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Removing effect of being on second line on adherence #285

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May 9, 2024
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Removing effect of being on second line on adherence #285

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13 changes: 4 additions & 9 deletions hiv_synthesis.sas
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Original file line number Diff line number Diff line change
Expand Up @@ -522,8 +522,7 @@ newp_seed = 7;
* reduced adherence in those with toxicity;
* add_eff_adh_nnrti; add_eff_adh_nnrti=round(0.10* exp(rand('normal')*0.30),.01);
* additional "effective" adh of nnrti due to longer half life;
* altered_adh_sec_line_pop; altered_adh_sec_line_pop = round(0.05 +(rand('normal')*0.05),.01);
* better adherence on second line (pi);

* adh_effect_of_meas_alert; %sample(adh_effect_of_meas_alert, 0.35 0.70 0.90, 0.15 0.7 0.15);
* poorer_cd4rise_fail_nn; poorer_cd4rise_fail_nn = round(-6 + (3 * rand('normal')),1);
* adjustment to degree of cd4 change for being on nnrti not pi when nactive <= 2 ;
Expand Down Expand Up @@ -1917,10 +1916,6 @@ if h < adh_effect_of_meas_alert then do;
end;


* ALTERED ADHERENCE SECOND LINE;

altered_adh_sec_line = altered_adh_sec_line_pop * exp(rand('normal')*1.0); altered_adh_sec_line = round(altered_adh_sec_line,0.01);

* effect of tox on adherence differs by individual;
red_adh_tox = red_adh_tox_pop * exp(rand('normal')*0.3); red_adh_tox=round(red_adh_tox,.01);

Expand Down Expand Up @@ -8983,7 +8978,7 @@ if o_nev=1 and p_nev_tm1 ne 1 then date_start_nev = caldate{t};
r=rand('uniform'); if c_tox_tm1=1 and r < 0.5 then adh=adh-red_adh_tox;

* reduced adherence if regimen is not 1 pill once a day - red_adh_multi_pill;
if o_zdv = 1 or o_taz = 1 or o_lpr = 1 then adh = adh - red_adh_multi_pill ;
if o_zdv = 1 or o_taz = 1 or o_lpr = 1 or o_dar = 1 then adh = adh - red_adh_multi_pill ;


* poorer "adherence" (lower drug levels) if have "current" tb or adc;
Expand Down Expand Up @@ -19133,7 +19128,7 @@ pr_art_init rate_lost prob_lost_art rate_return rate_restart rate_int_choic
rate_ch_art_init_str_10 rate_ch_art_init_str_3 clinic_not_aw_int_frac reg_option_104 ind_effect_art_hiv_disease_death incr_adh_poc_vl
res_trans_factor_nn res_trans_factor_ii rate_loss_persistence incr_rate_int_low_adh poorer_cd4rise_fail_nn
poorer_cd4rise_fail_ii rate_res_ten fold_change_mut_risk adh_effect_of_meas_alert pr_switch_line
prob_vl_meas_done red_adh_tb_adc red_adh_tox_pop red_adh_multi_pill_pop add_eff_adh_nnrti altered_adh_sec_line_pop prob_return_adc
prob_vl_meas_done red_adh_tb_adc red_adh_tox_pop red_adh_multi_pill_pop add_eff_adh_nnrti prob_return_adc
prob_lossdiag_adctb prob_lossdiag_non_tb_who3e higher_newp_less_engagement fold_tr switch_for_tox
rate_test_startprep_any rate_choose_stop_prep_oral prob_prep_oral_b circ_inc_rate circ_red_10_14 circ_inc_15_19 circ_red_20_30 circ_red_30_50
p_hard_reach_w hard_reach_higher_in_men p_hard_reach_m inc_cat base_rate_sw
Expand Down Expand Up @@ -21079,7 +21074,7 @@ pr_art_init rate_lost prob_lost_art rate_return rate_restart rate_int_choic
rate_ch_art_init_str_10 rate_ch_art_init_str_3 clinic_not_aw_int_frac reg_option_104 ind_effect_art_hiv_disease_death incr_adh_poc_vl
res_trans_factor_nn res_trans_factor_ii rate_loss_persistence incr_rate_int_low_adh poorer_cd4rise_fail_nn
poorer_cd4rise_fail_ii rate_res_ten fold_change_mut_risk adh_effect_of_meas_alert pr_switch_line
prob_vl_meas_done red_adh_tb_adc red_adh_tox_pop red_adh_multi_pill_pop add_eff_adh_nnrti altered_adh_sec_line_pop prob_return_adc
prob_vl_meas_done red_adh_tb_adc red_adh_tox_pop red_adh_multi_pill_pop add_eff_adh_nnrti prob_return_adc
prob_lossdiag_adctb prob_lossdiag_non_tb_who3e higher_newp_less_engagement fold_tr switch_for_tox
rate_test_startprep_any rate_choose_stop_prep_oral prob_prep_oral_b circ_inc_rate circ_red_10_14 circ_inc_15_19 circ_red_20_30 circ_red_30_50
p_hard_reach_w hard_reach_higher_in_men p_hard_reach_m inc_cat base_rate_sw
Expand Down
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