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Add eLife assessment to a reviewed preprint example
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davidcmoulton committed Jan 8, 2025
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}
}
},
"elifeAssessment": {
"title": "eLife assessment",
"id": "sa0",
"doi": "10.7554/eLife.09562.sa00",
"content": [
{
"type": "paragraph",
"text": "Collagen is a major component of extracellular matrix. The authors have identified a high-affinity inhibitory collagen receptor LAIR-1 and a soluble decoy receptor LAIR-2 (with even higher binding affinity to collagen), which can be therapeutically targeted to block tumor progression. Dr Meyaard and colleagues have also generated a dimeric LAIR-2 human IgG1 Fc fusion protein NC410 for therapeutic use. With humanized mouse models engrafted with functional human immune systems (PBMC), they have explored the anti-cancer efficacy of NC410 and revealed its impact on modulating immune responses. Furthermore, they extended this study to identify biomarkers of predictive value for NC410-based anti-cancer therapy."
}
],
"significance": [
"important"
],
"strength": [
"solid"
]
},
"version": 1
}

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