Skip to content

Commit

Permalink
update readme and release v0.4.2
Browse files Browse the repository at this point in the history
  • Loading branch information
Zilong-Li committed Feb 21, 2024
1 parent 237ccfd commit d698008
Show file tree
Hide file tree
Showing 2 changed files with 9 additions and 5 deletions.
3 changes: 2 additions & 1 deletion CHANGELOG.org
Original file line number Diff line number Diff line change
@@ -1,6 +1,7 @@
- v0.4.2
- fix slowness due to the ld logics

- add ld-clump functions

- v0.4.1
- fix ld windows
- keep sites with higher maf in /prune.in/
Expand Down
11 changes: 7 additions & 4 deletions README.org
Original file line number Diff line number Diff line change
Expand Up @@ -37,7 +37,7 @@ PCAone is a fast and memory efficient PCA tool implemented in C++ aiming at prov
- [[#output-files][Output files]]
- [[#running-mode][Running mode]]
- [[#normalization][Normalization]]
- [[#ld-prune][LD prune]]
- [[#ld-pruning-and-clumping][LD pruning and clumping]]
- [[#examples][Examples]]
- [[#citation][Citation]]
- [[#acknowledgements][Acknowledgements]]
Expand Down Expand Up @@ -269,12 +269,15 @@ PCAone will automatically apply the standard normalization for genetic data. Add
- 2: do count per median log transformation (usually for single cell RNA-seq data)
One should choose proper normalization method for specific type of data.

** LD prune
** LD pruning and clumping

This is a novel LD prune method on admixed population. For more details, see our paper.
This is a novel statistics on LD calculation in admixed population. For more details, see our paper.

#+begin_src shell
PCAone -b plink -k 3 -n 20 --svd 0 --ld-r2 0.8 --ld-window 1000000 --maf 0.05
# pruning
PCAone -b plink -k 3 --ld-r2 0.8 --ld-bp 1000000 --maf 0.05
# clumping
PCAone -b plink -k 3 --clump plink.assoc --clump-p1 0.0001 --clump-p2 0.01 --clump-r2 0.5 --maf 0.05
#+end_src

** Examples
Expand Down

0 comments on commit d698008

Please sign in to comment.