]
id: DOID:13366 ! Stiff-Person syndrome
is_a: DOID:480 ! movement disease
! A movement disease that is of unknown etiology characterized by progressive rigidity.

[Term]
id: DOID:13368 ! tinea profunda
is_a: DOID:12179 ! tinea corporis
! A tinea corporis that results_in fungal infection located_in skin, has_material_basis_in Trichophyton mentagrophytes and results_in_formation_of subcutaneous abscesses.

[Term]
id: DOID:13369 ! tinea manuum
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling.

[Term]
id: DOID:13371 ! scrub typhus
is_a: DOID:11256 ! typhus
! A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted_by trombiculid mites (Leptotrombidium deliense). The infection has_symptom fever, has_symptom headache, has_symptom muscle pain, has_symptom cough, has_symptom maculopapular rash, has_symptom eschar, has_symptom splenomegaly and has_symptom lymphadenopathy.

[Term]
id: DOID:13372 ! alpha 1-antitrypsin deficiency
is_a: DOID:2345 ! plasma protein metabolism disease
! A plasma protein metabolism disease that has_material_basis_in  defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells.

[Term]
id: DOID:13374 ! fibrodysplasia ossificans progressiva
is_a: DOID:65 ! connective tissue disease
! .A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene.

[Term]
id: DOID:13386 ! gastrointestinal anthrax
is_a: DOID:7427 ! anthrax disease
! An anthrax disease that results_in infection located_in mucosa of gastrointestinal tract, has_material_basis_in Bacillus anthracis, which is transmitted_by ingestion of anthrax-infected meat. The infection has_symptom lesions, has_symptom vomiting of blood, has_symptom severe diarrhea, has_symptom loss of appetite.

[Term]
id: DOID:13431 ! bejel
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in mucosa of mouth, located_in skin or located_in bone, has_material_basis_in Treponema pallidum subsp endemicum, which is transmitted_by contact or transmitted_by sharing of domestic utensils. The infection has_symptom moist patches in the mouth, has_symptom lumps in long bones, tissues around the mouth, nose, and roof of the mouth. These lumps destroy tissue, causing bones to be deformed and disfiguring the face.

[Term]
id: DOID:13444 ! glanders
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted_by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has_symptom fever, has_symptom chills, has_symptom sweating, has_symptom muscle aches, has_symptom chest pain, has_symptom muscle tightness, has_symptom headache, has_symptom mucopurulent nasal discharge, and has_symptom nodular lesions in the lungs.

[Term]
id: DOID:13450 ! coccidioidomycosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules.

[Term]
id: DOID:13481 ! thanatophoric dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results_in short arms and legs with excess folds of skin.

[Term]
id: DOID:13521 ! tetanus neonatorum
is_a: DOID:11338 ! tetanus
! A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has_symptom stiff body, has_symptom muscle spasms, has_symptom difficulty in breathing, and has_symptom exhaustion.

[Term]
id: DOID:13523 ! loiasis
is_a: DOID:1080 ! filariasis
! A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis.

[Term]
id: DOID:13533 ! osteopetrosis
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.

[Term]
id: DOID:13564 ! aspergillosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

[Term]
id: DOID:13565 ! neuroaspergillosis
is_a: DOID:13564 ! aspergillosis
! An aspergillosis that involves fungal infection of the central nervous system in immunocompromised patients caused by Aspergillus, presenting as a space-occupying lesion.

[Term]
id: DOID:1362 ! paranasal sinus sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant tumor of nasal sinuses that is located_in the paranasal sinus.

[Term]
id: DOID:13622 ! campylobacteriosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever.

[Term]
id: DOID:13628 ! favism
is_a: DOID:2862 ! glucosephosphate dehydrogenase deficiency
! A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans.

[Term]
id: DOID:13775 ! plantar wart
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in benign epithelial tumors located_in skin of the sole or toes of the foot, has_material_basis_in human papillomavirus (types 1, 2, 4 or 63), has_symptom lesions that appear on the sole of the foot.

[Term]
id: DOID:13777 ! epidermodysplasia verruciformis
is_a: DOID:0080003 ! autosomal recessive disease
! An autosomal recessive disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body.

[Term]
id: DOID:13778 ! chancroid
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is a sexually transmitted infection located_in skin of the genitals, has_material_basis_in Haemophilus ducreyi, which is transmitted_by sexual contact. The infection has_symptom painful and soft ulcers.

[Term]
id: DOID:13800 ! inclusion conjunctivitis
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus.

[Term]
id: DOID:13801 ! pharyngoconjunctival fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in pharynx or located_in conjunctiva, has_material_basis_in Human adenovirus 3 or has_material_basis_in Human adenovirus 7, which are transmitted_by droplet spread of respiratory secretions or transmitted_by fomites. The infection has_symptom fever, has_symptom lymphadenopathy of the neck, and has_symptom headache.

[Term]
id: DOID:13819 ! lymphogranuloma venereum
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis.

[Term]
id: DOID:13867 ! focal labyrinthitis
is_a: DOID:1468 ! labyrinthitis
! A labyrinthitis which is an infectious inflammatory disease of a circumscribed area of either the vestibular or the cochlear portion of the labyrinth, or of both together. This is caused by a chronic suppurative otitis media, mastoiditis, or cholesteatoma.

[Term]
id: DOID:13891 ! bird fancier's lung
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis which is caused by inhalation of antigens from avian excreta. The disease has_symptom abrupt onset of dyspnea, has_symptom cough, has_symptom malaise, and has_symptom fever, after exposure to antigen.

[Term]
id: DOID:13902 ! white piedra
is_a: DOID:0050133 ! superficial mycosis
! A superficial mycosis that is a superficial fungal infection of the hair shaft caused by Trichosporon beigelii. Infected hairs develop soft greyish-white nodules along the shaft.

[Term]
id: DOID:13911 ! achromatopsia
is_a: DOID:0080003 ! autosomal recessive disease
! An autosomal recessive disease that is characterized by a congenital color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels.

[Term]
id: DOID:1394 ! urinary schistosomiasis
is_a: DOID:1395 ! schistosomiasis
! A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer.

[Term]
id: DOID:1395 ! schistosomiasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria.

[Term]
id: DOID:13994 ! cleidocranial dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in underveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull.

[Term]
id: DOID:14019 ! Brucella canis brucellosis
is_a: DOID:11077 ! brucellosis
! A brucellosis involving an infection caused by Brucella canis [NCBITaxon:36855] in dogs and humans. The disease has_symptom fever, has_symptom sweats, has_symptom weakness, has_symptom weight loss, has_symptom headache, has_symptom lymphadenopathy and has_symptom splenomegaly.

[Term]
id: DOID:14040 ! autoimmune polyendocrine syndrome
is_a: DOID:0060005 ! autoimmune disease of endocrine system
! An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs.

[Term]
id: DOID:14042 ! bipolar I disorder
is_a: DOID:3312 ! bipolar disorder
! A bipolar disorder that is characterized by at least one manic or mixed episode.

[Term]
id: DOID:14049 ! phaeohyphomycosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals.

[Term]
id: DOID:14067 ! Plasmodium falciparum malaria
is_a: DOID:12365 ! malaria
! A malaria described as a severe form of the disease caused by a parasite Plasmodium falciparum, which is marked by irrregular recurrence of paroxysms and prolonged or continuous fever.

[Term]
id: DOID:14068 ! blackwater fever
is_a: DOID:12365 ! malaria
! A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax.

[Term]
id: DOID:14087 ! epicondylitis
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that results_in inflammation located_in epicondyle.

[Term]
id: DOID:14095 ! boutonneuse fever
is_a: DOID:11104 ! spotted fever
! A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities.

[Term]
id: DOID:14110 ! anus cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the anus.

[Term]
id: DOID:14115 ! toxic shock syndrome
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities.

[Term]
id: DOID:14179 ! Bruton-type agammaglobulinemia
is_a: DOID:2115 ! B cell deficiency
! A B cell deficiency that is caused by a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement.

[Term]
id: DOID:14239 ! gastrointestinal tularemia
is_a: DOID:2123 ! tularemia
! A tularemia that results in formation of ulcerative lesions located_in gastrointestinal tract. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom muscle aches, and has_symptom vomiting.

[Term]
id: DOID:14256 ! adult-onset Still's disease
is_a: DOID:848 ! arthritis
! An arthritis that is a rare from of inflammatory arthritis characterized by fevers, rash, and joint pain.

[Term]
id: DOID:14262 ! oral candidiasis
is_a: DOID:1508 ! candidiasis
! A candidiasis that involves fungal infection of the mucous membrane of the mouth by Candida species, which is characterized by thick white or cream-colored deposits on inflamed mucosal membranes.

[Term]
id: DOID:14319 ! pleuropneumonia
is_a: DOID:552 ! pneumonia
! A pneumonia accompanied by inflammation of the pleura and accumulation of pus in the pleural space caused by bacteria.

[Term]
id: DOID:14320 ! generalized anxiety disorder
is_a: DOID:2030 ! anxiety disorder
! An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation.

[Term]
id: DOID:14324 ! Plasmodium malariae malaria
is_a: DOID:12365 ! malaria
! A malaria caused by a parasite Plasmodium malariae, which is marked by recurrence of paroxysms at 72-hour intervals.

[Term]
id: DOID:14330 ! Parkinson's disease
is_a: DOID:1289 ! neurodegenerative disease
! A neurodegenerative disease that has_material_basis_in degeneration of the central nervous system that often impairs the sufferer's motor skills, speech, and other functions.

[Term]
id: DOID:14374 ! norwegian scabies
is_a: DOID:8295 ! scabies
! A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching.

[Term]
id: DOID:1441 ! spinocerebellar ataxia
is_a: DOID:2478 ! spinocerebellar degeneration
! A spinocerebellar degeneration that has_material_basis_in expanded CAG triplet repeats resulting in spinal cord and cerebellum degeneration.

[Term]
id: DOID:14415 ! Legg-Calve-Perthes Disease
is_a: DOID:8125 ! osteochondrosis
! An osteochondrosis that results_in death and fracture located_in hip joint.

[Term]
id: DOID:1442 ! Alpers syndrome
is_a: DOID:1443 ! cerebral degeneration
! A cerebral degeneration that results in progressive degeneration of grey matter in the cerebrum and has_symptom convulsions.

[Term]
id: DOID:14422 ! dipetalonemiasis
is_a: DOID:1080 ! filariasis
! A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

[Term]
id: DOID:14435 ! chronic tubotympanic suppurative otitis media
is_a: DOID:11506 ! suppurative otitis media
! A suppurative otitis media which is an inflammatory disease of the middle ear cleft characterized by the presence of a persisting perforation within the pars tensa of the tympanic membrane, intermittent profuse muco-purulent otorrhea and gradually progressive conductive hearing loss of more than 12 weeks duration. It is caused by episodes of upper respiratory infections.

[Term]
id: DOID:14453 ! farmer's lung
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness.

[Term]
id: DOID:14456 ! Brucella melitensis brucellosis
is_a: DOID:11077 ! brucellosis
! A brucellosis that involves an infection caused by Brucella melitensis [NCBITaxon:29459] in cattle, goats, sheep and humans. The disease has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom limb pain and has_symptom back pain.

[Term]
id: DOID:14457 ! Brucella abortus brucellosis
is_a: DOID:11077 ! brucellosis
! A brucellosis that involves an infection caused by Brucella abortus [NCBITaxon:235] in cattle and humans. The disease has_symptom fever, has_symptom chills, has_symptom sweats, has_symptom weight loss, has_symptom malaise, has_symptom headaches, has_symptom myalgia, and has_symptom arthralgia.

[Term]
id: DOID:14472 ! hantavirus pulmonary syndrome
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in lung, has_material_basis_in Sin Nombre virus, transmitted_by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted_by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted_by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted_by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted_by rice rat (Oligoryzomys longicaudatus). The infection has_symptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications.

[Term]
id: DOID:14484 ! sporotrichosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation.

[Term]
id: DOID:14512 ! candidal paronychia
is_a: DOID:1508 ! candidiasis
! A candidiasis that results_in fungal infection of the outer-most layer located_in nail, has_material_basis_in Candida species. The infection causes painful, red, swollen area around the nail, often at the cuticle or at the site of a hangnail or other injury.

[Term]
id: DOID:14515 ! WAGR syndrome
is_a: DOID:0080014 ! chromosomal disease
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14515 ! WAGR syndrome
is_a: DOID:2154 ! nephroblastoma
! A chromosomal disease that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes.

[Term]
id: DOID:14566 ! disease of cellular proliferation
is_a: DOID:4 ! disease
! A disease that is characterized by abnormally rapid cell division.

[Term]
id: DOID:14669 ! acrodysostosis
is_a: DOID:1934 ! dysostosis
! A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency.

[Term]
id: DOID:14687 ! diastrophic dysplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism.

[Term]
id: DOID:1470 ! major depressive disorder
is_a: DOID:1595 ! endogenous depression
! An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

[Term]
id: DOID:14705 ! Pfeiffer syndrome
is_a: DOID:12960 ! acrocephalosyndactylia
! An acrocephalosyndactylia that has_material_basis_in mutations in the FGFR1 and FGFR2 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14748 ! Sotos syndrome
is_a: DOID:0080003 ! autosomal recessive disease
! An autosomal recessive disease that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life.

[Term]
id: DOID:14761 ! Greig cephalopolysyndactyly syndrome
is_a: DOID:12960 ! acrocephalosyndactylia
! An acrocephalosyndactylia that has_material_basis_in mutation in the GLI3 gene which results_in abnormal development located_in limb, located_in head, located_in face.

[Term]
id: DOID:14764 ! Larsen syndrome
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that is characterized by large-joint dislocations and characteristic craniofacial abnormalities.

[Term]
id: DOID:14768 ! Saethre-Chotzen syndrome
is_a: DOID:12960 ! acrocephalosyndactylia
! An acrocephalosyndactylia that has_material_basis_in a genetic mutation in the TWIST1 gene which results_in premature fusion located_in skull.

[Term]
id: DOID:14780 ! KBG syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
is_a: DOID:0050325 ! genetic disorder
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:14796 ! Dubowitz Syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is a rare genetic disorder characterized by microcephaly, growth retardation and a characteristic facial appearance like small, round, triangular shaped with a pointed, receding chin, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids.

[Term]
id: DOID:14798 ! Blount's disease
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results_in inward turning of lower leg, located_in tibia, which fails to develop normally.

[Term]
id: DOID:1495 ! cystic echinococcosis
is_a: DOID:1496 ! echinococcosis
! An echinococcosis that is caused by the larvae of Echinococcus granulosus. Hepatic involvement can result in abdominal pain, a mass in the hepatic area, and biliary duct obstruction. Pulmonary involvement can produce chest pain, cough, and hemoptysis. Rupture of the cysts produce fever, urticaria, eosinophilia, and anaphylactic shock, as well as cyst dissemination. Brain, bone, heart can also be infected.

[Term]
id: DOID:1496 ! echinococcosis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys.

[Term]
id: DOID:1498 ! cholera
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock.

[Term]
id: DOID:15 ! reproductive system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in reproductive system organs.

[Term]
id: DOID:1509 ! avoidant personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction.

[Term]
id: DOID:154 ! mixed cell type cancer
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from two germinal layers of tissue.

[Term]
id: DOID:1540 ! parathyroid carcinoma
is_a: DOID:170 ! endocrine gland cancer
! An endocrine gland cancer located_in the parathyroid glands located in the neck.

[Term]
id: DOID:1562 ! chromoblastomycosis
is_a: DOID:0050135 ! subcutaneous mycosis
! A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection.

[Term]
id: DOID:1563 ! dermatomycosis
is_a: DOID:0050134 ! cutaneous mycosis
! A cutaneous mycosis that results_in fungal infection located_in skin or of its appendages, has_material_basis_in Ascomycota fungi other than the dermatophytes.

[Term]
id: DOID:1564 ! fungal infectious disease
is_a: DOID:0050117 ! disease by infectious agent
! A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body.

[Term]
id: DOID:1579 ! respiratory system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm.

[Term]
id: DOID:1583 ! laryngeal tuberculosis
is_a: DOID:2957 ! pulmonary tuberculosis
! A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia.

[Term]
id: DOID:1584 ! acute chest syndrome
is_a: DOID:10923 ! sickle cell anemia
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1584 ! acute chest syndrome
is_a: DOID:850 ! lung disease
! A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph.

[Term]
id: DOID:1595 ! endogenous depression
is_a: DOID:1596 ! mental depression
! A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.

[Term]
id: DOID:16 ! integumentary system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in the integumentary system  comprising the skin and its appendages.

[Term]
id: DOID:162 ! cancer
is_a: DOID:14566 ! disease of cellular proliferation
! A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis.

[Term]
id: DOID:1638 ! central nervous system tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that results in formation of tuberculomas located_in brain or located_in spinal cord.

[Term]
id: DOID:1639 ! skeletal tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that results in formation of lesions located_in bone.

[Term]
id: DOID:1642 ! breast adenomyoepithelioma
is_a: DOID:3004 ! breast myoepithelial neoplasm
! A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells.

[Term]
id: DOID:170 ! endocrine gland cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

[Term]
id: DOID:1712 ! aortic valve stenosis
is_a: DOID:1712 ! aortic valve stenosis
! Aortic valve stenosis is a aortic valve disease caused by the incomplete opening of the aortic valve. The aortic valve controls the direction of blood flow from the left ventricle to the aorta. When in good working order, the aortic valve does not impede the flow of blood between these two spaces. Under some circumstances, the aortic valve becomes narrower than normal, impeding the flow of blood. This is known as aortic valve stenosis, or aortic stenosis, often abbreviated AS.

[Term]
id: DOID:1731 ! histoplasmosis
is_a: DOID:0050292 ! primary systemic mycosis
! A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.

[Term]
id: DOID:1733 ! cryptosporidiosis
is_a: DOID:2113 ! coccidiosis
! A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:1749 ! squamous cell carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that derives_from squamous epithelial cells.

[Term]
id: DOID:175 ! vascular cancer
is_a: DOID:176 ! cardiovascular cancer
! A cardiovascular cancer that is located_in blood vessels.

[Term]
id: DOID:1754 ! mitral valve stenosis
is_a: DOID:1754 ! mitral valve stenosis
! Mitral valve stenosis is a rheumatic disease of mitral valve characterized by the narrowing of the orifice of the mitral valve of the heart. Most cases of mitral stenosis are due to disease in the heart secondary to rheumatic fever and the consequent rheumatic heart disease. Less common causes of mitral stenosis are calcification of the mitral valve leaflets, and as a form of congenital heart disease. However, there are primary causes of mitral stenosis that emanate from a cleft mitral valve. Other causes include Bacterial endocarditis where the vegetations may favor increase risk of stenosis.

[Term]
id: DOID:1759 ! American histoplasmosis
is_a: DOID:1731 ! histoplasmosis
! A histoplasmosis that results_in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains.

[Term]
id: DOID:1781 ! thyroid cancer
is_a: DOID:170 ! endocrine gland cancer
! An endocrine gland cancer located_in the thryoid gland located in the neck below the thyroid cartilage.

[Term]
id: DOID:1785 ! pituitary cancer
is_a: DOID:170 ! endocrine gland cancer
! An endocrine gland cancer located_in the pituitary gland located at the base of the brain.

[Term]
id: DOID:1787 ! pericarditis
is_a: DOID:114 ! heart disease
! A heart disease that is characterized by an inflammation of the pericardium and has_symptom chest pain.

[Term]
id: DOID:1790 ! malignant mesothelioma
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in meothelial tissue.

[Term]
id: DOID:1791 ! peritoneal carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is located_in the inside of the abdomen.

[Term]
id: DOID:1793 ! pancreatic cancer
is_a: DOID:170 ! endocrine gland cancer
! An endocrine gland cancer located_in the pancreas.

[Term]
id: DOID:1796 ! pancreas sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of pancreas that is located_in the pancreas.

[Term]
id: DOID:18 ! urinary system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra.

[Term]
id: DOID:180 ! ossifying fibroma
is_a: DOID:0060094 ! bone benign neoplasm
! A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma.

[Term]
id: DOID:1800 ! neuroendocrine carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that derives_from neuroendocrine cells.

[Term]
id: DOID:1825 ! childhood absence epilepsy
is_a: DOID:225 ! syndrome
! A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years.

[Term]
id: DOID:1826 ! epilepsy syndrome
is_a: DOID:936 ! brain disease
! A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenicnabnormality of the brain that is able to spontaneously gen-nerate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.

[Term]
id: DOID:184 ! bone cancer
is_a: DOID:0060100 ! musculoskeletal system cancer
! An musculoskeletal system cancer located_in bone that is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

[Term]
id: DOID:1858 ! McCune Albright syndrome
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It is caused by mutations in the GNAS1 gene.

[Term]
id: DOID:1858 ! McCune Albright syndrome
is_a: DOID:14038 ! precocious puberty
! An autosomal dominant disease that involves skin pigmentation, bone and hormonal problems along with premature puberty. It is caused by mutations in the GNAS1 gene.

[Term]
id: DOID:1862 ! jaw cancer
is_a: DOID:184 ! bone cancer
! A bone cancer and jaw disease that is located_in the jaw and results_in a swollen jaw, results_in numbness or a tingling sensation in jaw, and results_in an abnormal growth of the jaw bone.

[Term]
id: DOID:1883 ! hepatitis C
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:1909 ! melanoma
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from melanocytes which are found in skin, the bowel and the eye.

[Term]
id: DOID:192 ! sex cord-gonadal stromal tumor
is_a: DOID:193 ! reproductive organ cancer
! A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary and testis.

[Term]
id: DOID:1920 ! hyperuricemia
is_a: DOID:0060158 ! acquired metabolic disease
! An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood.

[Term]
id: DOID:1934 ! dysostosis
is_a: DOID:0080006 ! bone development disease
! A bone development disease that results_in defective ossification of located_in bone.

[Term]
id: DOID:1947 ! trichomoniasis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively.

[Term]
id: DOID:1963 ! fallopian tube carcinoma
is_a: DOID:1964 ! fallopian tube cancer
! A fallopian tube cancer that is located_in the fallopian tube.

[Term]
id: DOID:1964 ! fallopian tube cancer
is_a: DOID:193 ! reproductive organ cancer
! A female reproductive organ cancer that is located_in fallopian tube.

[Term]
id: DOID:1969 ! cerebral palsy
is_a: DOID:936 ! brain disease
! A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance.

[Term]
id: DOID:1974 ! adenosarcoma
is_a: DOID:1115 ! sarcoma
! A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

[Term]
id: DOID:1974 ! adenosarcoma
is_a: DOID:4236 ! carcinosarcoma
! A malignant mixed tumor and mullerian mixed tumor and sarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium.

[Term]
id: DOID:1995 ! rectum sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant tumor of rectum that is located_in the rectum.

[Term]
id: DOID:201 ! connective tissue cancer
is_a: DOID:0060100 ! musculoskeletal system cancer
! A musculoskeletal system cancer that is located_in connective tissue.

[Term]
id: DOID:2043 ! hepatitis B
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:2047 ! hepatitis D
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma.

[Term]
id: DOID:2048 ! autoimmune hepatitis
is_a: DOID:0060031 ! autoimmune disease of gastrointestinal tract
! An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells.

[Term]
id: DOID:205 ! hyperostosis
is_a: DOID:0080005 ! bone remodeling disease
! A bone remodeling disease that results in an abnormal growth of located_in bone.

[Term]
id: DOID:2058 ! chronic mucocutaneous candidiasis
is_a: DOID:1508 ! candidiasis
! A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp.

[Term]
id: DOID:206 ! hereditary multiple exostoses
is_a: DOID:203 ! exostosis
! An exostosis that has_material_basis_in a mutation on the genes EXT1, EXT2 and EXT3 which results_in multiple bony spurs throughout a child's growth.

[Term]
id: DOID:210 ! heel spur
is_a: DOID:203 ! exostosis
! An exostosis that results_in an abnormal growth located_in calcaneus.

[Term]
id: DOID:2113 ! coccidiosis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection.

[Term]
id: DOID:2122 ! pneumonic tularemia
is_a: DOID:2123 ! tularemia
! A tularemia that is located_in lungs. The bacteria are transmitted_by breathing dusts or aerosols containing the organisms. The infection has_symptom cough, has_symptom chest has_symptom pain, and has_symptom difficulty breathing.

[Term]
id: DOID:2123 ! tularemia
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted_by dog tick bite (Dermacentor variabilis), transmitted_by deer flies (Chrysops sp) or transmitted_by contact with infected animal tissues.

[Term]
id: DOID:2148 ! tuberculous oophoritis
is_a: DOID:2149 ! urogenital tuberculosis
! An urogenital tuberculosis that results_in inflammtion located_in ovary.

[Term]
id: DOID:2149 ! urogenital tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that is located_in urogenital system.

[Term]
id: DOID:2153 ! ovarian Wilms' cancer
is_a: DOID:2154 ! nephroblastoma
! A malignant neoplasm of ovary and nephroblastoma that is located_in the ovaries.

[Term]
id: DOID:2154 ! nephroblastoma
is_a: DOID:263 ! kidney cancer
! A kidney cancer that affects the kidneys and typically located_in children.

[Term]
id: DOID:222 ! perichondritis of auricle
is_a: DOID:9463 ! otitis externa
! A otitis externa involving infection of the tissue surrounding the cartilage of the earlobe (pinna), ear canal, or both. It may be caused by injury, burns, insect bites, ear piercing, or a boil on the ear. The common bacterial causative agent is Pseudomonas aeruginosa. Symptoms include redness, pain, fever, swelling of the earlobe and pus accumulation between the cartilage and the layer of connective tissue around it.

[Term]
id: DOID:2224 ! hemorrhagic thrombocythemia
is_a: DOID:2225 ! megakaryocytic tumor
! A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets.

[Term]
id: DOID:2224 ! hemorrhagic thrombocythemia
is_a: DOID:2228 ! thrombocytosis
! A chronic myeloproliferative and megakaryocytic tumor and thrombocytosis that is a rare chronic disorder that results_in the overproduction of platelets.

[Term]
id: DOID:2226 ! chronic myeloproliferative disease
is_a: DOID:0070004 ! myeloma
! A myeloma that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood.

[Term]
id: DOID:2228 ! thrombocytosis
is_a: DOID:0070004 ! myeloma
! A myeloma and blood platelet disorder that is characterized by the presence of high platelet counts in the blood.

[Term]
id: DOID:2247 ! spondylosis
is_a: DOID:0080010 ! bone structure disease
! An bone structure disease that involves degeneration between vertebra located_in vertebral column.

[Term]
id: DOID:2256 ! osteochondrodysplasia
is_a: DOID:0080006 ! bone development disease
! A bone development disease that results_in defective development of located_in cartilage or located_in bone.

[Term]
id: DOID:2272 ! vulvovaginal candidiasis
is_a: DOID:1508 ! candidiasis
! A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge.

[Term]
id: DOID:2297 ! leptospirosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted_by contact with water, food, or soil containing urine from the infected animals. The infection has_symptom jaundice, has_symptom chills, has_symptom fever, has_symptom muscle pain, and has_symptom hepatomegaly.

[Term]
id: DOID:2300 ! spondylolysis
is_a: DOID:0080010 ! bone structure disease
! A bone structure disease that involves a defect located_in lumbar vertebral column.

[Term]
id: DOID:2303 ! stereotypic movement disorder
is_a: DOID:0060038 ! specific developmental disorder
! A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking.

[Term]
id: DOID:231 ! motor neuron disease
is_a: DOID:1289 ! neurodegenerative disease
! A neurodegenerative disease that is located_in the motor neurones.

[Term]
id: DOID:2312 ! nocardiosis
is_a: DOID:0050340 ! opportunistic bacterial infectious disease
! An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy.

[Term]
id: DOID:2314 ! malt worker's lung
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis which is caused by inhalation of fungal spores of Aspergillus clavatus and Aspergillus fumigatus from moldy barley.

[Term]
id: DOID:2326 ! gastroenteritis
is_a: DOID:0050117 ! disease by infectious agent
! A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.

[Term]
id: DOID:2327 ! viral gastritis
is_a: DOID:0050117 ! disease by infectious agent
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by viruses. The symptoms include abdominal pain, indigestion, ulcer formation, abdominal bloating, nausea and vomiting.

[Term]
id: DOID:2340 ! craniosynostosis
is_a: DOID:11971 ! synostosis
! A synostosis that results_in premature fusion located_in skull.

[Term]
id: DOID:2354 ! myelophthisic anemia
is_a: DOID:0070004 ! myeloma
! A myeloma and anemia that is located_in some people with diseases that affect the bone marrow.

[Term]
id: DOID:2354 ! myelophthisic anemia
is_a: DOID:2355 ! anemia
! A myeloma and anemia that is located_in some people with diseases that affect the bone marrow.

[Term]
id: DOID:2365 ! West Nile encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted_by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis.

[Term]
id: DOID:2366 ! West Nile fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting.

[Term]
id: DOID:2403 ! aneurysm disease
is_a: DOID:178 ! vascular disease
! A vascular disease that is characterized by a localized, blood-filled balloon-like bulge in the wall of a blood vessel.

[Term]
id: DOID:2409 ! rhinosporidiosis
is_a: DOID:0050291 ! parasitic Ichthyosporea infectious disease
! A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

[Term]
id: DOID:2449 ! acromegaly
is_a: DOID:0014667 ! disease of metabolism
! A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb.

[Term]
id: DOID:2473 ! opportunistic mycosis
is_a: DOID:1564 ! fungal infectious disease
! A fungal infectious disease that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices.

[Term]
id: DOID:2476 ! hereditary spastic paraplegia
is_a: DOID:607 ! paraplegia
! A paraplegia that is characterized by progressive stiffness and contraction (spasticity) in the lower limbs.

[Term]
id: DOID:2531 ! hematologic cancer
is_a: DOID:0060083 ! immune system cancer
! An immune system cancer located_in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes.

[Term]
id: DOID:2544 ! extratemporal epilepsy
is_a: DOID:1826 ! epilepsy
! An epilepsy that is located_in an area of the brain other than the temporal lobe.

[Term]
id: DOID:2554 ! Letterer-Siwe disease
is_a: DOID:2571 ! Langerhans-cell histiocytosis
! A Langerhans-cell histiocytosis malignant neoplasm of abdomen that results_in an abnormal increase in the number of immune cells called histiocytes.

[Term]
id: DOID:2554 ! Letterer-Siwe disease
is_a: DOID:284 ! malignant neoplasm of abdomen
! A Langerhans-cell histiocytosis malignant neoplasm of abdomen that results_in an abnormal increase in the number of immune cells called histiocytes.

[Term]
id: DOID:2571 ! Langerhans-cell histiocytosis
is_a: DOID:0014667 ! disease of metabolism
! A disease of metabolism and histiocytic and dendritic cell cancer and histiocytosis and interstitial lung disease that results_in the proliferation of Langerhans cells.

[Term]
id: DOID:2571 ! Langerhans-cell histiocytosis
is_a: DOID:3082 ! interstitial lung disease
! A disease of metabolism and histiocytic and dendritic cell cancer and histiocytosis and interstitial lung disease that results_in the proliferation of Langerhans cells.

[Term]
id: DOID:2571 ! Langerhans-cell histiocytosis
is_a: DOID:3405 ! histiocytosis
! A disease of metabolism and histiocytic and dendritic cell cancer and histiocytosis and interstitial lung disease that results_in the proliferation of Langerhans cells.

[Term]
id: DOID:2571 ! Langerhans-cell histiocytosis
is_a: DOID:5621 ! histiocytic and dendritic cell cancer
! A disease of metabolism and histiocytic and dendritic cell cancer and histiocytosis and interstitial lung disease that results_in the proliferation of Langerhans cells.

[Term]
id: DOID:2580 ! rhizomelic chondrodysplasia punctata
is_a: DOID:630 ! genetic disease
! A genetic disease that is characterized by systemic shortening of the proximal bones (i.e. rhizomelia), seizures, recurrent respiratory tract infections, and congential cataracts and has_material_basis_in mutations of the alkyldihydroxyacetonephosphate synthase (alkyl-DHAP synthase) gene.

[Term]
id: DOID:2583 ! agammaglobulinemia
is_a: DOID:2115 ! B cell deficiency
! A B cell deficiency that is caused by a reduction in all types of gamma globulins.

[Term]
id: DOID:2596 ! larynx cancer
is_a: DOID:0050615 ! respiratory system cancer
! A respiratory system cancer that is located_in the larynx.

[Term]
id: DOID:263 ! kidney cancer
is_a: DOID:3996 ! urinary system cancer
! A urinary system cancer that is located_in the kidney.

[Term]
id: DOID:2632 ! papillary serous adenocarcinoma
is_a: DOID:3112 ! papillary adenocarcinoma
! A papillary adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures with psammoma bodies.

[Term]
id: DOID:265 ! spleen angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results_in a nonhematolymphoid malignant neoplasm of the spleen.

[Term]
id: DOID:265 ! spleen angiosarcoma
is_a: DOID:254 ! hemangioma of intra-abdominal structure
! An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results_in a nonhematolymphoid malignant neoplasm of the spleen.

[Term]
id: DOID:265 ! spleen angiosarcoma
is_a: DOID:266 ! malignant soft tissue neoplasm of the spleen
! An angiosarcoma and hemangioma of intra-abdominal structure and malignant soft tissue neoplasm of the spleen that results_in a nonhematolymphoid malignant neoplasm of the spleen.

[Term]
id: DOID:2661 ! myoepithelioma
is_a: DOID:305 ! carcinoma
! A carcinoma that is composed_of outgrowths of myoepithelial cells from a sweat gland.

[Term]
id: DOID:2671 ! transitional cell carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that derives_from transitional epithelial cells.

[Term]
id: DOID:268 ! liver angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver.

[Term]
id: DOID:268 ! liver angiosarcoma
is_a: DOID:254 ! hemangioma of intra-abdominal structure
! An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver.

[Term]
id: DOID:268 ! liver angiosarcoma
is_a: DOID:3571 ! liver cancer
! An angiosarcoma and sarcoma of liver and hemangioma of intra-abdominal structure and Ca liver - primary that is located_in the liver.

[Term]
id: DOID:2683 ! adenofibroma
is_a: DOID:0060084 ! cell type benign neoplasm
! A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands.

[Term]
id: DOID:270 ! liver sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver.

[Term]
id: DOID:270 ! liver sarcoma
is_a: DOID:902 ! malignant non-epithelial hepatic and intrahepatic bile duct neoplasm
! A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver.

[Term]
id: DOID:2703 ! synovitis
is_a: DOID:65 ! connective tissue disease
! A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling.

[Term]
id: DOID:2708 ! mushroom workers' lung
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis involving inflammation of the alveoli within the lung caused by hypersensitivity to the inhalation of organic dust particles derived from either the mushrooms, their spores or the compost in which the mushrooms are grown. It is usually caused by the spores of thermophilic actinomycetes.

[Term]
id: DOID:2710 ! sick building syndrome
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building.

[Term]
id: DOID:2747 ! glycogen storage disease
is_a: DOID:0014667 ! disease of metabolism
! A carbohydrate metabolic disease that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types.

[Term]
id: DOID:2749 ! glycogen storage disease I
is_a: DOID:2747 ! glycogen storage disease
! A glycogen storage disease that has_material_basis_in deficiency of the glucose-6-phosphatase enzyme which impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis and is characterized by accumulation of glycogen and fat in the liver and kidneys, resulting in hepatomegaly and renomegaly.

[Term]
id: DOID:2752 ! glycogen storage disease II
is_a: DOID:2747 ! glycogen storage disease
! A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to  an accumulation of glycogen in the lysosome.

[Term]
id: DOID:2755 ! Mycobacterium avium complex disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons.

[Term]
id: DOID:2769 ! tic disorder
is_a: DOID:0060038 ! specific developmental disorder
! A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

[Term]
id: DOID:2775 ! long bone adamantinoma
is_a: DOID:2776 ! adamantinoma
! An adamantinoma that is located_in the long bones and results_in focal epithelial differentiation.

[Term]
id: DOID:2776 ! adamantinoma
is_a: DOID:184 ! bone cancer
! A bone cancer that is located_in almost exclusively in the long bones.

[Term]
id: DOID:2784 ! lung sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of lung that is located_in the lung.

[Term]
id: DOID:2789 ! parasitic protozoa infectious disease
is_a: DOID:1398 ! parasitic infectious disease
! A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes.

[Term]
id: DOID:2790 ! necatoriasis
is_a: DOID:13250 ! diarrhea
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
is_a: DOID:2355 ! anemia
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2790 ! necatoriasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching.

[Term]
id: DOID:2797 ! idiopathic interstitial pneumonia
is_a: DOID:552 ! pneumonia
! A pneumonia located_in the lung parenchyma of unknown cause.

[Term]
id: DOID:28 ! endocrine system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

[Term]
id: DOID:2810 ! middle lobe syndrome
is_a: DOID:850 ! lung disease
! A lung disease that is defined as a recurrent or chronic collapse of the right middle lobe, right upper lobe or lingula of the lung. It is caused by endobronchial tumour, granulomatous infections, lymphadenopathy, foreign bodies, endobronchial silicotic nodules, inspissated mucus associated with cystic fibrosis or inflammation as a result of an infection.

[Term]
id: DOID:2832 ! geotrichosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that has_material_basis_in Galactomyces geotrichum, results_in systemic infection in immunocompromised people.

[Term]
id: DOID:2841 ! asthma
is_a: DOID:1176 ! bronchial disease
! A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptomrecurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

[Term]
id: DOID:2843 ! long QT syndrome
is_a: DOID:630 ! genetic disease
! An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles).

[Term]
id: DOID:2871 ! endometrial carcinoma
is_a: DOID:1380 ! endometrial cancer
! A endometrial cancer that is located_in the tissue lining the uterus.

[Term]
id: DOID:2877 ! larynx sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of larynx that is located_in the larynx.

[Term]
id: DOID:2893 ! cervix carcinoma
is_a: DOID:4362 ! cervical cancer
! A cervix uteri cancer that is located_in the cervix uteri or located_in the cervical area.

[Term]
id: DOID:2907 ! Goldenhar syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch.

[Term]
id: DOID:2914 ! immune system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in the immune system.

[Term]
id: DOID:2921 ! glomerulonephritis
is_a: DOID:10952 ! nephritis
! A nephritis that causes inflammation of the glomeruli located_in kidney.

[Term]
id: DOID:2929 ! Newcastle disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds.

[Term]
id: DOID:2934 ! aleutian mink disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammatory destruction located_in blood vessels of minks and rarely in humans, which has_material_basis_in Aleutian mink disease virus. The infection has_symptom weight loss, has_symptom hepatomegaly, has_symptom enlarged spleen, and has_symptom anemia.

[Term]
id: DOID:2942 ! bronchiolitis
is_a: DOID:850 ! lung disease
! A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen.

[Term]
id: DOID:2945 ! severe acute respiratory syndrome
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia.

[Term]
id: DOID:295 ! eye carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that arises_from the tissues that cover structures located_in the eye.

[Term]
id: DOID:2957 ! pulmonary tuberculosis
is_a: DOID:399 ! tuberculosis
! A tuberculosis that is a contagious disease located_in lungs. The infection has_symptom fever, has_symptom cough, has_symptom difficulty in breathing, has_symptom inflammatory infiltrations, has_symptom formation of tubercles, has_symptom caseation, has_symptom pleural effusion, and has_symptom fibrosis.

[Term]
id: DOID:2962 ! Cockayne syndrome
is_a: DOID:0080003 ! autosomal recessive disease
! An autosomal recessive disease that is caused by  rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging.

[Term]
id: DOID:2988 ! antiphospholipid syndrome
is_a: DOID:417 ! hypersensitivity reaction type II disease
! An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin).

[Term]
id: DOID:299 ! adenocarcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue.

[Term]
id: DOID:2994 ! germ cell cancer
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from germ cells.

[Term]
id: DOID:302 ! substance abuse
is_a: DOID:303 ! substance-related disorder
! A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning.

[Term]
id: DOID:3025 ! acinar cell carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells.

[Term]
id: DOID:3030 ! mucinous adenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin.

[Term]
id: DOID:305 ! carcinoma
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from epithelial cells.

[Term]
id: DOID:3055 ! paratyphoid fever
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly.

[Term]
id: DOID:3069 ! astrocytoma
is_a: DOID:3070 ! malignant glioma
! A malignant glioma that is has_material_basis_in astocyte cells, a type of glial cell, located_in the cerebrum.

[Term]
id: DOID:3070 ! malignant glioma
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in glial cells and is located_in brain or located_in spine.

[Term]
id: DOID:3093 ! nervous system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the nervous sytem that affects the central or peripheral nervous system.

[Term]
id: DOID:3095 ! germ cell and embryonal cancer
is_a: DOID:2994 ! germ cell cancer
! A germ cell cancer that is derived_from a mixture of germs cells and embryonal cells.

[Term]
id: DOID:3109 ! idiopathic CD4-positive T-lymphocytopenia
is_a: DOID:614 ! lymphopenia
! A lymphopenia that is caused by a reduction of CD4+ T lymphocytes.

[Term]
id: DOID:3110 ! papillary cystadenocarcinoma
is_a: DOID:3111 ! cystadenocarcinoma
! A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with cysts and papillary endophytic projections.

[Term]
id: DOID:3111 ! cystadenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed.

[Term]
id: DOID:3112 ! papillary adenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue.

[Term]
id: DOID:3113 ! papillary carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is derived_from epithelial cells with finger like projections.

[Term]
id: DOID:3114 ! serous cystadenocarcinoma
is_a: DOID:3111 ! cystadenocarcinoma
! A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions.

[Term]
id: DOID:3119 ! gastrointestinal system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.

[Term]
id: DOID:3121 ! gallbladder cancer
is_a: DOID:4607 ! biliary tract cancer
! A biliary tract cancer that is located_in the gallbladder.

[Term]
id: DOID:3162 ! malignant spindle cell melanoma
is_a: DOID:1909 ! melanoma
! A melanoma that is most commonly located_in sun-exposed skin and results_in_formation_ of spindle-like shaped cells that have a high recurrence rate even with treatment.

[Term]
id: DOID:3168 ! squamous cell neoplasm
is_a: DOID:0060084 ! cell type benign neoplasm
! A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities.

[Term]
id: DOID:321 ! tropical spastic paraparesis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms.

[Term]
id: DOID:3234 ! central nervous system lymphoma
is_a: DOID:2531 ! hematologic cancer
! A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system.

[Term]
id: DOID:3240 ! aspiration pneumonitis
is_a: DOID:225 ! syndrome
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
is_a: DOID:3455 ! cerebrovascular accident
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3240 ! aspiration pneumonitis
is_a: DOID:552 ! pneumonia
! A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disesae has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration.

[Term]
id: DOID:3241 ! lipid pneumonia
is_a: DOID:3240 ! aspiration pneumonitis
! An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent.

[Term]
id: DOID:3252 ! prostate rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:3254 ! bile duct rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of bile duct that is located_in the bile duct.

[Term]
id: DOID:3264 ! subacute leukemia
is_a: DOID:1036 ! chronic leukemia
! A leukemia that is in between acute and chronic leukemia and is characterized by a moderate duration or severity.

[Term]
id: DOID:3277 ! thymus cancer
is_a: DOID:0060083 ! immune system cancer
! An immune system cancer located_in the thymus.

[Term]
id: DOID:3292 ! monkeypox
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection of primates, rodents and humans, located_in skin, has_material_basis_in Monkeypox virus, which is transmitted_by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted_by fomites, and transmitted_by respiratory droplets. The infection has_symptom fever, has_symptom muscle ache, has_symptom headache, and has_symptom lymphadenopathy.

[Term]
id: DOID:3298 ! vaccinia
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches.

[Term]
id: DOID:3301 ! gonadoblastoma
is_a: DOID:0060084 ! cell type benign neoplasm
! A cell type benign neoplasm that is composed_of a mixture of gonadal elements.

[Term]
id: DOID:3302 ! chordoma
is_a: DOID:3303 ! notochordal cancer
! A notochordal cancer that derives_from cellular remnants of the notochord.

[Term]
id: DOID:3303 ! notochordal cancer
is_a: DOID:184 ! bone cancer
! An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord.

[Term]
id: DOID:3303 ! notochordal cancer
is_a: DOID:3350 ! mesenchymal cell neoplasm
! An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord.

[Term]
id: DOID:3303 ! notochordal cancer
is_a: DOID:688 ! embryonal cancer
! An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord.

[Term]
id: DOID:3308 ! embryonal carcinoma
is_a: DOID:688 ! embryonal cancer
! An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes.

[Term]
id: DOID:3310 ! atopic dermatitis
is_a: DOID:2723 ! dermatitis
! A dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking.

[Term]
id: DOID:334 ! histrionic personality disorder
is_a: DOID:1510 ! personality disorder
! A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood.

[Term]
id: DOID:3341 ! osteitis fibrosa
is_a: DOID:0080011 ! bone resorption disease
! A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone.

[Term]
id: DOID:3342 ! bone inflammation disease
is_a: DOID:0080001 ! bone disease
! A bone disease that results_in inflammation of the located_in bone.

[Term]
id: DOID:3350 ! mesenchymal cell neoplasm
is_a: DOID:0050687 ! cell type cancer
! A cell type cancer that has_material_basis_in abnormally proliferating cells derived_from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system.

[Term]
id: DOID:3394 ! ischemic heart disease
is_a: DOID:3978 ! extrinsic cardiomyopathy
! An extrinsic cardiomyopathy that is characterized by reduced blood supply to the cardiac muscles.

[Term]
id: DOID:3405 ! histiocytosis
is_a: DOID:1731 ! histoplasmosis
! A reticuloendotheliosis that is characterized by an excessive number of histiocytes.

[Term]
id: DOID:3436 ! viral laryngitis
is_a: DOID:9396 ! acute laryngitis
! A acute laryngitis which is caused by viral infection.

[Term]
id: DOID:3437 ! laryngitis
is_a: DOID:786 ! laryngeal disease
! A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption.

[Term]
id: DOID:3449 ! penis carcinoma
is_a: DOID:11615 ! penile cancer
! A penile cancer that is located_in the skin or tissues of the penis.

[Term]
id: DOID:345 ! uterine disease
is_a: DOID:229 ! female reproductive system disease
! A female reproductive system disease that is located_in the uterus.

[Term]
id: DOID:3451 ! skin carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is located_in tissues of the skin.

[Term]
id: DOID:3459 ! breast carcinoma
is_a: DOID:1612 ! breast cancer
! A breast cancer that derives_from breast tissue.

[Term]
id: DOID:3481 ! septicemic plague
is_a: DOID:3482 ! plague
! A plague that results_in infection located_in vasculature where bacterial endotoxins cause coagulation, which leads to formation of tiny clots throughout the body. The infection has_symptom fever, has_symptom chills, has_symptom prostration, has_symptom abdominal pain, has_symptom shock and has_symptom bleeding into skin and other organs.

[Term]
id: DOID:3482 ! plague
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food.

[Term]
id: DOID:3488 ! cellulitis
is_a: DOID:2985 ! chronic rejection of renal transplant
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3488 ! cellulitis
is_a: DOID:3488 ! cellulitis
! Cellulitis is a infectious disase where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion.

[Term]
id: DOID:3493 ! signet ring cell adenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance.

[Term]
id: DOID:3571 ! liver cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the liver.

[Term]
id: DOID:3603 ! mucinous cystadenocarcinoma
is_a: DOID:3111 ! cystadenocarcinoma
! A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells.

[Term]
id: DOID:3620 ! central nervous system cancer
is_a: DOID:3093 ! nervous system cancer
! A nervous system cancer that is located_in the central nervous system.

[Term]
id: DOID:3650 ! lactic acidosis
is_a: DOID:0060158 ! acquired metabolic disease
! An acquired metabolic disease that has_material_basis_in low pH in body tissues and blood accompanied by the buildup of lactate especially D-lactate.

[Term]
id: DOID:37 ! skin disease
is_a: DOID:16 ! integumentary system disease
! An integumentary system disease that is located_in skin.

[Term]
id: DOID:3728 ! acute allergic sanguinous otitis media
is_a: DOID:3696 ! acute sanguinous otitis media
! A acute sanguinous otitis media caused by an allergen.

[Term]
id: DOID:3733 ! theileriasis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks.

[Term]
id: DOID:3764 ! Denys-Drash syndrome
is_a: DOID:0080002 ! autosomal dominant disease
! An autosomal dominant disease that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene).

[Term]
id: DOID:381 ! arthropathy
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that is located_in joint.

[Term]
id: DOID:3891 ! placental insufficiency
is_a: DOID:780 ! placenta disease
! A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy.

[Term]
id: DOID:3905 ! lung carcinoma
is_a: DOID:1324 ! lung cancer
! A lung cancer that is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis.

[Term]
id: DOID:3950 ! adrenal carcinoma
is_a: DOID:3953 ! adrenal gland cancer
! An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland.

[Term]
id: DOID:3953 ! adrenal gland cancer
is_a: DOID:170 ! endocrine gland cancer
! An endocrine gland cancer located_in the adrenal glands which are located above the kidneys.

[Term]
id: DOID:399 ! tuberculosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes.

[Term]
id: DOID:3996 ! urinary system cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:4007 ! bladder carcinoma
is_a: DOID:11054 ! urinary bladder cancer
! A urinary bladder cancer that arises_from tissues of the bladder.

[Term]
id: DOID:402 ! oral tuberculosis
is_a: DOID:404 ! gastrointestinal tuberculosis
! A gastrointestinal tuberculosis that involves formation of painful ulcerative mucosal lesions located_in tongue, located_in palate, located_in maxilla or located_in mandible.

[Term]
id: DOID:4033 ! bacterial gastritis
is_a: DOID:0050117 ! disease by infectious agent
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by bacteria. The disease has_symptom abdominal pain, has_symptom indigestion, has_symptom ulcer formation, has_symptom abdominal bloating, has_symptom nausea and has_symptom vomiting.

[Term]
id: DOID:4034 ! fungal gastritis
is_a: DOID:0050117 ! disease by infectious agent
! A gastrointestinal system infectious disease that involves inflammation of the stomach lining caused by fungal infection in immunocompromised patients.

[Term]
id: DOID:404 ! gastrointestinal tuberculosis
is_a: DOID:0050599 ! abdominal tuberculosis
! An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting.

[Term]
id: DOID:4045 ! muscle cancer
is_a: DOID:0060100 ! musculoskeletal system cancer
! A musculoskeletal system cancer that is located_in muscle.

[Term]
id: DOID:4047 ! liver rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of liver that are located_in the liver.

[Term]
id: DOID:4049 ! mediastinum rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the mediastinum that is located_in the mediastinum and affects children and adolescents.

[Term]
id: DOID:4050 ! mediastinum sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant mediastinal mesenchymnal tumor that is located_in the mediastinum.

[Term]
id: DOID:4053 ! rectum rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the rectum that is located_in the rectum.

[Term]
id: DOID:4054 ! prostate sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of prostate that is located_in the prostate.

[Term]
id: DOID:4057 ! gallbladder rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and rhabdomyosarcoma that is located_in the gallbladder.

[Term]
id: DOID:4058 ! gallbladder sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4061 ! testis rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the testis that is located_in the testis.

[Term]
id: DOID:4062 ! testis sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of testis that is located_in the testis.

[Term]
id: DOID:4064 ! bile duct sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant tumor of extrahepatic bile duct that is located_in the bile duct.

[Term]
id: DOID:4066 ! anus rhabdomyosarcoma
is_a: DOID:3247 ! rhabdomyosarcoma
! A rhabdomyosarcoma and sarcoma of the anus that is located_in the anus.

[Term]
id: DOID:4067 ! anus sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of anus that is located_in the anus.

[Term]
id: DOID:407 ! hepatic tuberculosis
is_a: DOID:404 ! gastrointestinal tuberculosis
! A gastrointestinal tuberculosis that involves infection located_in liver, which results in the formation of tuberculous granulomas. The infection has_symptom fever, has_symptom anorexia, has_symptom weight loss, has_symptom abdominal pain and has_symptom jaundice.

[Term]
id: DOID:4078 ! tricuspid valve stenosis
is_a: DOID:4079 ! heart valve disease
! A heart valve disease which results in the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. It is almost always caused by rheumatic fever and is generally accompanied by mitral stenosis. Rare other causes include carcinoid syndrome, endocarditis, endomyocardial fibrosis, lupus erythematosus, right atrial myxoma and congenital tricuspid atresia.

[Term]
id: DOID:4110 ! parasitic ectoparasitic infectious disease
is_a: DOID:1398 ! parasitic infectious disease
! A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host.

[Term]
id: DOID:4111 ! cervical adenosarcoma
is_a: DOID:4112 ! cervical carcinosarcoma
! A cervical carcinosarcoma that is located_in the cervix.

[Term]
id: DOID:4113 ! uterine corpus adenosarcoma
is_a: DOID:1974 ! adenosarcoma
! An adenosarcoma and malignant uterine body mixed neoplasm that derives_from the glands that line the uterus.

[Term]
id: DOID:4115 ! ovarian mesodermal adenosarcoma
is_a: DOID:1974 ! adenosarcoma
! An adenosarcoma and malignant ovarian endometroid tumorthat is located_in the ovary.

[Term]
id: DOID:4117 ! vaginal adenosarcoma
is_a: DOID:136 ! vaginal carcinosarcoma
! A vaginal carcinosarcoma derives_from the glands that line the uterus.

[Term]
id: DOID:4123 ! nail disease
is_a: DOID:16 ! integumentary system disease
! An integumentary system disease that is located_in nail.

[Term]
id: DOID:4141 ! intraorbital meningioma
is_a: DOID:4142 ! meningioma by site
! A meningioma by site and orbital neoplasm that is located_in the area around the eye sockets of the skull and results_in pressure in the eyes, giving a bulging appearance.

[Term]
id: DOID:4143 ! orbital cancer
is_a: DOID:184 ! bone cancer
! A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis.

[Term]
id: DOID:4151 ! skull base chordoma
is_a: DOID:3302 ! chordoma
! A chordoma that is located_in the skull base.

[Term]
id: DOID:4152 ! chondroid chordoma
is_a: DOID:3302 ! chordoma
! A chordoma that histologically derives_from chordoma, derives_from chondroma, and derives_from chondrosarcoma.

[Term]
id: DOID:4153 ! spinal chordoma
is_a: DOID:3302 ! chordoma
! A chordoma that derives_from the spine.

[Term]
id: DOID:4156 ! primary syphilis
is_a: DOID:4166 ! syphilis
! A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes.

[Term]
id: DOID:4159 ! skin cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.

[Term]
id: DOID:4166 ! syphilis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years.

[Term]
id: DOID:418 ! systemic scleroderma
is_a: DOID:418 ! systemic scleroderma
! A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies.

[Term]
id: DOID:421 ! hair disease
is_a: DOID:16 ! integumentary system disease
! An integumentary system disease that is located_in hair.

[Term]
id: DOID:4233 ! clear cell sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated.

[Term]
id: DOID:4235 ! spindle cell sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy.

[Term]
id: DOID:4236 ! carcinosarcoma
is_a: DOID:154 ! mixed cell type cancer
! MERGED DEFINITION:nTARGET DEFINITION: A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components.n--------------------nSOURCE DEFINITION: A mullerian mixed tumor that is composed_of carcinoma of different mC<llerian types and composed_of homologous or heterologous sarcoma-like components.

[Term]
id: DOID:4242 ! kidney sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of kidney that is located_in the kidney's connective tissue.

[Term]
id: DOID:4253 ! melorheostosis
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex.

[Term]
id: DOID:4254 ! osteosclerosis
is_a: DOID:0080005 ! bone remodeling disease
! A bone remodeling disease that results_in abnormal elevated bone density or mass.

[Term]
id: DOID:4257 ! Caffey disease
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has_symptom soft-tissue swelling, has_symptom bone lesions, and has_symptom irritability.

[Term]
id: DOID:4258 ! Weissenbacher-ZweymC<ller syndrome
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results_in shortened long bones and distinct facial abnormalities.

[Term]
id: DOID:4270 ! encephalitozoonosis
is_a: DOID:4271 ! microsporidiosis
! A microsporidiosis that is a zoonotic infectious disease results_in disseminated fungal infection in dogs, cats, hamsters, guinea pigs, rats, mice and humans, has_material_basis_in Encephalitozoon cuniculi, has_material_basis_in Encephalitozoon intestinalis or has_material_basis_in Encephalitozoon hellem.

[Term]
id: DOID:4271 ! microsporidiosis
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that results_in systemic fungal infection in immunocompromised people, has_material_basis_in Microsporidia phylum members.

[Term]
id: DOID:4305 ! bone giant cell tumor
is_a: DOID:184 ! bone cancer
! A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell).

[Term]
id: DOID:4305 ! bone giant cell tumor
is_a: DOID:200 ! giant cell tumor
! A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell).

[Term]
id: DOID:4305 ! bone giant cell tumor
is_a: DOID:3347 ! osteosarcoma
! A giant cell tumor and bone cancer and bone tissue neoplasm that results_in the presence of multinucleated giant cells (osteoclast-like cell).

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4325 ! Ebola hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted_by contaminated fomites, or transmitted_by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4327 ! Marburg hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding.

[Term]
id: DOID:4336 ! tinea favosa
is_a: DOID:4337 ! tinea capitis
! A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

[Term]
id: DOID:4337 ! tinea capitis
is_a: DOID:8913 ! dermatophytosis
! A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern.

[Term]
id: DOID:4411 ! hepatitis E
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice.

[Term]
id: DOID:4442 ! cervical alveolar soft part sarcoma
is_a: DOID:4239 ! alveolar soft part sarcoma
! An alveolar soft part sarcoma and cervical soft tissue tumor and malignant neoplasm of cervix uteri that is located_in the cervix.

[Term]
id: DOID:4442 ! cervical alveolar soft part sarcoma
is_a: DOID:4443 ! cervical soft tissue tumor
! An alveolar soft part sarcoma and cervical soft tissue tumor and malignant neoplasm of cervix uteri that is located_in the cervix.

[Term]
id: DOID:4451 ! renal carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products).

[Term]
id: DOID:4468 ! clear cell adenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm.

[Term]
id: DOID:4480 ! achondroplasia
is_a: DOID:2256 ! osteochondrodysplasia
! An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone.

[Term]
id: DOID:4481 ! allergic rhinitis
is_a: DOID:4483 ! rhinitis
! A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.

[Term]
id: DOID:4483 ! rhinitis
is_a: DOID:0050117 ! disease by infectious agent
! A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

[Term]
id: DOID:4492 ! avian influenza
is_a: DOID:8469 ! influenza
! An influenza that results_in infection located_in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted_by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress.

[Term]
id: DOID:4501 ! orofaciodigital syndrome
is_a: DOID:630 ! genetic disease
! A genetic disease that is characterized by malformations of the face, oral cavity, and digits with polycystic kidney disease and variable involvement of the central nervous system and has_material_basis_in X-linked inheritance of an OFD gene.

[Term]
id: DOID:4504 ! central nervous system angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and sarcoma of central nervous system and mesenchymal non-meningothelial tumor of central nervous system that is located_in the central nervous system.

[Term]
id: DOID:4510 ! aorta angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma that is located_in the aorta.

[Term]
id: DOID:4511 ! breast angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and sarcoma of breast and vascular neoplasm of breast that is located_in the cells that line the blood vessels within the breast or underarm area.

[Term]
id: DOID:4513 ! gallbladder angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4513 ! gallbladder angiosarcoma
is_a: DOID:4058 ! gallbladder sarcoma
! An angiosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:4514 ! thyroid angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! A thyroid sarcoma and angiosarcoma that results_in a high prevalence of iodine-deficient goiter.

[Term]
id: DOID:4514 ! thyroid angiosarcoma
is_a: DOID:4515 ! thyroid sarcoma
! A thyroid sarcoma and angiosarcoma that results_in a high prevalence of iodine-deficient goiter.

[Term]
id: DOID:4515 ! thyroid sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of thyroid that is located_in the supporting cells of the thyroid.

[Term]
id: DOID:4517 ! skin angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and hemangioma of skin and malignant skin vascular tumor and sarcoma of skin that is located_in the skin and results_in an enlarged bruise (a blue-black nodule) and an unhealed ulceration.

[Term]
id: DOID:4524 ! prostate angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and sarcoma of prostate that is located_in the prostate.

[Term]
id: DOID:4525 ! mediastinum angiosarcoma
is_a: DOID:0001816 ! angiosarcoma
! An angiosarcoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:4531 ! mucoepidermoid carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells.

[Term]
id: DOID:4547 ! adult mesenchymal chondrosarcoma
is_a: DOID:4545 ! mesenchymal chondrosarcoma
! An adult sarcoma of soft tissue and mesenchymal chondrosarcoma that is located_in the cartilage.

[Term]
id: DOID:4606 ! bile duct cancer
is_a: DOID:4607 ! biliary tract cancer
! A biliary tract cancer that is located_in the bile duct.

[Term]
id: DOID:4607 ! biliary tract cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct.

[Term]
id: DOID:4624 ! Ollier disease
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet.

[Term]
id: DOID:4647 ! trilateral retinoblastoma
is_a: DOID:4650 ! bilateral retinoblastoma
! A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region.

[Term]
id: DOID:4647 ! trilateral retinoblastoma
is_a: DOID:4788 ! intracranial primitive neuroectodermal tumor
! A retinoblastoma that refers to bilateral retinoblastoma associated with an intracranial primitive neuroectodermal tumor located_in the pineal or suprasellar region.

[Term]
id: DOID:4653 ! intraocular retinoblastoma
is_a: DOID:768 ! retinoblastoma
! A retinoblastoma that is located_in the eye and has not spread to other parts of the body.

[Term]
id: DOID:4692 ! endophthalmitis
is_a: DOID:0050117 ! disease by infectious agent
! Endophthalmitis is a infectious disease consisting of an uncommon infection with Inflammation of the inside of the eye with the infection caused by bacteria, fungi or protozoa that have entered the eye during a surgical procedure, as the result of an injury or less commonly by traveling through the bloodstream to the eyeball.

[Term]
id: DOID:4692 ! endophthalmitis
is_a: DOID:4692 ! endophthalmitis
! Endophthalmitis is a infectious disease consisting of an uncommon infection with Inflammation of the inside of the eye with the infection caused by bacteria, fungi or protozoa that have entered the eye during a surgical procedure, as the result of an injury or less commonly by traveling through the bloodstream to the eyeball.

[Term]
id: DOID:4719 ! bone giant cell sarcoma
is_a: DOID:2705 ! malignant giant cell tumor
! A giant cell tumor of bone and malignant giant cell tumor that is composed_of multinucleated giant cells.

[Term]
id: DOID:4731 ! atrophic rhinitis
is_a: DOID:4483 ! rhinitis
! A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

[Term]
id: DOID:4744 ! placenta accreta
is_a: DOID:780 ! placenta disease
! A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium.

[Term]
id: DOID:4765 ! pulmonary blastoma
is_a: DOID:4766 ! embryoma
! An embryoma and malignant neoplasm of lung that derives_from tissues of the lung and derives_from pleura (a thin layer of tissue that covers the lungs and lines the interior wall of the chest cavity). It is most commonly effects children.

[Term]
id: DOID:4766 ! embryoma
is_a: DOID:4236 ! carcinosarcoma
! A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells.

[Term]
id: DOID:4766 ! embryoma
is_a: DOID:688 ! embryonal cancer
! A carcinosarcoma and embryonal cancer that is located_in embryonic tissue and results_in a mass of rapidly growing cells.

[Term]
id: DOID:4769 ! pleuropulmonary blastoma
is_a: DOID:4765 ! pulmonary blastoma
! A pulmonary blastoma that derives_from the lung or pleural cavity.

[Term]
id: DOID:4837 ! Gorham's disease
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones.

[Term]
id: DOID:4838 ! myoepithelial carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that derives_from myoepithelial cells.

[Term]
id: DOID:4866 ! adenoid cystic carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes.

[Term]
id: DOID:4885 ! Colorado tick fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue.

[Term]
id: DOID:4889 ! lymph node tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough.

[Term]
id: DOID:4890 ! juvenile myoclonic epilepsy
is_a: DOID:225 ! syndrome
! A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years.

[Term]
id: DOID:4903 ! granular cell carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that derives_from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

[Term]
id: DOID:4907 ! small intestine carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is located_in the small intestine.

[Term]
id: DOID:4908 ! anal carcinoma
is_a: DOID:14110 ! anus cancer
! A anus cancer that is located_in the anus.

[Term]
id: DOID:4917 ! villous adenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, with villous architecture.

[Term]
id: DOID:4929 ! tubular adenocarcinoma
is_a: DOID:299 ! adenocarcinoma
! An adenocarcinoma that derives_from epithelial cells originating in glandular tissue. The tumor has branched angular tubules embedded in a loose fibrous stroma.

[Term]
id: DOID:4939 ! ureter carcinoma
is_a: DOID:11819 ! ureter cancer
! An ureter cancer that is located_in the ureter.

[Term]
id: DOID:4948 ! gallbladder carcinoma
is_a: DOID:305 ! carcinoma
! A carcinoma that is located_in the tissues of the gallbladder.

[Term]
id: DOID:4952 ! postpoliomyelitis syndrome
is_a: DOID:4953 ! poliomyelitis
! A poliomyelitis that results_in atrophy located_in muscle, many years after the initial infection, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3. It is characterized by new weakening in muscles that were previously affected by the polio infection and in muscles that were unaffected. The infection has_symptom muscle weakness, has_symptom muscle pain, has_symptom sleep apnea, and has_symptom breathing problems.

[Term]
id: DOID:4953 ! poliomyelitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, has_symptom muscle spasms, and has_symptom acute flaccid paralysis.

[Term]
id: DOID:4960 ! bone marrow cancer
is_a: DOID:2531 ! hematologic cancer
! A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow.

[Term]
id: DOID:4962 ! pericardial tuberculosis
is_a: DOID:0050598 ! extrapulmonary tuberculosis
! An extrapulmonary tuberculosis that is located_in pericardium resulting in acute pericarditis, chronic pericardial effusion, cardiac tamponade or pericardial constriction.

[Term]
id: DOID:4971 ! myelofibrosis
is_a: DOID:0070004 ! myeloma
! A myeloma that is located_in the bone marrow which results_in bone marrow being replaced by fibrous (scar) tissue.

[Term]
id: DOID:4972 ! myelodysplastic myeloproliferative cancer
is_a: DOID:4960 ! bone marrow cancer
! A bone marrow cancer that is located_in the bone marrow and results_in the production of too many white blood cells. The cancer possess both dysplastic and proliferative features but are not properly classified as either.

[Term]
id: DOID:4974 ! actinobacillosis
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media.

[Term]
id: DOID:4986 ! nonparalytic poliomyelitis
is_a: DOID:4953 ! poliomyelitis
! A poliomyelitis that results_in destruction located_in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom vomiting, has_symptom fatigue, has_symptom neck stiffness, and has_symptom muscle spasms.

[Term]
id: DOID:4997 ! Camurati-Engelmann disease
is_a: DOID:4254 ! osteosclerosis
! An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone.

[Term]
id: DOID:4998 ! Langer-Giedion syndrome
is_a: DOID:203 ! exostosis
! An exostosis that has_material_basis_in mutation of the EXT1 and TRPS1 gene which results_in multiple exostosis along with short stature and cone-shaped ends located_in epiphysis. The disease has_symptom sparse scalp hair, has_symptom thin upper lip, has_symptom rounded nose.

[Term]
id: DOID:50 ! thyroid gland disease
is_a: DOID:28 ! endocrine system disease
! An endocrine system disease that is located_in the thyroid.

[Term]
id: DOID:5041 ! esophageal cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the esophagus.

[Term]
id: DOID:5052 ! melioidosis
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain.

[Term]
id: DOID:5074 ! malignant ependymoma
is_a: DOID:3070 ! malignant glioma
! A malignant glioma that is derived from ependymal cells, a type of glial cell, located_in ventricle lining within the central part of the brain.

[Term]
id: DOID:5090 ! sternum cancer
is_a: DOID:184 ! bone cancer
! A bone cancer and neoplasm of chest wall and sternal disorder that is located_in the sternum.

[Term]
id: DOID:5093 ! thoracic cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall.

[Term]
id: DOID:5154 ! borna disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment.

[Term]
id: DOID:5165 ! uterine corpus sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma that is located_in the muscles of the uterus or located_in other tissues that support the uterus.

[Term]
id: DOID:5183 ! hereditary Wilms' tumor
is_a: DOID:2154 ! nephroblastoma
! A nephroblastoma that results_in either bilateral disease or a family history of Wilms' tumour.

[Term]
id: DOID:5190 ! cervical Wilms' tumor
is_a: DOID:2154 ! nephroblastoma
! A nephroblastoma and malignant cervical mixed epithelial and mesenchymal neoplasm that is located_in the cervix.

[Term]
id: DOID:5204 ! fructose-1,6-bisphosphatase deficiency
is_a: DOID:2978 ! carbohydrate metabolic disorder
! A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis.

[Term]
id: DOID:5259 ! colon leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of colon that is located_in the colon.

[Term]
id: DOID:526 ! Human immunodeficiency virus infectious disease
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has_symptom diarrhea, has_symptom fatigue, has_symptom fever, has_symptom vaginal yeast infection, has_symptom headache, has_symptom mouth sores, has_symptom muscle aches, has_symptom sore throat, and has_symptom swollen lymph glands.

[Term]
id: DOID:5260 ! colon sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant tumor of colon that is located_in the colon.

[Term]
id: DOID:5262 ! heart sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant neoplasm of heart that is located_in the heart.

[Term]
id: DOID:5262 ! heart sarcoma
is_a: DOID:117 ! heart cancer
! A sarcoma and malignant neoplasm of heart that is located_in the heart.

[Term]
id: DOID:5265 ! lung leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of lung that is located_in the lung.

[Term]
id: DOID:5272 ! small intestinal sarcoma
is_a: DOID:1115 ! sarcoma
! A sarcoma and malignant tumor of small intestine that is located_in the small intestine.

[Term]
id: DOID:5275 ! gallbladder leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:5275 ! gallbladder leiomyosarcoma
is_a: DOID:4058 ! gallbladder sarcoma
! A leiomyosarcoma and gallbladder sarcoma that is located_in the gallbladder.

[Term]
id: DOID:5282 ! prostate leiomyosarcoma
is_a: DOID:4054 ! prostate sarcoma
! A prostate sarcoma that is located_in the prostate.

[Term]
id: DOID:5287 ! kidney leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
is_a: DOID:5165 ! uterine corpus sarcoma
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5289 ! uterus leiomyosarcoma
is_a: DOID:5290 ! uterine corpus smooth muscle neoplasm
! A uterine Corpus sarcoma and leiomyosarcoma and uterine Corpus smooth muscle neoplasm that is located_in the smooth muscle of the uterus.

[Term]
id: DOID:5292 ! mediastinum leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of the mediastinum that derive_from smooth muscle and are usually located_in the esophagus or located_in the main vessels.

[Term]
id: DOID:5293 ! extrahepatic bile duct leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of bile duct that is located_in the bile duct or located_in the outside of the liver.

[Term]
id: DOID:5296 ! liver leiomyosarcoma
is_a: DOID:1967 ! leiomyosarcoma
! A leiomyosarcoma and sarcoma of liver that is located_in the liver.

[Term]
id: DOID:53 ! pituitary gland disease
is_a: DOID:28 ! endocrine system disease
! An endocrine system disease that is located_in the pituitary gland.

[Term]
id: DOID:5313 ! vulvar alveolar soft part sarcoma
is_a: DOID:2096 ! vulvar sarcoma
! An alveolar soft part sarcoma and vulvar sarcoma that is located_in the vulva.

[Term]
id: DOID:5313 ! vulvar alveolar soft part sarcoma
is_a: DOID:4239 ! alveolar soft part sarcoma
! An alveolar soft part sarcoma and vulvar sarcoma that is located_in the vulva.

[Term]
id: DOID:5362 ! focal epithelial hyperplasia
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in mouth, has_material_basis_in human papillomavirus (types 13 or 32), has_symptom papules or nodules in the oral cavity.

[Term]
id: DOID:5381 ! bile duct adenoma
is_a: DOID:4607 ! biliary tract cancer
! An adenoma and biliary tract cancer that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma.

[Term]
id: DOID:5381 ! bile duct adenoma
is_a: DOID:657 ! adenoma
! An adenoma and biliary tract cancer that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma.

[Term]
id: DOID:5390 ! clear cell adenoma
is_a: DOID:657 ! adenoma
! An adenoma that is composed_of cells with a clear cytoplasm located_in ovary.

[Term]
id: DOID:5398 ! lipoadenoma
is_a: DOID:657 ! adenoma
! An adenoma that is composed_of adipose tissue.

[Term]
id: DOID:5401 ! water-clear cell adenoma
is_a: DOID:657 ! adenoma
! An adenoma that derives_from epithelial cells which have clear cytoplasm.

[Term]
id: DOID:5418 ! schizoaffective disorder
is_a: DOID:2468 ! psychotic disorder
! A psychotic disorder that is characterized by recurring episodes of nmood fluctuations and a loss of contact with reality.

[Term]
id: DOID:5419 ! schizophrenia
is_a: DOID:2468 ! psychotic disorder
! A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness.

[Term]
id: DOID:5482 ! cystadenofibroma
is_a: DOID:2683 ! adenofibroma
! An adenofibroma that is composed_of epithelial ovarian tissue.

[Term]
id: DOID:5488 ! mediastinum synovial sarcoma
is_a: DOID:5485 ! synovial sarcoma
! A sarcoma of the mediastinum and synovial sarcoma that is located_in the mediastinum.

[Term]
id: DOID:5501 ! Pediculus humanus capitis infestation
is_a: DOID:5502 ! lice infestation
! A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

[Term]
id: DOID:5513 ! Pediculus humanus corporis infestation
is_a: DOID:5502 ! lice infestation
! A lice infestation that is a cutaneous condition caused by parasitic infestation of body lice Pediculus humanus corporis, which feed on the human blood. Body lice can spread epidemic typhus, trench fever, and louse-borne relapsing fever.

[Term]
id: DOID:5517 ! stomach carcinoma
is_a: DOID:10534 ! stomach cancer
! A stomach cancer that is located_in the stomach.

[Term]
id: DOID:5524 ! adenoid squamous cell carcinoma
is_a: DOID:1749 ! squamous cell carcinoma
! A squamous cell carcinoma that is characterized by a tubular microscopic pattern and keratinocyte acantholysis.

[Term]
id: DOID:5546 ! femoral cancer
is_a: DOID:184 ! bone cancer
! A bone cancer that is located_in the femur.

[Term]
id: DOID:5559 ! mediastinal cancer
is_a: DOID:5093 ! thoracic cancer
! A thoracic cancer that is located_in the mediastinum.

[Term]
id: DOID:5583 ! lung giant cell carcinoma
is_a: DOID:3905 ! lung carcinoma
! A lung carcinoma that is located_in large undifferentiated cells.

[Term]
id: DOID:5612 ! spinal cancer
is_a: DOID:184 ! bone cancer
! A bone cancer and central nervous system neoplasm and spinal disease that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer).

[Term]
id: DOID:5621 ! histiocytic and dendritic cell cancer
is_a: DOID:1115 ! sarcoma
! A sarcoma and hematologic cancer that derives_from follicular lymphoma.

[Term]
id: DOID:5621 ! histiocytic and dendritic cell cancer
is_a: DOID:2531 ! hematologic cancer
! A sarcoma and hematologic cancer that derives_from follicular lymphoma.

[Term]
id: DOID:5696 ! larynx liposarcoma
is_a: DOID:3382 ! liposarcoma
! A liposarcoma and sarcoma of the larynx that is located_in the larynx.

[Term]
id: DOID:5699 ! kidney liposarcoma
is_a: DOID:3382 ! liposarcoma
! A liposarcoma and sarcoma of kidney that is located_in the kidney.

[Term]
id: DOID:5713 ! mediastinum liposarcoma
is_a: DOID:3382 ! liposarcoma
! A liposarcoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:5772 ! central nervous system hematologic cancer
is_a: DOID:2531 ! hematologic cancer
! A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system.

[Term]
id: DOID:5810 ! adenosine deaminase deficiency
is_a: DOID:627 ! severe combined immunodeficiency
! A severe combined immunodeficiency that is caused by a defective enzyme, adenosine deaminase (ADA), necessary for the breakdown of purines. Lack of ADA causes accumulation of dATP.

[Term]
id: DOID:5813 ! purine nucleoside phosphorylase deficiency
is_a: DOID:628 ! combined T cell and B cell immunodeficiency
! A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder caused by a mutaion in the PNP gene and characterized mainly by decreased T-cell function.

[Term]
id: DOID:5815 ! cerebral lymphoma
is_a: DOID:5815 ! cerebral lymphoma
! A CNS lymphoma and malignant cerebral lymphoma that affects the lymph cells and derives_from the brain.

[Term]
id: DOID:5822 ! gray zone lymphoma
is_a: DOID:0060058 ! lymphoma
! A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas.

[Term]
id: DOID:5870 ! eosinophilic pneumonia
is_a: DOID:552 ! pneumonia
! A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night.

[Term]
id: DOID:5875 ! retroperitoneal cancer
is_a: DOID:0050686 ! organ system cancer
! An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

[Term]
id: DOID:594 ! panic disorder
is_a: DOID:2030 ! anxiety disorder
! An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress.

[Term]
id: DOID:5983 ! kidney osteogenic sarcoma
is_a: DOID:3357 ! extraosseous osteosarcoma
! A sarcoma of kidney and extraosseous osteosarcoma that is located_in the kidney.

[Term]
id: DOID:599 ! specific phobia
is_a: DOID:591 ! phobic disorder
! A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations.

[Term]
id: DOID:600 ! animal phobia
is_a: DOID:599 ! specific phobia
! A specific phobia that involves a fear caused by the presence or thought of a specific animal that poses little or no danger at all.

[Term]
id: DOID:6000 ! congestive heart failure
is_a: DOID:114 ! heart disease
! A heart disease that is characterized by any structural or functional cardiacdisorder that impairs the ability of the heart to fill with or pump a sufficient amount ofblood throughout the body.

[Term]
id: DOID:6004 ! aleukemic leukemia
is_a: DOID:1240 ! leukemia
! A leukemia that arises from changes in the tissues forming white blood cells and characterized by a normal or decreased number of white blood cells in the circulating blood.

[Term]
id: DOID:6037 ! spindle cell intraocular melanoma
is_a: DOID:3162 ! malignant spindle cell melanoma
! An intraocular malanoma and malignant spindle cell melanoma that derives_from melanocytes in the uveal tract that results_in_formation_of spindle-shaped cells.

[Term]
id: DOID:6041 ! choroid spindle cell melanoma
is_a: DOID:6037 ! spindle cell intraocular melanoma
! A malignant melanoma of choroid and spindle cell intraocular melanoma that is located_in the choroid.

[Term]
id: DOID:6043 ! ciliary body spindle cell melanoma
is_a: DOID:6039 ! intraocular melanoma
! A malignant melanoma of ciliary body and spindle intraocular melanoma that is located_in the ciliary body.

[Term]
id: DOID:605 ! flying phobia
is_a: DOID:599 ! specific phobia
! A specific phobia that is characterized by a fear of flying.

[Term]
id: DOID:6088 ! acute stress disorder
is_a: DOID:2030 ! anxiety disorder
! An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD.

[Term]
id: DOID:6102 ! herpetic gastritis
is_a: DOID:2327 ! viral gastritis
! A viral gastritis that involves inflammation of the stomach lining caused by herpes simplex virus.

[Term]
id: DOID:6132 ! bronchitis
is_a: DOID:1176 ! bronchial disease
! A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness.

[Term]
id: DOID:6209 ! malignant mediastinum hemangiopericytoma
is_a: DOID:264 ! hemangiopericytoma
! A hemangiopericytoma and sarcoma of the mediastinum that is located_in the mediastinum.

[Term]
id: DOID:627 ! severe combined immunodeficiency
is_a: DOID:628 ! combined T cell and B cell immunodeficiency
! A combined T cell and B cell immunodeficiency that is caused by a defect in several genes encoding for B and T lymphocytes resulting in individuals with non-functional immune systems.

[Term]
id: DOID:630 ! genetic disease
is_a: DOID:4 ! disease
! A disease that has_material_basis_in genetic variations in the human genome.

[Term]
id: DOID:6313 ! clivus chondroid chordoma
is_a: DOID:4152 ! chondroid chordoma
! A chondroid chordoma and chordoma of the clivus that is located_in the clivus.

[Term]
id: DOID:635 ! acquired immunodeficiency syndrome
is_a: DOID:526 ! Human immunodeficiency virus infectious disease
! A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per B5L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS.

[Term]
id: DOID:6364 ! migraine
is_a: DOID:936 ! brain disease
! A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing.

[Term]
id: DOID:646 ! viral encephalitis
is_a: DOID:9588 ! encephalitis
! An encephalitis that involves inflammation of the brain caused by viral infection.

[Term]
id: DOID:6495 ! adult myxoid chondrosarcoma
is_a: DOID:5861 ! myxoid chondrosarcoma
! An adult sarcoma of soft tissue and myxoid chondrosarcoma that is composed_of multiple lobules of chondroblast-like cells, arranged in cords and strands, embedded in a myxoid stroma, and separated by fibrous septa.

[Term]
id: DOID:655 ! inherited metabolic disorder
is_a: DOID:0014667 ! disease of metabolism
! A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inhertied enzyme abnormality.

[Term]
id: DOID:657 ! adenoma
is_a: DOID:0060084 ! cell type benign neoplasm
! A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.

[Term]
id: DOID:6579 ! chest wall bone cancer
is_a: DOID:184 ! bone cancer
! A bone cancer and malignant neoplasm of chest wall that is located_in the chest wall.

[Term]
id: DOID:6579 ! chest wall bone cancer
is_a: DOID:6758 ! chest wall lymphoma
! A bone cancer and malignant neoplasm of chest wall that is located_in the chest wall.

[Term]
id: DOID:6676 ! Froelich's syndrome
is_a: DOID:225 ! syndrome
! A syndrome characterized by a combination of obesity, retarded development of the sex glands, and changes in secondary sex characteristics that results from impaired function or disease of the pituitary gland and hypothalamus.

[Term]
id: DOID:6678 ! tooth and nail syndrome
is_a: DOID:225 ! syndrome
! A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails.

[Term]
id: DOID:6682 ! spondylolisthesis
is_a: DOID:0080010 ! bone structure disease
! A bone structure disease that has_material_basis_in displacement located_in set of vertebrae.

[Term]
id: DOID:6688 ! autoimmune lymphoproliferative syndrome
is_a: DOID:2916 ! hypersensitivity reaction type IV disease
! A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen.

[Term]
id: DOID:6691 ! Aagenaes syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by congenital hypoplasia of lymph vessels, which causes lymphedema of the legs and recurrent cholestasis in infancy, and slow progress to hepatic cirrhosis and giant cell hepatitis with fibrosis of the portal tracts.

[Term]
id: DOID:6725 ! spinal stenosis
is_a: DOID:0080007 ! bone deterioration disease
! A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord.

[Term]
id: DOID:6741 ! bilateral breast cancer
is_a: DOID:3459 ! breast carcinoma
! A breast carcinoma that is characterized by an individual having breast cancer in both breasts, either simultaneously or at different times.

[Term]
id: DOID:6758 ! chest wall lymphoma
is_a: DOID:5093 ! thoracic cancer
! A thoracic cancer that is located_in the chest wall.

[Term]
id: DOID:6759 ! bone lymphoma
is_a: DOID:1356 ! lymphoma by site
! A bone cancer and lymphoma by site that results_in lymphoma starting in the bone.

[Term]
id: DOID:6759 ! bone lymphoma
is_a: DOID:184 ! bone cancer
! A bone cancer and lymphoma by site that results_in lymphoma starting in the bone.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
is_a: DOID:417 ! hypersensitivity reaction type II disease
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:676 ! juvenile rheumatoid arthritis
is_a: DOID:7148 ! rheumatoid arthritis
! A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint.

[Term]
id: DOID:680 ! tauopathy
is_a: DOID:1289 ! neurodegenerative disease
! A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain.

[Term]
id: DOID:6880 ! small bowel fibrosarcoma
is_a: DOID:3355 ! fibrosarcoma
! A fibrosarcoma of soft tissue and small intestinal sarcoma that is located_in the small bowel.

[Term]
id: DOID:6880 ! small bowel fibrosarcoma
is_a: DOID:5272 ! small intestinal sarcoma
! A fibrosarcoma of soft tissue and small intestinal sarcoma that is located_in the small bowel.

[Term]
id: DOID:7033 ! anisakiasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung.

[Term]
id: DOID:710 ! splenic manifestation of leukemia
is_a: DOID:1240 ! leukemia
! A leukemia that is located_in the spleen. It results_in an enlargement of the leukemia.

[Term]
id: DOID:711 ! refractory hairy cell leukemia
is_a: DOID:712 ! refractory hematologic cancer
! A refractory hematologic cancer that is_a mature B cell cancer that does not yield readily to treatment.

[Term]
id: DOID:712 ! refractory hematologic cancer
is_a: DOID:2531 ! hematologic cancer
! A hematologic cancer that is located_in the blood or bone marrow that doesn't respond to treatment.

[Term]
id: DOID:7146 ! Langerhans cell sarcoma
is_a: DOID:5621 ! histiocytic and dendritic cell cancer
! A histiocytic and dendritic cell cancer that derives_from the lymph nodes, derives_from the skin, derives_from the liver, derives_from the spleen and derives_from bones.

[Term]
id: DOID:7147 ! ankylosing spondylitis
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage.

[Term]
id: DOID:7148 ! rheumatoid arthritis
is_a: DOID:417 ! hypersensitivity reaction type II disease
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7148 ! rheumatoid arthritis
is_a: DOID:848 ! arthritis
! An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint.

[Term]
id: DOID:7152 ! prostate stromal sarcoma
is_a: DOID:2990 ! tumor of specialized prostatic stroma
! A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located_in the prostate.

[Term]
id: DOID:7152 ! prostate stromal sarcoma
is_a: DOID:4228 ! stromal sarcoma
! A stromal sarcoma and sarcoma of prostate and tumor of specialized prostatic stroma that is located_in the prostate.

[Term]
id: DOID:718 ! autoimmune hemolytic anemia
is_a: DOID:0060050 ! autoimmune disease of blood
! An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies.

[Term]
id: DOID:7188 ! autoimmune thyroiditis
is_a: DOID:0060005 ! autoimmune disease of endocrine system
! An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues.

[Term]
id: DOID:731 ! urinary system benign neoplasm
is_a: DOID:0060085 ! organ system benign neoplasm
! An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra.

[Term]
id: DOID:7328 ! iris spindle cell melanoma
is_a: DOID:6037 ! spindle cell intraocular melanoma
! A malignant melanoma of iris and spindle cell intraocular melanoma that is located_in the iris.

[Term]
id: DOID:7332 ! esophageal tuberculosis
is_a: DOID:404 ! gastrointestinal tuberculosis
! A gastrointestinal tuberculosis that involves formation of tuberculous ulcers located_in esophagus. The infection has_symptom dysphagia, has_symptom cough, has_symptom chest pain, has_symptom fever and has_symptom weight loss.

[Term]
id: DOID:7426 ! cutaneous anthrax
is_a: DOID:7427 ! anthrax disease
! An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center.

[Term]
id: DOID:7427 ! anthrax disease
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath.

[Term]
id: DOID:7489 ! Osgood-Schlatter's disease
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that involves rupture of the growth plate in children located_in tibia.

[Term]
id: DOID:754 ! bladder tuberculosis
is_a: DOID:2149 ! urogenital tuberculosis
! An urogenital tuberculosis that is located_in urinary bladder, which results in fibrosis of bladder wall muscles.

[Term]
id: DOID:7551 ! gonorrhea
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods.

[Term]
id: DOID:7615 ! sarcomatosis
is_a: DOID:1115 ! sarcoma
! A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body.

[Term]
id: DOID:768 ! retinoblastoma
is_a: DOID:769 ! neuroblastoma
! A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.

[Term]
id: DOID:768 ! retinoblastoma
is_a: DOID:771 ! retinal cell cancer
! A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina.

[Term]
id: DOID:77 ! gastrointestinal system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in the gastrointestinal tract.

[Term]
id: DOID:780 ! placenta disease
is_a: DOID:345 ! uterine disease
! A uterine disease that is located_in the placenta.

[Term]
id: DOID:7849 ! dendritic cell sarcoma
is_a: DOID:5621 ! histiocytic and dendritic cell cancer
! A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes.

[Term]
id: DOID:8022 ! liver fibrosarcoma
is_a: DOID:3355 ! fibrosarcoma
! A fibrosarcoma of soft tissue and sarcoma of liver that is located_in the liver.

[Term]
id: DOID:8125 ! osteochondrosis
is_a: DOID:0080008 ! ischemic bone disease
! An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone.

[Term]
id: DOID:813 ! septic arthritis
is_a: DOID:848 ! arthritis
! An arthritis that involves infection by a pathogen located_in joint.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:1024 ! leprosy
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:11336 ! rhinoscleroma
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:12663 ! blastomycosis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:1731 ! histoplasmosis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:2409 ! rhinosporidiosis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:399 ! tuberculosis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:4166 ! syphilis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:4483 ! rhinitis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:8252 ! chronic rhinitis
is_a: DOID:9065 ! leishmaniasis
! A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

[Term]
id: DOID:827 ! ureter tuberculosis
is_a: DOID:2149 ! urogenital tuberculosis
! An urogenital tuberculosis that is located_in ureter resulting in ureteral strictures.

[Term]
id: DOID:8295 ! scabies
is_a: DOID:7894 ! mite infestation
! A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades.

[Term]
id: DOID:8337 ! appendicitis
is_a: DOID:0050117 ! disease by infectious agent
! A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain,  in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever.

[Term]
id: DOID:8398 ! osteoarthritis
is_a: DOID:848 ! arthritis
! An arthritis that has_material_basis_in worn out cartilage located_in joint.

[Term]
id: DOID:8399 ! trombiculiasis
is_a: DOID:0050486 ! exanthem
! A mite infestation that involves rash caused by Leptotrombidium deliense.

[Term]
id: DOID:8399 ! trombiculiasis
is_a: DOID:7894 ! mite infestation
! A mite infestation that involves rash caused by Leptotrombidium deliense.

[Term]
id: DOID:84 ! osteochondritis dissecans
is_a: DOID:0080008 ! ischemic bone disease
! An ischemic bone disease that results_in necrosis located_in epiphysis.

[Term]
id: DOID:840 ! cork-handlers' disease
is_a: DOID:841 ! extrinsic allergic alveolitis
! An extrinsic allergic alveolitis caused by inhalation of cork dust containing the antigens produced by the fungus Penicillium glabrum. The symptoms include dyspnea, wheezing cough, fever and asthenia.

[Term]
id: DOID:841 ! extrinsic allergic alveolitis
is_a: DOID:3082 ! interstitial lung disease
! An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss.

[Term]
id: DOID:8461 ! Aicardi syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye.

[Term]
id: DOID:8469 ! influenza
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, located_in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness.

[Term]
id: DOID:8478 ! actinomycosis
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures.

[Term]
id: DOID:848 ! arthritis
is_a: DOID:3342 ! bone inflammation disease
! A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint.

[Term]
id: DOID:8484 ! maple bark strippers' lung
is_a: DOID:2473 ! opportunistic mycosis
! An opportunistic mycosis that is located_in lungs caused by inhalation of fungal spores while stripping the bark from maple logs, has_material_basis_in Cryptostroma corticale.

[Term]
id: DOID:8488 ! polyhydramnios
is_a: DOID:780 ! placenta disease
! A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac.

[Term]
id: DOID:8502 ! bullous skin disease
is_a: DOID:0060039 ! autoimmune disease of skin and connective tissue
! An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested.

[Term]
id: DOID:8504 ! impetigo
is_a: DOID:8504 ! impetigo
! Impetigo is a pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous.

[Term]
id: DOID:8506 ! bullous pemphigoid
is_a: DOID:0060039 ! autoimmune disease of skin and connective tissue
! An autoimmune disease of skin and connective tissue characterized by large blisters.

[Term]
id: DOID:8515 ! cor pulmonale
is_a: DOID:6000 ! congestive heart failure
! A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs.

[Term]
id: DOID:8533 ! hypopharynx cancer
is_a: DOID:0060119 ! pharynx cancer
! A pharynx cancer that is located_in the hypopharynx.

[Term]
id: DOID:8536 ! herpes zoster
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia.

[Term]
id: DOID:8544 ! chronic fatigue syndrome
is_a: DOID:225 ! syndrome
! A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to extertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions.

[Term]
id: DOID:8545 ! malignant hyperthermia
is_a: DOID:630 ! genetic disease
! A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.

[Term]
id: DOID:8566 ! herpes simplex
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person.

[Term]
id: DOID:8568 ! infectious mononucleosis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation, located_in pharynx, has_material_basis_in Human herpesvirus 4 and has_symptom fever, has_symptom fatigue, has_symptom lymphadenopathy, and has_symptom splenomegaly.

[Term]
id: DOID:8596 ! scarlet fever
is_a: DOID:974 ! upper respiratory tract disease
! An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash.

[Term]
id: DOID:8607 ! herpetic whitlow
is_a: DOID:8566 ! herpes simplex
! A herpes simplex that results_in infection located_in skin of the finger, toe, or thumb, has_material_basis_in Human herpesvirus 1 and has_material_basis_in Human herpesvirus 2 and has_symptom lesions, has_symptom fever, and has_symptom swollen lymph nodes.

[Term]
id: DOID:8618 ! oral cavity cancer
is_a: DOID:3119 ! gastrointestinal system cancer
! A gastrointestinal system cancer that is located_in the oral cavity.

[Term]
id: DOID:8622 ! measles
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash.

[Term]
id: DOID:863 ! nervous system disease
is_a: DOID:7 ! disease of anatomical entity
! A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system.

[Term]
id: DOID:8632 ! Kaposi's sarcoma
is_a: DOID:201 ! connective tissue cancer
! A connective tissue cancer  that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8).

[Term]
id: DOID:8659 ! chickenpox
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters.

[Term]
id: DOID:8670 ! eating disorder
is_a: DOID:0060038 ! specific developmental disorder
! A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health.

[Term]
id: DOID:8689 ! anorexia nervosa
is_a: DOID:8670 ! eating disorder
! An eating disorder characterized by refusal to maintain a healthy body weight, and an obsessive fear of gaining weight due to a distorted self image.

[Term]
id: DOID:870 ! neuropathy
is_a: DOID:863 ! nervous system disease
! A nervous system disease that is located_in nerves or nerve cells.

[Term]
id: DOID:8704 ! genital herpes
is_a: DOID:8566 ! herpes simplex
! A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands.

[Term]
id: DOID:8725 ! vascular dementia
is_a: DOID:1307 ! dementia
! A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain.

[Term]
id: DOID:8729 ! milker's nodule
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection of cattle and humans, located_in skin, has_material_basis_in Pseudocowpox virus, which is transmitted_by contact with the infected cow teats, or transmitted_by fomites. The infection results_in_formation_of lesions on the fingers, hands, and forearms and has_symptom fever, has_symptom lymphangitis, and has_symptom lymphadenopathy.

[Term]
id: DOID:873 ! anaerobic pneumonia
is_a: DOID:0050152 ! aspiration pneumonia
! An aspiration pneumonia caused by anaerobic bacteria like Bacteroides fragilis, Peptostreptococcus, anaerobic streptococci, Fusobacterium species (Fusobacterium nucleatum and Fusobacterium necrophoram). Lung abscess and empyema are diagnosed in this disease.

[Term]
id: DOID:8731 ! carotid body cancer
is_a: DOID:176 ! cardiovascular cancer
! A cardiovascular cancer that is characterized by an encapsulated, firm round mass at the bifurcation of the common carotid artery.

[Term]
id: DOID:8736 ! smallpox
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Variola virus, which is transmitted_by droplets from oral, nasal or pharyngeal mucosa, transmitted_by contact with the body fluids, or transmitted_by fomites. The infection results_in_formation_of lesions, first on the face, hands and forearms and later on the trunk.

[Term]
id: DOID:874 ! bacterial pneumonia
is_a: DOID:552 ! pneumonia
! A pneumonia involving inflammation of the lungs caused by bacteria.

[Term]
id: DOID:8761 ! megakaryocytic leukemia
is_a: DOID:1240 ! leukemia
! A leukemia that derives_from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers.

[Term]
id: DOID:8771 ! contagious pustular dermatitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis.

[Term]
id: DOID:8778 ! Crohn's disease
is_a: DOID:5295 ! intestinal disease
! An intestinal disease that involves inflammation located_in intestine.

[Term]
id: DOID:8781 ! rubella
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis.

[Term]
id: DOID:8867 ! molluscum contagiosum
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center.

[Term]
id: DOID:8912 ! tinea nigra
is_a: DOID:0050133 ! superficial mycosis
! A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions.

[Term]
id: DOID:8913 ! dermatophytosis
is_a: DOID:0050134 ! cutaneous mycosis
! A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source.

[Term]
id: DOID:8941 ! seborrheic infantile dermatitis
is_a: DOID:8741 ! seborrheic dermatitis
! A seborrheic dermatitis that involves fungal infection of the scalp of recently born babies caused by Malassezia furfur. It is occasionally linked to immune disorders. The symptoms include thick, crusty, yellow or brown scales over the child's scalp.

[Term]
id: DOID:8956 ! cowpox
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face.

[Term]
id: DOID:8970 ! subacute sclerosing panencephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection located_in brain, has_material_basis_in Measles virus which is immune resistant (which can be a result of a mutation of the virus itself).

[Term]
id: DOID:90 ! degenerative disc disease
is_a: DOID:0080007 ! bone deterioration disease
! A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc.

[Term]
id: DOID:9060 ! pityriasis versicolor
is_a: DOID:0050133 ! superficial mycosis
! A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales.

[Term]
id: DOID:9063 ! Ritter's disease
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability.

[Term]
id: DOID:9065 ! leishmaniasis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae).

[Term]
id: DOID:9111 ! cutaneous leishmaniasis
is_a: DOID:9065 ! leishmaniasis
! A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions.

[Term]
id: DOID:9113 ! granuloma inguinale
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers.

[Term]
id: DOID:9123 ! eczema herpeticum
is_a: DOID:8566 ! herpes simplex
! A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes.

[Term]
id: DOID:9146 ! visceral leishmaniasis
is_a: DOID:9065 ! leishmaniasis
! A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver.

[Term]
id: DOID:9153 ! variola minor
is_a: DOID:8736 ! smallpox
! A smallpox that results_in milder infection, located_in skin, has_material_basis_in Variola virus. The infection results_in_formation_of lesions.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
is_a: DOID:2985 ! chronic rejection of renal transplant
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9155 ! mucocutaneous leishmaniasis
is_a: DOID:9065 ! leishmaniasis
! A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa.

[Term]
id: DOID:9159 ! gas gangrene
is_a: DOID:0050339 ! commensal bacterial infectious disease
! A commensal bacterial infectious disease that results_in infection, located_in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has_symptom large blisters, has_symptom pain in the infected area, has_symptom myonecrosis, has_symptom gas production, and has_symptom sepsis.

[Term]
id: DOID:9181 ! amebiasis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs.

[Term]
id: DOID:9201 ! lichen planus
is_a: DOID:8574 ! lichen disease
! A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. The cause is not known.

[Term]
id: DOID:9210 ! geniculate herpes zoster
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache.

[Term]
id: DOID:9249 ! Beemer-Langer syndrome
is_a: DOID:225 ! syndrome
! A syndrome that results_in multiple congenital anomalies, including hydrops fetalis, facial and visceral abnormalities, short ribs, and short limbs without polydactyly.

[Term]
id: DOID:9250 ! acrocallosal syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation.

[Term]
id: DOID:9254 ! mast-cell leukemia
is_a: DOID:1240 ! leukemia
! A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood.

[Term]
id: DOID:9261 ! nasopharynx carcinoma
is_a: DOID:0050615 ! respiratory system cancer
! A respiratory system cancer that is located_in the nasopharynx, the uppermost region of the pharynx or "throat", where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.

[Term]
id: DOID:9269 ! maple syrup urine disease
is_a: DOID:0060159 ! organic acidemia
! An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures.

[Term]
id: DOID:9281 ! phenylketonuria
is_a: DOID:9252 ! amino acid metabolic disorder
! An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.

[Term]
id: DOID:9305 ! splenic tuberculosis
is_a: DOID:0050599 ! abdominal tuberculosis
! An abdominal tuberculosis that results_in formation of granulomas or abscesses located_in spleen.

[Term]
id: DOID:931 ! monieziasis
is_a: DOID:883 ! parasitic helminthiasis infectious disease
! A parasitic helminthiasis infectious disease that involves zoonotic infection caused by Moniezia expansa, the common tapeworm of sheep.

[Term]
id: DOID:9317 ! lymphangitis
is_a: DOID:75 ! lymphatic system disease
! A disease of lympoid system that results in inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning.

[Term]
id: DOID:934 ! viral infectious disease
is_a: DOID:0050117 ! disease by infectious agent
! A disease by infectious agent that results_in infection, has_material_basis_in Viruses.

[Term]
id: DOID:9360 ! intrinsic asthma
is_a: DOID:2841 ! asthma
! An asthma that is triggered by factors not related to allergies such as anxiety, stress, exercise, cold air, dry air, hyperventilation, smoke, viruses, chemical irritants, autonomic imbalance, hormonal deficiencies and psychogenic influences. It is characterized by airway obstruction and inflammation that is at least partially reversible with medication. The symptoms include coughing, wheezing, shortness of breath or rapid breathing, and chest tightness.

[Term]
id: DOID:9370 ! exophthalmos
is_a: DOID:5614 ! eye disease
! An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit.

[Term]
id: DOID:9392 ! tracheitis
is_a: DOID:3225 ! tracheal disease
! A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions.

[Term]
id: DOID:9395 ! croup
is_a: DOID:0050117 ! disease by infectious agent
! A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus.

[Term]
id: DOID:9415 ! allergic asthma
is_a: DOID:2841 ! asthma
! An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness.

[Term]
id: DOID:9463 ! otitis externa
is_a: DOID:2985 ! chronic rejection of renal transplant
! An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection.

[Term]
id: DOID:9463 ! otitis externa
is_a: DOID:379 ! external ear disease
! An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infection.

[Term]
id: DOID:9471 ! meningitis
is_a: DOID:0050117 ! disease by infectious agent
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
is_a: DOID:2985 ! chronic rejection of renal transplant
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9471 ! meningitis
is_a: DOID:9471 ! meningitis
! Meningitis is a nervous system infectious disease characterized as an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. Meningitis is a diffuse infection caused by a variety of different agents.

[Term]
id: DOID:9537 ! Lassa fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding.

[Term]
id: DOID:9538 ! multiple myeloma
is_a: DOID:0070004 ! myeloma
! A myeloma that is located_in the plasma cells in bone marrow.

[Term]
id: DOID:9551 ! smoldering myeloma
is_a: DOID:9538 ! multiple myeloma
! A multiple myeloma that is a slow growing type of myeloma in which abnormal plasma cells results_in too much of a single type of monoclonal antibody.

[Term]
id: DOID:9553 ! adrenal gland disease
is_a: DOID:28 ! endocrine system disease
! An endocrine system disease that is located_in the adrenal gland.

[Term]
id: DOID:9563 ! bronchiectasis
is_a: DOID:1176 ! bronchial disease
! A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances.

[Term]
id: DOID:9577 ! neonatal candidiasis
is_a: DOID:1508 ! candidiasis
! A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates.

[Term]
id: DOID:9584 ! Venezuelan equine encephalitis
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region.

[Term]
id: DOID:96 ! staphyloenterotoxemia
is_a: DOID:0050338 ! primary bacterial infectious disease
! A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness.

[Term]
id: DOID:9640 ! sarcocystosis
is_a: DOID:2113 ! coccidiosis
! A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy.

[Term]
id: DOID:9643 ! babesiosis
is_a: DOID:2789 ! parasitic protozoa infectious disease
! A parasitic protozoa infectious disease that has_symptommild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease.

[Term]
id: DOID:9667 ! placental abruption
is_a: DOID:780 ! placenta disease
! A placenta disease that is characterized by separation of the placental lining from the uterus of the mother.

[Term]
id: DOID:9681 ! cervical incompetence
is_a: DOID:2253 ! cervix disease
! A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term.

[Term]
id: DOID:9682 ! yellow fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that results_in infection, has_material_basis_in Yellow fever virus, which is transmitted_by Aedes, transmitted_by Haemagogus, or transmitted_by Sabethes species of mosquitoes. The infection has_symptom fever, has_symptom muscle pain, has_symptom backache, has_symptom headache, has_symptom shivers, has_symptom loss of appetite, has_symptom jaundice, and has_symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

[Term]
id: DOID:9733 ! renal tuberculosis
is_a: DOID:2149 ! urogenital tuberculosis
! An urogenital tuberculosis that results_in formation of granulomas located_in kidney.

[Term]
id: DOID:9735 ! acute allergic mucoid otitis media
is_a: DOID:9736 ! blue drum syndrome
! A blue drum syndrome caused by an allergen.

[Term]
id: DOID:9744 ! type 1 diabetes mellitus
is_a: DOID:9351 ! diabetes mellitus
! A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas.

[Term]
id: DOID:9765 ! emphysematous cholecystitis
is_a: DOID:104 ! bacterial infectious disease
! Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues.

[Term]
id: DOID:9765 ! emphysematous cholecystitis
is_a: DOID:9765 ! emphysematous cholecystitis
! Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues.

[Term]
id: DOID:9778 ! irritable bowel syndrome
is_a: DOID:225 ! syndrome
! A syndrome that is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.

[Term]
id: DOID:9786 ! bulbar polio
is_a: DOID:0050515 ! paralytic poliomyelitis
! A paralytic poliomyelitis that results_in destruction located_in motor neurons of brainstem, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted_by ingestion of food or water contaminated with feces, or transmitted_by direct contact with the oral secretions. The infection has_symptom difficulty breathing, has_symptom difficulty speaking, has_symptom difficulty swallowing, and has_symptom difficulty chewing.

[Term]
id: DOID:9801 ! tuberculous peritonitis
is_a: DOID:404 ! gastrointestinal tuberculosis
! A gastrointestinal tuberculosis that results_in inflammation located_in peritoneum, which results in formation of tubercles. The infection has_symptom abdominal discomfort, has_symptom pain, has_symptom distention from gas or fluid, has_symptom digestive disturbances and has_symptom emaciation.

[Term]
id: DOID:9808 ! Goodpasture syndrome
is_a: DOID:417 ! hypersensitivity reaction type II disease
! An autoimmune disease that is characterized by glomerulonephritis located_in kidney and hemorrhaging located_in lung.

[Term]
id: DOID:9828 ! neonatal abstinence syndrome
is_a: DOID:0060001 ! withdrawal disorder
! A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment.

[Term]
id: DOID:9856 ! congenital syphilis
is_a: DOID:4166 ! syphilis
! A syphilis that results_in a multisystem infection in the fetus via the placenta.

[Term]
id: DOID:9880 ! cardiovascular syphilis
is_a: DOID:8200 ! tertiary syphilis
! A tertiary syphilis that is manifested as aneurysm formation in the ascending aorta, caused by chronic inflammatory destruction of the vasa vasorum, insufficiency of the aortic valve, or narrowing of the coronary arteries.

[Term]
id: DOID:9909 ! hordeolum
is_a: DOID:9909 ! hordeolum
! Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
is_a: DOID:1301 ! RNA virus infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:992 ! Omsk hemorrhagic fever
is_a: DOID:934 ! viral infectious disease
! A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Omsk hemorrhagic fever virus, which is transmitted_by Dermacentor and transmitted_by Ixodes species of ticks. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom pain in lower and upper extremities, has_symptom stiff neck, has_symptom papulovesicular rash on the soft palate, has_symptom cervical lymphadenopathy, has_symptom conjunctival suffusion, has_symptom blood in the urine, and has_symptom blood in the sputum.

[Term]
id: DOID:9931 ! Waterhouse-Friderichsen syndrome
is_a: DOID:9552 ! adrenal gland hypofunction
! A meningococcal meningitis described as an adrenal gland hypofunction disease functionally, resulting from a meningococcal infection caused by the bacterium Neisseria meningitidis, which is characterized by hemorrhages in the adrenal glands, usually observed in severe cases of meningitis. Infection can also be caused by Streptococcus pneumoniae infection. Staphylococcus aureus has recently also been implicated in pediatric WFS. The symptoms include fever, rigors, vomiting, headache, rash, hypotension and septic shock.

[Term]
id: DOID:9931 ! Waterhouse-Friderichsen syndrome
is_a: DOID:9929 ! meningococcal meningitis
! A meningococcal meningitis described as an adrenal gland hypofunction disease functionally, resulting from a meningococcal infection caused by the bacterium Neisseria meningitidis, which is characterized by hemorrhages in the adrenal glands, usually observed in severe cases of meningitis. Infection can also be caused by Streptococcus pneumoniae infection. Staphylococcus aureus has recently also been implicated in pediatric WFS. The symptoms include fever, rigors, vomiting, headache, rash, hypotension and septic shock.

[Term]
id: DOID:9965 ! toxoplasmosis
is_a: DOID:2113 ! coccidiosis
! A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia.

[Term]
id: DOID:9988 ! tertiary neurosyphilis
is_a: DOID:8200 ! tertiary syphilis
! A tertiary syphilis that results_in infection located_in brain or located_in spinal cord.